HEALTHY PARTICIPANTS

This was a small, early-stage study to check if a new oral drug called AZD4144 is safe for people with obesity. Twenty-eight healthy adults with obesity took the drug or a placebo daily for up to 28 days. Researchers primarily looked for side effects and measured changes in blood…

This early-stage study tested the safety of a new asthma drug called IBI3002 in healthy volunteers and people with mild to moderate asthma. Researchers gave single doses to 52 participants to check for side effects and see how the drug moves through the body. The main goal was to…

This early-stage study tested the safety and how the body processes a new drug called IBI356 for atopic dermatitis (eczema). Researchers gave the drug to 99 healthy volunteers and people with moderate-to-severe eczema to check for side effects and measure drug levels in the blood…

This study tested if a new insulin formulation called NKF-INS(A) behaves the same way in the body as two already-approved insulin products. It involved 54 healthy male volunteers who received single doses of each insulin in a random order. Researchers carefully measured how fast …

This study tested whether a simple, 4-week exercise program using elastic bands could strengthen the hip muscles of young male basketball players. Twenty-one healthy athletes were split into two groups: one did the band exercises along with their regular training, while the other…

This study looked at whether short daytime naps could help young soccer players perform better and feel less tired. Sixteen healthy male players from a competitive team tried three different conditions: no nap, a 25-minute nap, or a 45-minute nap. Researchers then tested their ag…

This study tested whether drinking a commercially available high-protein yogurt drink helps muscles recover faster after tiring exercise. Healthy adults aged 18-45 were given either the protein drink or a placebo drink without protein. Researchers measured muscle soreness, streng…

This small, completed study tested whether a daily probiotic chocolate bar or capsule could improve well-being in healthy adults. Forty participants with moderate stress levels took either the chocolate or a capsule for four weeks. Researchers measured changes in stress, sleep, g…

This study tested whether a brief, guided virtual reality experience could help improve the mental well-being and reduce burnout for general practitioners (GPs). Twenty-one GPs participated in a single session using a VR program designed to promote psychological flexibility and r…

This study looked at whether spending time in nature could help improve people's stress levels and overall quality of life. It involved 100 healthy adults in Barcelona who participated in a nature-based therapy program. Researchers measured changes in stress, mood, and well-being…

This study tested if a short session of static neck stretching could lower blood pressure in healthy adults. Researchers measured blood pressure, tissue stiffness, and heart rate in 25 participants to see if stretching relaxes blood vessels. The goal was to see if this simple act…

This study tested whether a new electronic syringe causes less pain and stress than a standard syringe when giving numbing shots for dental procedures. It involved 40 healthy people who needed a tooth pulled for braces. Researchers measured the patients' self-reported pain and th…

This study aimed to create a reference guide for normal handgrip and leg strength in healthy 15-16 year old adolescents. Researchers used a handheld digital device to measure strength in 50 participants, following standard testing positions. The results will help doctors and rese…

This early-stage study tested how the experimental drug AZD4144 is processed by the body in people with different levels of kidney function. Researchers gave a single dose to 41 participants, including healthy volunteers and people with mild to severe kidney impairment or end-sta…

This study tested whether a new recipe for whole-wheat bread, enriched with carob molasses pulp and wheat germ, is better for health than standard bread. Researchers had 20 healthy young adults eat both types of bread on separate visits and measured their blood sugar and antioxid…

This early-stage study tested how eating food and taking another drug called cobicistat affect how the body absorbs and processes a single dose of an experimental medicine called plixorafenib. The study involved 28 healthy adults who stayed in a clinic for 19 days to receive the …

This study aimed to understand if breathing simulated wildfire smoke for one hour affects a blood marker linked to brain health. Twelve healthy, non-smoking adults participated. They each had two visits: one breathing clean air and one breathing simulated smoke, with blood draws …

This early-stage study tested how an experimental drug, AZD5004, interacts with several common medications, including cholesterol drugs (like atorvastatin) and a diabetes drug (repaglinide). It involved 49 healthy adult volunteers to see if taking AZD5004 changes how the body pro…

This study aimed to understand how a drug called MK-8527 is processed by the body in people with mild or moderate liver impairment. Researchers compared the drug's behavior in 18 participants—some with healthy livers and some with liver problems—after they received a single dose.…

This early study tested a single dose of a new, unapproved medicine called NNC0650-0013, which is being developed to potentially treat type 2 diabetes. The main goal was to check if the medicine is safe and to see how the body processes it. The study involved 11 healthy male volu…

This University of Washington study explored whether wearing a virtual reality headset affects how well people can remember words. Sixteen healthy adult students listened to word lists both with and without VR, then tried to recall them immediately. The research aimed to understa…

This was an early-stage study to check the safety and see how the body processes a new drug called UCB9741. It involved 40 healthy adult volunteers from Caucasian and Japanese backgrounds who received a single injection. The main goal was to monitor for any side effects and measu…

This study looked at how using a foam roller on the neck affects blood pressure and neck movement in healthy young adults. Researchers measured blood pressure, neck flexibility, and heart rate in 24 participants after they performed the foam rolling exercises. The goal was to und…

This early-stage study aimed to check the safety and see how the body processes a single dose of an experimental drug called AZD5148. It involved 84 healthy adult volunteers who received the drug or a placebo via injection. The main goal was to monitor for side effects and measur…

This was a first-in-human study to check the safety and see how the body processes a new drug called ATX101. It involved 24 healthy adults who received a single dose of the drug or a placebo. The main goal was to see if the drug was safe and to measure its levels in the blood ove…

This study compared how different versions of the drug TEV-56286 are absorbed by the body in healthy volunteers. Participants received different formulations to measure drug levels in their blood and check for safety issues. The goal was to understand which formulation works best…

This study tested a new tablet version of the medicine semaglutide in healthy volunteers. The main goal was to measure how much of the drug gets into the blood from the new tablet and compare it to an older tablet version. About 260 healthy participants took different doses of th…

This study tested two different methods of ultrasound-guided nerve stimulation to see which one better improves handgrip strength in healthy people. Researchers compared two electrical stimulation patterns applied through a needle near the median nerve in the forearm. The goal wa…

This study aimed to understand how a new drug called INCB123667 is processed by the body. Nine healthy male volunteers took a single oral dose containing a tiny, safe amount of radioactive tracer. Researchers then tracked exactly how much of the drug was absorbed, how long it sta…

This study aimed to understand a natural process where feeling pain in one part of the body (like the wrist) might reduce pain felt in another part (like the foot). Researchers tested 24 healthy university students to see if this pain reduction happens partly because the new pain…

This was an early-stage study to check if a new inhaled drug called AZD4604 is safe and how the body processes it. It involved 56 healthy Japanese and Chinese volunteers who received either the drug or a placebo. The main goal was to see if the drug caused any side effects and to…

This early-stage study aimed to understand how a new drug candidate, INCB099280, is processed by the body. Five healthy male volunteers took a single, specially labeled oral dose. Researchers then carefully measured how much of the drug was absorbed, how long it stayed in the bod…

This study aimed to understand how the experimental drug MK-5684 is processed by the body in men with severe or end-stage kidney disease. Researchers compared drug levels in the blood of 24 men—some with kidney disease and some healthy—after a single dose. The goal was to see if …

This early-stage study tested how an experimental breast cancer drug called camizestrant interacts with two common medications: midazolam (a sedative) and carbamazepine (an anti-seizure drug). Researchers enrolled 40 healthy postmenopausal women to measure how these drugs affect …

This study aimed to find out if a less strenuous type of cycling, called eccentric cycling, could improve fitness and strength as well as or better than regular cycling for people who don't exercise much. Researchers compared three different 12-week training programs in 43 health…

This research study aimed to understand how briefly stimulating specific brain areas with magnets affects how quickly healthy young adults pay attention to emotional pictures. Ninety-one participants received a 40-second magnetic stimulation session and then completed a computer …

This study aimed to understand how exercise might help protect the aging brain. Researchers had 60 healthy but inactive adults aged 50-80 complete a 12-week, supervised exercise program. They measured changes in thinking skills and specific hormones in the blood before and after …

This study tested a new, faster way to help healthy people adapt to hot conditions. Researchers had 26 young adults take a very hot, 5-minute bath every day for two weeks. They measured many body signals like heart rate and temperature to see if these short exposures were enough …

This early-stage study aimed to understand how three common types of medications—an antifungal, an antibiotic, and heartburn drugs—affect the body's processing of an experimental drug called INCB161734. It involved 63 healthy adult volunteers who took the experimental drug alone …

This early-stage study tested a new oral drug called INCB160058 in healthy adults to check its safety and see how the body processes it. Researchers gave single doses to 137 healthy volunteers to monitor for side effects and measure drug levels in the blood. The study also examin…

This early-stage study tested how the body absorbs a new drug called ZN-A-1041. Researchers compared how much of the drug got into the bloodstream when it was given as different types of pills versus a capsule. The study also planned to check if food or another stomach medicine a…

This was a first-in-human study to check the safety and see how the body processes a new drug called donzakimig. It involved 32 healthy Chinese and Japanese volunteers who received a single injection. The main goal was to see if the drug was safe and well-tolerated at two differe…

This study aimed to understand how the body absorbs, breaks down, and eliminates an experimental drug called PF-07220060. It involved 12 healthy adult men who received a single dose, either by mouth or by injection. Researchers collected blood, urine, and stool samples to track e…

This was the first study in people for a new drug called AZD2389. Its main goal was to check if the drug is safe and to see how the body absorbs and processes it. The study involved 120 healthy volunteers, including people of Japanese and Chinese descent, who received either the …

This study tested how an experimental cancer drug called capivasertib might change the way the body processes a common cholesterol-lowering drug, rosuvastatin. Twenty healthy volunteers took both drugs separately and together so researchers could measure the levels in their blood…

This study tested whether two different injection devices—a prefilled syringe and an autoinjector pen—deliver the same amount of an experimental drug called tozorakimab into the body. Researchers gave a single injection to 254 healthy volunteers and tracked the drug levels in the…

This study tested how safe new skin products are by applying them to healthy volunteers' backs for 24 hours. Researchers used patches to see if the products caused any redness, dryness, swelling, or other skin reactions. The goal was to gather safety information before these prod…

This study aimed to understand how body weight affects blood sugar levels after eating bread. Twenty healthy adults, half with normal weight and half with overweight or obesity, ate white and wholemeal bread on separate visits. Researchers measured their blood sugar over two hour…

This 5-day study tested whether a commercially available oral NAD+ supplement changes health-related biological markers in healthy adults aged 45-75. Researchers compared 60 participants who took either the supplement or a placebo, measuring NAD+ levels in blood cells and looking…

This study aimed to see if a new drug called CHS-1420 behaves the same way in the body as the established drug Humira (adalimumab). It involved 238 healthy Chinese adults who received a single dose of either drug. Researchers closely tracked the drug levels in the blood over time…

This was an early-stage study to check the safety and see how the body processes a new oral drug called AZD6793. It involved 39 healthy Japanese and Chinese volunteers who received either the drug or a placebo. The main goal was to understand the drug's side effects and how it mo…

This study tested a new tablet version of the diabetes medicine semaglutide (Rybelsus®) in 121 healthy men. The goal was to see how the amount of water taken with the pill and the timing of breakfast afterward affect how much medicine gets into the bloodstream. Participants took …

This study tested how the body absorbs an experimental medicine called ziltivekimab when given through different injection methods. Researchers compared a regular syringe with a pen-injector (similar to insulin pens) in 267 healthy volunteers. The goal was to understand how quick…

This study tested how an experimental heart medication called AZD0780 affects the way the body processes metformin, a common diabetes drug. Researchers gave both drugs to 14 healthy volunteers to measure how they interact in the body. The goal was to understand if taking these me…

This study tested how the experimental drug casdatifan interacts with two other common medications (itraconazole and phenytoin) in healthy adults. The goal was to see if these other drugs change how much casdatifan gets into a person's system and to check for safety. It involved …

This study looked at how a new prostate cancer drug, opevesostat, is processed by the body in men with moderate liver problems compared to healthy men. Researchers gave a single dose to 16 participants and measured drug levels in their blood over time to understand if liver impai…

This study aimed to understand how a new extended-release pain medication (NAL ER) interacts with two existing drugs for lung scarring (pirfenidone and nintedanib). It involved 132 healthy adult volunteers to measure drug levels in the body and check for safety when these medicat…

This study aimed to understand how safe and comfortable different ways of giving immunoglobulin G (IgG) injections under the skin are. It involved 82 healthy volunteers who received injections under varying conditions. The main goal was to measure pain, skin reactions, and overal…

This study tested how eating food affects the levels of a new drug called Admilparant in the body. It involved 56 healthy volunteers who took the drug either with or without food. The main goal was to measure how much of the drug gets into the bloodstream under these different co…

This study looked at how different ways of carrying a school backpack affect pressure on teenagers' feet. Researchers had 92 healthy teens stand and walk while carrying backpacks in different ways: on both shoulders, on just the right shoulder, on just the left shoulder, and with…

This study aims to see if a new drug called clofutriben changes how the body handles two other common drugs, midazolam (a sedative) and prednisolone (a steroid). It involved 16 healthy adults who took all three drugs while researchers took many blood, urine, and stool samples to …

This study aimed to understand how an experimental drug called vimseltinib might change how the body processes a common diabetes medication, metformin. It involved 22 healthy male volunteers who took both drugs to measure their levels in the blood and check for safety. The goal w…

This early-stage study aimed to understand how an investigational drug called vimseltinib might affect the body's processing of other medications. Researchers gave vimseltinib and a common cholesterol drug (rosuvastatin) to 20 healthy male volunteers to measure their interaction.…

This was the first study in humans for a new drug called AZD8965. Its main goal was to check if the drug is safe and to see how the body absorbs and processes it. The study involved 147 healthy volunteers, including specific groups of Japanese and Chinese participants. Researcher…

This study tested whether getting feedback from a virtual trainer during a VR workout affects how people feel and how accurately they move. Researchers had 28 healthy adults complete three short VR exercise sessions, each with a different type of feedback from the avatar: none, v…

This study tested how different injection locations affect how the body absorbs a fast-acting insulin called THDB0206. Researchers gave 27 healthy Chinese adults single insulin injections in different body areas to measure absorption speed and effects on blood sugar. The goal was…

This study aims to understand how the body's immune system responds to the standard rabies vaccine when it is given alongside an extra dose of rabies-fighting antibodies (RIG) at different times. Researchers will compare three groups of 30 healthy adults: one getting the standard…

This study aimed to understand how the size of a meal and the time of day it's eaten affect the body's metabolism and blood vessel function after eating. Researchers tested 20 healthy adults by giving them different meals and measuring how their bodies processed food and how thei…

This was an early-stage study to check the safety of a new drug called S-740792 in healthy people. Researchers gave different doses to 99 volunteers to see how their bodies handled the drug and if it caused any side effects. The main goal was to gather basic safety information to…

This was Pfizer's first study in people for an experimental oral medicine called PF-06414300. The main goal was to check its safety and see how the body absorbs and processes it. The study involved 63 healthy adults who took either the drug or a placebo dummy pill. Researchers cl…

This study tested a new tablet version of the drug minzasolmin to see how well it gets into the bloodstream compared to an older capsule form. It also checked if taking the new tablet with food changes how the body processes the drug. The study involved 18 healthy adult volunteer…

This study aimed to understand how two different versions of an oral antiviral suspension are absorbed by the body. It involved 18 healthy Chinese adults who each took both versions in a specific order, with a break in between. The main goal was to measure and compare drug levels…

This research study aimed to understand how a mild, non-invasive form of brain stimulation might affect how people regulate stress and imagine future events. It involved 60 healthy young adults who underwent a single MRI session where they performed stressful tasks and received e…

This early-stage study tested how a new drug called AZD5004 interacts with other medications in healthy volunteers. In one part, researchers checked if a common antifungal drug (itraconazole) changed how AZD5004 works in the body. In another part, they tested if AZD5004 changed h…

This study aimed to understand if simple neck exercises could improve flexibility in other parts of the body. Researchers tested 30 healthy young adults to see if stretching or using a massage roller on the neck could increase the range of motion not just in the neck, but also in…

This early-stage study aimed to understand how the body absorbs a common asthma relief drug (salbutamol) when it's delivered from an inhaler using a new, potentially more environmentally friendly propellant gas. Researchers compared this new propellant to the one currently used i…

This study tested how quickly three different anxiety/seizure medications start working in the brain. Researchers gave healthy volunteers either an inhaled alprazolam, an injected midazolam, or a nasal spray diazepam and measured brain wave changes. The goal was to see which medi…