Small intestine disorder

This study tests a surgery called total pancreatectomy with islet autotransplantation (TPIAT) in 30 adults with certain pancreatic tumors who are at high risk for a dangerous leak after standard surgery. The procedure removes the entire pancreas and transplants the insulin-making…

This trial tests whether a procedure called EUS-guided gallbladder drainage can prevent future gallbladder attacks in people who are too sick or frail for surgery. Participants are randomly assigned to receive either the drainage procedure or standard medical care. The study will…

This trial tests whether a patient's own immune cells, called tumor-infiltrating lymphocytes (TILs), can be grown in a lab and then given back to fight advanced gastrointestinal stromal tumors (GIST). The study includes people whose GIST has spread, come back, or cannot be remove…

This early-stage study tests the safety of an experimental drug called DCC-2618 in 10 people with advanced gastrointestinal stromal tumor (GIST) that has not responded to or cannot tolerate at least three prior treatments. The main goal is to see what side effects occur. This is …

This phase 3 trial compares a new drug, velzatinib, to the standard drug imatinib in 800 people with advanced gastrointestinal stromal tumors (GIST) that have spread or cannot be removed by surgery. The goal is to see if velzatinib can delay tumor growth better than imatinib. Par…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study tests whether using a gentle suction tube (negative-pressure drainage) is better than placing a small plastic tube (stent) in the pancreas to prevent pancreatitis after removing tumors from the duodenum. About 132 adults with early-stage tumors will be randomly assigne…

This study looks at whether adding a specific probiotic (containing Enterococcus faecium and Bacillus subtilis) to the antibiotic rifaximin can improve treatment for small intestinal bacterial overgrowth (SIBO), a condition that causes bloating, pain, and diarrhea. About 100 adul…

This early-stage study tests a new treatment for people with advanced ovarian cancer or other solid tumors that have come back or not responded to standard therapy. The treatment uses a patient's own immune cells that are genetically modified to better recognize and attack cancer…

This study tests a drug called esomeprazole, given through an IV, to prevent stress ulcers and acid reflux in 50 adults recovering from surgery in the intensive care unit (ICU). The goal is to see if it can keep stomach acid low enough to reduce the risk of bleeding. Participants…

This study will test a type of endoscopic surgery to remove certain stomach tumors that grow outward from the stomach wall. The goal is to see if this less invasive approach can completely remove the tumors and prevent them from coming back. The study will involve 20 participants…

This study tests whether a lab test (3D-PTA) that checks which chemotherapy drugs work best on a patient's tumor can improve outcomes after bile duct cancer surgery. About 98 adults with stage II/III bile duct cancer will be randomly assigned to receive either standard capecitabi…

This study tests a special capsule that patients swallow to check if their intestines are clear enough for a standard camera capsule. About 25 people with known or suspected intestinal narrowing will take part. They will swallow the patency capsule and get an X-ray within 30 hour…

This study tests a urine test that detects gluten peptides in children with celiac disease who are on a gluten-free diet. The goal is to see if this test helps doctors and families identify accidental gluten exposure better than standard blood tests. One hundred children aged 2 t…

This study will test whether a special ultrasound technique called elastography can help doctors tell the difference between harmless and cancerous growths in the chest and digestive tract. About 35 adults will get an endoscopic ultrasound with elastography, and the results will …

This study aims to translate and validate the Celiac Dietary Adherence Test (CDAT) for Polish children with celiac disease. Researchers will enroll 20 participants aged 2 to 18, along with their caregivers, to check if the Polish version accurately measures how well they follow a…

This study tests if inflating a small balloon in the stomach during surgery can prevent nausea, vomiting, and slow stomach emptying after pancreatic tumor removal. About 70 adults will be randomly assigned to get the balloon procedure or standard surgery. Researchers will track r…

This study tests whether a probiotic called Clostridium butyricum CBM588 can reduce diarrhea and improve quality of life in people who have had their pancreas removed due to cancer or other growths. About 158 patients will take either the probiotic or a placebo for three months a…

This study tests a diet rich in soluble fiber and natural osmotic sugars (the SOLOS diet) to see if it improves constipation symptoms in adults with functional bowel disorders like IBS-C. Researchers will track stool frequency, form, and symptom severity in 180 participants. The …

This study looks at whether a gluten-free diet can reduce inflammatory back pain. Researchers will split 50 people into two groups: one gets standard treatment, the other adds a gluten-free diet for a year. They'll measure pain levels and immune markers to see if the diet makes a…

This study tests a highly absorbable form of curcumin (from turmeric) in 72 adults with mid-to-low rectal cancer who are getting chemoradiation before surgery. The goal is to see if curcumin can reduce severe gut side effects like diarrhea and rectal pain. Researchers will also c…

This study tests whether acupuncture at a specific point called Yanglingquan can quickly reduce pain from biliary colic, a sharp pain caused by gallstones. Researchers will compare it to standard drug therapy in 248 adults aged 18 to 65. The goal is to see if this traditional Chi…

This study looks at whether non-diabetic patients who have pancreas surgery can safely avoid routine insulin afterward. About 290 adults will be randomly assigned to receive either standard insulin or no insulin after surgery. The goal is to see if skipping insulin keeps blood su…

This trial looks at whether keeping or removing a drainage tube (PTCD catheter) during pancreatic surgery leads to fewer complications. About 100 patients with jaundice from tumors will be randomly assigned to one of two groups. The main goal is to see which approach reduces seri…

This study will check 100 adults with chronic pancreatitis or who had part of their pancreas removed. Even though they take enzyme pills, they still have stomach pain, bloating, or diarrhea. Researchers will use breath tests to see if a condition called SIBO (too much bacteria in…

This study looks at how a prebiotic supplement called FiberSmart changes the bacteria in the small intestine of healthy adults. Thirty participants will take either the supplement or a placebo daily for 21 days. A special capsule is used to sample the small intestine directly, gi…

This study explores whether a simple ultrasound and a blood test can track celiac disease activity, potentially replacing the need for invasive intestinal biopsies. Researchers will scan the small bowel and measure antibody levels in 140 people, including newly diagnosed patients…

This study will watch how doctors use a special camera (endoscopic ultrasound) to diagnose suspected pancreatic or bile duct diseases in 2500 adults across Lombardy, Italy. The goal is to see how accurate the procedure is, how safe it is, and how quickly patients get a final diag…

This study reviews medical records of 450 children who had surgery for a blocked duodenum (duodenal atresia) over the past 20 years. Researchers want to find out how often bile duct and pancreas problems occur after surgery, and what might cause them. The goal is to better unders…

This observational study will compare teens with celiac disease who follow a gluten-free diet strictly versus those who don't, along with healthy peers. Researchers will test walking while doing mental tasks, memory, attention, muscle strength, quality of life, and fatigue. The g…

This study follows 250 adults in Finland who were previously screened for celiac disease to see how early diagnosis affects their long-term health, diet habits, and quality of life. Researchers will track symptoms, gluten-free diet adherence, and overall well-being. The goal is t…

This study looks at eating behaviors in teenagers aged 11-17 with celiac disease compared to healthy teens. Participants fill out questionnaires about their eating habits and concerns. A smaller group newly diagnosed with celiac disease will be followed for two years to see how t…

This registry study will collect medical information and biological samples from 1,000 people with gastrointestinal stromal tumors (GIST), a rare type of digestive tract cancer. The goal is to better understand how GIST behaves, especially in rare forms, and to identify factors t…

This study tests a digital diary called MyMedDiary in 120 children (ages 2-18) newly diagnosed with celiac disease. The app helps families track gluten-free foods and spot hidden sources of gluten. Researchers want to see if the app improves diet adherence compared to traditional…

This study looks at 140 children with celiac disease, ages 2 to 18, who have been on a gluten-free diet for at least 6 months. Researchers will compare a questionnaire and rapid urine/stool tests to standard blood tests to see which methods best measure diet adherence. The goal i…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…