Centre Hospitalier Universitaire, Amiens

This study compares two antibiotics, clarithromycin and azithromycin, for treating MAC lung infections, a serious bacterial lung disease. About 424 adults with MAC infection will receive one of the two drugs alongside standard treatments. The goal is to see if azithromycin works …

This study is for people who have severe facial injuries that cannot be fixed with standard surgery. Researchers will perform face transplants on 5 patients and check how well they regain the ability to close their mouth and feel touch, heat, and cold. To help the body accept the…

This study tests whether adding an inhaled antibiotic (amikacin liposome suspension) to standard care helps clear M. xenopi bacteria from the lungs faster. About 190 adults with this rare, hard-to-treat lung infection will receive either standard treatment alone or standard treat…

This study looks at people with a severe leaky heart valve (mitral regurgitation) who have no symptoms yet. It compares having surgery early to fix the valve versus waiting and monitoring the condition. The goal is to see which approach leads to fewer deaths or serious heart prob…

This study tests whether giving two steroids (hydrocortisone and fludrocortisone) to high-risk patients before heart surgery can lower the chance of serious complications like kidney injury and lung problems. The trial will include 196 adults with a EuroSCORE II above 4% who are …

This study tests whether sirolimus, a drug used to prevent organ rejection, can shrink severe arteriovenous malformations (AVMs) and ease symptoms. About 50 people aged 2 and older with advanced AVMs will take the drug for a year. The goal is to see if the drug reduces AVM size b…

This study tests a new way to give a common water pill (furosemide) to heart surgery patients who have too much fluid in their body. Doctors will use a simple urine test to decide the right dose, instead of guessing. The goal is to remove fluid more safely and effectively, which …

This study looks at whether certain DNA changes in saliva can help diagnose oral cancer (squamous cell carcinoma) more accurately. Researchers will collect saliva from 30 patients with oral cancer before and after surgery, and compare it to saliva from people without cancer. The …

This study tests whether a smartwatch can find hidden, symptom-free atrial fibrillation (AFib) in people who recently had heart surgery. About 324 adults will either use a smartwatch to record their heart's rhythm or receive standard monitoring for the first five days after leavi…

This study is testing whether a blood test measuring a protein called p-Tau217 can diagnose Alzheimer's disease as accurately as the current method, which requires a spinal tap. Researchers will compare results from blood and spinal fluid samples from 40 adults with suspected Alz…

This study tests whether adding an early PET scan right after the radioactive tracer is injected can better tell the difference between a brain tumor coming back and damage from radiation therapy. About 50 adults with brain metastases who already need a PET scan will get an extra…

This study compares a new, faster MRI that uses artificial intelligence to a standard MRI for measuring how well the heart pumps blood. It involves 61 adults with thickened heart muscle (left ventricular hypertrophy). The goal is to see if the faster method gives equally accurate…

This study tests whether an intelligent video system that automatically detects falls can reduce hospital visits better than a standard button-based alarm. About 395 adults aged 75+ who are at risk of falling will be followed for 90 days after returning home. The goal is to see i…

This study tests whether attaching a small cap to the endoscope helps doctors find and treat the source of upper stomach bleeding more quickly. About 72 adults with severe bleeding will be randomly assigned to standard endoscopy or cap-assisted endoscopy. The goal is to see if th…

This study tests whether extra nutrition support before and after surgery helps head and neck cancer patients avoid weight loss. Sixty adults having surgery for head and neck cancer will be split into two groups: one gets standard care, the other gets personalized diet advice, a …

This study tests whether a virtual reality headset playing hypnotic scenarios can reduce anxiety, pain, and resistance during hygiene care for people with Alzheimer's or related disorders who become agitated or oppositional. Researchers will compare VR-assisted care to standard c…

This study compares two relaxation tools—special glasses (Psio) and a virtual reality headset—against no relaxation tool to see which best reduces anxiety before orthopedic surgery. About 632 adults will be randomly assigned to one of the three groups. The goal is to improve pati…

This study looks at whether using a handheld breathing device (oscillating PEP) helps children (ages 8+) and adults with bronchiectasis feel better day-to-day. Researchers will ask 60 participants about their quality of life before and after using the device. The goal is to see i…

This study looks at whether hypnosis can help reduce anxiety in people having face surgery with local anesthesia. About 66 adults will be split into two groups: one gets standard care, the other gets hypnosis support. Researchers will measure anxiety levels before and after surge…

This study looks at whether using a co-dodo crib (a bedside sleeper) helps breastfeeding mothers and their newborns sleep better and bond more closely, compared to a standard crib. About 132 mothers and their full-term babies will be randomly assigned to use either a co-dodo or s…

This study compares two treatments for children with overactive bladder (OAB) of unknown cause: the standard medication oxybutynin and a nerve stimulation therapy (PTNS). About 124 children aged 6 to 16 will be randomly assigned to one treatment for three months. The goal is to s…

This study tests whether giving a long-acting inhaled medication before and after lung cancer surgery can lower the chance of serious lung complications. It includes 266 adults with lung cancer who are at high risk for these problems. Participants will receive the inhaled treatme…

This study tests whether using a virtual reality (VR) program can reduce discomfort for patients in the surgical intensive care unit (ICU) after major heart, lung, or abdominal surgery. About 194 adults will be randomly assigned to either receive VR sessions twice a day during th…

This study compares a newer type of nerve block (serratus plane block) to standard local anesthesia for pain control during chest tube placement in intensive care patients. About 70 awake, non-intubated adults will be enrolled. The goal is to see if the nerve block reduces pain s…

This study aims to develop a way to measure facial muscles using MRI scans in people with facial paralysis. Currently, doctors rely on subjective scales to assess muscle function, but this method could provide objective measurements like muscle thickness and volume. The goal is t…

This study looks at a protein called annexin A2 on the surface of certain white blood cells (monocytes) in people with antiphospholipid syndrome, a condition that raises the risk of blood clots and pregnancy complications. Researchers will compare the amount of this protein betwe…

This study looks at how blood sugar levels change throughout the day in women with polycystic ovary syndrome (PCOS). PCOS is common and can raise the risk of diabetes, but not all types of PCOS are the same. Researchers will use a small sensor to track glucose for several days in…

This study looks at how a newborn's brain and blood flow work together in the first minutes after birth. Researchers will place a small patch on the baby's scalp to measure brain activity and oxygen levels. The goal is to learn more about how babies adjust to life outside the wom…

This study looks at cancer patients who have a superficial vein clot (a clot just under the skin). Since there are no clear guidelines for treating these patients, doctors want to see which blood thinner treatments work best in everyday practice. About 1,576 adults with active ca…

This study explores how targeted brain stimulation can improve movement speed in people who have had a stroke. Researchers will first test healthy volunteers to map brain areas linked to reaction time, then apply a specific stimulation pattern to stroke patients. The goal is to u…

This study looks at whether stopping antibiotics early is safe for people 65 and older who are in the hospital for a viral lung infection. Many older patients get antibiotics even when they don't have a bacterial infection, which can cause side effects. The researchers will compa…

This study looks at eye problems in people with craniosynostosis, a condition where skull bones close too early. Researchers will check for issues like crossed eyes, lazy eye, and pressure inside the head. The goal is to better understand these eye problems to help improve care.

This study looks at how pesticides and the bacteria living in the gut and reproductive organs may be linked to infertility in women with endometriosis. Researchers will measure DNA damage and compare these factors between 160 women with and without the condition. The goal is to f…

This study looks at how narcolepsy (types 1 and 2) and idiopathic hypersomnia affect social thinking and decision-making. Researchers will test 75 adults using computer tasks and questionnaires. The goal is to better understand these conditions and guide future therapies.

This study follows 945 women with Crohn's disease or ulcerative colitis to see how pregnancy affects their condition. Researchers will track disease flares during pregnancy, after childbirth, and while breastfeeding. The goal is to better understand and manage IBD in women of chi…

This study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, weakens the immune system over time. Researchers will measure immune markers in 24 patients before and after 6 and 12 months of treatment. The goal is to understand infection risks in th…

This study looks at whether measuring the function of the right upper heart chamber using ultrasound can help predict who will develop an irregular heartbeat after heart surgery. About 334 adults having planned bypass surgery will be enrolled. The goal is to see if changes in thi…

This study looks at whether taking a hot bath before or after muscle-damaging exercise helps muscles recover faster. Researchers will measure muscle function and a protein called HSP70, which helps protect and repair cells. The study involves 96 healthy young male athletes who ex…

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This study checks how well the eCential surgical robot places screws in the spine during surgery. About 45 people aged 5 and older who need spinal screws will take part. The goal is to see if the robot improves screw placement accuracy and reduces complications.

This study examines how certain immune cells called monocytes influence the effectiveness of CART cell therapy in people with multiple myeloma. Researchers will analyze blood samples before and after treatment to see if monocyte levels and types can predict how well the therapy w…

This study aims to find the genetic factors that cause orofacial clefts (cleft lip and palate) in people whose cause is unknown. Researchers will use a technique called whole exome sequencing to read the DNA of 30 participants. The goal is to better understand the biology behind …

This study looks at bone marrow stem cells from 50 people with Waldenström macroglobulinemia (a rare blood cancer) and compares them to stem cells from healthy volunteers. The goal is to understand how these cells interact with cancer cells and contribute to the disease. No treat…

This study tests whether a quick, finger-prick blood test for C-reactive protein (CRP) can predict a serious complication called anastomotic leak after planned colorectal surgery. The goal is to catch leaks earlier, reduce the need for repeated blood draws, and help patients reco…

This study is testing whether placing 15 plants in two rooms of a hospital lab can reduce the amount of formaldehyde in the air. Formaldehyde is a chemical used to preserve tissue samples, but it is toxic to people who breathe it in. Researchers will measure the air and staff uri…

This study looks at whether certain brain chemicals can predict survival in people with glioblastoma (a fast-growing brain cancer) that has returned after standard treatment. Researchers will measure these chemicals with special scans 7 and 28 days after starting the drug bevaciz…

This study looks at whether the intense pain people feel right before emergency surgery can turn into chronic pain that lasts for months. Researchers will follow 693 adults having emergency orthopedic or abdominal surgery. They want to see if the level of pain before surgery pred…

This study follows 102 women who had fertility preservation before cancer treatment to see what happens long after they are in remission. Researchers want to know if women use their stored eggs or tissue, have spontaneous pregnancies, or decide not to have children. The goal is t…

This study looks at a serious condition where the heart fails to pump blood and blood vessels widen too much, often after a heart attack or heart surgery. Researchers will review medical records from 2,500 adults in French hospitals to learn more about who gets this condition and…

This study looks at whether giving mothers IV fluids before delivery affects how much weight their newborns lose in the first two days of life. Researchers will review medical records of 200 mothers and their full-term, formula-fed babies. The goal is to understand if fluid intak…

This study looks for new genetic causes of congenital sideroblastic anemia, a rare blood disorder where the body cannot properly use iron to make red blood cells. Researchers will analyze DNA from 20 people whose genetic cause is still unknown. The goal is to find and confirm new…

This study will screen 300 children aged 2 to 18 for familial hypercholesterolemia, a genetic condition that causes very high cholesterol and greatly increases the risk of early heart disease. Currently, only about 5% of affected children are diagnosed. By testing a broad group o…

This study tests a special MRI technique to measure blood flow in branches of the external carotid artery, which supplies blood to the face and neck. Researchers will compare healthy volunteers with people who have had radiation therapy, artery embolization, or reconstructive sur…

This study aims to validate a French translation of the MEPS/MEPI score, a tool that measures elbow pain and function, for children aged 4 to 17. Researchers will enroll 170 participants, including those with and without elbow injuries, to ensure the translation is accurate and r…

This study looks at how feelings of resentment and forgiveness impact the quality of life of people living with HIV. Researchers will follow 206 participants for one year to see if a forgiving attitude is linked to better well-being. The goal is to understand how forgiveness migh…

This study looks at how brain damage affects reaction time in people with Alzheimer's disease. Researchers will measure simple reaction times in 155 adults aged 40 to 85 with mild cognitive impairment or mild dementia. The goal is to better understand attention problems linked to…

This study tests whether a robot can help surgeons place bone tunnels more accurately during ACL knee reconstruction. Thirty patients aged 10 to 45 with ACL tears will have surgery using the Rosa robot to guide tunnel placement. The goal is to see if robotic assistance improves p…

This study compares a new, high-resolution DNA mapping technique (optical genome mapping) with standard methods to detect genetic changes in patients with certain blood cancers (polycythemia vera, essential thrombocythemia, or myelofibrosis). The goal is to see if the new method …

This study is for people with Waldenström Macroglobulinemia, a rare blood cancer. Researchers want to see if detecting tumor DNA in the blood after 6 months of treatment can predict whether the cancer will come back within 3 years. About 90 participants will provide blood samples…

This study uses eye-tracking technology to measure how much attention people with facial palsy pay to faces with abnormal movement, compared to healthy volunteers. Researchers want to understand if patients focus differently on facial features. The study involves 60 participants …

This study looks at how hearing sensitivity (hyperacusis) may help language skills in children and adults with Williams syndrome. Researchers will use brain scans (EEG-NIRS) and questionnaires to compare participants with Williams syndrome, Down syndrome, and typical development.…

This study aims to find hidden genetic changes in people with orofacial clefts (cleft lip/palate) who have not received a genetic diagnosis. Researchers will use a new, high-resolution DNA mapping technique called optical genome mapping to look for structural variations that stan…

This study looks at how well two different software programs measure heart function in people with septic shock, a life-threatening condition. Researchers will use existing heart ultrasound images from 60 adult patients to compare the measurements and see if they agree. The goal …

This study is looking at whether a protein called vasorin (Vasn) in the blood can help doctors quickly tell the difference between septic shock (caused by infection) and other types of shock (like after heart surgery). Currently, the best test for this is not always accurate. The…

This study looks at why some lupus patients get false positive results on tests for anti-HLA antibodies, which can make it harder to get an organ transplant. Researchers will study stored blood samples from 30 lupus patients who have no known risk factors for these antibodies. Th…

This study is looking at whether certain gene changes (variants) in a protein called annexin A2 are linked to strokes that happen for no clear reason, especially in younger adults. Researchers will compare blood samples from 240 people who have had a stroke with no known cause. T…

This study tests a new, non-invasive ultrasound method to measure diaphragm movement in patients on breathing machines. Researchers will track diaphragm strain during a spontaneous breathing trial to see if it can detect early signs of diaphragm weakness. The goal is to find a si…

This study looks at how well a procedure called TIPS works for people with a rare liver disease called Porto-Sinusoidal Vascular Disease (PSVD) that causes high blood pressure in the liver. Researchers will compare 360 patients who had TIPS for PSVD with similar patients who had …