Small intestine disorder

This study tested a Novavax COVID-19 booster vaccine in 21 people with weakened immune systems due to inflammatory bowel disease or organ transplants. The goal was to see if the booster improved antibody levels and immune protection against COVID-19. Participants had already rece…

This study looks at the long-term safety of imatinib, a daily pill for certain cancers like GIST and CML. It includes 250 patients who were already benefiting from imatinib in a previous Novartis trial and continue taking it. The main goal is to track side effects over time, with…

This early-phase trial tested two drugs together—pembrolizumab (Keytruda) and XL888—in 47 people with advanced gastrointestinal cancers like colorectal and pancreatic cancer that had spread or could not be removed. The main goal was to find the safest dose and check for side effe…

This study tested whether giving pantoprazole (a stomach acid reducer) to critically ill ICU patients prevents stress ulcers and reduces death. Over 3,300 adults at high risk were randomly assigned to receive pantoprazole or a placebo daily while in the ICU. Researchers tracked d…

This study looked at whether a probiotic called LP-LDL can lower cholesterol and improve heart health in adults with celiac disease. 50 participants took the probiotic to see if it reduced their cholesterol levels and body mass index. The goal was to find a safe way to manage hea…

This study tested whether the drug ritlecitinib could prevent intestinal damage and symptoms when people with celiac disease ate gluten. 62 adults with well-controlled celiac disease (on a gluten-free diet) took either the drug or a placebo along with a daily gluten challenge. Th…

This phase 2 trial compares two oral targeted drugs—ripretinib and sunitinib—in 108 people with advanced gastrointestinal stromal tumors (GIST) whose cancer has worsened on or who cannot tolerate imatinib. The main goal is to see which drug better delays cancer growth. Participan…

This phase II trial tested the chemotherapy drug paclitaxel in 40 patients with advanced or metastatic gastrointestinal stromal tumor (GIST) whose cancer had stopped responding to three standard treatments: imatinib, sunitinib, and regorafenib. The study focused on patients with …

This study tested a new way to reconnect the pancreas to the intestine during Whipple surgery for certain cancers. The new method uses a stent and wraps the connection with omentum (fatty tissue) to try to prevent leaks. 48 patients were split into two groups to compare the new t…

This Phase 2 trial tested whether TAK-101, given as an intravenous infusion, can reduce gluten-related symptoms and immune activation in adults with well-controlled celiac disease who follow a gluten-free diet. Participants received two doses of TAK-101 or placebo, and all were l…

This study tested a pharmacist-driven protocol to stop stomach ulcer prevention drugs in ICU patients when they are no longer needed. The goal was to reduce unnecessary medication and side effects without increasing the risk of stomach bleeding. The trial included 120 adult ICU p…

This study tested adding lenalidomide to a standard chemotherapy regimen (EPOCH-R) in 55 people with aggressive B-cell lymphomas linked to the MYC gene. The goal was to find the best dose and see if the combination improves how long patients live without their cancer getting wors…

This early-phase trial tested two cancer drugs—imatinib mesylate and cyclophosphamide—given daily by mouth to 26 people with rare, advanced tumors that had no standard treatment. The main goal was to find the safest dose of imatinib when combined with a fixed dose of cyclophospha…

This completed Phase 3 study tested the drug D961H (esomeprazole) in 50 Japanese children to see if it can prevent reflux esophagitis from coming back and stop stomach or duodenal ulcers from recurring in kids taking NSAIDs or low-dose aspirin. Children took the drug for up to 52…

This study compared two surgical methods—laparoscopic (keyhole) and open surgery—for treating a rare cancer near the pancreas called periampullary adenocarcinoma. Forty patients were enrolled to see which approach led to fewer complications like pancreatic fistula. The goal was t…

This phase 2 trial tested the safety of P28GST, a protein from a parasite, in 10 adults with moderate Crohn's disease. Participants received three injections over three months. The goal was to see if the protein could safely control inflammation, especially after intestinal surge…

This study looked at how safe and effective the drug avapritinib is for Chinese patients with a rare type of stomach cancer called gastrointestinal stromal tumor (GIST). Researchers observed 61 patients in real-world clinics, not in a controlled lab setting. The goal was to track…

This study compared miniinvasive (robotic or laparoscopic) Whipple surgery to the traditional open approach in 320 patients with pancreatic, bile duct, or ampulla of Vater cancers. The goal was to see which method leads to fewer complications like pancreatic leaks, bleeding, or i…

This phase 4 trial tested the drug nilotinib in 34 adults with advanced GIST that could not be removed by surgery. The goal was to see how many patients had their tumors shrink or stay stable after 6 months. Researchers measured response using standard tumor scans. The study prov…

This completed Phase 4 trial tested a new surgical technique during Whipple surgery for resectable periampullary tumors. The method uses an omental patch and surgical glue to reinforce the pancreatic connection, aiming to reduce leaks, bleeding, and stomach emptying problems. Thi…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study monitored 688 people in South Korea with ulcerative colitis, Crohn's disease, or pouchitis who were treated with Kynteles (vedolizumab) as part of their normal care. The main goal was to track side effects, and researchers also looked at how many patients saw symptom i…

This early-phase trial tested a new drug called NB003 in 258 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check the drug's safety, find the right dose, and see if it could shrink tumors. The study is now complete, an…

This study compared robotic-assisted pancreatic surgery to the standard open approach for people with pancreatic and related tumors. Researchers wanted to see if robotic surgery could help patients recover faster after the operation. A total of 268 patients took part across multi…

This study tested a drug called KAN-101 in 55 adults with celiac disease who had been on a gluten-free diet for at least a year. Participants received either KAN-101 or a placebo, then underwent a two-week gluten challenge. The drug appeared to reduce gluten-induced damage to the…

This study tested a combination of two drugs—pembrolizumab (an immunotherapy) and cyclophosphamide (a chemotherapy)—in 129 people with advanced sarcomas that had spread or could not be removed by surgery. The goal was to see if the combination could shrink tumors or stop them fro…

This study compares two surgeries—One Anastomosis Gastric Bypass and Duodenojejunostomy—for treating Superior Mesenteric Artery Syndrome (SMAS), a rare condition where the duodenum is compressed, causing severe nausea, vomiting, and weight loss. Twenty participants were randomly …

This study tested a new drug called TPM502 in 28 adults with celiac disease. The goal was to see if two infusions of TPM502 could safely train the immune system to tolerate gluten, potentially reducing the need for a lifelong gluten-free diet. Participants received either TPM502 …

This study looked at whether taking probiotic supplements alongside the antibiotic rifaximin helps people with SIBO feel better. 129 adults with bloating or constipation took either probiotics or a placebo for 3 months. The goal was to see if the combination reduced symptoms and …

This pilot study tested a highly targeted form of radiation called stereotactic body radiation therapy (SBRT) in 36 patients with pancreatic cancer that could not be removed by surgery or had come back after other treatments. The main goal was to see how safe the treatment was by…

This study tested a doctor-designed dose adjustment algorithm to prevent unplanned delays in FOLFOX chemotherapy for people with cancers of the colon, stomach, esophagus, and other digestive organs. 52 adults participated, and the goal was to see if the algorithm could keep treat…

This study looked at 73 adults with Crohn's disease who needed surgery to remove a diseased part of the bowel. Researchers compared two different ways to reconnect the healthy ends: one that removes the fatty tissue around the bowel (mesentery) and one that keeps it (Kono-S). The…

This study tested a combination of two drugs—avelumab (an immunotherapy) and axitinib (a targeted therapy)—in 58 adults with advanced gastrointestinal stromal tumor (GIST) that had worsened after standard treatments. The main goal was to see how many patients were still cancer-fr…

This study looked at how well a special biopsy method called EUS-FNB can diagnose hard-to-reach tumors in the abdomen, such as those near the bile duct or small intestine. Researchers reviewed data from 131 patients who had this procedure over 10 years. The goal was to see if thi…

This early-stage study tested whether a single oral dose of HB-2121 is safe in adults. Researchers monitored 18 participants for side effects and tracked how the drug moves through the body over 30 days. The goal is to develop a new way to diagnose celiac disease.

This study tested an artificial intelligence model that combines CT scans, digital pathology images, and patient history to improve diagnosis and risk prediction for gastrointestinal stromal tumors (GISTs). Researchers enrolled 300 patients with suspected stomach tumors. The AI a…

This study looked at 208 children who had a procedure called balloon enteroscopy to find problems in the small intestine. Researchers compared two types—single-balloon and double-balloon—to see which one worked better and was safer. The goal was to help doctors choose the best me…

This study looked at whether a newer type of blood test (CLIA) can reliably diagnose celiac disease without needing a biopsy of the small intestine. Researchers analyzed data from 765 adults who had both the blood test and a biopsy. The goal was to find the right cutoff value tha…

This study looked at 116 people with small-intestine neuroendocrine tumors to see if a blood test or a shorter urine collection could replace the standard 24-hour urine test for diagnosis. The goal was to find a simpler, equally accurate way to measure a key tumor marker called 5…

This study tested a new way to check gallbladder function using ultrasound after drinking special fatty acids. 100 adults with normal bile ducts took part. The goal was to see if this method can accurately measure how well the gallbladder squeezes and empties.

This study tested whether giving a daily mix of two types of friendly bacteria (Lactobacilli) to children at genetic risk could prevent or slow down autoimmune diseases like celiac disease, type 1 diabetes, and thyroid problems. The researchers enrolled 202 children who already h…

This pilot study tested an 8-week course of a multi-ingredient nutritional supplement (AV1PD1A) in 9 adults with hydrogen-dominant small intestinal bacterial overgrowth (SIBO). The main goal was to see if the supplement was safe and tolerable. Participants took three capsules dai…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study looked at whether cutting out certain carbs (FODMAPs) can help people with celiac disease who still have stomach issues even after following a gluten-free diet. Researchers surveyed and then ran a controlled trial with 80 adults who had celiac disease and irritable bow…

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This Phase 2 trial tested paltusotine, an oral drug, in 36 adults with carcinoid syndrome. The study looked at safety and how the body processes the drug at different doses. Participants were randomly assigned to 40 mg or 80 mg daily, with dose adjustments allowed. The goal is to…

This study looked at whether a low FODMAP diet (LFD) can reduce stomach symptoms and improve nutrition in people with small intestinal bacterial overgrowth (SIBO). 51 adults who had finished antibiotic treatment were split into two groups: one followed the LFD, the other ate norm…

This phase 2 trial looked at whether adding acupuncture and acupressure to oral cryotherapy (sucking on ice chips) can reduce nerve pain caused by oxaliplatin chemotherapy in people with gastrointestinal cancers. 78 patients were split into two groups: one got cryotherapy alone, …

This study looked at whether a tailored physical activity program could improve bone density in 15 children and teens with inflammatory bowel disease (IBD). Kids with IBD often have weaker bones due to inflammation, medication, and lower activity levels. The program focused on mo…

This study tested whether a device that gently stimulates the vagus nerve through the ear could reduce delayed stomach emptying after a major pancreatic surgery (pancreaticoduodenectomy). 84 patients were randomly assigned to receive the stimulation during surgery or not. The goa…

This study tested a drug called PRV-015 in 388 adults with celiac disease who still had symptoms like belly pain and bloating even after following a strict gluten-free diet. The goal was to see if the drug could reduce these symptoms better than a placebo. Participants took the d…

This study tested whether taking zinc supplements and applying a strong steroid cream (clobetasol) can prevent or reduce hand-foot skin reaction, a common and painful side effect of the cancer drug regorafenib. About 150 patients starting regorafenib were split into three groups:…

This completed study looked at how common celiac disease is in Spain and what factors might influence it. Researchers tested nearly 5,000 people of all ages across five regions using blood tests and biopsies. They aimed to understand why earlier studies found different rates in c…

This completed study looked at 328 patients with intermediate or high-risk gastrointestinal stromal tumors (GISTs) who took imatinib after surgery. The goal was to find the best dose that balances effectiveness in preventing tumor return with the risk of side effects. Researchers…

This study tested a special gluten-free food guide designed to help children and teens (ages 5-18) with newly diagnosed celiac disease eat a healthier diet. Forty participants received either standard care or the new guide. Researchers measured diet quality and how well they foll…

This study looked at whether taking a bowel-cleaning liquid before a capsule endoscopy helps doctors see the small intestine better and find more problems. 230 adults scheduled for the procedure were randomly assigned to get either a split dose, a single morning dose, or no speci…

This completed study from Oslo University Hospital involved 33 adults with celiac disease who followed a strict gluten-free diet. Over five separate one-day challenges, participants consumed wheat gluten, barley gluten, hydrolyzed barley gluten, or a placebo. Researchers measured…

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This study looked at 500 women with non-celiac wheat sensitivity (NCWS) to see if they have more gynaecological issues than healthy women or those with celiac disease or irritable bowel syndrome. Researchers also tested whether a gluten-free diet could improve these problems. A s…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study looked at 42 adults with both H. pylori infection and small intestinal bacterial overgrowth (SIBO). Researchers used advanced DNA and chemical tests on stool samples to map the types of gut bacteria and their byproducts. The goal was to better understand how these two …

This study involved 71 children with celiac disease who follow a lifelong gluten-free diet. Researchers measured their eating habits, symptoms, and quality of life, and looked for biomarkers in blood and stool to better monitor their health. The goal was to understand dietary imb…

This study looks back at 700 patients who had endoscopic treatment for gastrointestinal submucosal tumors at Xijing Hospital. Researchers want to know how often the tumors are completely removed, what complications occur, and whether the tumors come back over time. The goal is to…

This study tested a technique called cold snare to collect larger pieces of tissue from the duodenum during a routine endoscopy. Researchers wanted to see if these samples were good enough for detailed analysis, including single cell RNA sequencing. The study involved 13 people a…

This study looked at how gastric bypass surgery changes the bacteria in the small intestine. Researchers measured hydrogen in the breath of 51 severely obese patients before surgery and at several points up to 2 years after. The goal was to find out how often bacterial overgrowth…

This study looked at whether two easy-to-use frailty checklists (FRAIL and FiND) can predict severe side effects from chemotherapy in adults aged 65 and older with gastrointestinal cancers. Researchers followed 84 patients who had already had surgery and were receiving standard c…

This completed observational study looked at 492 patients with metastatic gastrointestinal stromal tumors (GIST) in France between 1990 and 2018. Researchers analyzed real-world treatment patterns, including which drugs were used and in what order, and how many patients got acces…

This completed observational study in Germany followed 10 patients with advanced gastrointestinal stromal tumor (GIST) who had already tried three or more prior treatments. Researchers tracked how ripretinib affected their quality of life and disease control in everyday clinical …

This study measured levels of the laxative PEG 3350 and its breakdown products in the blood and urine of 158 children who were already taking it, compared to children not taking it. The goal was simply to learn how the body processes this medicine, not to change any treatments. R…

This completed observational study collected over 3,700 PillCam SB3 capsule endoscopy videos from standard care procedures. The goal was to build a large database of images showing both normal and diseased small intestine tissue. Researchers will use this data to develop and vali…

This study looked at how patients recover after robotic surgery to remove part of the pancreas (pancreaticoduodenectomy). It included 91 adults with tumors in the pancreas or nearby areas. The main goal was to see how long they stayed in the hospital and how quickly they returned…

This study looked at 559 patients who had their gallbladder removed laparoscopically to find out when surgical drains are truly needed. Drains are sometimes placed to prevent fluid buildup or infection, but many studies show they aren't always necessary. The goal is to help docto…

This study looked at whether certain proteins in the blood can predict if the drug vedolizumab (Entyvio) will reduce inflammation in the small bowel of people with Crohn's disease. Researchers used MRI scans to measure changes in the bowel wall after treatment. The goal is to hel…

This study takes small tissue samples from people with inflammatory bowel disease (IBD) and healthy volunteers to grow 'mini guts' (organoids) in the lab. Researchers will then expose these organoids to radiation to mimic radiation enteritis and test potential treatments. The goa…

This completed study followed 44 adults who had Whipple surgery for cancers near the pancreas. Researchers measured changes in the remaining pancreas, including its size, metabolism, and nutrition levels, before surgery and at 3 and 6 months after. The goal was to learn how the b…