Nationwide french study aims to settle debate on best way to remove large colon polyps

NCT ID NCT04592003

Recruiting now Knowledge-focused Sponsor: University Hospital, Limoges Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is collecting data from 1,200 people across France who are having a procedure called endoscopic submucosal dissection (ESD) to remove large polyps or early cancers from the colon. ESD allows doctors to remove the entire lesion in one piece, which helps with accurate analysis and lowers the chance of the polyp coming back. However, it is more complex and has a higher risk of complications than standard methods. The goal is to gather real-world evidence on how safe and effective ESD is in expert centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Endoscopic submucosal dissection (a procedure to remove abnormal tissue from the colon using a scope)
What this could lead to: If successful, this study could help clarify when ESD is the best option for removing large colorectal polyps, potentially reducing recurrence and the need for repeat procedures.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove that ESD is better than other methods. The procedure carries risks like perforation (about 4%) and is more complex and costly.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal cancer polyp of large intestine

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER COLORECTAL ENDOSCOPIC SUBMUCOSAL RESECTION POLYPS COLORECTAL

Contacts and locations

Locations

CHRU de Brest
RECRUITING

Brest, 29200, France
CHU d'Amiens
RECRUITING

Amiens, 80054, France
CHU de Besançon
RECRUITING

Besançon, 25000, France
CHU de Bordeaux
RECRUITING

Bordeaux, 33400, France
CHU de Dijon
RECRUITING

Dijon, 21000, France
CHU de Limoges
RECRUITING

Limoges, 87045, France
CHU de Montpellier
RECRUITING

Montpellier, 34090, France
CHU de Nancy
RECRUITING

Nancy, 54035, France
CHU de Nantes
RECRUITING

Nantes, 44093, France
CHU de Nice
RECRUITING

Nice, 06200, France
CHU de Nîmes
RECRUITING

Nîmes, 30029, France
CHU de Rennes
RECRUITING

Rennes, 35000, France
CHU de Rouen
RECRUITING

Rouen, 76031, France
CHU de Strasbourg
RECRUITING

Strasbourg, 67000, France
CHU de Toulouse
RECRUITING

Toulouse, 31400, France
Clinique Jules Vernes
RECRUITING

Nantes, 44000, France
Clinique Santé Atlantique
RECRUITING

Saint-Herblain, 44800, France
Clinique de l'Anjou
RECRUITING

Angers, 49044, France
Hopital Edouard Herriot
RECRUITING

Lyon, 69003, France
Hôpital Cochin - APHP
RECRUITING

Paris, 75014, France
Hôpital Européen
RECRUITING

Marseille, 13003, France
Hôpital Européen Georges Pompidou-APHP
RECRUITING

Paris, 75015, France
Hôpital Jean Mermoz
RECRUITING

Lyon, 69008, France
Hôpital St Antoine
RECRUITING

Paris, 75012, France
Hôpital St Joseph
RECRUITING

Paris, 75014, France

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