Beth Israel Deaconess Medical Center

This study tested a new type of vaccine made by fusing a patient's own cancer cells with their immune cells (dendritic cells). The goal was to see if this personalized vaccine is safe and can trigger the immune system to attack advanced melanoma. Twenty adults with progressive, m…

This study tested whether delivering DASH diet groceries to the homes of Black adults in Boston-area food deserts could lower their blood pressure. 180 participants with mildly high blood pressure who were not on medication received the groceries. The goal was to see if better ac…

This study tested a new drug called GO-203-2C in 33 adults with acute myeloid leukemia (AML) that had come back or not responded to standard treatment. The drug targets cancer cells while leaving healthy cells alone. The goal was to find the safest dose and see if adding it to an…

This study tested whether adding an experimental antibody (CT-011) and a personalized cancer vaccine to standard stem cell transplant is safe and helps prevent multiple myeloma from coming back. 35 adults with multiple myeloma participated. The goal was to see if the combination …

This study looked at whether using a HEPA air purifier at home can improve lung health in adults with a type of COPD called eosinophilic COPD. 178 people took part, with half getting real purifiers and half getting fake ones. The main goal was to see if the purifiers helped with …

This study tested whether zafirlukast, an asthma drug, can slow or stop ovarian cancer growth in people whose CA-125 levels are rising but have no other signs of disease. Only 5 participants were enrolled. The goal was to see if the drug could lower CA-125 levels by at least half…

This study tested a new type of vaccine made by fusing a patient's own tumor cells with immune cells from a healthy donor. The goal was to see if these 'fusion cells' are safe and can help the immune system attack advanced kidney cancer. 40 adults with stage IV kidney cancer rece…

This study tested the drug abatacept in 56 people who had chronic graft-versus-host disease (cGVHD) that did not get better with standard steroid treatment. cGVHD happens when donor immune cells attack the patient's own body after a stem cell or bone marrow transplant. The goal w…

This study tested whether the chemotherapy drug cisplatin works better than the standard combination of doxorubicin and cyclophosphamide (AC) for women with newly diagnosed breast cancer who have a BRCA gene mutation. About 118 women took part, receiving either cisplatin or AC be…

This study tested a personalized vaccine for people with advanced kidney cancer. The vaccine was made by fusing a patient's own tumor cells with their immune cells (dendritic cells) to help the body fight the cancer. The main goal was to check the vaccine's safety and side effect…

This study tested whether very low doses of a protein called IL-2, given as shots under the skin for 4 weeks, could increase the number of helpful immune cells (Tregs) in liver transplant recipients. The goal was to see if this approach might improve the body's acceptance of the …

This study tested a new blood test that measures how well platelets work in people taking common heart medications like aspirin and clopidogrel. Researchers compared this new test to the current standard test in 112 healthy volunteers and severely obese individuals. The goal was …

This study tested a new imaging technique called restriction spectrum imaging (RSI) for breast cancer screening. Researchers compared RSI to standard breast MRI in 460 women to see if it could detect cancer just as well. The goal was to find a faster or simpler screening option w…

This study tested a device that checks for anemia (low iron) in pregnant women without a blood draw. It included 124 pregnant or postpartum adults. The goal was to see if the non-invasive device gives the same results as standard blood tests.

This study tested whether giving a common painkiller (acetaminophen) through an IV every 6 hours could prevent delirium—sudden confusion—in older adults after heart surgery. About 900 patients aged 60 and older took part. The goal was to see if this simple, low-cost approach coul…

This study tested a daily synbiotic supplement (DS-01) in 48 adults with irritable bowel syndrome (IBS) to see if it is safe and helps improve gut health. Participants took either the supplement or a placebo for 12 weeks. The main goal was to check for side effects and see how th…

This pilot study tested a brief cognitive behavioral therapy (CBT) program to help older adults (55+) reduce or stop their use of benzodiazepines, which are commonly prescribed for insomnia and anxiety but can be risky with age. Seventeen participants received up to three therapy…

This study tested whether giving low-dose nitrous oxide (laughing gas) during a urodynamic study (a test for urinary symptoms) changes key bladder measurements like capacity and pressure. 19 adults scheduled for the test took part. If the measurements stay the same, nitrous oxide…

This small study tested whether a noninvasive electrical stimulation technique, targeted to a specific brain area (the right superior temporal sulcus), could reduce hallucinations in people with psychosis. Twelve participants who were actively experiencing hallucinations received…

This study looked at whether using high-flow nasal oxygen during upper endoscopy can prevent blood oxygen levels from dropping too low in patients at high risk, such as those with sleep apnea or obesity. 180 patients were randomly assigned to receive either standard oxygen or hig…

This small pilot study looked at whether a 12-week tai chi program is practical and helpful for people with chronic obstructive pulmonary disease (COPD). Ten adults with COPD were randomly assigned to either tai chi or usual care. The study focused on whether tai chi could improv…

This study tested three different doses of spinal morphine (50, 150, or 250 micrograms) to see which provides the longest pain relief after a C-section. 72 healthy women participated, and researchers measured how long until they needed extra pain medication. The goal is to improv…

This study tested whether using the EyeControl-Pro, a device that lets patients communicate by moving their eyes, could reduce delirium in older adults on breathing machines in the ICU. The trial involved 160 patients aged 50 and older. Researchers compared those using the active…

This study tested a special anesthesia method during heart surgery to see if it could reduce confusion, pain, and the need for blood pressure medicines in older adults. 70 people aged 60 and older took part. The approach used brain monitoring to guide anesthesia and a planned pai…

This study tested whether levetiracetam, a medication used for epilepsy, can calm overactive brain activity and improve memory and thinking in people with early Alzheimer's disease. Researchers measured brain signals and cognitive performance in 58 participants before and after t…

This study compared two common anti-nausea drugs, dexamethasone and ondansetron, in 100 women having a planned or non-labor cesarean delivery. The goal was to see which drug works better as a first-line treatment to prevent nausea and vomiting after surgery. Researchers measured …

This study tested whether a gentle, non-invasive brain stimulation technique (transcranial electrical stimulation) could reduce symptoms of mania in people with bipolar or schizoaffective disorder. Fourteen participants received the stimulation targeting a brain region linked to …

This study tested whether an ultrasound-guided nerve block can control pain as well as standard opioid injections for people with a broken hip in the emergency room. 44 adults with moderate to severe pain took part. Researchers measured pain relief using a standard pain scale.

This study tested whether a multi-port epidural catheter provides better pain relief than a standard single-port catheter after chest or upper abdomen surgery. 240 adults took part. The main goal was to see which type reduced the need for extra pain medicine or catheter replaceme…

This study tested whether the sleep medication suvorexant can help older adults (60+) sleep better and reduce confusion (delirium) after heart surgery in the intensive care unit. One hundred participants received either suvorexant or a placebo for seven nights. The goal was to se…

This small pilot study looked at whether adding mindful attention to a walking program helps people with metabolic syndrome stick with physical activity. 34 participants were assigned to walking only, mindfulness only, walking plus mindfulness, or no program. The goal was to see …

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Both are standard techniques used during screening. The goal was to learn which appr…

This study looked at whether a 15-minute meditation practice called Shoonya can help people stay mentally sharp and maintain healthy sleep patterns after a night of no sleep. Researchers compared regular meditators with non-meditators who nap. The goal was to see if meditation bu…

This study tested a website designed to help doctors and women aged 75 to 89 talk about the benefits and drawbacks of mammograms. The goal was to support informed decision-making. 155 participants took part, including patients, family members, and healthcare providers.

This study compared two methods for placing epidural catheters in 110 women in labor: the traditional technique using touch (palpation) and one using ultrasound imaging. The goal was to see if ultrasound helps place the needle more accurately and reduces risks. Results will help …

This study looked at how galcanezumab, a newer migraine prevention drug, affects the brain. Researchers used MRI scans to measure changes in brain structure in 64 adults with chronic migraine. The goal was to learn whether the drug works inside or outside the brain, not to test i…

This study looked at whether a daily 21-minute meditation practice called Shambhavi Mahamudra Kriya can change brain health in healthy adults aged 20 to 65. Researchers measured brain activity and structure using EEG and MRI scans over six months. The goal was to understand how m…

This pilot study tested whether a multi-component prehabilitation program—including physical therapy, nutrition counseling, and meditation—is feasible for older adults (70+ or 65+ with high risk) scheduled for major elective surgery. The program aimed to improve strength and reco…

This study looked at how ketorolac, a non-steroidal anti-inflammatory drug (NSAID) used for pain after cesarean delivery, affects platelet function and blood clotting. Researchers measured clotting in 40 women undergoing scheduled C-sections using special blood tests. The goal wa…

This study looked at whether people who meditate have a younger-looking brain age and different sleep patterns compared to non-meditators. About 108 adults in Massachusetts wore special headbands and rings while sleeping for five nights. The goal was to see if meditation is linke…

This study looked at whether using less oxygen (70% or 40% instead of the usual 100%) just before removing a breathing tube after surgery could reduce lung collapse. 48 adults having elective surgery took part. The researchers measured lung collapse using a special imaging techni…

This study tested a program called InVEST that provides one-on-one support for young people ages 12-22 who are at high risk for psychosis. The goal was to see if the program is practical and helpful for improving their ability to function at school or work. 26 participants took p…

This study tested whether an AI system could safely and effectively take a patient's medical history before an urgent care visit. About 100 adults spoke with the AI, supervised by a doctor, before seeing their primary care provider. Researchers measured safety, patient and doctor…