Protozoa infectious disease

This trial tests different doses of tafenoquine, a single-dose drug, to see if it can effectively cure Plasmodium vivax malaria by targeting dormant liver stages. The study involves 820 people in Southeast Asia with confirmed vivax malaria. Researchers aim to find a dose that pre…

This study compares two oral treatments for trichomonas, a common sexually transmitted infection. About 1,200 women and men with a positive test will receive either a single dose of secnidazole or multiple doses of metronidazole over several days. The goal is to see which approac…

This study tests a new triple-drug combination (artemether-lumefantrine-amodiaquine) against standard two-drug treatments for uncomplicated malaria. About 1680 people with malaria will receive one of the treatments and be monitored for 42 days. The goal is to see if the triple th…

This study aims to develop a vaccine to prevent malaria during pregnancy. Researchers will test potential vaccines in the lab using blood samples from pregnant women aged 15-25 in Mali. The goal is to see if these vaccines can block the malaria parasite from attaching to the plac…

This phase 2 trial tests a new malaria vaccine (PfSPZ-LARC2) designed to stop the malaria parasite in the liver before it can cause illness. The study involves 300 healthy women of childbearing age in Mali who plan to become pregnant. Participants receive three doses of the vacci…

This early-stage trial tests a new malaria vaccine (PfSPZ-LARC2) in 58 healthy adults who have never had malaria. The vaccine uses weakened malaria parasites that stop growing in the liver and cannot cause blood infection. Researchers will check if it is safe and if it protects a…

This study tests a new malaria vaccine in 180 healthy adults aged 18-50 in Burkina Faso. The vaccine uses weakened malaria parasites that stop growing in the liver, so they cannot cause blood-stage infection. Participants receive either one or two doses of the vaccine or a placeb…

This study tests the R21/Matrix-M malaria vaccine in about 964 African infants to find the best timing for shots. Researchers compare a compressed schedule (6, 10, 14 weeks) with relaxed schedules (2, 4, 6 months or 3, 6, 9 months) to see which works best with other routine vacci…

This study tests a new malaria vaccine designed to target the parasite at different stages of its life cycle. Researchers will give the vaccine to 56 healthy adults (18-35 years) and children (5-17 months) in Burkina Faso to check its safety and how well it triggers an immune res…

This study tests a booster shot of the R21/Matrix-M malaria vaccine in 40 school-age children in Burkina Faso who already received four doses years earlier. Half get the standard child dose, half get a higher adult dose. Researchers will check for side effects and measure antibod…

This study is testing whether giving the RTS,S/AS01E malaria vaccine (Mosquirix) in lower doses or on different schedules is safe and triggers a strong immune response in healthy children aged 5 months to 5 years. The goal is to find simpler ways to vaccinate children in areas wh…

This trial in Benin tests different ways to help caregivers give children a 3-day course of malaria prevention medicine each month for three months after leaving the hospital. The children, all under 10, were hospitalized with severe malaria or severe anemia. Some families get ho…

This study at the National Institutes of Health evaluates and treats people aged 3 and older with known or suspected parasitic infections, such as malaria, intestinal worms, and others. Participants receive standard medical care, not experimental treatments. The goal is to monito…

This study tests an experimental drug called LXE408 in 130 adults with chronic Chagas disease who do not have severe organ damage. The goal is to see if LXE408 can clear or reduce the parasite level in the blood over 6 months, compared to placebo and standard treatment. Participa…

This study tests an experimental drug called EDI048 for cryptosporidiosis, a diarrheal disease caused by a parasite. Healthy adults will be deliberately infected with the parasite and then given either EDI048 or a placebo to see if the drug reduces diarrhea severity. The goal is …

This trial evaluates the safety of a single intravenous dose of DON, an experimental drug, in healthy adults, adults with uncomplicated malaria, and children aged 12 months to 14 years with cerebral malaria. Researchers will monitor side effects and measure how the drug moves thr…

This study tests whether adding imatinib, a drug currently used for cancer, to the standard malaria treatment (artemether + lumefantrine) can clear the malaria parasite faster and fight drug resistance. About 1,100 adults with mild to moderate malaria will receive either the stan…

This study tests whether using a device that heats skin lesions to 50°C for 30 seconds can effectively treat cutaneous leishmaniasis in primary health centers in Ethiopia. 103 patients aged 12 to 60 with up to four lesions will receive thermotherapy and be monitored for 90 days. …

This Phase 3 trial tests whether adding steroid eye drops to standard anti-parasitic treatment improves vision in people with acanthamoeba keratitis, a rare but serious eye infection. About 232 participants who still have eye inflammation after one month of standard care will rec…

This phase 3 trial tests whether a plant-based tincture made from arnica flowers can safely and effectively heal skin ulcers caused by cutaneous leishmaniasis, a parasitic disease spread by sandflies. About 96 people aged 12 and older with confirmed infection will receive either …

This study tests a new way to find and treat a type of malaria (P. vivax) that can hide in the liver and come back months later. Researchers will use a simple blood test to find people who have been infected recently, then give them a treatment to clear the hidden parasites. The …

This study tests a single dose of tafenoquine in 30 children in Papua New Guinea who have vivax malaria. The goal is to see how the drug moves through the body and if it is safe. Vivax malaria can come back because it hides in the liver, and this drug aims to clear it completely.

This study looks at how safe and effective primaquine is for treating vivax malaria in people with intermediate or deficient G6PD enzyme levels. About 100 adults with confirmed malaria and G6PD deficiency will receive either a high daily dose or a weekly dose of primaquine. The g…

This study will give a combination of two malaria drugs (dihydroartemisinin-piperaquine and primaquine) to entire communities in Ghana every two months for two years. The goal is to see if this approach can reduce the number of people carrying malaria parasites, even those with n…

This study looks at whether adding echinacea (Immulant®) to standard care can reduce symptoms and parasite levels in children aged 5–12 with weakened immune systems who have cryptosporidiosis, a diarrheal infection. About 60 children will take part. The goal is to see if the supp…

This phase 2 study tests the drug tafenoquine in 40 adults with chronic babesiosis who have severe fatigue. The goal is to see if tafenoquine can reduce fatigue and clear the Babesia parasite from the blood. Participants take the drug and report their fatigue levels using a stand…

This expanded access program provides tafenoquine, an antimalarial drug, to immunocompromised patients with persistent babesiosis (a tick-borne illness) who haven't gotten better with standard treatments. Participants take the drug daily for 4 days, then weekly until they test ne…

This study tests different ways to deliver malaria prevention medicine to children under 10 who were hospitalized with severe malaria or severe anemia in Kenya. The goal is to see which method helps more children take all their doses and avoid getting sick again. About 600 childr…

This study tests whether adding the antimalarial drug tafenoquine to standard care helps hospitalized babesiosis patients recover faster. About 33 adults with confirmed Babesia infection will receive either tafenoquine or a placebo, plus standard antibiotics. Researchers will tra…

This study tests newer antimalarial drugs to see if they work as well as the current standard treatment for malaria in early pregnancy. It involves 1,510 pregnant women in Africa. The goal is to find treatments that are both effective and safe for the mother and baby.

This study tests whether giving a whole blood transfusion can help children under 5 with severe malaria and very low platelet counts survive. The trial is enrolling 132 children in Zambia. Researchers will compare death rates and blood changes between those who get a transfusion …

This study tests whether injecting the antibiotic ciprofloxacin directly into skin sores caused by leishmaniasis works as well as the standard treatment, sodium stibogluconate. Eighty people with one to seven sores will be randomly assigned to receive weekly injections of one dru…

This study tests whether injecting the antibiotic levofloxacin directly into skin sores caused by leishmaniasis can cure them. Forty adults with up to seven sores will receive weekly injections for up to six weeks and be monitored for 90 days. The goal is to see if the sores heal…

This study will test a new diagnostic device called the Nanopath assay, which aims to quickly detect bacteria or yeast causing vaginitis. Up to 1000 women with symptoms like itching or discharge will provide vaginal swab samples, either collected by a clinician or themselves. The…

This study will evaluate two rapid diagnostic tests (RDTs) for chronic Chagas disease in over 3,200 people at public health sites in Argentina. The goal is to see if these simple, point-of-care tests can accurately detect the infection, making diagnosis faster and more accessible…

This study aims to see if a new PCR-based test can diagnose malaria, leishmania, and pneumocystis infections faster and more accurately than current methods. Researchers will analyze about 200 stored samples from patients. The goal is to improve diagnosis and species identificati…

This study is testing a new finger prick device that can detect Toxoplasma infection from a drop of blood. Researchers will compare the device's results to a standard lab test in 210 adults, including pregnant women. The goal is to see if the finger prick test is accurate and eas…

This pilot study tests whether giving a malaria drug (dihydroartemisinin piperaquine) to household members of pregnant women can help prevent malaria in the mothers. About 300 participants in Uganda will receive either a single dose or monthly doses. The goal is to see if this ap…

This study is checking how effective the R21/Matrix-M malaria vaccine is at protecting children under 5 in Burkina Faso and Uganda, where malaria is common. Researchers will compare vaccination history in children who test positive for malaria against those who test negative. The…

This early-stage trial tests whether two new long-acting injectable drugs, MMV055 and MMV371, are safe and how they work in the body. Up to 72 healthy adults will receive one or two shots and be monitored for up to 48 weeks. The goal is to find a dose that could one day prevent m…

This study in Botswana tests whether offering sexually transmitted infection (STI) testing alongside HIV prevention medication (PrEP) helps more pregnant women start and continue using PrEP. About 600 pregnant women without HIV will be split into two groups: one gets standard car…

This study tests whether giving anti-malarial drugs to everyone in a village can eliminate vivax malaria. Over 7,500 people in Peru will be split into two groups: one receiving standard care (bed nets, screening) and the other also receiving mass drug administration. The goal is …

This study in Chad compares two ways of giving the R21 malaria vaccine to children. One group gets the vaccine as part of regular childhood shots, while the other gets it at the same time as seasonal malaria prevention medicine. The goal is to see if the combined approach works j…

This study looks at whether the R21/Matrix-M malaria vaccine can also reduce the risk of invasive non-typhoidal Salmonella (iNTS), a serious bacterial infection. Researchers will follow 10,000 children under 5 in the Democratic Republic of Congo who come to health centers with fe…

This study is testing whether giving entire communities antimalarial drugs along with a malaria vaccine can reduce the spread of the disease better than drugs alone, vaccine alone, or no extra intervention. About 10,000 people aged 6 months and older in malaria-prone villages wil…

This study in Uganda tests whether adding lab tests for common sexually transmitted infections (STIs) to standard HIV risk screening helps more women start and stick with PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to …

This small study tests a bracelet called Keen2 that detects hair-pulling episodes in adults with trichotillomania. For 8 weeks, participants wear the device and log what they were doing or feeling when pulling occurred. The bracelet then sends personalized alerts to help them use…

This large observational study in Mali is following up to 15,000 pregnant women and children to understand why some get malaria and others don't. Researchers are looking at immune responses, parasite features, and other factors that influence infection and disease severity. The g…

This study collects biological samples like blood, saliva, and urine from 300 adults aged 18-70, both with and without blood disorders such as sickle cell disease and thalassemia. The goal is to use these samples for research to better understand these conditions and related dise…

This study screens healthy adults aged 18 to 50 to see if they can join future malaria research trials. The goal is to find safe and effective malaria vaccines, drugs, or prevention methods. Participants will have a medical history check, physical exam, and blood and urine tests.…

This study looks at how leishmaniasis infections progress and respond to treatment. It involves up to 289 people aged 3 to 100 with known or suspected leishmaniasis. Researchers will collect blood and tissue samples to learn more about the disease and test different treatments. T…

This study gives healthy adults a controlled malaria infection using donated blood containing the P. vivax parasite. Researchers will monitor how the infection develops, how the immune system responds, and whether mosquitoes can pick up the parasite from participants. The goal is…

This study tests whether it is possible to set up a system to monitor antibiotic resistance at a general referral hospital in semirural Kinshasa, Democratic Republic of Congo. Researchers will enroll about 210 patients with suspected bloodstream infections to collect blood sample…

This early-stage study will check if a new experimental drug for malaria, called GSK3772701, changes how the body processes other medications. Twenty healthy adults aged 18 to 55 will take both GSK3772701 and a common probe drug called midazolam. The goal is to see if GSK3772701 …

This study looks at how cryptosporidiosis, a diarrheal disease, affects children aged 6 months to 5 years in countries where it is common. Researchers will track how long diarrhea lasts and how dehydrated children become. The goal is to better understand the disease to guide futu…

This study tracks 200 children in Italy with leishmaniasis, a parasitic infection that can affect the skin or internal organs. Researchers will look at how quickly the disease is diagnosed and treated, and how that affects recovery, relapse, and death rates. The goal is to identi…

This study aims to find the smallest number of infected mosquito bites needed to give healthy adults malaria. Twenty-four volunteers will be bitten by 1, 2, or 3 mosquitoes carrying the Plasmodium vivax parasite. The results will help researchers develop better ways to test futur…

This study looks at 20 adults in Ethiopia who have both HIV and visceral leishmaniasis (a serious parasitic disease). Researchers want to find out why the parasite keeps coming back in some patients and how to better monitor treatment. Participants provide samples and attend foll…

This study is collecting information on pregnancy and malaria in 9,500 women aged 15-49 in Kalifabougou, Mali. Researchers will track pregnancies, malaria cases, and pregnancy outcomes like preterm birth and anemia. The goal is to better understand these health issues in the comm…

This study aims to uncover genetic mutations or variations linked to uveitis, an inflammatory eye disease. Researchers will collect blood samples from 1,500 patients with uveitis (including infectious types) and analyze their DNA. The goal is to better understand what causes the …

This study follows 380 children in Uganda for two years to understand how malaria and HIV treatments interact. Half the children have HIV and half do not. Researchers will measure changes in body weight, blood sugar, and drug levels to find the best ways to treat both infections …

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study looks at 55 women who have a chronic (long-term) infection with the Toxoplasma parasite and also have a mental health condition like schizophrenia, depression, or bipolar disorder. Researchers want to see if tiny molecules called microRNAs in the blood can help tell th…

This observational study will follow 500 adults and children in the DRC who come to the clinic with a fever. Researchers want to see if using a simple blood test (CRP), a WHO antibiotic guidebook, or electronic decision tools can help doctors prescribe antibiotics more appropriat…

This study looks back at 100 cases of human babesiosis, a rare tick-borne disease, diagnosed in France between 2000 and 2024. Researchers want to describe who gets it, what symptoms they have, and how they are treated. The goal is to improve recognition and care, especially for v…

This study aims to safely give healthy Thai adults a controlled malaria infection using frozen infected blood cells. Researchers will monitor participants closely in a hospital to find the best dose for future studies. The goal is to learn more about the malaria parasite and help…

This study looks back at medical records of 30 non-HIV patients with weakened immune systems who had toxoplasmosis, a brain infection. The goal is to understand how many are affected and how to better diagnose and treat them. Researchers will track survival rates to improve care …

This study tests whether a digital vaccination record system linked to fingerprints can help more children in Ghana complete their malaria vaccine series and other routine shots. About 4,700 pregnant women and mothers of young children will take part. The system will automaticall…

This study aims to better understand how the spleen filters and responds to abnormal blood cells in various diseases. Researchers will collect spleen tissue and blood from 100 adults undergoing planned splenectomy. By perfusing the spleen in the lab, they hope to uncover its role…