Could a blood transfusion save kids with severe malaria?
NCT ID NCT05711485
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 33 times
Summary
This study tests whether giving a whole blood transfusion can help children under 5 with severe malaria and very low platelet counts survive. The trial is enrolling 132 children in Zambia. Researchers will compare death rates and changes in blood counts between those who receive the transfusion and those who do not.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Johns Hopkins Bloomberg School of Public Health
NOT_YET_RECRUITINGBaltimore, Maryland, 21205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tropical Diseases Research Centre
RECRUITINGNdola, Copperbelt, Zambia
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
whole blood transfusion
What this could lead to
If it works, this could provide a simple, low-cost treatment to reduce deaths from severe malaria in children.
What could go wrong
This is a small, early-stage trial (132 children) in one country, so results may not apply elsewhere. Transfusions carry risks like infection or allergic reactions.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.