COLON CANCER

This is a first-in-human study testing a new experimental drug called 212Pb-DOTAM-GRPR1 in adults with advanced cancers that have returned or spread. The main goal is to find a safe and tolerable dose. Researchers will also check if the drug, which delivers radiation directly to …

This study is comparing a newer, less invasive procedure (endoscopic full-thickness resection) to standard surgery for treating early-stage colon cancer. It aims to see which method is safer in the short term and better at preventing cancer from coming back in the long term. The …

This study is testing a specific type of surgical thread (MonoPlus®) to see if it is as good as or better than current methods at preventing leaks where the intestine is reconnected after colon cancer surgery. It will involve 249 adults having planned surgery for right-sided colo…

This study is testing whether a new immunotherapy drug called QL1706, given before surgery, works better than standard treatments for a specific type of colon cancer. It will involve 363 adults with a genetic feature in their tumor (MSI-H/dMMR) that makes it more likely to respon…

This study is testing a new combination of four cancer drugs for people with advanced colorectal cancer that has continued to grow despite previous treatments. The goal is to see if this alternating drug schedule can stop or slow the cancer's progression. About 50 participants wi…

This study is testing whether giving chemotherapy before surgery helps more patients with blocked colon cancer complete their full treatment plan. It involves 232 patients whose initial blockage was relieved with a colostomy. The goal is to see if starting chemo before tumor remo…

This study is testing a minimally invasive procedure called TACE for patients with advanced lung cancer or cancer that has spread to the lungs. TACE works by injecting chemotherapy directly into the artery feeding the tumor and then blocking that artery to cut off the tumor's blo…

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This study is testing whether giving immunotherapy drugs before surgery can help surgeons completely remove advanced colon tumors while preserving nearby organs. It focuses on patients whose cancer has a specific genetic feature that makes it respond poorly to standard chemothera…

This trial is testing a less invasive surgery for people with early-stage colon cancer. It aims to remove just the tumor area and a few key lymph nodes, instead of a large section of the colon, to reduce complications and recovery time. The goal is to see if this organ-sparing ap…

This study is testing whether a support program called CARES helps rural cancer patients start treatment sooner and complete it faster. The program provides navigation help and counseling sessions alongside usual cancer care. Researchers will compare outcomes for 320 patients who…

This is the first study in people to test a new drug called CBI-1214, which is designed to help the body's own immune cells attack cancer. It is for adults with advanced or metastatic colorectal cancer that has continued to grow despite prior standard treatments. The main goals a…

This study is testing whether adding the drug fruquintinib to a standard chemotherapy regimen (FOLFIRI) can better control advanced colorectal cancer that has spread. It is for people whose cancer has worsened after their first treatment. The main goals are to see if this combina…

This study aims to find out if a minimally invasive 'keyhole' (laparoscopic) surgery is as good as or better than traditional open surgery for removing right-sided colon cancer. Researchers will compare how completely the cancer is removed, recovery times, and long-term survival …

This study is testing if an immunotherapy drug called cemiplimab can effectively control a specific type of colon cancer that has a DNA repair defect (dMMR/MSI-H). The goal is to see if the drug can shrink or eliminate the tumor enough that some patients might avoid having surger…

This early-stage study is testing a new type of treatment called CAR-T cell therapy for people with advanced cancers that have a specific marker (CEA) and have stopped responding to standard treatments like chemotherapy. The main goals are to find a safe dose and see if the treat…

This study is testing which of two common drugs works better to support the body's defenses and recovery after colon cancer surgery. One hundred patients will be randomly assigned to receive either an infusion of lidocaine or a high dose of dexamethasone during their operation. R…

This trial is testing a new type of gene therapy for people with advanced pancreatic, colon, and other cancers that have a specific genetic change called KRAS G12V. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer c…

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This is the first study in people testing a new experimental cancer drug called PHN-012. It aims to find a safe dose and see if it can shrink tumors in patients with advanced colon, lung, or pancreatic cancer who have no other standard treatments left. The study will enroll about…

This study is testing a two-step treatment for people with locally advanced colon cancer. First, patients receive standard chemotherapy. Then, they receive the same chemotherapy combined with an immunotherapy drug (Serplulimab) before having surgery. Researchers want to see if th…

This early-stage trial is testing a new oral drug called RSC-1255 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how well the drug is tolerated, both alone and combined with another medicati…

This study is testing if giving the numbing medicine lidocaine during and after colon cancer surgery helps patients recover better. Researchers will compare it to a placebo and a steroid to see if it reduces pain, lowers the need for strong painkillers (opioids), and helps the bo…

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have come back or spread. The therapy, called Tmod CAR T, is designed to recognize and kill cancer cells while using a built-in safety switch to protect the patient's healthy …

This study is testing a new three-part treatment for people with high-risk colon cancer that hasn't spread. The goal is to shrink the tumor as much as possible before surgery. Patients receive a very low dose of radiation designed to spare lymph nodes, along with standard chemoth…

This study is testing a new blood test designed to detect five different cancers (breast, colon, pancreatic, ovarian, and lung) at an early stage. Researchers will analyze tiny particles in the blood using a special light-based technique and artificial intelligence. The goal is t…

This study is testing new radioactive tracer chemicals for PET/CT scans to see if they can better detect and monitor cancers of the digestive system, including stomach, colon, liver, and pancreatic cancer. About 400 adults with confirmed or suspected digestive cancer will receive…

This study is developing a new blood test that uses artificial intelligence to analyze tiny genetic signals from tumors. The goal is to more accurately identify patients with high-risk colon cancer before they have surgery, which could help doctors decide who might benefit from r…

This study is testing a new type of PET/CT scan to see if it can better detect when colon cancer has spread to lymph nodes or other organs. It will compare this new scan to current standard imaging methods. The goal is to see if the new scan is more accurate at finding cancer spr…

This study is testing if wearing surgical gloves during chemotherapy can prevent a common and painful side effect called nerve damage in the hands. It is for adults with colon cancer who are starting a specific chemotherapy drug called oxaliplatin. The goal is to see if this simp…

This study is testing whether a special home support program helps frail, older adults recover better after colon cancer surgery. The program includes a health check, diet advice, and exercise guidance provided at home after leaving the hospital. Researchers will compare recovery…

This study is testing whether yoga and mindfulness training can help improve the quality of life for people who have survived lung, colon, or non-Hodgkin's lymphoma cancer. Researchers will enroll 100 adult survivors who finished their main cancer treatments at least six months a…

This study is testing whether virtual reality (VR) can help reduce pain and improve quality of life for people with gastrointestinal cancers. Researchers will compare three approaches: VR that teaches pain management skills, VR designed to distract from pain, and a basic VR contr…

This study is testing a free, 8-12 week exercise program designed specifically for people who have or have had cancer. The program offers twice-weekly supervised classes, either online or in-person, to help participants improve their fitness, manage cancer-related symptoms like f…

This study is testing if surgeons can safely preserve a specific artery (the left colic artery) during surgery for colon, rectal, or ovarian cancer. The goal is to see if keeping this artery open provides better blood flow to the remaining colon, which could help it heal better a…

This study aims to collect detailed genetic information and health records from 25,000 adults who have cancer or are at risk of developing it. Researchers will analyze this data to better understand how cancer develops and to identify potential targets for future treatments. The …

This study aims to understand the inherited genetic factors that cause lymphoma, leukemia, and related cancers within families. Researchers are recruiting individuals and their family members who have a personal or family history of these diseases. The main goal is to collect DNA…

This study aims to see if analyzing tiny bits of tumor DNA found in blood and stool (called ctDNA) can help doctors better manage treatment for people with cancers of the digestive system, like pancreatic, colon, and bile duct cancer. It will observe 100 patients to see if these …

This study aims to create a library of blood samples from cancer patients and people at high risk for cancer. Researchers will collect these 'liquid biopsies' to help future studies develop better ways to detect cancer early and monitor treatment. The study involves 2,500 partici…

This study is testing a blood test that looks for tiny pieces of tumor DNA to see if it can detect cancer recurrence earlier than standard scans. It aims to enroll 100 adults, including people with various solid tumors and healthy volunteers. The goal is to gather information tha…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This research program aims to learn how people understand and act on unexpected genetic findings that could impact their health, even if those findings weren't the original reason for their genetic test. Researchers are enrolling 5,000 people who have received such findings to co…

This study aims to better understand how liver tumors respond to a targeted radiation treatment called Y90 radioembolization. Researchers will collect small tissue samples from participants' tumors after treatment to examine the effects. The findings could help improve how this t…

This study is a long-term health check-up for people who previously received experimental cancer vaccines in other research trials. It aims to monitor their health for up to 15 years to ensure the vaccines are safe in the long run. Participants will have annual check-ups or phone…

This study aims to understand how the community of bacteria in your gut (the microbiome) and what you eat might influence the risk and severity of diarrhea caused by chemotherapy for colon cancer. Researchers will collect stool samples, diet records, and blood from about 11 parti…

This study aims to understand how colorectal cancer survivors feel and function in the years after their treatment ends. Researchers will follow 368 working-age survivors for up to 2 years, checking in at 6, 12, and 24 months. The goal is to identify common long-term side effects…

This study aims to collect blood and other samples from adults with cancer to help scientists better understand how cancer affects the immune system and tumor biology. Participants provide samples for lab analysis, but this is not a treatment study. The goal is to gather knowledg…

This study aims to see if changes in what people buy—like pain relief or digestive aids—can serve as an early warning sign for certain cancers. Researchers will compare the shopping history of 1,450 recently diagnosed cancer patients with 1,450 people without cancer, using up to …