COLON CANCER

This trial tested a new treatment for people with advanced gastrointestinal cancers (like stomach, colon, or pancreatic cancer) that had spread and stopped responding to standard therapy. Doctors took immune cells from each patient's tumor, used CRISPR gene editing to remove a ge…

This study tested a combination of three drugs (encorafenib, binimetinib, and cetuximab) given before surgery to people with a specific type of colorectal cancer that has a BRAF V600E mutation. Only 2 participants were enrolled. The goal was to see how well the drugs shrink the t…

This early-phase trial tested a new treatment for people with advanced cancers (like pancreatic, stomach, or colon cancer) that have a specific genetic change called KRAS G12D. Doctors took participants' own white blood cells, modified them in a lab to better recognize and attack…

This early-phase study tested the safety and best dose of combining two drugs, regorafenib and nivolumab, in 52 people with advanced colorectal cancer that had stopped responding to standard treatments. The goal was to see if this combination could help control the disease. Parti…

This study tested an experimental drug called CTX-009 in 49 adults with metastatic colorectal cancer that had worsened after two or three prior treatments. The goal was to see if the drug could shrink tumors or stop cancer growth. Participants received CTX-009 and were monitored …

This study tested a combination of two drugs, palbociclib and cetuximab, in 24 adults with a specific type of metastatic colon cancer that had not responded to standard treatments. The goal was to see if the combination could shrink or stabilize tumors. While the treatment aimed …

This study looked at how well people aged 75 and older with stage III colon cancer handle chemotherapy after surgery. Researchers measured changes in daily living activities, side effects, and quality of life. The goal is to better identify which older patients can benefit from c…

This early-phase study tested a new immunotherapy approach in 15 colon cancer patients who had completed standard treatments but still had tiny traces of cancer DNA in their blood (minimal residual disease). The treatment combined specially activated cord blood natural killer (CB…

This study looked at whether taking vitamin D and aspirin daily, along with exercise and a low-fat diet, could help prevent colorectal cancer from returning in 16 patients who had no visible tumors but still had cancer DNA in their blood. The goal was to see if these lifestyle ch…

This study tested a new blood test designed to find colorectal cancer early in people at average risk. Nearly 49,000 adults aged 45 to 85 gave a blood sample before their routine colonoscopy. The goal was to see how well the blood test could detect cancer and advanced growths com…

This study looked at three different screening methods—colonoscopy, a pill-sized camera (colon capsule), and a stool test—to find colorectal cancer or pre-cancerous growths in people aged 45 and older who have a parent, sibling, or child with colorectal cancer. The goal was to se…

This study tested whether offering a simple blood test (Guardant SHIELD) helps more people complete colon cancer screening compared to usual care. About 2,000 adults aged 45-75 who were behind on screening took part. The main goal was to see if more people got screened within 3 m…

This study looked at whether a 6-week supervised exercise program could improve quality of life and reduce fatigue in 78 adults with breast or colon cancer. Some participants were also receiving chemotherapy, radiation, or hormone therapy. The researchers measured changes in qual…

This study looked at whether a high-flow nasal cannula (a device that delivers warm, humidified oxygen) can reduce the risk of dangerously low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. Researchers enrolled 80 adult…

This study tested two standard pain control methods after colon or rectal surgery: a local anesthetic delivered through small tubes placed near the surgical site (preperitoneal) versus an epidural. Researchers measured pain scores and the need for extra pain medication in 98 adul…

This study tested a personalized rehabilitation program for 150 adults who finished treatment for colorectal cancer. The program connects patients with specialists like physiotherapists, dietitians, and psychologists based on their individual needs. The goal was to improve qualit…

This study looked at 200 adults having elective colorectal surgery for colon cancer, rectal cancer, or diverticulosis. It compared two pain management methods: a TAP block (an injection into the abdominal wall) versus epidural anesthesia. The goal was to see which method provides…

This study looked at 70 adults with colorectal cancer to see how common muscle loss (sarcopenia) is before surgery and whether it leads to more complications or longer hospital stays. Researchers measured muscle strength, mass, and physical performance. The goal was to find high-…

This study looked at over 3,600 people with early to mid-stage colon cancer to see where cancer spreads to lymph nodes and how much bowel and surrounding tissue should be removed during surgery. The goal was to provide clear evidence for surgeons on the best way to operate. Parti…

This study looked at how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from the same households to understand how culture and family ties help or hinder these conversations. The goal i…

This study looked at 1,471 people with colon cancer to see how their tumor's DNA repair system (called MMR status) affects where the cancer spreads and how long they live. Researchers compared two groups: those with normal repair (pMMR) and those with faulty repair (dMMR). The go…

This study looked at 1500 colon cancer patients to see if a new system for classifying lymph node spread could better predict survival. Researchers compared the standard method (counting nodes) with a new approach that also considers where the nodes are located and includes cance…

This study tested whether iPhones and Apple Watches can help monitor symptoms and activity levels in people with cancer. 49 adults receiving cancer treatment at the NIH wore an Apple Watch and used an iPhone for 4 months. The goal was to see if these devices could reliably measur…

This study tested whether text message reminders work better than phone calls to get people to complete a simple at-home colon cancer screening test (FIT). Over 1,200 adults from NYU family health centers took part. The goal was to see if texts could boost screening rates and hel…

This study looked at 320 men to find out if a digital rectal exam works better when the patient lies on their back (supine) or on their side (lateral decubitus). The goal was to see which position allows the doctor to do a more complete exam. Participants had conditions like colo…

This study looked at how DNA from tumors changes in the blood before, during, and after surgery for breast, prostate, or colon cancer. Thirty adults having curative surgery provided blood samples to track these DNA levels. The goal was to gather basic information that could help …

This study tested a 12-week web-based diet program with text messaging for 50 colorectal cancer survivors. The goal was to see if the program was easy to use and could help people eat more vegetables, whole grains, and fish while cutting back on red meat and sweets. Participants …

This study tested an AI system called EndoStyle that can change the look of colonoscopy images to match different types of equipment. 40 doctors were shown real and AI-transformed images to see if they could tell the difference. The goal is to help train AI systems using more var…

This study looked at whether practicing mindfulness can reduce chronic stress and lower colon cancer risk factors in Black women aged 45-65 who live in high-crime Chicago neighborhoods. Twenty-four women who had a past colon polyp and reported high stress took part. The goal was …

This study looked back at over 7,000 people who had surgery for stage I to III colon cancer. Researchers wanted to understand how the tumor stage and lymph node involvement affect the chance of cancer returning and survival. The goal is to help doctors better predict outcomes and…

This study reviewed how closely eight hospitals in Rome followed Enhanced Recovery After Surgery (ERAS) protocols for 1,000 patients having colorectal surgery. The goal was to see if following these steps leads to fewer complications and shorter hospital stays. The research did n…

This study enrolled 60 Spanish-speaking Latino adults from a church in Chapel Hill to see if an educational session could improve their knowledge of colorectal cancer and willingness to join cancer clinical trials. Participants watched videos in Spanish and completed questionnair…