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Could a hidden thyroid problem worsen rheumatoid arthritis?

NCT ID NCT07793786

Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time

Summary

Researchers are measuring how often subclinical hypothyroidism, a mild form of underactive thyroid, occurs in people with rheumatoid arthritis compared to healthy people. They will also check whether this thyroid condition relates to higher disease activity or more severe joint involvement. The study includes 150 adults, half with rheumatoid arthritis and half without, who will undergo blood tests and joint exams.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the study finds a link, it could point toward routine thyroid screening for rheumatoid arthritis patients to help manage disease activity.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The results may not apply beyond the specific group studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients aged 18 years and older diagnosed with rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria attending the Rheumatology Unit, Internal Medicine Department, Assiut University Hospitals, as well as age- and sex-matched apparently healthy control individuals recruited from hospital staff and patient companions with no history of joint disease or thyroid disorders.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years, either sex * Diagnosis of rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria (for the case group) * Apparently healthy individuals with no history of joint disease or known thyroid disorder, matched for age and sex (for the control group) * Willingness to provide written informed consent Exclusion Criteria: * Known pre-existing thyroid disease diagnosed prior to rheumatoid arthritis onset * Current or recent (within 6 months) use of medications known to affect thyroid function (e.g., amiodarone, lithium, interferon) * Pregnancy or lactation * Other systemic autoimmune diseases that could independently affect thyroid function (e.g., systemic lupus erythematosus, overlap syndromes) * History of thyroid surgery or radioactive iodine therapy * Chronic kidney or liver disease * Ongoing severe infections * Malignancy

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Conditions

The condition(s) this trial relates to.

hypothyroidism rheumatoid arthritis thyroid gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rheumatoid arthritis Subclinical hypothyroidism Thyroid dysfunction

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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