Disease

This trial tests whether giving a lower dose of radiation in just two sessions can reduce urinary side effects for men with intermediate-risk prostate cancer. All participants receive radiation on an MR-Linac, a machine that combines MRI imaging with radiotherapy for precise targ…

This study follows 200 adults who receive the Shoulder iD™ implant to treat severe rotator cuff tears or shoulder arthritis. Researchers measure how well the shoulder works and how often the implant needs to be fixed or replaced over 10 years. Participants attend regular check-up…

This study is testing a new knee implant called the Persona SoluTion PPS femur in 200 adults who need total knee replacement. The goal is to see if it safely improves knee function and reduces pain over two years. Participants will have their knee health measured before surgery a…

This study looks at whether giving an extra dose of the antibiotic cefoxitin during appendix removal surgery can better prevent infections compared to the usual single dose before surgery. Researchers will measure antibiotic levels in blood, fat, and appendix tissue from 46 parti…

This trial tests a new device called the Edwards SAPIEN M3 System for people with severe mitral regurgitation, a condition where a heart valve leaks blood backward. The device is placed using a thin tube threaded through blood vessels, avoiding open-heart surgery. The study inclu…

This phase 2 trial tests whether adding the drug daratumumab to a standard chemotherapy combination (bortezomib, cyclophosphamide, and dexamethasone) works better than the current standard (bortezomib, thalidomide, and dexamethasone) for newly diagnosed multiple myeloma patients …

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study was designed to test a combination of two drugs—golcadomide and nivolumab—in people with non-Hodgkin lymphoma whose cancer did not respond or came back after CAR-T cell therapy. The goal was to find a safe dose and see if the combo could shrink tumors. However, the tri…

This study tests a new medicine, WIN378, for adults with moderate or severe asthma. WIN378 blocks a protein that causes lung inflammation, which may improve asthma control. About 136 participants will receive either WIN378 or a placebo to check safety, how the drug works in the b…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study tests several experimental treatments at once in critically ill COVID-19 patients who need high-flow oxygen or a ventilator. The goal is to quickly find which treatments can reduce deaths and shorten the time patients need breathing support. About 1,500 adults in the h…

This early-stage study tests a genetically engineered virus (rQNestin34.5v.2) that is injected directly into recurrent brain tumors to see if it is safe and what dose works best. About 62 adults with certain types of brain cancer that have come back or worsened are taking part. T…

This study tests the safety and effectiveness of neratinib, a targeted cancer drug, in children whose solid tumors, brain tumors, lymphoma, or leukemia have come back or not responded to standard treatments. The drug is taken by mouth daily in 28-day cycles. The main goal is to f…

This early-stage trial tests whether a stimulant drug (methylphenidate, also known as Ritalin) given through an IV can safely help people with severe brain injuries regain consciousness. Ten adults in a coma or minimally conscious state will receive increasing doses to check for …

This pilot study tests whether the immune-boosting drug pembrolizumab can shrink early-stage NK/T-cell lymphoma in patients who have not yet had chemotherapy. Nineteen participants will receive the drug every three weeks. The goal is to see if this approach can control the diseas…

Researchers compare two types of CT scanners for imaging heart arteries in people with suspected chronic coronary syndrome. One scanner uses standard energy-integrating detectors, while the other uses newer photon-counting detectors that may produce clearer pictures with fewer fa…

This study aims to develop an artificial intelligence (AI) model that combines two advanced imaging techniques—multiparametric MRI and PSMA PET/CT—to more accurately diagnose prostate cancer. By analyzing data from up to 1,500 patients, the AI model is designed to identify clinic…

This study is testing whether two simple, non-invasive tests—a breath test (FeNO) and a blood test (eosinophil count)—can accurately diagnose asthma in children aged 6 to 17. Currently, diagnosing asthma often requires complex hospital-based breathing tests. The researchers aim t…

Researchers are testing whether artificial intelligence can combine ultrasound images with routine health data to track changes in a person's physiology over time. The study enrolls adults with heart, lung, kidney, or blood vessel conditions, as well as healthy volunteers. The go…

This study looks at whether a test that checks for a specific gene marker (SIX6) in urine or tissue can predict if bladder cancer will come back after surgery. Researchers will compare SIX6 levels in 177 patients who had low-risk bladder cancer to see if the test can tell who is …

Researchers at Sohag University are testing whether magnetic resonance imaging (MRI) can accurately identify the underlying cause of hip pain in 50 patients. The study will measure how often MRI detects specific problems like labral tears, cartilage damage, or fractures. It will …

This study tests new MRI techniques to reduce image problems caused by movement during scans. Researchers will add short experimental sequences to routine MRIs in 21 patients of any age at Memorial Sloan Kettering. The goal is to compare image quality and see if these new methods…

This study compares a new radioactive tracer called 18F-DCFPyL with standard tracers to see if it can better detect where prostate cancer has spread in the body. About 96 men with metastatic prostate cancer will receive both tracers and undergo PET/CT scans. The goal is to measur…

This study tests whether a machine-learning system can accurately interpret focused cardiac ultrasound images taken at the point of care, such as in an emergency room or clinic. About 3,000 adults who need a heart ultrasound will have their images analyzed by the AI, and the resu…

This study compares common diagnostic tests for asthma in adults to see which ones, alone or combined, most accurately identify the condition. Participants with suspected asthma will undergo spirometry, FeNO, oscillometry, and a bronchial provocation challenge. Researchers will c…

This study is testing a new blood test that looks at RNA from tiny particles called exosomes to diagnose prostate cancer. Researchers will enroll 1,600 men with elevated PSA levels or other signs of prostate cancer. The goal is to see if this test can accurately detect cancer and…

This trial is developing an artificial intelligence system that reads electrocardiograms (ECGs) to detect congenital heart disease in children. Researchers are collecting ECG data from thousands of children, including those with common and rare heart defects, to train a deep-lear…

This study tests whether a non-invasive device called Vivio can accurately track heart failure status by measuring blood pressure in the lungs. Researchers will compare Vivio readings to those from an implanted CardioMEMS sensor in 500 adults over age 21 who already have or will …

This study is testing whether a new blood test called ClarityDX Prostate can better identify men who have clinically significant prostate cancer. The test is given to men aged 40-75 with elevated PSA levels (3 ng/mL or higher) who are already scheduled for a prostate biopsy. Rese…

This study explores whether a new screening procedure can detect cerebral palsy (CP) earlier in high-risk infants using video recordings and artificial intelligence. Traditionally, CP is diagnosed between 12 and 24 months of age, but earlier detection could lead to better outcome…

This study is developing and testing an artificial intelligence model that analyzes images of skin biopsies to tell the difference between malignant lymphomas (like mycosis fungoides) and benign conditions that look similar. The AI will be trained on hundreds of archived slides a…

This study is developing a blood test that looks for specific DNA changes to find colorectal cancer early, even before symptoms appear. Researchers are analyzing blood samples from 500 people with and without cancer to see how accurate the test is. The goal is to create a simple,…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests whether a smartphone app can accurately detect anemia by analyzing images of the lower eyelid. The app uses artificial intelligence to estimate hemoglobin levels without a blood draw. Researchers will compare the app's results to standard lab tests in 3,000 adult…

This study tests an artificial intelligence system that combines blood tests, lab data, and ultrasound images to better diagnose prostate cancer in men with borderline PSA levels (4-10 ng/mL). The goal is to reduce unnecessary biopsies by accurately identifying who truly has canc…

This study tests a new ultrasound technique called SonoPODography (SPG) to diagnose superficial endometriosis, the most common form of the disease. Currently, diagnosis requires invasive surgery. The procedure involves injecting saline into the pelvis to create a clearer view of …

This study looks at whether a simple menstrual blood sample can help predict endometriosis in women aged 18-40 with symptoms like pelvic pain. Researchers will analyze cells in the blood to find patterns linked to the disease. The goal is to create a test that helps decide if sur…

This study aims to create a diagnostic test that can tell the difference between precancerous skin lesions (actinic keratoses) that will turn into skin cancer and those that will go away on their own. Researchers will study tissue samples from 140 patients with skin cancer and pr…

This study collects blood samples from 872 people with lung nodules to develop artificial intelligence (AI) tools that can help diagnose lung cancer earlier and more accurately. The goal is to combine blood tests with CT scans to improve detection and reduce the need for invasive…

This study follows 300 children aged 9 to 14 with obesity to see if ultrasound and MRI can detect early signs of liver disease. Researchers will compare imaging markers like liver fat and stiffness with standard tests. The goal is to improve diagnosis and monitoring without invas…

This study compares a new technique that combines cone-beam CT scans with a robotic bronchoscope against standard methods for taking lung tissue samples. The goal is to see if the new approach can diagnose lung cancer and other lung diseases more accurately. About 300 adults who …

This study looks at whether existing blood markers can accurately identify the underlying cause of heart failure in 511 patients. Researchers aim to improve diagnosis and potentially reduce healthcare costs by avoiding unnecessary tests. Participants were recently diagnosed with …

This study tests a lollipop-shaped device called CandyCollect to see if it can detect strep throat in children ages 5-17. Kids suck on the lollipop for a few minutes, and it captures bacteria in special channels. Researchers compare results to standard throat swabs to see if the …

This study was designed to check how well a new saliva test, called Endotest®, can diagnose endometriosis. Researchers planned to test the test's repeatability, how time of day affects results, and sample stability. The study was withdrawn before enrolling any participants, so no…

This study tests a device called Endosign, which is a sponge on a string that patients swallow to collect cells from the esophagus. The goal is to see if this simple, non-sedation method can provide good enough samples to replace regular endoscopies for monitoring Barrett's esoph…

This study explores whether eye-tracking technology in a virtual reality headset can help identify schizophrenia, bipolar disorder, and depression. Researchers will compare eye movement patterns of 120 participants (including healthy controls) to find specific markers for each co…

This study enrolls 4,000 people with urothelial carcinoma to test whether artificial intelligence can predict HER2 expression using MRI scans and pathology images. The goal is to create a model that accurately assesses HER2 status without needing invasive biopsies, helping doctor…

This study aimed to see if a soft membrane placed on the eye could diagnose microbial keratitis (a serious eye infection) better and more comfortably than the standard scrape test. Researchers planned to compare the two methods in adults with new corneal infections. However, the …

Acute heart failure is a life-threatening condition where the heart suddenly can't pump blood, but its symptoms often mimic other illnesses, causing delays in diagnosis. Researchers developed a computer algorithm called CoDE-HF that combines a blood test (NT-proBNP) with patient …

This observational study will enroll 2000 people with suspected or confirmed cardiac masses (tumors or blood clots) to see if cardiovascular magnetic resonance (CMR) can accurately tell what the mass is and guide treatment. Participants will get a CMR scan and be followed for 3 y…

This study compares two ways to take tissue samples from lung nodules that are hard to reach with a regular bronchoscope. About 228 adults aged 18 to 90 with suspicious lung nodules will be randomly assigned to get either an ultra-thin cryobiopsy or a forceps biopsy, both guided …

This study looks at whether whole genome sequencing can help doctors diagnose genetic disorders faster in newborns admitted to intensive care. Researchers will compare the time to diagnosis and care costs for 400 infants who receive this advanced genetic test versus standard test…

This study compares a new AI system, called COSMO, against 30 board-certified pathologists to see who can more accurately diagnose brain, lung, and kidney cancers. Both the AI and the pathologists will review the same 300 de-identified tissue images. The goal is to see if AI can …

This study tests whether a new DNA-sequencing technique (metagenomic next-generation sequencing) can identify the cause of pneumonia faster than standard methods. About 114 ICU patients on ventilators will be randomly assigned to receive either the new test or usual care. The goa…

This study looks at whether measuring kappa free light chains (KFLC) in spinal fluid can replace the standard test (oligoclonal bands) for diagnosing multiple sclerosis (MS) and its early stage, clinically isolated syndrome (CIS). Researchers will compare both tests in over 1,100…

This study tests a new way to classify heart attacks based on whether a coronary artery is fully blocked (occlusion) or not, instead of the traditional ST-elevation vs non-ST-elevation method. Researchers will compare outcomes in 6,000 patients to see if the new approach leads to…

This study tests a goal-setting program for adults with knee problems like arthritis or injuries. Participants work with their surgeon to create specific, measurable goals and track progress. The aim is to see if this approach helps patients achieve their treatment goals and impr…

This study looks at whether training one leg at a time on a bike can help people with idiopathic pulmonary fibrosis (IPF) exercise longer. IPF makes it hard to breathe, so using fewer muscles may allow a better workout. The trial will compare one-legged cycling to the usual two-l…

This study tests whether adding an extra numbing injection inside the prostate can reduce pain during a prostate biopsy. Fifty men undergoing the procedure will receive either standard numbing of the skin or the standard plus the extra injection. Pain levels are measured before, …

This study tests whether wearing a virtual reality (VR) headset during dental treatment can reduce fear and stress in children with mild intellectual disabilities or autism spectrum disorder. Two hundred children aged 6 to 12 will either receive standard dental care or use a VR h…

This study tests a specific osteopathic protocol (PO2S) for people with acute or subacute non-specific back pain (less than 3 months). 50 participants will receive two 30-minute sessions one week apart, with a crossover design. The main goal is to see if pain levels improve after…

This study tests whether rinsing the nose with a xylitol solution can reduce sinus symptoms in adults with cystic fibrosis. Participants will use both xylitol and standard saline rinses at different times to compare effects. The goal is to see if xylitol, a natural sugar alcohol,…

This study compares two treatments—elagolix and oral contraceptive pills (OCPs)—to see which better reduces pelvic pain from endometriosis. About 90 women aged 18-45 with confirmed endometriosis will report their pain levels over 24 weeks. The goal is to help doctors choose the b…

This study tests whether injecting a 5% dextrose (sugar water) solution around the nerve in the wrist can reduce pain and improve hand function in people with mild to moderate carpal tunnel syndrome. About 96 adults who haven't gotten better with standard care will receive the in…

This study planned to see if a TENS device could reduce pain and improve quality of life in adolescents and young adults with endometriosis-related chronic pelvic pain. It was withdrawn before any participants were enrolled, so no data was collected. The goal was to offer a non-d…

This study screens up to 10,000 people with blood disorders or healthy volunteers to see if they can safely join other active research studies at the National Heart, Lung, and Blood Institute. Participants undergo clinical, imaging, and lab tests. If no suitable study is availabl…

This study aims to find early markers of Parkinson's disease, multiple system atrophy, and Lewy body dementia by analyzing samples from the nose, blood, and urine. Researchers will compare results from 180 people with these conditions and healthy volunteers. The goal is to improv…

This study looks at whether having a heart doctor check patients during a COPD flare-up helps find and treat hidden heart problems. 150 hospitalized adults with COPD are randomly assigned to see only a lung doctor or also a heart doctor. Researchers then track changes in heart tr…

This study follows up to 500 people with acute or chronic inflammatory disorders, such as infections or immune problems, over time. Researchers will monitor participants with standard tests and may screen them for other studies. The goal is to better understand these conditions a…

This study looks at whether taking muco-active agents (mucus-thinning drugs like N-acetylcysteine and ambroxol) after a lung cancer diagnosis is linked to better outcomes in people who also have COPD. Researchers will analyze data from a large Korean database, comparing those who…

This study tested whether a special PET imaging probe called [68Ga]CBP8 can measure scarring (fibrosis) in the hearts of people with cardiac amyloidosis, a rare condition where abnormal proteins build up in the heart. Researchers compared 18 participants with cardiac amyloidosis …

This study follows about 80 adults who receive the EasyMove total ankle prosthesis for severe ankle arthritis caused by injury, wear-and-tear, or rheumatoid arthritis. Researchers will monitor how often the implant loosens and needs revision, as well as pain, mobility, and functi…

This study uses MRI scans to track changes in the jaw joint over 18 months in people with degenerative joint disease. Researchers will compare these scans to those from healthy volunteers to learn more about how the disease progresses. No drugs or contrast agents are used. The go…

This study was designed to see if doctors could use an ultrasound machine to guide a diagnostic nerve block for low back pain. The procedure involves injecting numbing medicine near the small joints in the spine. However, the study was withdrawn before enrolling any participants,…

This study looks at 300 pregnant women who have an epidural during labor. It compares leaving a catheter in place all the time versus inserting and removing it every few hours. The goal is to see which method leads to fewer bladder issues and infections after giving birth.

This study follows 640 adults with normal cognition, mild cognitive impairment, or Alzheimer's disease to track brain changes over time. Researchers use advanced brain scans and genetic tests to understand how Alzheimer's develops. The goal is to find better ways to diagnose and …

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with clinical information to build machine learning models that might one d…

This study analyzes data from over 45,000 people diagnosed with colon or ovarian cancer in England between 2016 and 2017. Researchers are looking for differences in how quickly people are diagnosed and what treatments they receive, based on their socioeconomic status. The goal is…

This study follows over 1,800 adults who had early-stage lung cancer treatment to see how often they get CT scans and whether scanning every 6 months helps them live longer than yearly scans. Researchers will also check if scan frequency differs by race, income, or location. The …

This study is testing a new way to analyze MRI brain scans, called Cortical Disarray Measurement (CDM), to see if it can help diagnose Alzheimer's disease more accurately. Researchers will follow 400 people with mild memory or thinking problems over time, comparing CDM results wi…

This study follows nearly 20,000 patients who had major non-cardiac surgery to see how often heart injury occurs and what happens a year later. Researchers are looking at death rates and major heart complications. The goal is to better understand who is at risk and how to improve…

This study looks back at the experiences of 37 people with colorectal cancer treated at a single hospital. Researchers are tracking how long patients survive after diagnosis. No new treatments are being tested; the goal is to learn from real-world outcomes.

This study brings together small groups of anesthesiologists from different European countries to discuss what would encourage them to use neuromuscular monitoring more often. Neuromuscular monitoring tracks how well muscle relaxants are wearing off after surgery, which can help …

This study looks at whether a CT scan done right after removing a lung tumor can help surgeons decide if they need to remove more tissue. Currently, doctors only know if the cancer is fully removed after the surgery, when a pathologist checks the tissue. By getting immediate feed…

This study compares a new total body PET scanner (Omni TB) with conventional PET in 25 adult cancer patients. The new scanner can image the whole body at once with higher sensitivity, potentially allowing shorter scan times and lower radiation doses. Researchers will assess wheth…

This study tests a structured phonics program called ALFABETO in first and second graders to see if it improves reading and writing more than usual teaching methods. About 1,400 children from schools in Italy will take part, with some classes using the program and others using th…

This study screened over 16,600 adults aged 45-70 with at least one risk factor (like high blood pressure or smoking) but no known heart disease. Researchers used ultrasound and simple blood and urine tests to find hidden signs of atherosclerosis, pre-diabetes, and kidney disease…

This study investigates why some people develop chronic sinusitis with nasal polyps, focusing on how epigenetic changes and viruses might trigger the disease. Researchers will analyze tissue samples from 60 participants, including patients with active disease, those in remission,…

This study examines how well immunotherapy works for people with both lung cancer and pulmonary fibrosis (scarred lungs). Researchers will compare 200 patients with both conditions to similar patients without scarring, tracking survival and side effects. They also analyze tumor t…

This study was designed to see how chronic sinusitis affects the tiny hair-like cells (cilia) that help clear mucus from the nose. Researchers planned to use special glowing nano-sticks to measure how well these cells work. However, the study was withdrawn before any participants…

This study looks at the bacteria living in the nose and sinuses of people with chronic sinusitis, allergies, and healthy individuals. By analyzing tissue samples from 285 participants, researchers hope to identify which bacteria are linked to long-term inflammation. The goal is t…

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This observational study will enroll 10,000 adults with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle thickens. Researchers will combine genetic tests, advanced heart imaging, and blood markers to create better tools for early diagnosis and to predict risk…

This study follows 52 elite junior ice hockey players over a season to understand how head impacts affect the brain and body. Players wear helmet sensors to record impacts, plus heart rate monitors and cognitive tests to detect subtle changes. The goal is to improve concussion de…

This study follows 80 people with Neurofibromatosis type 1 (NF1) who are at high risk for developing malignant peripheral nerve sheath tumors (MPNST). Researchers will use yearly whole-body MRI scans, blood samples, and checkups to track changes in nerve lesions over time. The go…

This study will use advanced cardiac MRI scans to look at different patterns of heart inflammation in 5,000 people with myocarditis or inflammatory cardiomyopathy. The goal is to see if certain MRI findings can better predict who will have serious heart problems later, like heart…

This study looks at whether a personalized brain-training program can improve memory and thinking in older adults (60+) who have high blood pressure but no dementia. 120 participants will be randomly assigned to either the adaptive training or a placebo version for 12 weeks. The …

This study is testing whether simple blood tests can accurately diagnose dementia in everyday clinic settings. Over 3,000 people aged 45 and older with memory problems will give blood samples and answer questionnaires. Researchers will check how reliable and acceptable these bloo…

Researchers at Massachusetts General Hospital are testing a new device that goes through the nose to take pictures of the small intestine. The study includes 30 healthy adults and pregnant women in their second trimester. The goal is to see if people can tolerate the device and i…

This study looks at how children aged 12 to 17, their parents, and healthcare staff remember the conversation when cancer was first diagnosed. Researchers will interview each group and analyze the memories for common themes and differences. The goal is to learn more about how the…

This study reviews medical records of 200 people hospitalized with unexplained meningitis or meningoencephalitis. Researchers want to see if adding a test for tick-borne encephalitis (TBE) helps find more cases. No new drug or treatment is being tested—only the impact of a change…