Nationwide french study aims to settle debate on best way to remove large colon polyps

NCT ID NCT04592003

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is collecting data from 1,200 people across France who are having a procedure called endoscopic submucosal dissection (ESD) to remove large polyps or early cancers from the colon. ESD allows doctors to remove the entire lesion in one piece, which helps with accurate analysis and lowers the chance of the polyp coming back. However, it is more complex and has a higher risk of complications than standard methods. The goal is to gather real-world evidence on how safe and effective ESD is in expert centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Endoscopic submucosal dissection (a procedure to remove abnormal tissue from the colon using a scope)

What this could lead to

If successful, this study could help clarify when ESD is the best option for removing large colorectal polyps, potentially reducing recurrence and the need for repeat procedures.

What could go wrong

This is an observational study, not a controlled trial, so it cannot prove that ESD is better than other methods. The procedure carries risks like perforation (about 4%) and is more complex and costly.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal cancer polyp of large intestine

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • CHRU de Brest

    RECRUITING

    Brest, 29200, France

    Contact Email: •••••@•••••

  • CHU d'Amiens

    RECRUITING

    Amiens, 80054, France

    Contact Email: •••••@•••••

  • CHU de Besançon

    RECRUITING

    Besançon, 25000, France

    Contact Email: •••••@•••••

  • CHU de Bordeaux

    RECRUITING

    Bordeaux, 33400, France

    Contact Email: •••••@•••••

  • CHU de Dijon

    RECRUITING

    Dijon, 21000, France

    Contact Email: •••••@•••••

  • CHU de Limoges

    RECRUITING

    Limoges, 87045, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • CHU de Montpellier

    RECRUITING

    Montpellier, 34090, France

    Contact Email: •••••@•••••

  • CHU de Nancy

    RECRUITING

    Nancy, 54035, France

    Contact Email: •••••@•••••

  • CHU de Nantes

    RECRUITING

    Nantes, 44093, France

    Contact Email: •••••@•••••

  • CHU de Nice

    RECRUITING

    Nice, 06200, France

    Contact Email: •••••@•••••

  • CHU de Nîmes

    RECRUITING

    Nîmes, 30029, France

    Contact Email: •••••@•••••

  • CHU de Rennes

    RECRUITING

    Rennes, 35000, France

    Contact Email: •••••@•••••

  • CHU de Rouen

    RECRUITING

    Rouen, 76031, France

    Contact Email: •••••@•••••

  • CHU de Strasbourg

    RECRUITING

    Strasbourg, 67000, France

    Contact Email: •••••@•••••

  • CHU de Toulouse

    RECRUITING

    Toulouse, 31400, France

    Contact Email: •••••@•••••

  • Clinique Jules Vernes

    RECRUITING

    Nantes, 44000, France

    Contact Email: •••••@•••••

  • Clinique Santé Atlantique

    RECRUITING

    Saint-Herblain, 44800, France

    Contact Email: •••••@•••••

  • Clinique de l'Anjou

    RECRUITING

    Angers, 49044, France

    Contact Email: •••••@•••••

  • Hopital Edouard Herriot

    RECRUITING

    Lyon, 69003, France

    Contact Email: •••••@•••••

  • Hôpital Cochin - APHP

    RECRUITING

    Paris, 75014, France

    Contact Email: •••••@•••••

  • Hôpital Européen

    RECRUITING

    Marseille, 13003, France

    Contact Email: •••••@•••••

  • Hôpital Européen Georges Pompidou-APHP

    RECRUITING

    Paris, 75015, France

    Contact Email: •••••@•••••

  • Hôpital Jean Mermoz

    RECRUITING

    Lyon, 69008, France

    Contact Email: •••••@•••••

    Contact

  • Hôpital St Antoine

    RECRUITING

    Paris, 75012, France

    Contact Email: •••••@•••••

  • Hôpital St Joseph

    RECRUITING

    Paris, 75014, France

    Contact Email: •••••@•••••