COLON CANCER

This study tested a new combination treatment for people with colon cancer who had surgery and chemotherapy but still had tiny amounts of cancer left in their blood. The treatment used specially prepared immune cells (CB-NK cells) from donors, given along with the drug cetuximab.…

This study tested a combination of three targeted drugs (encorafenib, binimetinib, and cetuximab) given for 8 weeks before surgery to people with a specific genetic type of localized colon cancer (BRAF V600E mutated). The goal was to see if this 'neoadjuvant' approach could shrin…

This study tested whether a combination of daily aspirin, vitamin D, a low-fat diet, and regular exercise could help prevent colorectal cancer from coming back. It involved 16 patients who had completed their main cancer treatment but still had tiny traces of cancer DNA in their …

This early-phase trial tested a new cell therapy for people with advanced gastrointestinal cancers that had stopped responding to standard treatments. Researchers collected a patient's own immune cells from a tumor, used CRISPR gene editing to remove a molecular 'brake' (CISH), a…

This study tested whether combining two targeted drugs, palbociclib and cetuximab, could help control advanced colon cancer that has spread. It involved 24 patients whose cancer had specific genetic features and who had already tried other treatments. The goal was to see if hitti…

This study tested the safety and best dose of a combination of two drugs, regorafenib and nivolumab, for people with advanced colorectal cancer that had stopped responding to standard treatments. The main goal was to see how much of the drug combination patients could tolerate an…

This study tested whether elderly patients (age 75+) can tolerate chemotherapy after colon cancer surgery without losing their ability to perform daily activities. Researchers compared patients who received 6 months of chemotherapy pills to those who had observation only. The mai…

This study tested a new web and text message program designed to help people who have had colorectal cancer eat healthier. Researchers wanted to see if the program was easy to use and acceptable to 50 cancer survivors over 12 weeks. The goal is to help survivors make dietary choi…

This early-phase trial tested a new personalized therapy for advanced gastrointestinal and other cancers driven by a specific genetic flaw called RAS G12D. Researchers collected a patient's own immune cells, genetically modified them in a lab to recognize and attack cancer cells …

This study aimed to find out if lying on one's side or lying on one's back is better for a digital rectal exam. Doctors performed the exam on 320 men with various colon or rectal conditions to see which position allowed for a more complete check. The goal was to improve the accur…

This study tested whether offering a simple blood test could help more people get screened for colon cancer. It involved over 2,000 adults aged 45-75 who were overdue for their screening. Researchers compared how many people completed screening when offered the blood test versus …

This study compared three different methods for detecting colon cancer in people with a family history of the disease. Researchers tested whether a swallowable camera capsule or a simple annual stool test could be as effective as traditional colonoscopy. The goal was to find safe…

This study tested whether a simple blood test using artificial intelligence could detect colorectal cancer early. Researchers collected blood samples from nearly 49,000 average-risk adults aged 45-85 who were already scheduled for routine colonoscopy screening. The goal was to se…

This small pilot study tested whether an 8-week mindfulness program could help reduce chronic stress and related biological factors that may increase colon cancer risk. It involved 24 Black women, aged 45-65, living in high-stress Chicago neighborhoods who were already at elevate…

This study tested whether sending text message reminders helps more people complete their at-home colon cancer screening test (called a FIT kit) compared to the usual phone call reminders. Researchers enrolled over 1,200 adult patients from NYU family health clinics. They measure…

This study tested whether a 6-week program of supervised exercise could improve quality of life and reduce fatigue for people with breast or colon cancer. It involved 78 patients, some of whom were also receiving standard cancer treatments like chemotherapy. Researchers compared …

This study compared two methods for managing pain after planned colon or rectal surgery. Researchers tested a newer nerve-block injection (TAP block) against the traditional epidural to see which better controlled pain and improved recovery. The trial involved 200 adults undergoi…

This study compared two standard methods for controlling pain after colon or rectal surgery. Researchers tested whether a simpler method using a local pain medication catheter placed near the surgical site works as well as the more complex epidural method. They measured patients'…

This pilot study tested whether a coordinated, personalized rehabilitation program could improve life quality for colorectal cancer patients. 150 patients in Slovenia were assigned to either receive standard care or a new pathway connecting them to specialists like physiotherapis…

This study tested whether a special high-flow nasal oxygen device could help prevent low oxygen levels during sedated endoscopy procedures. It focused on 80 patients at high risk for obstructive sleep apnea who were undergoing stomach or colon exams. Researchers compared breathin…

This study aimed to understand how Mexican American families talk about their risk for common diseases like diabetes, heart disease, and cancer. Researchers worked with 498 adults from multigenerational households to see if sharing personalized risk information with the whole fam…

This study tested whether smartphones and smartwatches could be used to reliably measure symptoms like fatigue and changes in activity in cancer patients. Researchers enrolled 49 adults with various cancers who were already receiving treatment. They used iPhones and Apple Watches…

This study tested a new AI system called EndoStyle that can change the look of colonoscopy images to match different medical equipment brands. Doctors experienced in colonoscopy viewed sequences of images and tried to identify which ones were altered by the AI. The goal is to see…

This study looked back at medical records of 7,259 colon cancer patients who had surgery to remove their tumors. Researchers analyzed how the size of the original tumor and whether it had spread to lymph nodes influenced if and where the cancer came back. The goal is to better un…

This study looked at 1,471 colon cancer patients to understand how a specific protein status in the tumor (called MMR status) relates to how the cancer spreads to lymph nodes and patient survival. The goal was to gather evidence to help doctors decide the best extent of lymph nod…

This study aimed to understand and address why Latino individuals are underrepresented in cancer clinical trials. Researchers worked with 60 Spanish-speaking Latino adults from a local church, showing them educational videos about colorectal cancer and asking about their knowledg…

This international study aimed to find the best amount of bowel and surrounding lymph nodes to remove during colon cancer surgery. Researchers observed over 3,600 patients who had surgery to see how far the cancer had spread. The goal was to gather evidence to help surgeons decid…

This study aimed to understand how common muscle loss (sarcopenia) is in people about to have colorectal cancer surgery and how it affects their recovery. Researchers followed 70 patients, measuring their muscle strength, mass, and physical ability before surgery. They then track…

This study looked at 1,500 colon cancer patients to see if a new way of classifying lymph node spread could better predict patient survival. Researchers analyzed where cancer spread in the lymph nodes and compared it to current staging systems. The goal was to create a more accur…

This study checked how closely eight hospitals in Rome followed established recovery guidelines for patients having colon surgery for cancer or diverticulitis. It involved 1000 patients and aimed to see if following the guidelines more closely led to fewer complications and short…

This study aimed to understand how cancer DNA in the blood changes before, during, and after surgery. Researchers followed 30 patients with breast, prostate, or colon cancer undergoing curative surgery. They measured specific cancer DNA fragments in blood samples to create a base…