OSTEOARTHRITIS

This study follows 737 people who received a Persona knee replacement to see how well the implant works over time. Participants had severe knee pain from conditions like arthritis or injury. The goal is to measure implant survival and improve knee function.

This study looks at how well a new knee replacement system works for people with painful knee conditions like arthritis or previous knee surgery failure. About 255 participants will get the new system and be followed for up to 10 years. The goal is to see if it improves knee alig…

This study follows 200 adults getting a shoulder replacement with the Zimmer Trabecular Metal Reverse Shoulder System. It aims to see how long the implant lasts and how well it relieves pain and improves function in people with arthritis, fractures, or failed prior shoulder repla…

This study looks at whether giving a single high dose of vitamin D to patients with low levels before hip or knee replacement surgery can lower the chance of problems like infection. About 200 adults with osteoarthritis and low vitamin D will take part. Researchers will track inf…

This study compares two types of total knee replacements: one that uses bone cement to hold the implant in place and one that does not. The goal is to see which approach provides better pain relief, function, and implant survival over time. About 300 people with knee pain from ar…

This study follows 777 people aged 18-75 who received a Persona knee implant to treat severe knee pain or disability from conditions like osteoarthritis or rheumatoid arthritis. Researchers are checking how long the implant lasts, how safe it is, and how well it improves pain and…

This study aimed to test whether a single injection of a person's own fat-derived cells (stromal vascular fraction) could safely treat knee arthritis caused by a past injury. It was designed for adults aged 18-45 with moderate knee arthritis and significant pain. However, the tri…

This study looks at how well a knee replacement system works for people with arthritis or knee damage. About 299 patients received the implant to see if it reduces pain and helps them move better. The goal is to show that the implant lasts and improves daily life.

This study looked at how well a metal plate (A.L.P.S. Proximal Humerus Plating System) works for fixing broken upper arm bones. It included 135 adults who needed surgery for a fresh fracture. The main goal was to see how many people needed another surgery within a year due to pro…

This study is checking how safe and well a new shoulder implant, the Sidus Stem-Free Shoulder, works for people with severe shoulder arthritis. About 152 people who need a shoulder replacement are taking part. The study looks at pain, movement, and quality of life after surgery.

This study is testing a new knee implant called Persona Ti-Nidium in 240 adults who need a total knee replacement due to arthritis or other knee problems. The goal is to see if the implant is safe and helps people move better and feel less pain. Participants will have surgery and…

This study looks at how well a new hip replacement system, called CATALYSTEM, works in 119 people who need a total hip replacement. The main goal is to check if the implant stays in place without problems two years after surgery. The study includes patients with conditions like a…

This study looks at whether different types of resistance exercise (like lifting weights) can help prevent osteoporosis (weak bones) and osteoarthritis (joint pain) in women aged 50 to 70 who have gone through menopause. Researchers will measure changes in bone density, muscle si…

This study looks at how well a new cementless knee replacement works for people with osteoarthritis. About 540 adults aged 22 to 80 will get the implant and report their ability to do daily activities over two years. The goal is to see if the implant improves function and reduces…

This study follows 40 adults aged 55 and older with osteoarthritis who are receiving low-dose radiation as part of their usual care. Researchers will track changes in pain, function, and quality of life over a year to see if this treatment helps when other options haven't worked.…

This study tests whether turmeric capsules can lower inflammation and pain in adults with knee osteoarthritis. 72 participants will take either turmeric or a placebo daily for 3 weeks, tracking symptoms and painkiller use. The goal is to see if turmeric improves inflammatory mark…

This study tests whether shortwave diathermy, a type of deep heat therapy, can reduce pain and improve hand function in people with hand osteoarthritis. 36 adults aged 35-75 with hand osteoarthritis will receive either real or placebo shortwave treatments. Researchers will measur…

This study compares a newer, muscle-sparing surgical approach for total shoulder replacement to the traditional method in 108 adults with arthritis. The goal is to see if the newer technique leads to better shoulder function and tendon health after surgery. Participants are rando…

This study tests whether gloves embedded with semiconductors can reduce pain and improve hand function in people with hand osteoarthritis. About 140 adults aged 40–75 with confirmed hand OA will wear either the active gloves or a placebo version. Researchers will measure changes …

This study tests a new procedure called genicular artery embolization using SakuraBead, a dissolvable bead that blocks small blood vessels in the knee to reduce pain. It involves 89 adults aged 40-79 with moderate to severe knee osteoarthritis that hasn't improved with standard t…

This study tests whether gentle electrical and ultrasound brain stimulation can reduce pain and improve daily function in people with knee osteoarthritis. About 64 adults with chronic knee pain will receive either real or fake (sham) stimulation to see if it lowers pain scores. T…

This study aimed to test a new pain management procedure for people with chronic knee pain who cannot have surgery. The treatment involved injecting doxycycline into certain blood vessels around the knee to reduce pain. However, the study was withdrawn before any participants wer…

This study looks at whether an AI chatbot can help people with hip or knee osteoarthritis feel less anxious and more confident when making treatment decisions. About 100 adults will chat with the AI before their regular surgeon visit. Researchers will measure changes in decision-…

This study looks at two different designs for knee replacement implants: one made entirely of a special plastic and another with a metal backing. Researchers want to see which one moves less inside the bone over two years, using a precise X-ray technique. About 60 people with kne…

This study is creating a collection of joint fluid samples from 149 adults with osteoarthritis or pre-arthritis. Researchers will analyze these samples for biomarkers that might help diagnose the disease earlier or track its progression. The goal is to better understand how osteo…

This study is watching 230 adults who get a G7 hip replacement system to see how long the implant lasts and how well it works. It includes people with hip arthritis or other joint damage. The goal is to gather real-world data on implant survival and patient recovery, not to test …

This study follows 757 people who received a Persona Partial Knee System to treat knee arthritis, bone death, or certain knee injuries. The goal is to see how long the implant lasts and how well patients function afterward. Participants complete questionnaires about their knee fu…

This study looks at whether a new way of paying for healthcare, called bundled payments, improves quality and lowers costs. Researchers will analyze Medicare data from 440 provider organizations for common conditions like osteoarthritis and pneumonia. The goal is to see if this p…

This study looks at how knee osteoarthritis (KOA) impacts daily activities and quality of life in 100 adults aged 45 to 75. Researchers will use both questionnaires and simple physical tests like walking and standing to better understand knee function. The goal is to improve how …

This study is building a large national registry of 30,000 people who are scheduled for hip or knee replacement surgery. The goal is to collect information on pain, physical function, and any complications before and after surgery. By analyzing this data, researchers hope to find…

This study collects information on how well a shoulder replacement implant works over time in about 194 people. It includes patients with arthritis, bone death, or previous failed treatments. The goal is to track implant survival and shoulder function for up to 10 years after sur…