Beth Israel Deaconess Medical Center

This study tests a personalized vaccine made from a patient's own leukemia cells and immune cells. The goal is to see if the vaccine can help prevent the cancer from coming back after chemotherapy. It is for adults aged 55 and older with acute myeloid leukemia (AML) who are in re…

This study tests whether using a computer dashboard to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 participants will receive either dashboard-guided or standard dosing. The goal is to se…

This early-phase study tests a custom-made cancer vaccine (DC/AML fusion vaccine) for people with acute myeloid leukemia (AML) who have recently had a stem cell transplant. The vaccine is designed to teach the body's immune cells to recognize and attack remaining leukemia cells. …

This study tests a higher dose of the drug fulvestrant (Faslodex) as a first treatment for postmenopausal women with a type of advanced breast cancer that is fueled by hormones. The goal is to see if the higher dose works better than the standard dose at controlling the cancer. A…

This study tests whether delivering DASH diet groceries to the homes of Black adults with high blood pressure can help lower their blood pressure. Participants live in Boston-area neighborhoods with limited access to healthy food. The goal is to see if better food access can impr…

This study tests the immune drug nivolumab in 29 men whose prostate cancer has returned after initial treatment, shown by rising PSA levels. The goal is to see if the drug can stabilize or lower PSA and keep the cancer from growing for at least 12 weeks. Participants receive nivo…

This study tests a drug called olaparib in people with metastatic breast cancer that has spread beyond the breast. Participants must have a specific gene change in their tumor that may make it sensitive to this drug. The goal is to see if olaparib can shrink tumors or slow cancer…

This study looks at how well a two-step cervical cancer screening process works in Botswana. It uses an HPV test first, followed by a visual exam, to find early signs of cancer. About 3,000 women aged 25 and older, including those living with HIV, will take part. The goal is to f…

This study checks if a computer model called PRISM can accurately predict a person's risk of developing pancreatic cancer using their electronic health records. Over 6 million adults aged 40 and older from across the US are being tracked to see how well the model works. The goal …

This study tests three new methods—electrical impedance, nerve excitability tracking, and ultrasound—to see if they can reliably diagnose myofascial pain syndrome. Researchers will compare results from 90 people with and without the condition. The goal is to find better, more obj…

This study looks at whether long-acting HIV prevention shots (CAB-LA) are safe and work well for breastfeeding mothers after childbirth. About 500 new mothers in Botswana will get the shots and be followed for 24 months along with their babies. The goal is to see if this method c…

This study tests a simple checklist called CMOT (Comfort Measures Only Time Out) to help ICU teams reduce distress when removing a breathing tube from a dying patient. About 184 patients and their healthcare teams will take part across four ICUs. The goal is to see if the checkli…

This study tests whether an accelerated schedule of transcranial magnetic stimulation (TMS) is safe and effective for treating symptoms of psychotic disorders like schizophrenia. About 20 adults with schizophrenia, schizoaffective disorder, or early warning signs of psychosis wil…

This study looks at how the weight-loss drug Saxenda (liraglutide) changes brain activity related to appetite and food cravings. About 28 obese adults will have brain scans before and after treatment to see how the drug affects hunger-control centers. The goal is to better unders…

This study looks at two common pain medicines, fentanyl and hydromorphone, for patients in the intensive care unit (ICU) who need a breathing machine. The goal is to see if one works better for managing pain and sedation. About 300 adults will take part, and researchers will trac…

This study tests an oral drug called abrocitinib against a placebo in 46 adults with Long COVID who suffer from severe fatigue. Participants take the drug daily for 12 weeks to see if it improves their energy and overall health. The goal is to find a safe, effective treatment for…

This study looks at whether tai chi exercises and wearable fitness trackers can help people who have had a heart attack (acute coronary syndrome) become more physically active. About 70 adults who are currently inactive will take part. The goal is to see if this approach is enjoy…

This study looks at how well the lungs work in adults who are on a heart-lung machine (VA-ECMO) and a breathing tube. Researchers will test a method to adjust the breathing machine settings using special imaging and pressure measurements. The goal is to find the best settings to …

This study looks at whether a new, less invasive way to measure bone tissue properties can better identify women at risk for hip and wrist fractures. Researchers will compare these measurements to standard bone density tests. The goal is to improve fracture risk assessment beyond…

This study aimed to see if biofeedback-based trunk control training could improve walking in older adults with chronic low back pain. It planned to compare 20 older adults with back pain and 20 healthy volunteers. However, the study was withdrawn before enrolling anyone, so no re…

This study aims to find the genetic causes of calcific aortic valve disease, a condition where the heart valve hardens. Researchers will collect tissue from 1,000 patients having valve surgery to look for gene activity patterns. The goal is to understand why some people develop t…

This study looks at whether a short course of hormone therapy can make prostate cancer cells more visible on a special PET scan (PSMA PET). About 15 men with prostate cancer that has returned after initial treatment will take standard hormone pills for a few weeks and then get a …

This study follows 500 adults over age 65 who are getting a new implantable defibrillator (ICD) for the first time. Researchers will track their health, daily function, and quality of life for 18 months, with optional follow-up up to 10 years. The goal is to better understand how…

This pilot study tests whether using a gentler, low-intensity breathing machine during robot-assisted surgery can reduce lung collapse and breathing problems after surgery. About 60 adults having planned robotic surgery will be randomly assigned to either the gentler breathing me…

This study reviewed records of 70,000 adults who had non-urinary surgery under general anesthesia. Researchers compared two types of drugs used to reverse muscle relaxants—sugammadex versus neostigmine—to see which one leads to fewer delays in leaving the recovery room due to tro…

This study looks at how the weight-loss drug lorcaserin affects brain areas that control appetite and eating. About 40 obese adults will have brain scans (fMRI) and body composition tests to measure changes. The goal is to understand how the drug works in the brain, not to test i…

This study aims to find the genes that cause certain inherited kidney diseases, such as Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome. Researchers will collect saliva and urine samples from up to 2,050 participants, including patients, their family members, and…

This study checks if a computer model called LIRIC can accurately predict who will develop liver cancer using electronic health records. Researchers will track 6 million adults aged 40 and older without a history of liver cancer to see how well the model works. The goal is to imp…