COLON CANCER

This study tests a new drug called QL1706 given before surgery for people with a specific type of colon cancer (MSI-H/dMMR) that has not spread too far. About 363 participants will either get QL1706 or standard care. The goal is to see if the drug can completely eliminate the tum…

This study looks at 1,000 adults with colon cancer that has caused a blockage in the large bowel. It compares having emergency surgery right away versus first placing a stent or creating a stoma (an opening in the belly) to relieve the blockage, followed by surgery later. The goa…

This early-stage study tests a new treatment using a patient's own immune cells, engineered to target a protein called CEA found on certain cancer cells. It is for adults with advanced lung, stomach, colon, rectal, esophageal, or pancreatic cancer who have not responded to standa…

This early-phase study tests a new drug called RSC-1255, alone or with hydroxychloroquine, in people with advanced solid tumors (like lung, colon, pancreatic cancer, or glioblastoma) that have stopped responding to standard treatments. The goal is to find a safe dose and see if t…

This study is for people with a specific type of high-risk colon cancer that usually doesn't respond well to immunotherapy alone. The researchers are testing whether adding a very low dose of radiation to the standard chemotherapy and immunotherapy can help the immune system figh…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors (like colorectal, lung, or pancreatic cancer) that have lost a specific marker on their cells. The treatment uses the patient's own immune cells, modified to target cancer cells while protecti…

This study tests if giving chemotherapy before surgery (instead of only after) helps people with blocked colon cancer get the full planned treatment. About 232 adults with stable tumor genetics will be randomly assigned to standard care or the new approach. The goal is to see if …

This study tests a new way of giving three chemotherapy drugs (TAS-102, oxaliplatin, and irinotecan) along with a targeted therapy (bevacizumab) to people with advanced colorectal cancer that has stopped responding to standard treatments. The goal is to see if this combination ca…

This study is for people with early-stage colon cancer (stage I) who currently need a colectomy to remove part of the colon. The SENTRY trial tests a less invasive option: removing only the tumor and nearby lymph nodes using a camera and a special dye. The goal is to see if this …

This study tests a new treatment for people with certain advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12V. The treatment involves taking a patient's own white blood cells, modifying them in a lab to better recognize…

This early-stage study tests a new drug called CBI-1214 in people with advanced colorectal cancer that has not responded to standard treatments. The drug works by helping the body's immune cells attack cancer cells. The main goals are to check safety and find the best dose, while…

This study compares a new, less invasive procedure called endoscopic full-thickness resection (eFTR) to standard surgery for early-stage colon cancer. About 434 participants will be randomly assigned to one of the two treatments. The goal is to see if eFTR is as safe and effectiv…

This study tests whether giving immunotherapy before surgery can help completely remove T4 colon cancers that have a genetic feature called dMMR. These cancers often don't respond to standard chemotherapy. The trial aims to see if this approach increases the chance of clean surgi…

This early-stage study tests a new drug called PHN-012 in people with advanced colon, pancreatic, or lung cancers that have stopped responding to standard treatments. The drug is an antibody-drug conjugate, designed to deliver a cancer-killing agent directly to tumor cells. The m…

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This study tests whether giving chemotherapy plus an immunotherapy drug before surgery can help people with locally advanced colon cancer. About 56 adults with a specific type of colon cancer will receive the treatment and then have standard surgery. The main goal is to see if th…

This study tests a combination of two cancer drugs (fruquintinib and FOLFIRI) as a second treatment option for people with metastatic colorectal cancer whose first treatment stopped working. About 60 adults will receive the drug combo to see if it can slow cancer growth and how s…

This study compares laparoscopic (keyhole) surgery to traditional open surgery for removing the right side of the colon in people with right colon cancer. Both surgeries use a special technique called complete mesocolic excision (CME) to remove the cancer and surrounding tissue. …

This study tests a procedure called TACE (chemoembolization) for people with non-small cell lung cancer or lung tumors that have spread from other cancers. Doctors inject chemotherapy directly into the artery feeding the tumor, then block that artery with tiny beads. This traps t…

This study tests a new drug that delivers radiation directly to cancer cells with a specific marker (GRPR). It is for adults with advanced cancers like prostate, breast, lung, or colon cancer that have come back or spread. The main goal is to find a safe dose and check for side e…

This study is testing a new type of PET/CT imaging that uses special probes to target and highlight digestive system cancers, including cancers of the liver, stomach, colon, pancreas, and more. Researchers want to see how these probes spread in the body and how well they can find…

This study is testing a new type of PET scan (called 18F-FAPI-74) to see if it can find colon cancer that has spread to lymph nodes or other organs better than current scans. The study will involve 100 people with colon cancer, either at first diagnosis or when a return of cancer…

This study is testing a new blood test that uses laser technology and artificial intelligence to find early signs of breast, colon, pancreatic, ovarian, and lung cancers. Researchers will collect blood samples from 1,400 people aged 45 and older who have or are suspected to have …

This study looks at whether the things people buy at stores—like painkillers or indigestion remedies—could be early warning signs of cancer. Many cancers cause vague symptoms that people treat with over-the-counter products before seeing a doctor. Researchers will compare the sho…

This study tests if wearing surgical gloves during oxaliplatin chemotherapy can prevent hand nerve damage (peripheral neuropathy) in colon cancer patients. About 84 adults with advanced colon cancer will be randomly assigned to wear gloves or not during treatment. The goal is to …

This study tests whether a digital app (Open Food Facts) plus nutrition education can help 170 people at high risk for breast, pancreas, colon cancer, or with Lynch syndrome or BRCA mutations improve their diet quality. Participants will use the app to reduce ultra-processed food…

This study tests a home-based recovery program for older, frail patients after colon cancer surgery. The program includes a health check, diet advice, and exercise guidance at home. Researchers want to see if this extra support helps patients recover better and feel healthier com…

This study tests whether giving lidocaine during colon cancer surgery can reduce pain and the need for strong painkillers (opioids) afterward. It also looks at how quickly the bowel starts working again. About 100 adults having laparoscopic colon resection will be randomly assign…

This study tests an 8 to 12-week exercise program for people with or past cancer. The program includes supervised exercise classes, either online or in person. The goal is to help participants become more active and reduce cancer-related symptoms like fatigue. About 740 adults ac…

This study tests whether giving lidocaine (a numbing medicine) or high-dose dexamethasone (a strong anti-inflammatory) during colon cancer surgery can improve the body's immune response and help patients recover better. About 100 adults having colon cancer surgery will be randoml…

This study looks at whether yoga and mindfulness can improve the social, emotional, and physical well-being of people who have had lung, colon, or non-Hodgkin's lymphoma cancer. Researchers will also check if these practices affect epigenetics—how our environment turns genes on o…

This study tests whether using virtual reality (VR) can reduce severe belly pain in people with digestive tract cancers. 360 participants will be split into three groups: one using skills-based VR, one using distraction VR, and a sham control group. Researchers will track pain, a…

This study looks at how radiation from a procedure called Y90 radioembolization damages liver tumors that have spread from colorectal cancer. Researchers will take small tissue samples (biopsies) from the tumors after treatment to see how much cell death and injury occurs. The go…

This study looks at whether a specific suture material (MonoPlus®) can reduce the chance of leaks where the intestine is reconnected after colon cancer surgery. About 249 adults having this surgery will be enrolled and followed for 30 days. The goal is to see if this material wor…

This study looks at whether a digital app can help cancer patients get genetic testing directly from their oncologist, instead of visiting a separate genetics clinic. The goal is to see if this approach reduces patient distress and improves care. About 180 adults with breast, pro…

This study looks at people who have a gene variant (called a secondary finding) that was found during genetic testing for another reason. Researchers want to learn how these variants affect health and how people understand and share their results. Up to 5,000 participants will co…

This study collects blood and other samples from adults with cancer to learn how certain immune cells change before and after chemotherapy. It does not provide any treatment. Up to 1,750 participants will give blood samples, and some may also provide tissue, urine, or stool. The …

This study follows up with people who previously took part in cancer vaccine studies using gene therapy. It does not give any new treatment. Instead, it checks their health once a year for 15 years to watch for any long-term side effects. Up to 750 participants with various cance…

This study looks at whether a blood or stool test that detects tumor DNA (called ctDNA) can help doctors better manage gastrointestinal cancers like pancreas, colon, and bile duct cancer. About 100 adults with these cancers will provide samples, and researchers will track surviva…

This study aims to uncover the genetic roots of lymphomas, leukemias, multiple myeloma, and similar diseases by collecting DNA and blood samples from people who have these conditions and their family members. Researchers will analyze the samples to find genes that increase the ri…

This study tests a program called CARES that provides advocacy, resources, education, and support to rural cancer patients. The goal is to see if it helps them start treatment sooner after diagnosis and finish it faster. The study will include 320 adults with solid tumors like lu…

This study follows 368 colorectal cancer survivors aged 25-65 to see how their quality of life changes 6, 12, and 24 months after treatment. Researchers will use questionnaires to measure physical, mental, and social well-being, and look for late side effects linked to their spec…

This study looks at whether keeping the left colic artery intact during surgery for colorectal or ovarian cancer helps maintain better blood flow to the colon. About 50 adults scheduled for left-sided colon, rectal, or ovarian cancer surgery will participate. Researchers will mea…

This study aims to collect and analyze genetic information from 25,000 adults who either have cancer or are at risk of developing it. Researchers will look at tumor DNA and other health records to better understand what drives different cancers. The goal is to find new ways to de…

This study looks at whether a combination of special nutritional supplements (HMB and vitamin D) and a structured exercise program can help adults with colon cancer regain muscle strength and improve recovery after surgery. About 120 participants will be randomly assigned to diff…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…

This study looks at how the bacteria in your gut and what you eat can influence diarrhea caused by chemotherapy in people with colon cancer. Researchers will collect stool samples and diet surveys from 11 participants to build a tool that predicts who is at higher risk for this s…

This study is testing whether a blood test that looks for tumor DNA (ctDNA) can find cancer returning sooner than standard scans. Researchers will follow 100 people with various solid tumors to see if early detection leads to better treatment options. The goal is to improve how w…

This study tests whether daily CT scans can help doctors see and protect the ovaries during pelvic radiation in women under 50 with various cancers. The goal is to keep radiation doses to the ovaries low enough to avoid early menopause and infertility. Ten participants will recei…

This study looks at whether cleaning the bowel before surgery for colon cancer helps prevent infections. About 74 people having laparoscopic right colon removal will be randomly assigned to receive or skip bowel prep. The main goal is to see if bowel prep reduces surgical site in…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to the cancer care team helps people aged 70 and older with gastrointestinal cancers. Researchers want to see if this approach is practical and if it reduces unplanned hospital v…

This study aims to improve how doctors determine the stage of colon cancer before surgery and decide who should receive chemotherapy beforehand. Researchers are analyzing blood samples from 400 colon cancer patients to find specific molecules (exosomal microRNAs) that can be comb…

This study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…