New drug UCB9741 tested for safety in healthy people
NCT ID NCT06315335
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tested the safety and tolerability of a single dose of UCB9741 in 40 healthy adults, including both Caucasian and Japanese participants. Half received the drug and half a placebo, with neither participants nor researchers knowing who got what. The study focused on side effects and how the drug moves through the body, not on treating any disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- UCB9741
- What could go wrong
- This is an early Phase 1 study in healthy volunteers, so it cannot show whether the drug works for any disease. The main goal is safety, not treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
-
40 people
The number who actually took part.
- Started
-
Jul 2024
- Finished
-
Jan 2025
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 55 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: For all subjects: * Male or female between 18 to 55 years old, overtly healthy * Female participants must not be pregnant or breastfeeding * Female participants must be either of non-childbearing potential or using a highly efficient birth control method * Male participants must use acceptable contraception and refrain from sperm donation during the study 90 days * Body mass Index within the range 18 to 30 kg/m\^2 (inclusive) For Japanese subjects only: Japanese descent as evidenced in appearance and verbal confirmation of familial heritage and is of Japanese descent with all 4 grandparents For Caucasian subjects only: Caucasian descent as evidenced in appearance and verbal confirmation of familial heritage and is of Caucasian descent with all 4 grandparents Exclusion criteria: * Participant has a known hypersensitivity to any components of the investigational medicinal product (IMP) or other biologic drugs or humanized antibodies (mAbs) * Participant has clinically significant multiple or severe drug allergies, intolerance to topical corticosteroids, or severe posttreatment hypersensitivity reactions * Participant has abnormal blood pressure (BP) (outside the normal range) * Participant has alanine aminotransferase (ALT), aspartate aminotransferase (AST), or alkaline phosphatase (ALP) \>1.5x upper limit of normal (ULN) * Participant has a recent history or currently active clinically-significant bacterial, fungal, endoparasite, or viral (including hospitalization for coronavirus disease 2019 (COVID-19)) infection (within 6 months of the Screening Visit) * Participant has a history of inflammatory bowel disease (includes Crohn's disease and ulcerative colitis) * Participant has a history of diabetes * Study participant has a corrected QT interval (QTc) \>450msec for male study participants or \>470msec for female study participants * Participant has sensitivity to heparin or heparin-induced thrombocytopenia * Participant has a positive test for substance of abuse, or is a regular alcohol consumer defined as an average weekly intake of \>14 units * Participant has received any prescription or nonprescription medicines within 14 days (or 5 half-lives of the respective drug, whichever is longer) prior to the Baseline Visit, other than contraceptives or occasional use of analgesic * Participant has received Bacillus Calmette-Guerin vaccinations within 1 year prior to the Baseline Visit or within 90 days after the final dose of investigational medicinal product (IMP) * Participant has been treated with biologic agents (such as mAbs, including marketed drugs) within 3 months or 5 half-lives (whichever is longer) prior to the Baseline Visit * Participant has participated in another study of an IMP within the previous 90 days or 5 half-lives of the IMP (whichever longer), or is currently participating in another study of an IMP
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Up0118 10001
Glendale, California, 91206, United States
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