COLON CANCER

This early-stage study is testing a new oral drug, GSK4418959, for adults with advanced solid tumors that have specific genetic features (called dMMR or MSI-H). The main goals are to find a safe dose, see how the body processes the drug, and check if it can shrink tumors, either …

This early-stage trial is testing the safety and best dose of a new drug, adagrasib, when combined with two existing cancer drugs (cetuximab and irinotecan). It is for adults with advanced colorectal cancer that has a specific genetic change called KRAS G12C and has stopped respo…

This study is testing an oral medication called selpercatinib (LOXO-292) for people with advanced solid tumors that have a specific genetic change in the RET gene. The goal is to find a safe dose and see if the drug can shrink these difficult-to-treat cancers. It is for patients …

This study is testing whether using a Fitbit and a mobile app can help patients recover better after major surgery for gastrointestinal cancers. About 107 patients were randomly assigned to either use the app and tracker along with their usual care, or to receive usual care alone…

This is the first human study of an experimental oral medication called HBI-2438 for people with advanced solid tumors that have a specific genetic change called KRAS G12C. The main goals are to find the highest safe dose and understand how the body processes the drug. The study …

This study aims to help more people complete a necessary colonoscopy after an abnormal stool test for colorectal cancer. It tests a two-part program: training clinic teams in best practices and providing patients with tech tools for instructions and scheduling help. The goal is t…

This study compares two common techniques doctors use to remove colon polyps during routine colonoscopies. Researchers want to know which method—cold snare piecemeal resection or cold endoscopic mucosal resection—is more effective at completely removing polyps that could turn int…

This study is testing a new combination of three immunotherapy drugs for people with advanced cancers that have not responded well to standard treatments. It focuses on cancers linked to HPV (like cervical, throat, and anal cancers) and certain colon cancers. The main goals are t…

This study is testing whether daily postbiotic gummy supplements can help protect the balance of gut bacteria in people undergoing colon cancer surgery. Thirty patients scheduled for surgery will take either the postbiotic gummy or a placebo daily before and after their operation…

This study is testing whether a combination of two drugs, cabozantinib and nivolumab, can help control advanced colorectal cancer that has stopped responding to standard treatments. It will involve about 48 adults whose cancer has spread and is a specific type called microsatelli…

This study compares two approaches for treating locally advanced colon cancer. One group receives three cycles of chemotherapy before surgery, while the other receives the standard treatment of surgery followed by eight cycles of chemotherapy. The goal is to see if the pre-surger…

This study is testing whether a 12-week aerobic exercise program can help prevent cancer from coming back in people who have finished treatment for colon or rectal cancer. Researchers will measure changes in blood markers related to inflammation and cancer cells. The goal is to u…

This early-stage trial is testing whether adding an experimental oral drug called AZD6244 to standard chemotherapy is safe for people with advanced cancers like breast, lung, colon, and kidney cancer. The study will find the highest dose patients can tolerate and track how the bo…

This study aims to determine which of two common surgeries is better for treating colon cancer located at a specific bend in the colon called the splenic flexure. It will follow about 140 patients from multiple hospitals in Turkey and Europe, comparing a smaller, targeted surgery…

This large study is testing if giving chemotherapy before surgery is better than the usual approach of giving it after surgery for people with locally advanced colon cancer. The goal is to see if this 'pre-surgery' chemo can kill hidden cancer cells earlier, potentially preventin…

This study is testing whether starting chemotherapy 10 to 14 days after colon cancer surgery is better than starting later. It involves 303 people with stage III colon cancer who will receive a standard chemotherapy regimen. The main goal is to see if the earlier start improves 3…

This study is testing a new glowing surgical clip designed to help surgeons precisely locate colon tumors during minimally invasive surgery. Researchers will compare this clip to the current standard method, which uses a special dye injected near the tumor. The goal is to see if …

This is a small, early-stage study to test a new type of imaging scan. The scan uses a special radioactive tracer that attaches to a protein (CEA) made by many cancers. The goal is to see if this new scan can find cancer spots that standard imaging tests might miss in patients wi…

This study is testing whether a compound from green tea, called EGCG, can help prevent colon cancer from coming back after surgery. It involves patients with early-stage colon cancer who have had their tumor surgically removed. Some participants will take the EGCG supplement dail…

This study is testing whether a health education program led by specialized nurses can help improve quality of life and reduce symptoms of anxiety and depression in adults living with a digestive ostomy after surgery. The program involves workshops and follow-up care for about 70…

This study is testing if applying cold therapy (cryotherapy) to the hands and feet during chemotherapy can prevent nerve damage, a common and debilitating side effect. It involves 40 adults with stage III colon cancer who are starting a specific chemotherapy regimen. The goal is …

This study is testing whether a 6-week online therapy program can help reduce anxiety and depression in people who have finished cancer treatment. The program, based on Acceptance and Commitment Therapy, teaches skills for managing difficult thoughts and feelings. Researchers wil…

This study aims to gather long-term health information from people who have been prescribed the Cologuard stool test for colorectal cancer screening. It will follow 150,000 participants in the United States to see how often they get follow-up colonoscopies after a positive test a…

This study aims to find new markers in blood and imaging scans that could help doctors better detect colon cancer and predict its likelihood of spreading to the liver. It involves 51 adults who are already scheduled for colon cancer surgery. The research focuses on gathering info…

This study is testing whether a new payment model that encourages better care coordination improves health outcomes and reduces costs for cancer patients in Hawaii. It involves 7 participants with breast, colon, or lung cancer who receive chemotherapy through specific Hawaii prov…

This study aimed to understand why some people get a positive result on a common stool test for colon cancer, but then a follow-up colonoscopy finds nothing wrong. Researchers wanted to check if a person's genetic tendency to bleed a little more easily could cause these 'false po…

This study is testing a new program to help family members of people with hereditary cancer get genetic testing. The program includes a website and a personal guide. Researchers want to see if this approach makes it easier for families to understand and act on their genetic cance…

This study aims to discover new types of inherited gene changes that might explain why some people develop cancer. Researchers are studying cancer patients along with their unaffected parents to look for gene differences that appear in the child but not the parents. The goal is t…