HEALTHY PARTICIPANTS

This early-stage study tested a new drug called AZD6234 in 104 healthy adults with overweight or obesity. The main goal was to check if the drug is safe and tolerable when given as repeated injections under the skin. Researchers also looked at how the drug moves through the body.…

This early-stage study tested a new daily pill, AZD4144, in 28 adults with obesity to see if it is safe and how it affects body inflammation. Participants took either the drug or a placebo for a short time. The main goals were to check for side effects and measure changes in bloo…

This early-stage study tested a new drug called IBI356 to see if it is safe and how the body processes it. The trial included 99 healthy adults and people with atopic dermatitis (a type of eczema). Researchers monitored side effects and vital signs to determine if the drug is saf…

This pilot study tested whether a daily probiotic and grape extract supplement, or a functional chocolate bar with the same ingredients, could improve well-being in 40 healthy adults with moderate stress. Participants took one of the two products for 4 weeks, and researchers meas…

This early-stage study tested a single dose of IBI3002 in 52 healthy adults and people with mild to moderate asthma to see if it is safe and how the body processes it. Participants were randomly assigned to receive either the drug or a placebo, and were monitored for about 5 week…

This study tested whether a short, personalized virtual reality (VR) experience could help general practitioners (GPs) feel better and cope with stress. Twenty-one healthy GPs used a 10-minute VR program that used metaphors to encourage reflection on their values and challenges. …

This study tested PeptiSleep, a plant-based capsule, in 120 healthy adults over 6 weeks. Participants took either PeptiSleep or a placebo daily and wore a sleep tracker. The goal was to see if PeptiSleep improves sleep quality, morning alertness, and overall well-being.

This study tested whether a special dental syringe called Dentapen causes less pain and stress during numbing shots compared to a regular syringe. Forty healthy people who needed a tooth extraction took part. They rated their pain and had their heart rate monitored to measure str…

This study looked at whether taking a short nap (25 or 45 minutes) helps teenage soccer players perform better. Sixteen male players from a Turkish club completed agility and sprint tests after napping or staying awake. Results showed that napping improved agility and made player…

This study tested whether giving the drug tozorakimab with two different injection devices (an autoinjector and a prefilled syringe) leads to similar drug levels in the body. It involved 254 healthy adults who received a single dose under the skin. The goal was to see if the devi…

This study looked at how a drug called vimseltinib changes the way the body handles metformin, a common diabetes medicine. Twenty-two healthy men took both drugs and had their blood levels measured. The goal was to understand drug interactions, not to treat any disease. The study…

This study looked at how much of the drug rozanolixizumab appears in breast milk after a single dose. Fifteen healthy lactating women who had already decided to stop breastfeeding took part. Researchers collected milk samples over 7 days to measure drug levels and estimate how mu…

This study looked at how a new drug called AZD5004 affects the way the body processes several common medicines, including cholesterol-lowering statins and a diabetes drug. Healthy adults aged 18 to 55 took part to see if combining these drugs changes their levels in the blood. Th…

This early-stage study tested the safety and how the body handles a new drug called AZD6793 in 39 healthy Japanese and Chinese adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. The goal was to gath…

This study looked at how the experimental prostate cancer drug opevesostat stays in the body over time. Researchers compared 16 men with moderate liver impairment to healthy men. The goal was to see if liver problems affect drug levels, which helps doctors decide on safe dosing.

This early-stage study tested a single dose of a new drug, AZD5148, in 84 healthy adults to see if it is safe and how the body processes it. Participants received the drug either as a shot into a vein or muscle. The study did not aim to treat any disease, but to gather important …

This study looked at whether a single session of roller massage could lower blood pressure in healthy young adults. Researchers measured changes in tissue hardness and blood pressure after massage. The goal was to understand how massage might affect the body's blood pressure cont…

This study tested whether a new medicine called CHS-1420 works similarly in the body to the approved drug Humira. 238 healthy Chinese adults received a single injection of either drug and had their blood levels measured over time. The goal was to check if the two drugs are absorb…

This study tested two different ultrasound-guided nerve stimulation protocols on 86 healthy adults to see which one better improves handgrip strength. Participants received a single 10-minute session targeting the median nerve. The goal was to learn which stimulation pattern work…

This study looked at whether capivasertib changes how the body handles rosuvastatin, a cholesterol-lowering drug. Twenty healthy adults took rosuvastatin alone and then with capivasertib. Researchers measured drug levels in the blood to see if there is an interaction. The results…

This study looked at how three common drugs (itraconazole, rifampin, and acid reducers) change the levels of an experimental medicine called INCB161734 in the body. 63 healthy adults aged 18-55 took part. The goal was to gather safety and dosing information, not to treat any dise…

This study tested whether stretching or self-massaging the neck could improve flexibility in both the neck and the hip on the same side of the body. Thirty healthy adults each tried both techniques on separate days. Researchers measured range of motion and tissue stiffness before…

This study looked at how a new drug called casdatifan interacts with two other common drugs (itraconazole and phenytoin) in 14 healthy adults. The goal was to measure drug levels in the blood and check for side effects. Participants were healthy volunteers aged 18-55 who did not …

This study explored whether body weight influences blood sugar spikes after eating. Twenty healthy adults (10 normal weight, 10 overweight/obese) ate white or wholemeal bread with orange juice and butter. Their blood sugar was measured before eating and at several points afterwar…

This study looked at how vimseltinib affects two important drug transporters (BCRP and OATP1B1) in 20 healthy men. Participants took rosuvastatin, a common cholesterol drug, to measure these effects. The goal was to gather safety and drug interaction information, not to treat any…

This study looked at how a gentle electrical current applied to the scalp (tDCS) changes the way healthy adults handle stress and imagine future events. Sixty volunteers aged 18-30 had one MRI session where they received either real or fake stimulation while their brain activity …

This study looked at how two different versions of the experimental drug LY4064809 enter the bloodstream and how long the body takes to remove them. It involved 24 healthy adults who stayed at a research center for about one month. The goal was to gather information, not to treat…

This study looked at whether a 12-week exercise program (three times a week) could improve thinking skills in healthy adults aged 50 to 80. Researchers measured hormones like leptin and irisin, as well as other markers related to brain health. The goal was to understand how exerc…

This study tested how quickly Staccato alprazolam (an inhaled sedative) affects brain activity compared to two other sedatives given by IV or nasal spray. Fifty-five healthy adults received single doses and had their brain waves measured. The goal was to see which drug acts faste…

This early-stage study tested a single dose of the experimental drug UCB9741 in 40 healthy adults (Caucasian and Japanese) to check its safety and how the body processes it. Participants received either the drug or a placebo by injection. The goal was not to treat any disease, bu…

This study looked at how breathing in wildfire smoke for just one hour affects healthy adults' brains. Researchers measured a blood marker called p-tau, which is linked to memory and thinking problems. Twelve healthy people aged 18-40 took part, each having two visits: one breath…

This study looked at how two common drugs—carbamazepine and itraconazole—change the way a new drug called AP31969 is processed in the body. Twenty-eight healthy adults took AP31969 alone and with each of the other drugs to measure differences in drug levels. The goal is to unders…

This early-stage study tested the safety and how the body processes a single dose of donzakimig in 32 healthy Chinese and Japanese adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. Since this is a …

This study looked at how the drug MK-5684 is processed in the bodies of men with severe kidney disease or end-stage kidney disease compared to healthy men. Researchers measured drug levels in the blood over time and checked for side effects. The goal was to understand how kidney …

This study looked at how carrying a school backpack on one shoulder versus both shoulders changes the pressure on the soles of the feet in healthy adolescents aged 12 to 18. Researchers measured foot pressure and contact area while teens stood and walked with no backpack, a backp…

This early-stage study tested a new medicine called NNC0650-0013, which may one day treat type 2 diabetes. Eleven healthy men received a single injection of the drug or a placebo to check for safety and how the body processes it. The study lasted 11 to 17 weeks and required three…

This study tested whether immersive virtual reality can reduce pain, anxiety, and even cause temporary memory loss in healthy adults. Sixteen participants from the University of Washington took part. Researchers measured how well they remembered words and how distracted they felt…

This early-stage study tested the safety and how the body processes an inhaled drug called AZD4604. It involved 56 healthy Japanese and Chinese adults who received either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not to tr…

This study looked at how healthy adults' immune systems respond to the rabies vaccine, with or without added antibodies. Thirty participants received the vaccine in different schedules. The goal was to measure antibody levels over time, not to treat or prevent rabies directly.

This study looked at how healthy adult men process and eliminate a single dose of the drug quemliclustat. Eight participants received a radioactive-labeled version of the drug so researchers could track it in blood, urine, and feces. The goal was to understand how the drug leaves…

This study looked at whether taking a short, daily 5-minute bath in 113°F (45°C) water for two weeks can help the body adapt to heat. Twenty-six healthy adults took part. Researchers measured changes in body temperature, heart rate, and other signs to see if this quick method wor…

This study looked at how an experimental drug called AZD0780 changes the way the body processes metformin, a standard diabetes medication. Fourteen healthy adults took both drugs in a fixed order, and researchers measured drug levels and side effects. The goal was purely to gathe…

This study looked at how the drug camizestrant affects another drug (midazolam) and how a common seizure drug (carbamazepine) affects camizestrant. It involved 40 healthy postmenopausal women and did not aim to treat any disease. The goal was to gather safety and interaction info…

This study looked at how well different versions of the drug TEV-56286 are absorbed by the body. It involved 47 healthy adults who took single doses of the drug in different forms. The main goal was to compare the new formulations to the original capsule. The study also monitored…

This study looked at how the number of calories in a meal and the time of day you eat affect your body's metabolism and blood vessel health. Twenty healthy adults took part. The goal was to understand how different meal sizes and eating later in the day change the way your body b…

This study looked at how a nature-based therapy program affects stress and quality of life in 100 healthy adults living in Barcelona. Participants were smartphone users aged 18 and older, and the program involved spending time in coastal urban nature. The goal was to measure chan…

This study tested 50 healthy adolescents aged 15-16 to find normal handgrip strength values using a digital device. Participants did simple strength tests for their hands and legs. The results will help doctors compare strength in sick or injured patients in the future.

This study tested a new insulin (NKF-INS(A)) to see if it works the same as two already-approved insulins (US-NovoLog and EU-NovoRapid). Fifty-four healthy men received a single dose of each insulin in a random order, and researchers measured how the body absorbed and responded t…

This study looked at how a drug called elenestinib changes the way the body processes midazolam (a sedative) and a common birth control pill. Twenty healthy adult women took these drugs with and without elenestinib, and had blood tests to measure drug levels. The goal was to unde…

This early-stage study tested a new drug called INCB160058 in 137 healthy adults aged 18 to 55. The main goal was to check the drug's safety and how it moves through the body, not to treat any disease. Participants took a single dose by mouth, and researchers monitored side effec…

This early-stage study tested the safety and how the body handles a new drug called S-740792 in 99 healthy adults. Researchers gave single and multiple doses, checked the effect of food, and looked for interactions with another drug. The goal was to gather basic safety informatio…

This study looked at how eating a high-fat or low-fat meal changes the way the body absorbs a new drug called ammoxetine. Eighteen healthy adults took a single dose of the drug under different meal conditions. The goal was to understand food effects, not to treat any disease.

This early-stage study tested the safety of a new drug called AZD2389 in 120 healthy adults. Researchers gave single or multiple doses to see how the body handles the drug and if it causes side effects. The goal was not to treat any disease, but to gather important safety informa…

This study looked at how a high-fat, high-calorie meal changes the amount of two drugs (zibotentan and dapagliflozin) in the blood of 26 healthy adults. Participants took the drug combination once with food and once without, and researchers measured drug levels and side effects. …

This study tested a 5-day course of an oral NAD+ supplement in 60 healthy adults aged 45-75. Researchers measured changes in blood markers and NAD+ levels compared to a placebo. The goal was to understand if the supplement affects health-related molecules and is safe for short-te…

This study looked at how a new drug called AZD5004 interacts with two other medications in healthy people. In one part, researchers checked if taking itraconazole (an antifungal) changes how the body processes AZD5004. In another part, they tested if AZD5004 affects the levels of…

This study looked at how taking plixorafenib with or without food, and with another drug called cobicistat, changes the amount of plixorafenib in the blood. 28 healthy adults aged 18-55 took part. The goal was to gather safety and drug-level information, not to treat any disease.

This study looked at how a single dose of the experimental drug INCB099280 moves through and leaves the bodies of 5 healthy men aged 35 to 55. Researchers measured radioactivity in urine, feces, and blood to understand how the drug is absorbed, broken down, and eliminated. The go…

This study looked at whether a 4-week program of elastic band exercises could improve hip strength and agility in 21 healthy young male basketball players aged 15-18. One group did the band exercises plus regular training, while the other group only did regular training. The goal…

This study looked at how taking the drug admilparant with or without food changes its levels in the blood. Fifty-six healthy adults took the drug under different conditions. The results will help doctors decide the best way to take this medicine.

This study looked at whether getting real-time feedback from a virtual trainer avatar during virtual reality exercise improves how people feel and how accurately they move. Twenty-eight healthy adults aged 18 to 50 did three short VR exercise sessions: one with no feedback, one w…

This study looked at whether whole-wheat bread enriched with carob molasses powder and germ can improve blood sugar response and antioxidant levels in healthy adults. Twenty volunteers aged 19-35 ate both standard and enriched bread on separate days, and their blood was tested ov…

This study looked at how a short, painless brain stimulation technique called continuous theta burst stimulation (cTBS) changes the way healthy young adults pay attention to emotional pictures, like a crying child or a smiling baby. 91 volunteers received either real or fake stim…

This study looked at how the body absorbs and processes different forms of the experimental drug ziltivekimab. It involved 267 healthy adults who received a single injection under the skin, either with a syringe or a pen-injector. The goal was to compare how well each method work…

This study looked at how taking ammoxetine hydrochloride tablets with or without food changes the drug levels in the blood. Fourteen healthy adults aged 18 to 45 took part. The goal was to understand food's effect on drug absorption, not to treat any disease.

This completed Phase 1 study enrolled 9 healthy men aged 18-55 to see how a single oral dose of the drug INCB123667 (with a radioactive tracer) is absorbed, processed, and eliminated. The main goal was to measure total radioactivity in urine and feces and identify drug byproducts…

This study tested whether a short virtual reality (VR) self-help program could increase hope and well-being in healthy young adults aged 18-30. Forty participants completed five sessions, starting with an in-person VR experience followed by audio and video materials at home. They…

This early-stage study tested the safety and tolerability of a new drug called LY4060874 in 121 healthy adults. Participants were monitored for side effects and how the drug moved through their bodies. The study did not aim to treat any disease, only to gather initial safety data…

This study tested whether a short session of neck stretching can lower blood pressure in 25 healthy adults. Researchers measured blood pressure, tissue stiffness, and heart rate before and after stretching. The goal was to see if stretching relaxes blood vessels and helps the bod…

This study looked at how different cycling workouts affect muscle strength and fitness in 45 sedentary but healthy adults. Participants did either eccentric (lengthening) or concentric (shortening) cycling exercises for 14 weeks. The goal was to see which type of training works b…

This study looked at how the drug MK-8527 moves through the body in people with mild or moderate liver impairment compared to healthy people. 18 adults took a single dose, and researchers measured drug levels over time. The goal was to understand if liver problems change how the …

This early-stage study tested a new medicine called PF-06414300 in 63 healthy adults aged 18 to 65. The goal was to check safety and measure how the drug moves through the body. Participants received either the drug or a placebo in one or two parts of the study. This trial does n…

This study looked at how a new tablet version of the drug minzasolmin is absorbed by the body compared to an older capsule form. It also checked if eating food changes how the tablet works. Eighteen healthy adults took part to help researchers understand the drug's behavior, not …

This study tested whether a commercially available high-protein yoghurt drink helps muscles recover after intense exercise. 62 healthy adults aged 18-45 took part. Researchers measured amino acid levels in the blood and markers of muscle damage, soreness, and physical function ov…

This study looked at how a new insulin (THDB0206) works when injected into different body areas. 27 healthy Chinese adults received a single dose in three different spots on separate days. Researchers measured how fast the insulin was absorbed and how it affected blood sugar. The…

This study tested how a single session of resistance exercise (like lifting weights) with or without extra stretching affects blood vessels and blood pressure in healthy adults. 27 healthy men took part and were measured before, right after, and 30 minutes after exercise. The goa…

This study tested a new tablet form of the medicine semaglutide in healthy adults. The goal was to see how much of the drug gets into the blood with the new tablet compared to the current version. About 264 participants took different doses for up to 21 weeks, and their blood lev…

This early-stage study tested the safety of a new drug called CDX-622 in 85 healthy adults aged 18 to 55. Participants received either the drug or a placebo, and researchers monitored for side effects, drug levels in the blood, and changes in certain body chemicals. The goal was …

This study looked at how the brain naturally reduces pain when a person feels two painful sensations at the same time. Researchers wanted to see if paying attention to one pain can help turn down the other. Twenty-four healthy University of Washington students took part, rating t…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This study looked at how two different versions of an experimental drug are absorbed by the body. It involved 18 healthy Chinese adults who took each version once under fasting conditions. The goal was to compare the drug levels in their blood, not to treat any disease.

This study looked at how healthy men absorb, process, and eliminate a drug called PF-07220060. Twelve men took the drug by mouth or by mouth plus an injection. Researchers measured the drug in blood, urine, and stool to understand how it travels through the body. This study did n…

This study looked at how foam rolling the neck area affects blood pressure and neck flexibility in 24 healthy young adults. Researchers measured changes right after rolling and checked if more rolling led to bigger effects. The goal was to learn more about how this simple techniq…

This study looked at how a long-acting painkiller (nalbuphine ER) interacts with two lung fibrosis drugs (pirfenidone and nintedanib) in 132 healthy adults. Researchers measured drug levels in the blood and checked for side effects. The goal was to see if these drugs can be safel…

This study looked at how healthy adults tolerate injections of immunoglobulin G (a type of antibody) given under the skin. Researchers tested different injection conditions to see which caused the least pain and side effects. The goal was to gather safety information, not to trea…

This study looked at how different amounts of water and delays before breakfast affect levels of a new semaglutide tablet in the blood. 121 healthy men took the tablet daily for 10 days. The goal was to find the best way to take the medicine for future use.

This study tested a new propellant (HFA-152a) in salbutamol inhalers to see if it delivers the drug similarly to the current propellant (HFA-134a). Sixty healthy adults aged 18-55 received single doses of 200 or 800 micrograms in a crossover design. The goal was to compare how mu…

This early-stage study tested the safety of a new drug, AZD8965, in 147 healthy adults, including Japanese and Chinese participants. Researchers gave single or multiple doses to see how the body processes the drug and whether food affects it. The goal was to gather safety informa…

This study looked at whether a new drug called clofutriben affects how the body processes two other drugs, midazolam and prednisolone. Sixteen healthy adults took clofutriben daily for 16 days along with single doses of the other drugs. The goal was to measure drug levels in the …

This early-stage study tested the safety of a new drug called ATX101 in 24 healthy adults. Participants received a single dose through a vein, and researchers monitored for side effects and how the drug moved through the body. The goal was not to treat any disease, but to gather …

This study checked if certain skin products are safe by applying them to the skin of 26 healthy adults for 24 hours. Researchers looked for reactions like redness, dryness, or swelling. The goal was simply to gather safety information, not to treat or cure any disease.

This study looked at how the body absorbs ZN-A-1041 when given as a tablet compared to a capsule. It involved 18 healthy adults who took the drug in different forms. The goal was to see which form works best and how food or stomach acid medicine might affect absorption. No partic…