Rheumatoid arthritis

This early study tests an experimental drug called STR-P005 in people with autoimmune diseases that have come back or not improved with standard treatments. The drug is given through an IV in multiple doses. The main goal is to check safety and see how the body handles the drug. …

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This study tests whether freeze-dried fecal bacteria, given as oral capsules, can improve symptoms in 40 adults with active rheumatoid arthritis that hasn't responded to standard drugs. Participants will receive either the fecal transplant or a placebo for 24 weeks. The main goal…

This 52-week study will compare three drugs—tocilizumab, telitacicept, and methotrexate—in 204 people with rheumatoid arthritis who also have interstitial lung disease. The main goal is to see which drug best improves lung function. Participants will continue their usual arthriti…

This early-phase trial is testing whether stem cells from donated bone marrow (CG-BM1) are safe for people with ankylosing spondylitis, a chronic inflammatory arthritis. Forty adults aged 18 to 40 will receive either the stem cells or a placebo by IV once a week for four weeks. T…

This study will compare two drugs, tofacitinib and upadacitinib, added to standard methotrexate treatment for rheumatoid arthritis. One hundred adults in Pakistan will take one of the two drugs daily for six months. Researchers will measure disease activity and side effects to se…

This study tests whether adding a Chinese herbal formula (Si Miao Xiao Bi Tang) to standard rheumatoid arthritis medication can improve symptoms. About 132 adults with active RA will receive either the herbal medicine or a placebo for 12 weeks. The main goal is to see if more peo…

This early study tests a new drug called STR-P005 in 18 people with autoimmune diseases that have not responded to standard treatments. The main goal is to check safety and find the best dose. Participants receive the drug by infusion in different schedules, and researchers will …

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This study compares two ways of giving the drug tocilizumab to people with rheumatoid arthritis that is under control. One method uses a fixed dose for everyone, while the other adjusts the dose based on weight. The goal is to see if the simpler fixed-dose method works just as we…

This early-stage trial tests a new drug called KT502 in 27 adults with moderate to severe rheumatoid arthritis. The drug is designed to deplete certain immune cells (B cells) that contribute to joint inflammation. The main goal is to check safety and find the right dose, not yet …

This phase 2 trial tests whether disulfiram, a drug already approved for alcohol use disorder, can safely reduce joint inflammation in people with rheumatoid arthritis who are overweight. Twenty adults with active arthritis despite standard treatment will take either disulfiram o…

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This early-phase trial tests a new stem cell treatment (HS_SW01) for people with ankylosing spondylitis, a type of arthritis that causes spine pain and stiffness. The study will include 18 adults aged 18 to 65. Researchers aim to check if the treatment is safe and if it helps red…

This early-phase study tests a new treatment called BEN301, which uses specially engineered immune cells (CAR-Tregs) to calm overactive immune responses in people with autoimmune diseases like scleroderma, rheumatoid arthritis, lupus, and inflammatory muscle disease. The trial wi…

This study tests whether adding deucravacitinib to standard therapy helps adults with psoriatic arthritis that is not well controlled. About 128 participants will receive the combination and be monitored for 48 weeks. The goal is to reduce skin and joint symptoms and improve qual…

This study tests whether adding venlafaxine, a common antidepressant, to standard rheumatoid arthritis (RA) treatment can better control disease activity. About 70 adults with moderate to severe RA who are already on stable medication will receive either venlafaxine or a placebo …

This study follows 150 adults with moderate-to-severe rheumatoid arthritis who have received the SetPoint System, an implanted device that uses nerve stimulation to control inflammation. Researchers will monitor device safety, ease of use, and how well it controls disease activit…

This early study tests a new treatment called CD19/BCMA CAR-T for people with severe autoimmune diseases like lupus and Sjögren's syndrome that haven't improved with standard care. The treatment involves taking a patient's own immune cells, modifying them to target specific immun…

This study tests whether temporarily stopping methotrexate for 2 weeks after receiving a pneumonia vaccine (PCV20) helps the vaccine work better in adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus. About 192 participants with stable, low disease activi…

This study will follow 100 adults who receive the 5C® MEDic Knee System during knee replacement surgery. Researchers want to see how long the implant lasts without needing another operation and track any complications over 5 years. Participants will also fill out health questionn…

This Phase 4 trial tests ivarmacitinib, a once-daily pill, in 100 adults with moderate-to-severe rheumatoid arthritis who did not improve on standard drugs. The study will measure joint symptom improvement after 12 weeks and monitor safety. Ivarmacitinib works by blocking inflamm…

This early-stage study tests a new drug, BMS-986528, in 84 adults with rheumatoid arthritis that hasn't responded well to other treatments. The main goal is to check safety and how the body processes the drug. Researchers will also look for signs that it might help control the di…

This study tests a new drug called TQH3906 for people with active psoriatic arthritis, a condition causing joint pain and skin patches. About 156 adults will receive either TQH3906, a placebo, or an existing drug (tofacitinib) for 12 weeks. The main goal is to see if TQH3906 impr…

This study compares two treatment combinations for adults with psoriatic arthritis who did not get enough relief from methotrexate alone. One group will receive apremilast plus methotrexate, the other adalimumab plus methotrexate. Researchers will measure joint and skin disease a…

This study tests whether the drug upadacitinib can reduce how often people with axial spondyloarthritis (a type of arthritis affecting the spine) get sudden eye inflammation (acute anterior uveitis). About 200 adults who have had at least one eye flare in the past year will take …

This study tests an experimental drug called QLS12010 in 180 adults with moderate-to-severe rheumatoid arthritis. Participants are randomly assigned to receive different doses of the drug or a placebo for 12 weeks. The main goal is to see if the drug reduces joint swelling and te…

This study looks at whether baricitinib, a drug for rheumatoid arthritis, can improve blood clotting and cholesterol levels compared to standard treatments. About 100 adults with active RA will take baricitinib for 3 months. Researchers will measure changes in clotting markers an…

This early-stage study tests a single infusion of stem cells from donated umbilical cords in 16 adults with moderate to severe rheumatoid arthritis that hasn't improved with standard treatments. The main goal is to check safety and side effects over 52 weeks, while also looking f…

This Phase 2 trial tests whether adding a lab-made antibody called natrunix to standard methotrexate treatment helps people with moderate to severe rheumatoid arthritis who haven't improved enough on methotrexate alone. About 108 participants will receive weekly shots of either n…

This study tests whether semaglutide (Ozempic), a drug used for diabetes and weight loss, can slow the buildup of plaque in arteries of people with psoriatic arthritis who do not have diabetes. Forty participants will receive either semaglutide or no additional treatment for 24 w…

This study tests whether adding a very low dose of the steroid prednisolone (4 mg daily for 4 weeks, then tapering off) to standard treatment helps control symptoms in people newly diagnosed with active rheumatoid arthritis. About 112 adults will be randomly assigned to receive e…

This study compares two strategies for slowly reducing prednisolone (a steroid) in people with stable rheumatoid arthritis. One method splits a 5 mg tablet into halves, the other reduces by 1 mg at a time. Over six months, 206 participants will be followed to see which approach k…

This study tests whether a Mediterranean diet can lower disease activity and improve quality of life in 110 people with axial spondyloarthritis (a type of arthritis affecting the spine) who are already on biologic therapy. Participants will either follow a structured Mediterranea…

This study tests a new treatment using CD19 CAR T-cells for people with severe autoimmune diseases that haven't improved with standard therapies. About 30 participants will receive a single dose of these engineered immune cells after chemotherapy. The goal is to see if it's safe …

Rheumatoid arthritis and gout can look alike, making them hard to tell apart early. This study will use ultrasound to see if it can reliably distinguish between the two conditions. Researchers will examine 100 adults with suspected or confirmed arthritis, scoring joint inflammati…

This study tests a special imaging agent (99mTc-NTP 15-5) to see if it can spot arthritis-damaged joints in the hands and tell the difference between osteoarthritis and rheumatoid arthritis. About 80 adults with one of these conditions will get a scan. The goal is to improve diag…

This study will test a special ultrasound technique called shear-wave elastography to see if it can better detect tendon inflammation (enthesitis) in people with psoriatic arthritis. Researchers will compare this method with standard ultrasound and also look at how it relates to …

This study will test whether artificial intelligence can accurately tell the difference between inflammatory arthritis (like rheumatoid arthritis) and degenerative arthritis (like osteoarthritis) in people aged 60 and older. Researchers will compare the AI's analysis of X-rays, M…

This study tests whether a single dose of amoxicillin before a simple tooth extraction can prevent infections in people with autoimmune rheumatic diseases who are on immune-suppressing medications. Researchers will compare infection rates between those who get the antibiotic and …

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study tests whether adding an oral supplement (PEA) to a series of knee injections (adelmidrol and hyaluronic acid) can better reduce pain and improve function in people with knee arthritis. The injections aim to protect the joint from damage, while the supplement may help c…

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study tests whether the drug vilamakitug can reduce symptoms of axial spondyloarthritis, a type of arthritis that causes back pain and stiffness. About 150 adults with active disease will receive either the drug or a placebo. The main goal is to see if more people get at lea…

This study looks at whether a drug called acemetacin can reduce pain and control disease activity in adults with active axial spondyloarthritis, a type of inflammatory arthritis that mainly affects the spine. About 150 people aged 18 to 65 will take a daily pill for 4 weeks. Rese…

This pilot study will test whether a nurse-led telehealth self-monitoring program is acceptable and practical for people with rheumatoid arthritis. 104 adults who recently had a flare or medication change will use a web platform to report symptoms monthly. A rheumatology nurse wi…

This study tests whether a structured progressive resistance training program can improve muscle strength in adults with rheumatoid arthritis (RA). About 118 participants will either do supervised exercises 3 times a week for 6 weeks or continue their usual care. Researchers will…

This study will test whether a 6-week aerobic exercise program can improve quality of life, mood, and fatigue in women with rheumatoid arthritis. Sixty-four participants with low disease activity will either continue standard care or add five weekly exercise sessions. Researchers…

This study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 …

This study tests whether adding lavender aromatherapy massage to standard care can reduce pain and improve wrist movement in people with rheumatoid arthritis. About 100 adults with stable medication will be randomly assigned to get the massage or not. Researchers will measure pai…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce chronic pain in people with psoriatic arthritis. Researchers will give 40 adults with low disease activity but ongoing pain either real rTMS o…

This study tests whether a mild electrical stimulation (called subthreshold stimulation) can reduce fatigue and improve leg muscle function in people with rheumatoid arthritis. Researchers will also measure inflammation and daily function. The study will include 84 adults aged 30…

This study tests whether using ultrasound therapy before a steroid injection into the joint can improve pain and swelling for people with arthritis. About 100 adults with arthritis in their arms or legs will receive the combined treatment. The goal is to see if the ultrasound hel…

This study tests whether a 12-week program of high-intensity interval training and strength training can improve heart and metabolic health in people with psoriatic arthritis. Researchers will also measure changes in fitness, pain, fatigue, and quality of life. The trial plans to…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study will test two non-drug approaches—pain neuroscience education and vagus nerve stimulation—against traditional exercise in 36 people with rheumatoid arthritis. The goal is to see which method best reduces pain, improves quality of life, and lowers inflammation over 8 we…

This study looks at whether combining resistance exercises with an anti-inflammatory diet can reduce pain, improve daily function, and boost quality of life in people with rheumatoid arthritis. About 100 adults with low to moderate disease activity will follow a structured progra…

This study tests whether an artificial intelligence system can create personalized exercise plans for people with rheumatoid arthritis. 147 patients with mild-to-moderate disease will be split into three groups: one using the AI system via a smartphone app, one using paper exerci…

This study tests a therapeutic education program designed to improve self-image and self-esteem in adults with chronic inflammatory rheumatic diseases like rheumatoid arthritis and spondyloarthritis. Sixty participants will complete questionnaires and interviews before and after …

This study tests whether two different capsule forms of the experimental drug SKI-O-703 are absorbed similarly in the body. About 48 healthy adults (Korean and Caucasian) will take a single dose of each form on separate days, with blood samples taken to compare drug levels. The r…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study will check 45 adults with ankylosing spondylitis for peripheral neuropathy (nerve damage in the arms and legs) using nerve conduction tests. Researchers want to see if nerve problems are linked to higher disease activity, increased pain sensitivity, and worse quality o…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This observational study follows 400 adults with psoriatic arthritis who are starting a new biologic or targeted synthetic drug as part of their routine care. Researchers want to see if treatment response differs based on how many prior advanced therapies a person has tried, and …

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks back at medical records of 3,500 adults who had a first-time knee replacement to compare different brands of knee implants. Researchers want to see which implant leads to better knee function, fewer complications, and lower costs over time. The goal is to help do…

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study aims to learn which FDA-approved rheumatoid arthritis (RA) medication works best for each individual patient. Researchers will enroll 18 adults with newly diagnosed, moderately to severely active RA. Participants will try up to four different RA drugs in a random order…

This study will look at the health records of 350 people with psoriasis in Costa Rica to find out how many also have conditions like obesity, diabetes, high blood pressure, heart disease, or psoriatic arthritis. Researchers want to understand how these problems relate to psoriasi…

This study will measure the activity of a gene called TNFAIP3 in 110 people with ankylosing spondylitis or psoriatic arthritis. The goal is to see if the gene's expression is linked to how active the disease is. Researchers will use a blood test to check gene levels and compare t…

This study tests whether a smartphone app can help people with rheumatoid arthritis, spondyloarthritis, or psoriatic arthritis learn how to use their anti-rheumatic drugs more safely. About 144 adults will either use the app or receive standard care with a website. The goal is to…

This observational registry will follow 50 patients with psoriasis or psoriatic arthritis who are receiving IL-23 inhibitors (guselkumab or risankizumab) as part of their routine care in Costa Rica. Researchers will track how well the drugs improve skin and joint symptoms and qua…

This study looks at how fear of movement (kinesiophobia) affects daily function in people with rheumatoid arthritis. Researchers will compare 200 RA patients with 200 healthy volunteers to understand links between fear, pain, fatigue, mood, and muscle loss. The goal is to find no…

This observational study will measure levels of certain immune proteins (IL-17, IL-38, IL-41) and the HLA-B27 gene in 84 people with ankylosing spondylitis and a healthy control group. The goal is to see if these markers are linked to disease activity and severity. No treatment i…

This study aims to see if certain markers in the blood (CCR6 and CCL20) are linked to rheumatoid arthritis. Researchers will compare 60 adults with RA to healthy people. The goal is to learn more about the disease, not to test a new treatment.

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study looks at a blood protein called FAP, which is linked to tissue scarring and inflammation. Researchers will measure FAP levels in people with rheumatoid arthritis and systemic sclerosis, as well as healthy volunteers, and compare them with standard tests and lung functi…

This study will check if a protein called Tim-3 on certain white blood cells (neutrophils) is linked to disease activity in people with ankylosing spondylitis. Researchers will measure Tim-3 levels and compare them with inflammation markers and MRI scans of the hip and sacroiliac…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks at a protein called isthmin-1 in the blood of people with rheumatoid arthritis (RA) compared to healthy volunteers. Researchers want to see if higher levels of this protein match up with more active disease, as seen on ultrasound scans. The goal is to find a simp…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study looks at how two different exercise programs—high-intensity intervals and moderate continuous activity—affect a blood marker called irisin, as well as disease activity, physical function, and quality of life in people with axial spondyloarthritis. About 75 adults with …

This study will measure harmful molecules called AGEs in 300 people with various rheumatic diseases (like rheumatoid arthritis and ankylosing spondylitis) and compare them to healthy volunteers. AGEs build up over time and can cause inflammation. Researchers will use a non-invasi…

This study will compare blood test results and ultrasound images of joints in 72 people with rheumatoid arthritis. Half are taking JAK inhibitors, and half are on traditional treatments. The goal is to see if certain blood markers can reliably show how active the disease is, whic…

This study looks at whether regular video calls with a lung specialist can help people in rural areas who have a rare lung disease linked to autoimmune conditions like rheumatoid arthritis. Ten adults will get care through a team that includes local doctors and a specialist at Ma…

This study follows 150 people at different risk levels for rheumatoid arthritis (RA) to see what factors might lead to the disease. Participants provide blood, urine, stool, and saliva samples, and answer questions about their lifestyle. The goal is to identify triggers like smok…

This study follows 100 children aged 6 to 17 with juvenile psoriatic or enthesitis-related arthritis who are taking secukinumab. Researchers will observe how doctors adjust treatment after the disease becomes inactive, and whether patients experience flares. The goal is to learn …

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …

This study looks at how two types of rheumatoid arthritis (RA) drugs—anti-TNF-α and non-TNF-α—affect patients' aerobic capacity, muscle strength, fatigue, and heart disease risk factors. Researchers will measure oxygen use during exercise, muscle strength, and disease activity in…

This study looks at whether two substances in the blood, called MMP7 and MMP9, can help identify lung disease in people with rheumatoid arthritis. Researchers will compare 81 participants: those with rheumatoid arthritis and lung disease, those with rheumatoid arthritis alone, an…

This study will collect health information, samples, and data from 100 people in Luxembourg (800 total across Europe) who have rheumatoid diseases and are starting or changing treatment. Researchers hope to find patterns that can predict which treatments work best for each person…

This study uses computer simulations to better understand how a subcutaneous (under-the-skin) form of the drug infliximab works in people with inflammatory bowel disease (IBD) and rheumatoid arthritis. Researchers will analyze data from previous trials to create a model that pred…