A new ultrasound technique could spot hidden inflammation in psoriatic arthritis
NCT ID NCT07785089
First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time
Summary
This study tests whether a newer ultrasound technique, shear wave elastography, can better detect inflammation at tendon and ligament attachment sites (entheses) in people with psoriatic arthritis compared to standard ultrasound. Researchers will compare imaging results from 60 participants—half with psoriatic arthritis and half healthy controls—to see if the new method reveals differences in tissue stiffness. The goal is to improve early detection and understanding of enthesitis, which is common in this condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Shear wave elastography, grayscale ultrasonography, and Power Doppler ultrasonography
- What this could lead to
- If successful, this could improve early detection of enthesitis in psoriatic arthritis, potentially leading to better disease management and outcomes.
- What could go wrong
- This is an observational study, so it won't directly test a treatment. The imaging technique may not prove more useful than standard ultrasound, and results may not generalize beyond this specific group.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
-
Jul 2026
An estimate. Start dates often move.
- Expected to finish
-
Jul 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population will consist of adult patients (≥18 years) diagnosed with psoriatic arthritis according to the Classification Criteria for Psoriatic Arthritis (CASPAR) who are followed at the Rheumatology outpatient clinic of Marmara University Pendik Education and Research Hospital, and age- and sex-matched healthy volunteers without inflammatory rheumatic disease. Patients with psoriatic arthritis will undergo clinical evaluation, laboratory assessment, grayscale ultrasonography, Power Doppler ultrasonography, and shear wave elastography of bilateral enthesis sites included in the Madrid Sonography Enthesitis Index (MASEI). Demographic data will be collected from healthy volunteers, who will undergo the same ultrasonographic and shear wave elastography assessments.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Psoriatic arthritis group: 1. Adults aged 18 years or older. 2. Diagnosis of psoriatic arthritis according to the Classification Criteria for Psoriatic Arthritis (CASPAR). 3. Ability to provide written informed consent. 4. Willingness to undergo clinical assessment, laboratory evaluation, grayscale ultrasonography, Power Doppler ultrasonography, and shear wave elastography. * Healthy control group: 1. Adults aged 18 years or older. 2. No history or diagnosis of inflammatory rheumatic disease. 3. Age- and sex-matched to the psoriatic arthritis group. 4. Ability to provide written informed consent. 5. Willingness to undergo grayscale ultrasonography, Power Doppler ultrasonography, and shear wave elastography. Exclusion Criteria: * Psoriatic arthritis group: 1. Age younger than 18 years. 2. Refusal to participate in the study or inability/unwillingness to provide written informed consent. 3. Inability to complete the clinical or ultrasonographic assessments. 4. History of surgery, fracture, major trauma, or tendon rupture involving the enthesis sites to be evaluated. 5. Local corticosteroid injection, platelet-rich plasma (PRP), prolotherapy, or other local interventional treatment at the enthesis sites to be evaluated within the previous 3 months. 6. Presence of acute traumatic tendinopathy, active soft tissue infection, open wound, or ulcer at the enthesis sites to be evaluated. 7. Diagnosis of another inflammatory rheumatic disease or connective tissue disease other than psoriatic arthritis. 8. Active infection, active malignancy, or severe systemic disease that may interfere with study assessments. * Healthy control group: 1. Age younger than 18 years. 2. Refusal to participate in the study or inability/unwillingness to provide written informed consent. 3. Inability to complete the clinical or ultrasonographic assessments. 4. History or diagnosis of psoriasis, psoriatic arthritis, or any other inflammatory rheumatic disease. 5. History of surgery, fracture, major trauma, or tendon rupture involving the enthesis sites to be evaluated. 6. Local corticosteroid injection, platelet-rich plasma (PRP), prolotherapy, or other local interventional treatment at the enthesis sites to be evaluated within the previous 3 months. 7. Presence of acute traumatic tendinopathy, active soft tissue infection, open wound, or ulcer at the enthesis sites to be evaluated. 8. Active infection, active malignancy, or severe systemic disease that may interfere with study assessments.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Enthesitis are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Ocular surface changes and meibomian gland dysfunction in rheumatologic patients: a Cross-Sectional analytical study
- Can a questionnaire capture the real burden of psoriatic arthritis?
- Can a new pill calm psoriatic arthritis joint pain?
- A personal nurse and a plan: could this ease the daily burden of arthritis?
- Can one pill tame four autoimmune diseases? a Long-Term trial puts it to the test
- A softer path to stronger muscles for arthritis?