Osteogenesis imperfecta and a reduction of bone mineral density.

This trial investigates whether doxercalciferol, a form of vitamin D, can prevent bone loss in the spine and thigh bone in postmenopausal women with low bone density. Participants take either doxercalciferol or a placebo daily for two years, with bone density measured at the star…

This study tested whether adding natural ingredients like garlic oil and nattokinase to standard hormone replacement therapy (HRT) could reduce the risk of blood clots in menopausal women. The trial involved 60 women divided into premenopausal and postmenopausal groups. Researche…

This study tested whether the drug abaloparatide (Tymlos) can reduce bone loss after total knee replacement in people with osteoporosis or osteopenia. 58 participants took the drug for 18 months. The main goal was to see if bone density around the new knee improved compared to be…

This study looked at how different recreational exercises—swimming, Pilates, and walking—affect muscle strength and balance in women at risk for osteoporosis. 60 women who had not exercised regularly took part. The goal was to see which activity might help prevent falls and fract…

This study tested whether combining a Mediterranean diet with progressive resistance training could improve bone density in adults aged 65 and older. Over 12 months, 22 participants followed the diet and exercise program, while 19 received no structured intervention. Researchers …

This study looked at two osteoporosis medications—romosozumab and denosumab—in 54 people who take long-term steroids and have weak bones. Participants first received either romosozumab for 12 months followed by denosumab, or denosumab alone for 24 months. Then everyone stayed on …

This study looked at 45 people with osteoporosis caused by long-term steroid use. Participants had stopped taking denosumab and were switched to either zoledronic acid or alendronate at different times. The goal was to see which timing and drug best controlled bone loss markers. …

This study looked at whether surgery helps people over 65 with mild primary hyperparathyroidism (high calcium levels) compared to just monitoring them. The goal was to see if surgery improves bone density and lowers fracture risk. A total of 102 participants were randomly assigne…

This study tested whether alendronate, a drug used for osteoporosis, can improve bone density in people with HIV. 140 participants received either alendronate or a placebo, along with calcium and vitamin D, for 2 years. The goal was to see if the drug could strengthen bones and r…

This study tested whether denosumab, a drug given as a shot every 6 months, can improve bone density in people with osteoporosis caused by systemic mastocytosis. 24 adults with the condition took part. The goal was to see if the drug strengthens bones and prevents fractures bette…

This study tested whether a daily supplement made from kefir peptides could help heal broken bones faster in postmenopausal women with osteoporosis. Thirty women with upper arm or wrist fractures were randomly assigned to receive either the kefir supplement or standard care alone…

This study tested whether taking daily probiotics (Lactobacillus plantarum and Lactobacillus paracasei) for 12 months could improve bone density in postmenopausal women with low bone mass. 170 women participated, taking either the probiotic or a placebo. The goal was to see if th…

This phase 3 trial tested a new biosimilar drug called ENZ215 (a form of denosumab) against the established drug Prolia in 504 postmenopausal women with osteoporosis. The goal was to see if ENZ215 works as well as Prolia in improving bone density and reducing bone breakdown marke…

This study tested a new way to rebuild lost jawbone using donated tooth material guided by artificial intelligence. Twenty-two people with bone loss in the upper jaw received either a solid block or a thin shell of treated tooth material, placed with a dental implant at the same …

This study tested whether romosozumab, a drug that builds bone, can improve bone density in women with anorexia nervosa. Thirty women received either romosozumab or a placebo for 12 months, followed by a single dose of zoledronic acid. The goal was to see if bone density and stru…

This study tested whether a bone-building drug (teriparatide) and a vibrating platform, alone or together, could improve bone density in 60 adults with chronic spinal cord injury who had low bone mass. Participants received daily injections of teriparatide, used a vibration devic…

This study looked at whether adding eldecalcitol (a vitamin D-like drug) to denosumab (a bone-strengthening shot) works better than denosumab with regular vitamin D for postmenopausal women with weak bones (osteoporosis). About 100 women took part for 12 months. The main goal was…

This study looked at the best way to prevent bone loss after stopping denosumab, a common osteoporosis treatment. Researchers tested giving alendronate first, then zoledronate, versus zoledronate alone in 44 postmenopausal women and men over 50. The goal was to see which approach…

This study tested whether taking a soluble corn fiber supplement for one year could improve bone health in healthy adolescents aged 10-13. 177 teens were randomly assigned to receive either the fiber supplement, fiber plus calcium, a placebo, or placebo plus calcium. Bone density…

This study tested the safety of romosozumab (Evenity) in 100 postmenopausal women in India who have osteoporosis and a high risk of bone fractures. Researchers tracked side effects, serious events, and changes in lab tests and vital signs. They also measured bone density changes …

This study tested whether denosumab, a drug used for osteoporosis, can improve bone density in women with anorexia nervosa. Thirty women received either denosumab or placebo injections over 12 months, with an optional year of alendronate. The goal was to see if bone density and s…

Bariatric surgery can lead to bone loss and increase fracture risk. This study tested whether denosumab, a drug used for osteoporosis, could prevent that bone loss. The trial included 36 postmenopausal women and men aged 50 and older who were planning weight-loss surgery. Partici…

This pilot study tested whether a year of monthly romosozumab injections, followed by a year of weekly alendronate pills, can improve bone health in women with chronic spinal cord injury and osteoporosis. Twelve non-ambulatory women participated. The goal was to see if this two-s…

This study tested whether a 12-week program of exercise and a nutritional supplement (containing HMB, protein, vitamin D, and omega-3) could improve muscle strength and mass in people with both osteoporosis and sarcopenia (age-related muscle loss). Thirteen participants were rand…

This study looked at whether moderate aerobic exercise or resistance exercise is better for improving bone density in postmenopausal women with type 2 diabetes and osteoporosis. Fifty women aged 50-60 did either treadmill walking or resistance training three times a week for 12 w…

This phase 3 trial tested whether a biosimilar called Bmab 1000 works as well as the established drug Prolia® for treating osteoporosis in postmenopausal women. 479 women aged 55-79 with osteoporosis received either Bmab 1000 or Prolia® as an injection every 6 months. The study m…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This completed study tested whether Rho AI software can accurately detect osteoporosis from X-ray images. Researchers used 800 de-identified images from patients who had joint or spine surgery. The goal was to see if the AI could correctly identify low bone density, which could h…

This study tested a portable ultrasound device to measure bone thickness and porosity in 50 adults over 50 years old. The goal was to see if this radiation-free method could help identify people at risk for osteoporotic fractures as accurately as standard X-ray scans. The approac…

This study tested how well a new type of CT scanner measures bone density compared to the standard DXA scan. 167 adults who already needed a CT scan also had a DXA scan. The goal was to see if the CT could accurately detect osteoporosis and how to make the scan even better.

This study tested a simple questionnaire to find women at risk for osteoporosis during their hospital stay. Over 3,200 women aged 50-80 answered questions about risk factors, and those at risk were offered a bone density scan. The goal was to catch osteoporosis earlier and connec…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested whether a single infusion of zoledronic acid can prevent bone and muscle loss in adults aged 35 and older who are undergoing bariatric surgery. Fifty-nine participants were randomly assigned to receive either the drug or a placebo. The main goal was to measure c…

This study looked at whether taking resveratrol (a natural compound found in grapes and red wine) every day could help prevent bone loss in postmenopausal women with low bone mass. 52 women who were 1 to 10 years past menopause took part. Researchers measured bone health through …

This study tested whether atenolol, a widely used beta blocker for heart conditions, can prevent bone loss in postmenopausal women. 420 healthy women aged 50-75 took either atenolol or a placebo daily for a period. The main goal was to see if the drug slowed bone density loss in …

This study tested a procedure called Periodontally Accelerated Osteogenic Orthodontics (PAOO) in 20 adults getting braces. The goal was to see if it could prevent bone loss and gum recession on the front of the lower teeth. The procedure combines a small cut in the gum with a bon…

This pilot study tested a virtual program designed to help older men at high risk for fractures reduce their risk of falls and broken bones. The program included personalized exercise plans delivered through a smartphone app and virtual nutrition counseling. Researchers enrolled …

This study tested whether taking a probiotic called Lactobacillus acidophilus can help prevent bone loss and osteoporosis in women after menopause. 90 women aged 45-70 with a BMI between 27 and 35 took either the probiotic or a placebo. Researchers measured calcium levels and bon…

This study tested a program to help women over 50 who had a wrist or arm fracture get proper follow-up care for osteoporosis. The program included oral advice, a leaflet, and phone reminders to see their doctor and get a bone density test. 436 women took part, and the study compa…

This study tested whether a single dose of zoledronic acid, a drug already used for osteoporosis, can prevent the rapid bone loss that often follows a spinal cord injury. Researchers enrolled 60 adults who had recently lost the ability to walk due to injury. They measured changes…

This study tested whether a virtual rehabilitation program called VIVA is feasible for people with spine fractures caused by osteoporosis. The program includes weekly online sessions to help reduce pain and improve movement and quality of life. The study involved 34 participants …

This study tested whether playing balance games on a Wii Fit board could help women aged 40-60 who have osteoporosis after a mastectomy. Sixty women participated, and their balance was measured before and after eight weeks of training. The goal was to see if this fun, home-like e…

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…

This study followed 88 children and young adults with types III and IV osteogenesis imperfecta (brittle bone disease) to track how the condition changes over time. Researchers measured bone density, lung and heart function, hearing, and movement abilities. The goal was to better …

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This completed pilot study aimed to estimate how common osteoporosis is in France, starting with the Alpes-Maritimes region. Researchers enrolled 800 participants who each received a bone densitometry scan. The study was observational and did not test any treatment.

This study checked whether women over 50 who had severe osteoporotic fractures (like hip or spine breaks) were scheduled for osteoporosis treatment at Nîmes University Hospital. Researchers reviewed hospital records of 500 patients to see if treatment was planned. The goal was to…

This study observed 30 elderly patients (over 65) who had a specific type of neck fracture (odontoid fracture) from a minor fall or low-energy injury. Researchers measured bone density, vitamin D levels, and other bone health markers to understand why these fractures happen. They…

This study looked at 47 people with bullous pemphigoid, a blistering skin condition, who were treated with high-dose topical corticosteroids (clobetasol propionate) for 6 months. Researchers measured bone mineral density at the start, at 3 months, and at 6 months to see if the tr…

This study looked at bone density in 448 men with hemophilia and healthy volunteers to see how common bone loss is. Participants had a bone density scan and some gave blood samples. The goal was to understand if hemophilia itself, not just lack of activity, leads to weaker bones.

This study followed 220 adults with phenylketonuria (PKU) in France to learn how the disease affects them later in life. Researchers looked for signs of cognitive decline, neurological problems, and how the disease impacts quality of life and social integration. No new treatment …

This completed study tested a smart wearable device called gaitQ that monitors and cues walking in people with long-term movement conditions like Parkinson's, stroke, multiple sclerosis, and arthritis. Researchers collected movement data from 98 participants in a lab to see if th…

This study looked at how teriparatide (Forsteo), a daily injection, builds new bone in postmenopausal women with osteoporosis. Nineteen women took the drug for two years. The goal was not to test if it works, but to understand exactly how it changes bone density and turnover over…

This pilot study looked at how weight loss affects bone density in overweight or obese men. 44 men either followed a reduced-calorie diet to lose weight or maintained their weight for 6 months. Researchers measured changes in bone density and quality to see if weight loss has any…

This study followed 59 nurses during their first year of work to see if night shifts harm bone health. Researchers measured bone density and markers of bone turnover in night shift nurses compared to day shift nurses. The goal was to understand if shift work increases the risk of…

This completed study evaluated existing osteoporosis patient education programs in Danish municipalities. Researchers compared over 3,000 people who took part in group education sessions (covering medication, diet, and exercise) with a matched group who did not. They measured eff…

This study tested whether a special CT scan (DECT) can better predict fracture risk in women with osteoporosis than the usual bone density test (DEXA). Seven women aged 60 or older participated. The goal was to develop a computer tool that analyzes bone structure from the scan to…

This study looked at whether the difference between how long it takes someone to actually perform a 'get up and walk' test versus how long they imagine it takes can predict future falls. Researchers followed 67 osteoporosis patients for a year after the tests. The goal was to see…

This study examined how conditions like diabetes, smoking, heart disease, and osteoporosis affect the health of dental implants. Researchers looked at 93 people with 314 implants that had been in place for at least three years. They found that these systemic factors can influence…

This study looked at whether eating only during a 9-hour window each day (time-restricted eating) affects bone health, weight, and gut bacteria in overweight or obese older women. 49 postmenopausal women were randomly assigned to either eat within a 9-hour window or a 12-hour win…

This study looked at 70 elderly women, half with osteoporosis and half without, to see if lower body muscle strength is linked to bone density. Researchers measured hip and knee strength using a special machine and compared it to bone scans. The goal was to better understand risk…

This study looked at why girls with Rett syndrome often develop weak bones (osteoporosis) at a very young age. Researchers checked bone density, looked at medical history, and measured certain proteins in the blood. The goal was to find risk factors and understand the biological …

This completed study looked at 86 patients who had a fracture possibly due to weak bones (osteoporosis). Researchers wanted to see if the calcium supplements patients were prescribed matched what they actually got from food. Many patients get calcium pills even if their diet alre…

This completed study looked at 44 stroke patients to see how their bone density differs between the paralyzed and non-paralyzed leg. Researchers measured bone density in the hip and spine using a special X-ray scan. The goal was to better understand which clinical factors are lin…

This study looked at whether using regular CT scans (already done for other reasons) can better predict the risk of spine fractures in people over 50, compared to the standard FRAX risk score. Researchers analyzed CT images from nearly 2,800 adults taken five years apart. The goa…

This study looked at a process called autophagy, which is how cells clean out damaged parts, in 82 women over 65 with osteoporosis. Some also had Alzheimer's disease. Researchers measured autophagy levels in bone cells from hip samples to see if poor cell cleanup links bone loss …

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This study tested whether educational podcasts and videos created by artificial intelligence could improve knowledge about osteoporosis and digital health literacy. Sixty adults aged 45 and older with osteoporosis or at risk for it received either audio or video content based on …

This early-stage study tested several new oral tablet versions of a bone-building hormone (hPTH 1-34) in 45 healthy men aged 18-35. The goal was to see how well the body absorbs these new tablets compared to an existing oral tablet and a standard daily injection. Researchers meas…

This study examined the relationship between metabolic syndrome and vitamin D levels in 549 older adults (65+). Researchers collected health questionnaires and blood samples to understand how these factors are connected. The goal was to gather knowledge, not to test a treatment.

This study tested whether CT scans can better measure bone health and predict fracture risk in 560 smokers with and without COPD. Researchers used CT images of the spine and ankle to assess bone structure, alongside standard bone density tests. The goal is to create a more accura…

This study looked at whether the smallest meaningful change in bone density measurements is different for people with obesity compared to those without. Researchers measured bone density twice in 120 adults with a BMI over 30. The goal was to improve accuracy when using bone scan…

This study followed 82 postmenopausal women with rheumatoid arthritis to see how their bone density changed over time. Researchers compared different arthritis medications and osteoporosis treatments to understand which approaches best protect bone health. The goal was to gather …

This study looked at whether working night shifts for just three nights in a row can disrupt bone health. Twenty healthy adults aged 20-40 either followed a normal sleep schedule or stayed awake at night and slept during the day. Researchers measured bone turnover markers to see …

This study aimed to understand how fat cells in bone marrow contribute to bone loss in osteoporosis. Researchers took bone cells from 20 adults undergoing hip replacement surgery and exposed them to secretions from fat cells in the lab. By measuring changes in gene activity, they…

This study examined 80 postmenopausal women to see if there is a connection between gum (periodontal) disease and osteoporosis. Researchers measured two substances in blood and gum fluid called sclerostin and TNF-α, which may help explain how these conditions affect each other. T…

This study followed 215 people newly diagnosed with HIV in Hong Kong to see how often they developed non-AIDS conditions like high blood pressure, diabetes, bone thinning, and kidney problems. Participants were on different anti-retroviral regimens, and researchers compared the r…

This study followed 180 people with anorexia nervosa for up to 4 years to see how their bone density changed over time. Researchers measured bone mineral density using a special X-ray scan and also checked blood levels of certain hormones linked to fat tissue. The goal was to und…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study aimed to find risk factors for osteoporosis in people with cystic fibrosis. Researchers took blood samples to study monocytes, which can turn into osteoclasts—cells that break down bone. They also tested how CFTR modulators affect these bone cells. The study included 2…

This study tested whether sending three text message reminders to adults over 50 who had a low-trauma fracture would encourage them to get a bone density test. The goal was to improve screening for osteoporosis, a condition that weakens bones. Researchers enrolled 97 patients fro…

This study looked at nearly 20,000 adults with asthma to see if long-term use of inhaled or oral steroids increases the risk of osteoporosis (weak bones) and other metabolic diseases like diabetes and high blood pressure. Researchers compared people who took higher total doses of…

This completed study tested a centralized Bone Health Service model to improve osteoporosis screening in male veterans aged 65 and older. Over 3,500 veterans from primary care teams took part. The goal was to see if a dedicated bone health team could increase screening rates and …

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This completed study looked back at the medical records of 74 adolescent girls aged 12 to 21 who had bone density scans. Researchers wanted to find out which girls are most at risk for low bone density (osteopenia or osteoporosis), especially those with missed periods or other gy…

This study looked at whether eating more Greek yogurt for 8 weeks could improve bone health and lower inflammation in adults aged 55 and older. Forty participants either ate yogurt with or without exercise, or just exercised without yogurt. Researchers measured blood markers of b…

This study looked at 66 postmenopausal women with osteoporosis who were either taking alendronate (a common bone-strengthening drug) or not. Researchers measured how well the jawbone healed after a tooth extraction using X-rays taken right after, then at 30 and 90 days. The goal …

This study looked at 66 adults with Osteogenesis Imperfecta (brittle bone disease) to see if small molecules called microRNAs in the blood are linked to how severe the condition is. Researchers compared people with mild (type 1) and severe (type 3) forms, plus healthy controls. T…