A new ultrasound technique could spot hidden inflammation in psoriatic arthritis

NCT ID NCT07785089

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First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This study tests whether a newer ultrasound technique, shear wave elastography, can better detect inflammation at tendon and ligament attachment sites (entheses) in people with psoriatic arthritis compared to standard ultrasound. Researchers will compare imaging results from 60 participants—half with psoriatic arthritis and half healthy controls—to see if the new method reveals differences in tissue stiffness. The goal is to improve early detection and understanding of enthesitis, which is common in this condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Shear wave elastography, grayscale ultrasonography, and Power Doppler ultrasonography
What this could lead to
If successful, this could improve early detection of enthesitis in psoriatic arthritis, potentially leading to better disease management and outcomes.
What could go wrong
This is an observational study, so it won't directly test a treatment. The imaging technique may not prove more useful than standard ultrasound, and results may not generalize beyond this specific group.

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Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adult patients (≥18 years) diagnosed with psoriatic arthritis according to the Classification Criteria for Psoriatic Arthritis (CASPAR) who are followed at the Rheumatology outpatient clinic of Marmara University Pendik Education and Research Hospital, and age- and sex-matched healthy volunteers without inflammatory rheumatic disease. Patients with psoriatic arthritis will undergo clinical evaluation, laboratory assessment, grayscale ultrasonography, Power Doppler ultrasonography, and shear wave elastography of bilateral enthesis sites included in the Madrid Sonography Enthesitis Index (MASEI). Demographic data will be collected from healthy volunteers, who will undergo the same ultrasonographic and shear wave elastography assessments.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Psoriatic arthritis group: 1. Adults aged 18 years or older. 2. Diagnosis of psoriatic arthritis according to the Classification Criteria for Psoriatic Arthritis (CASPAR). 3. Ability to provide written informed consent. 4. Willingness to undergo clinical assessment, laboratory evaluation, grayscale ultrasonography, Power Doppler ultrasonography, and shear wave elastography. * Healthy control group: 1. Adults aged 18 years or older. 2. No history or diagnosis of inflammatory rheumatic disease. 3. Age- and sex-matched to the psoriatic arthritis group. 4. Ability to provide written informed consent. 5. Willingness to undergo grayscale ultrasonography, Power Doppler ultrasonography, and shear wave elastography. Exclusion Criteria: * Psoriatic arthritis group: 1. Age younger than 18 years. 2. Refusal to participate in the study or inability/unwillingness to provide written informed consent. 3. Inability to complete the clinical or ultrasonographic assessments. 4. History of surgery, fracture, major trauma, or tendon rupture involving the enthesis sites to be evaluated. 5. Local corticosteroid injection, platelet-rich plasma (PRP), prolotherapy, or other local interventional treatment at the enthesis sites to be evaluated within the previous 3 months. 6. Presence of acute traumatic tendinopathy, active soft tissue infection, open wound, or ulcer at the enthesis sites to be evaluated. 7. Diagnosis of another inflammatory rheumatic disease or connective tissue disease other than psoriatic arthritis. 8. Active infection, active malignancy, or severe systemic disease that may interfere with study assessments. * Healthy control group: 1. Age younger than 18 years. 2. Refusal to participate in the study or inability/unwillingness to provide written informed consent. 3. Inability to complete the clinical or ultrasonographic assessments. 4. History or diagnosis of psoriasis, psoriatic arthritis, or any other inflammatory rheumatic disease. 5. History of surgery, fracture, major trauma, or tendon rupture involving the enthesis sites to be evaluated. 6. Local corticosteroid injection, platelet-rich plasma (PRP), prolotherapy, or other local interventional treatment at the enthesis sites to be evaluated within the previous 3 months. 7. Presence of acute traumatic tendinopathy, active soft tissue infection, open wound, or ulcer at the enthesis sites to be evaluated. 8. Active infection, active malignancy, or severe systemic disease that may interfere with study assessments.

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Conditions

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