Polyp

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This study will compare three FDA-approved biologic drugs (dupilumab, omalizumab, and mepolizumab) in 504 adults with chronic sinusitis and nasal polyps. The goal is to see which drug works best for different patients and whether simple tests can predict who will improve the most…

This study tests if the drug eRapa can slow disease progression in adults with Familial Adenomatous Polyposis (FAP), a condition that causes many polyps in the gut and raises cancer risk. About 168 participants will take eRapa or a placebo daily every other week. Researchers will…

This study follows 900 adults with severe chronic sinusitis and nasal polyps who are taking biologic drugs. Researchers will track how these treatments affect quality of life, symptoms, and side effects over 5 years. The goal is to see which patients benefit most based on their h…

This study is testing whether a special milk called UNICLA-A2 can reduce inflammation and improve gut health in people at high risk for colorectal cancer who have already had polyps removed. The milk comes from cows with a specific protein type and is enriched with omega-3 and se…

This study is testing a robotic device that doctors use through the anus to remove benign growths (polyps, adenomas) from the rectum and sigmoid colon. The goal is to see if the device can remove the entire growth in one piece safely, without causing bleeding or a hole in the bow…

This study tests a new device called EndoTEM, which helps doctors use two instruments at once to remove large polyps from the lower colon. The goal is to see if it is safe and can remove the entire polyp in one piece. Thirty adults with large polyps or early cancer in the rectum …

This study follows 404 people who previously had either an AI-assisted or conventional colonoscopy. Researchers want to see if AI help lowers the risk of developing advanced colon polyps later. Participants will undergo a surveillance colonoscopy to check for new growths.

This trial compares two doses of a dye called indocyanine green (ICG) given before laparoscopic gallbladder removal. The dye helps surgeons see the bile ducts clearly, which may reduce the risk of accidental injury. One group gets the standard dose hours before surgery; the other…

This study compares two endoscopic procedures—argon plasma coagulation (APC) and endoscopic mucosal resection (EMR)—for treating small (1 cm or smaller) precancerous growths in the stomach called gastric adenomas with low-grade dysplasia. About 160 adults will be randomly assigne…

This study tests whether a 6-month diet change can reduce inflammation and improve metabolism in obese adults who have had colon polyps. Participants and their household partners will follow a special eating plan. The goal is to see if diet can lower the risk of developing colore…

This study tests a freezing device called Nitrofreeze Skin Tag for removing skin tags. 56 healthy adults will have their skin tags frozen up to three times over 60 days. A blinded doctor will check if the skin tag disappears. The goal is to see if it works better than a similar p…

This study compares two methods used during colonoscopy to remove large, flat colon polyps: marking the edges before removal or using heat to treat the edges after removal. The goal is to see which method better prevents polyps from growing back. About 342 adults with polyps 20 m…

This study looks at whether people with severe nasal polyps who have been symptom-free for at least a year on biologic drugs like Dupixent or Nucala can safely stop taking them. 66 participants will either stop their medication or continue as usual, and researchers will track if …

This study looks at whether adding a procedure that removes lymphoid tissue in the back of the nose to standard sinus surgery can better control inflammation in people with nasal polyps. Thirty-two adults with nasal polyps will be randomly assigned to get either standard surgery …

This study compares two methods for finding precancerous colon polyps during colonoscopy. Both methods use water instead of air to inflate the colon and an AI system to spot polyps. One group also uses a special light filter called linked-color imaging. The goal is to see if the …

This study tests whether adding a hot tool to the standard cold removal of large colon polyps lowers the chance of polyps growing back. About 194 adults with flat or slightly raised polyps at least 20 mm wide will be randomly assigned to one of two procedures. Participants will h…

This study tests whether a daily ketone supplement (BHB) is safe and tolerable for people with Familial Adenomatous Polyposis (FAP), a genetic condition that causes many colon polyps and often leads to surgery. Twenty participants will take the supplement for two weeks to see if …

This study is testing a new blood test called DENEB that looks for tiny molecules (microRNAs) to find colorectal cancer and precancerous polyps early. Researchers will collect blood samples from 2,000 people who are also getting a colonoscopy. The goal is to see if the blood test…

This study is testing whether a real-time artificial intelligence system can help doctors find more sessile serrated lesions (a type of precancerous polyp) during colonoscopy. About 628 adults aged 40-80 will be randomly assigned to have a colonoscopy with or without the AI aid. …

This study is testing a new capsule camera (CapsoCam Colon) that you swallow to detect colon polyps. About 330 adults aged 45-75 will swallow the capsule and then have a standard colonoscopy for comparison. The goal is to see if the capsule, with AI help, can accurately find poly…

This study compares two ways to monitor older adults (ages 65-82) who have had colon polyps in the past: an annual stool test (FIT) or a colonoscopy every few years. About 9,000 participants will be randomly assigned to one of the two methods and followed for up to 11 years to se…

This study tests an AI tool called EndoAIM that helps doctors measure the size of polyps found during a colonoscopy. Accurate size measurement is important because larger polyps (over 10 mm) have a higher risk of becoming cancer. The study will enroll 278 adults undergoing colono…

This study is testing a blood test (called a liquid biopsy) to see if it can find colorectal cancer, pre-cancerous growths (adenomas), and cancers linked to Lynch syndrome at an early stage. Researchers will enroll 1,200 people who have already had a colonoscopy. The goal is to s…

This study compares two ways to monitor people who have had polyps removed from their colon: a fecal test that checks for blood in stool versus a standard colonoscopy. Researchers want to see if the simpler stool test is just as good at catching new cancers or high-risk polyps. A…

This study tests a tool called SCALE-EYE that helps doctors measure the size of polyps during a colonoscopy. The goal is to see if it works better than current methods and can reduce the number of follow-up colonoscopies, waste, and carbon footprint. About 241 people aged 55-80 h…

This study compares AI-assisted colonoscopy to conventional colonoscopy in 915 adults aged 50 and older. The goal is to see if AI helps doctors detect more polyps and better classify them as benign or malignant. Researchers will also compare costs between the two methods.

This study tests a new microwave-based device, called MiWEndo, that is used during a standard colonoscopy to help doctors find polyps in the colon. About 50 people who already have a polyp in their rectum will take part. The goal is to see if the device is safe and can find more …

This study looks at whether people who have had 1 or 2 small, non-cancerous polyps removed can safely wait 10 years for their next colonoscopy instead of the usual 5 years. About 9,500 adults aged 45-69 will be randomly assigned to one of two schedules: a colonoscopy at 5 and 10 …

This early-phase study tests the safety of a drug called ONC201 (dordaviprone) in 36 adults at high risk for colorectal cancer due to familial adenomatous polyposis (FAP) or a history of many polyps. The drug aims to kill precancerous cells without harming normal ones. Researcher…

This study tests different amounts of exercise to see if it can prevent colorectal polyps from returning in people with Familial Adenomatous Polyposis (FAP). About 32 participants will follow a personalized treadmill program at home for 26 weeks. Researchers will check how well p…

This study tests whether using a computer-aided detection (CADe) system during screening colonoscopy helps find and remove more advanced polyps, potentially lowering the risk of colorectal cancer. About 592 adults at increased risk for colorectal cancer will be randomly assigned …

This study tests a new device called GripTract-GI for removing complex colon polyps. It compares the device to the usual method in 30 adults. The goal is to see if it reduces complications, shortens procedure time, and allows for complete removal in one piece.

This study tests whether injecting platelet-rich plasma (PRP) into the vocal cords during surgery helps people recover their voice better than surgery alone. Sixty-four adults with benign vocal cord growths (like polyps or nodules) will be split into two groups: one gets PRP plus…

This study looks at whether endoscopic sinus surgery can improve sleep in people with chronic sinusitis and nasal polyps. Researchers will measure sleep quality before and after surgery in 30 participants. The goal is to see if removing polyps and opening blocked sinuses helps wi…

This study compares two sedative drugs, remimazolam and propofol, in 90 adults having colonoscopy to remove polyps. The goal is to see which drug keeps the heart and breathing more stable during the procedure. Results may help choose safer sedation for routine colonoscopies.

This study tests whether a high-flow nasal cannula (HFNC) can prevent dangerous drops in oxygen levels during sedated gastrointestinal endoscopy in critically ill patients. Researchers will compare HFNC with standard nasal oxygen in 450 adults with serious health conditions. The …

This study tests whether a numbing injection (nerve block) given during vocal cord surgery can reduce pain, coughing, and improve voice recovery afterward. About 28 adults with benign vocal cord growths will receive either the numbing medicine or a saltwater placebo. Researchers …

This study compares two ways to treat chronic sinusitis with nasal polyps: a new in-clinic procedure done under local anesthesia versus standard sinus surgery in an operating room. Researchers will enroll 140 adults to see if the in-clinic approach controls symptoms just as well,…

This study compares two types of gallbladder removal surgery for non-cancerous conditions like gallstones or polyps. About 276 adults will be randomly assigned to either robotic or standard laparoscopic surgery. The main goal is to see if robotic surgery is as safe as the traditi…

This study looks at whether using lower pressure gas during laparoscopic large bowel surgery can protect the gut and help patients recover faster. About 125 adults having certain types of colon surgery will be randomly assigned to different pressure levels. The goal is to see if …

This study tests whether a technique called cold snare polypectomy can safely remove 10-20 mm colon polyps without using heat. About 120 adults will have their polyps removed this way during a colonoscopy. The goal is to see if it works well and causes fewer complications than tr…

This study looks at people with smell loss caused by chronic rhinosinusitis. Participants will undergo a 3-month smell training program. Researchers will measure changes in smell function, mental health, and immune markers in blood and tissue samples. The goal is to understand th…

This study is testing a digital platform called the Genetics Navigator to see if it can reduce distress for people undergoing genetic testing. The platform provides education, counseling, and management recommendations. Researchers will compare it to standard care in 170 adults a…

This study looks at how voice sounds change when people strain their vocal cords. Researchers will measure specific voice features in 100 adults, some with and some without vocal cord injury. The goal is to find early warning signs that could help prevent voice damage before it h…

This study looks at how different face shapes (horizontal vs. vertical growers) affect tooth movement after braces are removed, during the retention phase when retainers are worn. Researchers will track 44 people over 12 months using 3D scans to see if teeth shift differently bas…

This study follows 3,500 adults with large colon polyps (20 mm or bigger) to see how well current removal methods work. Doctors will record details about the patients, polyps, and procedures. The goal is to learn what leads to successful removal without surgery and to track any c…

This study aims to create a database of vocal health in people aged 4 to 65 with no voice problems, and compare them to children with voice disorders. Participants will perform simple voice tasks into a device that measures airflow and pressure. The goal is to find the best way t…

This study is testing whether an artificial intelligence system called GI Genius can help doctors find more polyps during colonoscopy. Polyps are growths that can sometimes turn into cancer. The study will include about 764 adults having a colonoscopy at a hospital in Singapore. …

This study tests whether using a patient's existing CT scan to guide the colonoscope can make the procedure faster, less painful, and easier for doctors. About 200 adults getting a colonoscopy will be randomly assigned to standard or CT-assisted insertion. The goal is to see if t…

This study follows 1,200 adults with asthma (with or without nasal polyps) for up to 7 years to see how their condition changes over time. Researchers will track symptoms, treatments, and biomarkers in blood and breath. The goal is to better understand different types of asthma a…

This study looks at the genes in colon polyps from people with MASH (a type of fatty liver disease) compared to those without fatty liver. Researchers want to find specific gene patterns that might signal higher risk. About 100 adults already scheduled for polyp removal will dona…

This study is testing a new device that uses small electric pulses to destroy colon polyps during a colonoscopy. Researchers want to see if it is safe and effective for removing polyps. Thirty adults with at least one polyp larger than 5mm in the lower colon will be enrolled. The…

This study tests whether a digital training program called Colo-ID helps doctors better predict the type of colon polyps they see during a colonoscopy. About 1,500 adults with at least one polyp will take part. Doctors will record their predictions before and after training, and …

This study collects images and videos of large colon polyps from 5,000 people undergoing colonoscopy. The goal is to train an artificial intelligence system to automatically predict whether a polyp has invaded deeper layers of the bowel wall. No drugs or treatments are tested—onl…

This study looks at how adding beans to the diet affects bowel and metabolic health in 25 overweight adults aged 30-80 who are scheduled for a colonoscopy. Participants will drink a bean smoothie for two weeks, and researchers will measure changes in gut bacteria, blood markers, …

This study aims to collect blood, nasal fluid, skin cells, urine, and medical data from 10,000 people aged 3 to 100 with allergies, asthma, eczema, or sinus issues. Participants will have up to 3 years of follow-up visits and questionnaires. The goal is to create a large reposito…

This study tests whether a short video training can improve doctors' ability to detect cancer recurrence at colonoscopy scars. 141 endoscopists of all experience levels will view 15 images before and after a learning tool, answering questions about scar recognition and recurrence…

This study collects high-quality videos from routine colonoscopy screenings to help test and improve an automatic polyp detection device. About 700 adults undergoing standard colonoscopy will have their procedure recorded. The goal is to gather enough good footage to evaluate how…

This study is collecting data from 1,200 people across France who are having a procedure called endoscopic submucosal dissection (ESD) to remove large polyps or early cancers from the colon. ESD allows doctors to remove the entire lesion in one piece, which helps with accurate an…

This study is collecting tissue and blood samples from 1,730 people with early gastric cancer or precancerous stomach growths. Researchers will analyze the genetic profiles of these samples to find markers that could help diagnose these conditions early and predict if the cancer …

This study collects tissue samples, medical data, and family histories from over 1,100 people being screened for colorectal or endometrial cancer. Researchers hope to discover new genes and mechanisms that increase cancer risk, especially in hereditary cancer syndromes. The goal …