OSTEOARTHRITIS

This study looks at how well the Incompass Total Ankle System works and how safe it is for people with ankle arthritis. About 200 adults who need ankle replacement surgery will be followed for a few years. Researchers will review X-rays and ask patients about pain and daily activ…

This study tests whether giving a nutritional drink to patients who are malnourished before hip or knee replacement surgery can improve their blood markers of nutrition. The study will enroll 72 adults aged 55 to 95 who are scheduled for joint replacement. Researchers will measur…

This study compares SPECT-CT and MRI scans to see which is better at diagnosing painful osteoarthritis in the ankle, hindfoot, and midfoot. Researchers will enroll 132 adults with suspected arthritis and measure how accurately each scan detects the condition. The goal is to impro…

This study aims to develop faster and more reliable MRI scans to detect early signs of osteoarthritis and other joint diseases before they show up on X-rays. Researchers will test these new methods on 88 healthy volunteers and patients with ACL tears or early cartilage problems a…

This study tests whether sending information and making two phone calls can encourage older adults with osteoarthritis to join SilverSneakers exercise programs. About 1,454 seniors across the U.S. who have free access but haven't used it will be followed for two years. The goal i…

This study tests whether a treatment made from a patient's own cells can safely reduce pain and inflammation from hip osteoarthritis. Researchers will track changes in pain, movement, and quality of life in up to 4,000 adults aged 18 to 90. The goal is to ease symptoms, not cure …

This study tests a once-daily pill called orforglipron in 800 people with knee osteoarthritis who are overweight or have obesity. The goal is to see if it reduces knee pain and improves physical function compared to a placebo. Participants will be in the study for about 74 weeks.

This study tests a 6-month mobile program that combines physical activity, healthy eating, and group support to help older adults with knee or hip arthritis reduce pain and improve daily function. Two hundred participants aged 65+ will be randomly assigned to the program or usual…

This phase 3 study tests a once-weekly injection called eloralintide in 900 adults who have both osteoarthritis of the knee and obesity or overweight. The goal is to see if the drug reduces knee pain and body weight compared to a placebo. Participants will be in the study for abo…

This study tests whether injecting Botox into the thumb joint can reduce pain and improve hand function in people with base-of-thumb osteoarthritis. 120 adults with moderate to severe thumb pain will receive either Botox, a mix of Botox and saline, or plain saline injections, plu…

This study tests whether a treatment made from a patient's own cells can safely reduce pain and swelling from shoulder osteoarthritis. Researchers will first treat 50 people, then expand to 4,000. The goal is to see if the therapy helps with daily activities and possibly rebuilds…

This study is testing whether a treatment made from a patient's own cells can safely reduce pain and inflammation caused by knee osteoarthritis. Researchers will first try it in 50 people, then expand to about 4,000. They will use knee surveys, pain scales, and MRI scans to see i…

This study tests whether ThermaCare Knee Heatwraps can reduce knee pain in people with moderate osteoarthritis. About 80 adults aged 19-69 will wear the wraps for 8 hours a day over 7 days. The main goal is to see if pain levels drop after 3 days of treatment, measured using a si…

This study tests a new treatment called OA-SYS for people with moderate to severe knee osteoarthritis. The main goal is to see if it is safe and well-tolerated. Researchers will also check if it reduces pain and the need for pain relievers. About 400 adults aged 35 to 75 with kne…

This study compares two advanced technologies used during total knee replacement surgery: computer-assisted navigation and robotic-arm assistance. The goal is to see which method helps patients feel less aware of their artificial knee and improves daily function. About 140 adults…

This study looks at whether low-impact group exercise classes, combined with standard dietitian and behavioral health visits, can lower pain scores in adults with knee, hip, or ankle osteoarthritis. About 10,000 participants aged 18 and older will attend classes three times a wee…

This study tests whether an injection made from donated amniotic tissue can reduce pain and improve knee function in people with knee osteoarthritis. About 160 adults with moderate knee arthritis will receive either the amniotic injection, a standard hyaluronic acid injection, or…

This study tests two ways to help people with osteoarthritis manage their pain: sending text messages to encourage physical activity counseling, and supporting them to join a walking program called Walk with Ease. The goal is to see which approach works best for people in communi…

This study looks at how 45, 90, or 150 minutes of physical activity each week affects arthritis symptoms like pain and mobility. Researchers will track changes in walking distance and other physical functions. The goal is to find the most effective amount of exercise for people w…

This study tests whether high-intensity pulsed electromagnetic field therapy can reduce pain and improve strength in older adults with knee osteoarthritis. About 64 people aged 60 and older will receive the therapy on their knee or both knee and thigh, plus a home exercise progra…

This study looks at 100 people aged 40-60 with mild hip problems like arthritis or labral tears. It compares getting a combined steroid and hyaluronic acid injection alone versus the same injection plus physiotherapy. The goal is to see if adding physiotherapy leads to better pai…

This study tests an investigational drug called ALT001 for knee osteoarthritis. About 30 adults aged 50 to 75 will receive either a low dose, high dose, or placebo injection into the knee every two weeks for six doses. The goal is to see if it reduces pain, improves joint functio…

This early study tests if a procedure called arterial embolization, using a substance called Lipiodol, is safe for people with painful hand osteoarthritis that hasn't improved with standard treatments. Fifteen participants will receive the procedure and be monitored for 6 months …

This study tests whether a supplement made from boswellia, turmeric, and grape extracts can reduce pain and stiffness in adults with knee or hip osteoarthritis. Thirty participants will take the supplement and a placebo for four weeks each, then report their symptoms. The goal is…

This study compares a new hydrogel injection (Arthrosamid) to a standard steroid shot for treating knee osteoarthritis. About 200 adults with knee pain and arthritis will receive one of the two injections and be followed for up to a year. The goal is to see if the hydrogel provid…

This study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. It blocks abnormal blood vessels in the knee to reduce pain and improve function. Twenty adults aged 40–70 will be randomly assigned to get the procedure plus …

This study tests whether CartiPRO, an approved collagen injection, can safely reduce knee pain in people with osteoarthritis or cartilage damage. About 194 adults will receive two injections 24 weeks apart. Researchers will measure pain, knee function, and quality of life over 36…

This study looks at how accurately surgeons can place a new hip cup using a non-invasive navigation system during total hip replacement. About 118 adults with hip conditions like arthritis or avascular necrosis will take part. The goal is to see if the system helps achieve the pl…

This study aims to create an AI tool that can predict a person's risk of developing five common diseases: type 2 diabetes, heart disease, breast cancer, low back pain, and osteoarthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical reco…

This study tests whether platelet-rich plasma (PRP) injections into the knee change certain proteins in the blood of people with knee osteoarthritis. About 60 participants, ages 18 to 70, will receive either PRP or a saltwater placebo injection, and researchers will compare prote…

This study looks at how the brain and nerves contribute to long-term muscle and joint pain, such as arthritis, fibromyalgia, and back pain. Researchers will use a simple questionnaire and pain sensitivity tests to see if they can better diagnose and guide treatment. About 250 adu…

This study looks at whether a 3-month virtual program called Choose to Move Replacement Ready is practical for people waiting for hip or knee replacement surgery due to osteoarthritis. About 60 participants will answer surveys and interviews about their activity, pain, and well-b…

This study looks at whether a type of artificial intelligence (AI) can help doctors better identify complications in people with rheumatoid arthritis (RA). Researchers will use AI to suggest possible complications from patient records and see if doctors agree with and use those s…

This study will follow 10,000 people who are having hip or knee replacement surgery to see how they recover and how well their new joints work over time. Participants will fill out surveys about pain, function, and satisfaction before and after surgery. The goal is to learn what …