Beth Israel Deaconess Medical Center

This study tests a flexible microwave probe that can be guided through a bronchoscope to destroy small lung cancer nodules (up to 3 cm). Ten people with early-stage lung cancer will receive the procedure, and researchers will check if it works as planned and how much tumor tissue…

This study compares standard mechanical ventilation to a personalized approach that adjusts breathing machine settings based on each patient's lung stress. It aims to see if the tailored strategy improves survival in 1,100 adults with acute respiratory distress syndrome (ARDS), a…

This study looks at whether people who had a brain hemorrhage (bleeding stroke) should keep taking statins or stop them. It involves 1,456 adults aged 50 and older who were on statins before their stroke. Researchers will also check if a person's genes affect the best choice. The…

This study tests if adding surgery to close gaps between lung lobes before placing one-way valves can improve breathing in people with severe emphysema or COPD. About 20 participants will either receive the combined procedure or standard medical care. The goal is to see if this a…

This study tests whether the drug epcoritamab can help people with follicular lymphoma who still have signs of cancer after their first round of chemoimmunotherapy. About 35 adults with advanced-stage disease will receive epcoritamab as a second treatment. The main goal is to see…

This study tests whether adding raloxifene to a standard BPH drug (finasteride) works better than finasteride alone. About 242 men with BPH will take either the combination or finasteride plus a placebo for 12 months. The goal is to see if the combination leads to a greater impro…

This study tests whether grafts modified by doctors during surgery can safely repair complex aortic aneurysms in patients who are too high-risk for standard surgery. About 220 participants with different types of aortic damage will be followed for up to 5 years to check survival,…

This study tests a surgical procedure for people with severe emphysema or COPD who did not get better after a less invasive lung volume reduction treatment. The surgery aims to complete the natural separations between lung lobes and remove scar tissue to improve breathing. About …

This study is testing a new combination of treatments—radiation beads, immunotherapy, and chemotherapy—for people with advanced bile duct cancer that cannot be removed by surgery. The goal is to see if this triple therapy can slow or stop the cancer from growing. About 30 adults …

This study compares high flow oxygen to standard oxygen for adults with dangerously low blood oxygen (acute hypoxemia) in five East African hospitals. Researchers want to see if high flow oxygen lowers death rates and uses oxygen more efficiently. About 1,600 participants will be…

This study tests whether giving a short course of intravenous hydrocortisone (a steroid) to adults with severe acute pancreatitis in the ICU can reduce inflammation and improve recovery. Researchers aim to see if it shortens hospital stays and prevents complications like respirat…

This study tests a medicated foam (roflumilast) applied to the skin for hidradenitis suppurativa, a condition causing painful lumps. About 20 adults with mild to moderate disease will use the foam for 16 weeks. The goal is to see if it reduces the number of inflamed bumps safely.

This study is testing whether getting healthy, DASH-diet groceries delivered to your home, along with help from a dietitian, can lower blood pressure in adults with high blood pressure. About 150 people in Florida, Georgia, and Tennessee will take part. Participants will eat only…

This study is testing a device called the mScan that uses a tiny, painless electrical current to measure muscle health. It takes about 6 seconds and is held against the skin. Researchers want to see if it can give similar results to an MRI, which takes longer and can be uncomfort…

This study tests a program of sleep coaching, brain games, and non-opioid pain relief given before and after heart surgery. The goal is to prevent delirium (sudden confusion and agitation) in adults aged 60 and older. About 400 participants will be randomly assigned to the progra…

This study tests whether a gentle, non-invasive brain stimulation technique called HD-tDCS can improve word-finding and memory problems in people who have had a traumatic brain injury (TBI) at least one year ago. About 24 adults aged 18 to 85 will receive either real or fake (sha…

This study looks at whether dry needling can reduce pain from trigger points (tight, tender spots) in the trapezius muscle, which runs from the neck to the shoulders. About 70 adults with myofascial pain will receive either dry needling or a placebo treatment. Researchers will us…

This study tests a new, non-invasive treatment for people with drug-resistant epilepsy, whose seizures are not controlled by medication. The treatment uses infrared light, which has shown promise in animal studies for reducing seizures. Researchers will treat 13 adults with daily…

This study tests whether a CPAP machine, normally used for sleep apnea, can help people with excessive central airway collapse (a floppy windpipe) walk farther and feel less breathless. About 32 adults will be randomly assigned to use either a real CPAP or a sham device during a …

This study tests whether using a pelvic wand to massage the perineum during late pregnancy and labor helps women feel more in control during childbirth and improves pelvic health afterward. About 140 pregnant women planning to give birth at Beth Israel Deaconess Medical Center wi…

This small study is testing a mind-body program for adults who have chronic migraines (at least 5 headache days per month). The goal is to see if the program is practical and helpful for reducing migraine-related disability and improving quality of life. Participants will attend …

This study tests whether letting men control their own nitrous oxide (laughing gas) during a vasectomy can lower pain and anxiety. About 35 men scheduled for a vasectomy will use a mask to adjust their gas level as needed. The goal is to see if this approach improves comfort and …

This study tests a new way to improve sleep in people aged 60 and older with mild cognitive impairment (MCI) or subjective cognitive decline. It combines a safe, gentle brain stimulation technique (transcranial magnetic stimulation) with cognitive behavioral therapy for insomnia.…

This study looks at whether a mind-body program can help people with long-term back pain feel better and move more easily. About 150 adults with chronic back pain will be randomly assigned to the mind-body program, a different mind-body approach, or their usual care. The goal is …

This study tests a decision aid and training for surgeons to help women aged 70 and older with low-risk stage I breast cancer make better-informed treatment decisions. About 402 participants will be enrolled across 7 U.S. health systems. The goal is to reduce aggressive treatment…

This study tests whether using ultrasound to guide a numbing injection (hematoma block) works better than the traditional method of injecting without imaging for people with a broken wrist. About 115 adults in the emergency department will take part. The goal is to see which appr…

This study tests whether a mind-body program can reduce symptoms like pain, fatigue, and dizziness in people with Long COVID. About 180 adults will be randomly assigned to the program, usual care, or another mind-body activity. The goal is to see if the program improves daily fun…

This study tests a new way to treat persistent air leaks (PALs) in the lungs, a condition that can keep people in the hospital for a long time. About 20 adults who cannot have surgery will get a combination of a blood patch and a tiny valve placed in the airway during a scope pro…

This study tests a new rehabilitation method for people who lost part of their vision after a stroke. It combines gentle electrical brain stimulation with visual exercises, sometimes using virtual reality, to try to speed up recovery of sight in the blind area. The study involves…

This pilot study is testing whether a mind-body intervention can improve daily function and reduce pain in 40 adults with chronic upper extremity pain (like repetitive stress injury). Participants will learn mental techniques to manage pain and will be followed for changes in arm…

This study tests whether injecting a small amount of saline into the spinal fluid can quickly reverse leg weakness caused by spinal anesthesia after joint replacement surgery. About 20 adults having elective lower extremity joint replacement will receive the saline through a tiny…

This early-phase study looks at how heat stress changes kidney function in 28 healthy, fit volunteers. Researchers want to understand the body's chemical responses and whether taking vitamin B3 (niacinamide) can influence those changes. The goal is to gather knowledge, not to tre…

This study looks at 320 people who recently developed a psychotic disorder (like schizophrenia or bipolar I). Researchers will use brain scans, eye-tracking, and genetic tests to see if they can predict who will respond best to treatment. Participants attend four visits over one …

This study screens healthy adults aged 18 and older to see if they qualify for future vaccine or treatment trials for infectious diseases. It collects basic health and demographic information to match volunteers with upcoming studies. No experimental treatment is given—it is pure…

This study is screening up to 1,395 adults who are at higher risk for pancreatic cancer to find early, treatable signs of the disease. Participants will undergo imaging and follow-up based on standard guidelines. The goal is to catch dangerous lesions or early-stage cancer before…

This study aims to understand why some men with an enlarged prostate do not respond to the drug Finasteride. Researchers will use MRI scans and symptom questionnaires to find markers that can predict treatment resistance. The goal is to help doctors identify non-responders early …

This study looks at why women after menopause have a higher chance of developing a type of heart failure called diastolic heart failure. Researchers will collect heart tissue from 500 women having heart surgery to study how the loss of estrogen affects heart energy and blood vess…

This study is testing a device called the mScan to see if it can track how ALS progresses over time. Researchers will measure electrical signals in muscles and compare them to standard tests. The goal is to find a simple, objective way to monitor the disease that could be used at…

This study looks at how sleep apnea (a condition where breathing stops and starts during sleep) might affect people with multiple sclerosis (MS). Researchers will collect medical records, MRI scans, and sleep test results from 800 adults with MS to see if sleep apnea is linked to…

This study is looking for ways to detect early signs of serious infection, like sepsis, using simple blood tests. Researchers will follow 4200 adults with and without infections to see if certain markers can predict who is at risk for death or organ failure. The goal is to help d…

This study tests if low-cost, single-use bronchoscopes (thin tubes used to look inside the lungs) can safely replace reusable ones for routine lung procedures. About 20 adults will undergo a lung exam with the disposable scope. Doctors will rate the scope's quality, handling, and…

This study uses special imaging to map the lymphatic system in the arms of healthy women and breast cancer survivors who did not develop swelling (lymphedema). The goal is to learn how these alternate pathways work and why some people avoid lymphedema after lymph node removal. Ab…

This study watches brain activity and blood oxygen levels in 100 adults aged 60 and older during major non-cardiac surgery. The goal is to find the best blood pressure range for each person to protect brain health and reduce confusion after surgery. Participants wear stickers on …

This study looks at whether pregnant women with high-risk conditions like diabetes or high blood pressure can use a device at home to check their baby's heart rate. Fifty participants will try the remote monitor for 30 minutes, three times a week, starting at 32 weeks. The goal i…

This study looks at whether transferring embryos after 3 days or 5 days leads to more live births in IVF patients who have 5 or fewer embryos. About 1,126 people will take part, and researchers will also track patient satisfaction and complications. The goal is to help doctors an…

This study looks at whether using remote alerts from heart devices (like pacemakers or defibrillators) can lead to better care than the usual guidelines. About 120 adults with these devices will be randomly assigned to one of two monitoring approaches. The goal is to see which me…

This study looks at how not getting enough sleep or having insomnia changes the way people handle their emotions. Researchers will compare three groups: people who sleep only 4 hours for three nights, people with insomnia, and healthy sleepers. Participants will do emotion tasks …

This study looks at brown fat, a special type of fat that burns energy and may help control metabolism. Researchers will collect small samples of brown and white fat from 40 healthy adults during planned surgeries. The goal is to understand how brown fat works at the cellular lev…

This study follows 500 people with early Alzheimer's disease who are receiving anti-amyloid antibody treatment. Researchers will track how well the drugs slow down memory and thinking problems, and watch for side effects. The goal is to learn more about who benefits and how long …

This study tests whether a simple, step-by-step guide (called a linear cognitive aid) helps emergency medical teams treat children in life-threatening situations. About 80 EMS providers will use the guide during realistic practice scenarios. The goal is to see if the guide is eas…

This study looks at how a natural brain chemical called allopregnanolone affects depression in women going through menopause. Researchers will give a related substance (pregnenolone) to 80 women aged 40-60 with depressive symptoms. The goal is to understand the link between this …

This study looks at how quickly the stomach empties in women during early labor when they drink either water or a carbohydrate sports drink. About 108 women will participate, some with and some without epidural pain relief. The goal is to understand stomach emptying times, which …

This study tests a new program called Doula Link, which gives doulas extra training and resources to support the mental health of pregnant and new parents. About 90 doulas and their clients will take part. The goal is to see if the program is practical and liked by users, and if …