COLON CANCER

This study tests a combination of two drugs, cabozantinib and nivolumab, in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if the combination can stop or shrink the cancer for at least 16 weeks. About 48 adults with a spec…

This study tests whether giving chemotherapy before surgery can help prevent colon cancer from coming back. About 708 adults with locally advanced colon cancer will either receive chemo before surgery or standard treatment. The goal is to see if the pre-surgery approach improves …

This study tests a combination of three drugs (entinostat, PDS01ADC, and bintrafusp alfa) in adults with advanced cancers linked to HPV or certain colon cancers that haven't responded well to standard treatments. The goal is to find a safe dose and see if the combo can shrink tum…

This study compares giving chemotherapy before surgery (3 cycles) to the standard approach of surgery followed by 8 cycles of chemo in 250 people with locally advanced colon cancer. The goal is to see if the pre-surgery chemo can reduce or eliminate the need for post-surgery chem…

This study looked at whether starting chemotherapy 10 to 14 days after surgery for stage III colon cancer is safer and more effective than the usual approach of waiting more than 2 weeks. About 300 patients took part. The goal was to see if earlier treatment improves the chance o…

This study compares two methods for removing medium-to-large colon polyps during a colonoscopy: cold snare piecemeal resection (CSPR) and cold snare endoscopic mucosal resection (Cold EMR). The goal is to see which technique removes polyps more completely, reducing the risk of co…

This study tests whether taking postbiotic supplements after colon cancer surgery can help restore healthy gut bacteria. The surgery and antibiotics often disrupt the natural balance of bacteria in the gut. The trial will compare changes in gut bacteria diversity between people w…

This study tests a new fluorescent clip that glows under special lights to help surgeons locate colon tumors during minimally invasive surgery. About 110 adults with colon cancer will be randomly assigned to receive either the clip or a standard dye injection before surgery. The …

This study tests a new drug called AZD6244 given with standard chemotherapy for people with advanced solid tumors (like breast, colon, lung, melanoma, or kidney cancer) that have no curative options. The main goal is to see if the combination is safe and tolerable, and to find th…

This study tested an oral drug called selpercatinib in 857 people with advanced solid tumors that have a specific RET gene change. The goal was to see if the drug is safe and can shrink tumors. While it may control the cancer, it is not a cure, and ongoing treatment is needed.

This early-phase study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic) that have a specific genetic change called KRAS G12C. The main goal is to find the safest dose and check for side effects. About 44 adults who have tried other tre…

This early-phase trial tests a new drug called adagrasib (MRTX849) combined with two other drugs (cetuximab and irinotecan) in people with colorectal cancer that has a specific genetic change (KRAS G12C). The main goal is to find a safe dose and check for side effects. About 24 a…

This study tests if the drug cemiplimab can control a specific type of colon cancer (called dMMR or MSI-H) without needing surgery. About 50 adults with this cancer will receive the drug and be monitored for side effects and cancer response. The goal is to see if the drug alone c…

This study tests an experimental oral drug (GSK4418959) in adults with advanced solid tumors that have specific genetic features (dMMR or MSI-H). The drug aims to shrink tumors by blocking a DNA repair protein. The trial will check safety, side effects, and how well the drug work…

This study follows 150,000 people in the U.S. who were prescribed the Cologuard stool test for colorectal cancer screening. Researchers want to see how many people get a follow-up colonoscopy after a positive result, how often cancer is found, and how these numbers compare to nat…

This study tests a special PET scan that uses a radioactive antibody (64Cu-M5A) to find cancers that produce a protein called CEA. About 20 adults with various CEA-positive cancers will receive the injection and have scans over two days. The goal is to see if this method can dete…

This study tests a combination of team-based clinic practices and patient-friendly technology to help more people complete a colonoscopy after an abnormal stool-based screening test. The goal is to catch colon cancer early or prevent it entirely. About 2,000 adults who speak Engl…

This early-phase study tests whether a green tea compound called EGCG can help prevent colon cancer from returning in people who have had surgery to remove their tumor. About 51 adults with early-stage colon or rectal cancer will take EGCG or a placebo before and after surgery. T…

This study looks at whether health education from nurses can improve quality of life and reduce anxiety and depression in people who have a stoma after digestive surgery. About 70 adult patients with a permanent or long-term ostomy will take part. They will attend workshops and r…

This study tests whether a 6-week online therapy program (acceptance and commitment therapy) can reduce anxiety and depression in 32 cancer survivors who have finished treatment. Participants will be randomly assigned to either the therapy group or a waiting list. The study measu…

This study tests whether using a FitBit and a mobile app can help people who have had surgery for stomach, liver, colon, or other GI cancers avoid going back to the hospital. About 107 adults who own a smartphone and are scheduled for surgery will either use the devices or get us…

This study looks at whether applying cold (cryotherapy) can help prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with stage III colon cancer. About 40 participants will be randomly assigned to receive cryotherapy or not during their standard chemo. The …

This study looks at two different surgeries for a rare type of colon cancer located at the splenic flexure. About 140 patients will be split into two groups: one getting a smaller surgery (removing only the tumor section) and the other a larger surgery (removing more colon and ly…

This pilot study aims to find better ways to detect if colon cancer is likely to spread to the liver. Researchers are testing new imaging and blood-based lab tests in 51 people undergoing surgery for colon cancer or benign colon growths. The goal is to improve early detection and…

This study collects DNA from over 21,000 people with different cancers (like breast, colon, and lung) in New York. Researchers will look for inherited gene changes that might be linked to cancer. The goal is to find clues for future studies, not to test a treatment.

This study aimed to see if certain genes that make people more prone to bleeding could cause a stool test for colon cancer to show a false-positive result. Researchers planned to collect saliva samples from people who had a positive stool test but a normal colonoscopy, and compar…

This study looks at how exercise might change the body's biology to lower the risk of colorectal cancer returning. Researchers will measure inflammation and other markers in 60 patients who have finished their cancer treatment. The goal is to understand the biological processes b…

This study searches for brand-new gene changes that appear in a person with cancer but not in their parents. By comparing cancer patients, their healthy parents, and other family members, researchers hope to uncover genetic clues that raise cancer risk. The goal is to better iden…

This study looks at whether a new way of paying for cancer care can help doctors work together better and improve health outcomes for patients with breast, colon, or lung cancer. The study involves 7 participants and compares the new payment model to the usual way of paying for c…

This study looks at whether using a physical activity screener, along with exercise coaching and self-monitoring, can help breast and colon cancer survivors increase their physical activity and reduce sitting time. About 20 survivors aged 50 or older who finished primary cancer t…

This study looks at whether a website and a genetic family navigator can help more family members of people with hereditary cancer get genetic testing. About 205 adults who have a known cancer gene mutation and their relatives will take part. The goal is to see if this approach m…