Cure My Disease

Don't miss your cure!

 Log in / Sign up

New pill could ease carcinoid syndrome Flare-Ups

NCT ID NCT05361668

Completed Symptom relief Sponsor: Crinetics Pharmaceuticals Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tested paltusotine, an oral drug, in 36 adults with carcinoid syndrome. The study looked at safety and how the body processes the drug at different doses. Participants were randomly assigned to 40 mg or 80 mg daily, with dose adjustments allowed. The goal is to find a convenient pill option to manage symptoms like diarrhea and flushing.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

paltusotine

What this could lead to

If successful, paltusotine could offer a new oral option to control symptoms like diarrhea and flushing in people with carcinoid syndrome.

What could go wrong

This is an early Phase 2 trial with only 36 participants. The drug may not prove effective or safe in larger studies, and side effects are still being evaluated.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CARCINOID SYNDROME are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

carcinoid syndrome carcinoid tumor cecum neuroendocrine tumor G1 enterochromaffin cell serotonin-producing pancreatic neuroendocrine tumor ileal neuroendocrine tumor G1 intestinal neuroendocrine tumor G1 liver neuroendocrine carcinoma neuroendocrine neoplasm serotonin syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOID CARCINOID INTESTINE TUMOR CARCINOID SYNDROME CARCINOID SYNDROME DIARRHEA CARCINOID TUMOR CARCINOID TUMOR OF CECUM CARCINOID TUMOR OF ILEUM CARCINOID TUMOR OF LIVER CARCINOID TUMOR OF PANCREAS

Contacts and locations

Locations

  • Crinetics Study Site

    Los Angeles, California, 90048, United States

  • Crinetics Study Site

    Los Angeles, California, 90095, United States

  • Crinetics Study Site

    Newport Beach, California, 92663, United States

  • Crinetics Study Site

    Stanford, California, 94305, United States

  • Crinetics Study Site

    Miami, Florida, 33136, United States

  • Crinetics Study Site

    Iowa City, Iowa, 52242, United States

  • Crinetics Study Site

    Lexington, Kentucky, 40506, United States

  • Crinetics Study Site

    New Orleans, Louisiana, 70112, United States

  • Crinetics Study Site

    Boston, Massachusetts, 02118, United States

  • Crinetics Study Site

    Rochester, Minnesota, 55905, United States

  • Crinetics Study Site

    New York, New York, 10029, United States

  • Crinetics Study Site

    Stony Brook, New York, 11794, United States

  • Crinetics Study Site

    Cleveland, Ohio, 44106, United States

  • Crinetics Study Site

    Columbus, Ohio, 43210, United States

  • Crinetics Study Site

    Houston, Texas, 77030, United States

  • Crinetics Study Site

    CABA, Buenos Aires, C1180 AAX, Argentina

  • Crinetics Study Site

    CABA, Buenos Aires, C1264AAA, Argentina

  • Crinetics Study Site

    CABA, Buenos Aires, C1426ANZ, Argentina

  • Crinetics Study Site

    CABA, C1017AAS, Argentina

  • Crinetics Study Site

    CABA, C1425BGH, Argentina

  • Crinetics Study Site

    Fortaleza, Ceará, 60430-275, Brazil

  • Crinetics Study Site

    Rio de Janeiro, Rio de Janeiro, 20231-092, Brazil

  • Crinetics Study Site

    Rio de Janeiro, Rio de Janeiro, 22281-100, Brazil

  • Crinetics Study Site

    Criciúma, Santa Catarina, 88811508, Brazil

  • Crinetics Study Site

    São Paulo, São Paulo, 01509-010, Brazil

  • Crinetics Study Site

    Rio de Janeiro, 22061-080, Brazil

  • Crinetics Study Site

    Toronto, M4N 3M5, Canada

  • Crinetics Study Site

    Mexico City, Cuauhtemoc, 06100, Mexico

  • Crinetics Study Site

    Querétaro City, Querétaro, 76000, Mexico

  • Crinetics Study Site

    Querétaro City, Querétaro, 76070, Mexico

  • Crinetics Study Site

    Katowice, 40-514, Poland

  • Crinetics Study Site

    Warsaw, 02-351, Poland

  • Crinetics Study Site

    Wroclaw, 53-413, Poland

  • Crinetics Study Site Peru #1

    Lima, 15036, Peru

  • Crinetics Study Site Peru #2

    Lima, 15036, Peru