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Knee OA study sheds light on muscle oxygen recovery

NCT ID NCT07471204

Knowledge-focused Sponsor: Bahçeşehir University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared muscle oxygen levels in the thigh muscle of 34 people with and without knee osteoarthritis. Participants did a simple squat exercise while a device measured oxygen in the muscle. The goal was to understand how knee OA affects muscle function and recovery, which could lead to better rehabilitation strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help design better, more personalized exercise programs for people with knee osteoarthritis.
What could go wrong
This is a small, observational study with only 34 participants. It does not test a treatment, so it may not lead to direct patient benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

34 people

The number who actually took part.

Started

Mar 2026

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adults aged 45-65 years, including individuals diagnosed with knee osteoarthritis (Kellgren-Lawrence grade 2-3) according to the American College of Rheumatology criteria and age- and sex-matched healthy controls. All participants will meet the predefined eligibility criteria and provide written informed consent prior to participation.

Ages

45 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 45 and 65 years * Body mass index (BMI) below 30 kg/m² * Willingness to participate in the study Additional criteria for the knee osteoarthritis group: * Diagnosis of knee osteoarthritis confirmed by a physician according to the American College of Rheumatology diagnostic criteria * Bilateral knee osteoarthritis classified as Kellgren-Lawrence grade 2 or 3 Exclusion Criteria: * Presence of another orthopedic or rheumatologic condition affecting the lower extremity * Uncontrolled hypertension * Presence of lower extremity arterial or venous disorders * Presence of a neurological disease * Cognitive, learning, or perception impairments * Knee extension deficit * Physical activity level exceeding 600 MET-min/week according to the International Physical Activity Questionnaire Short Form (IPAQ-SF) * Participation in a physiotherapy and rehabilitation program for knee osteoarthritis within the last 6 months * Intra-articular knee injection within the past 6 months

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Conditions

The condition(s) this trial relates to.

osteoarthritis susceptibility 6 osteoarthritis, knee Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy participants Osteoarthritis of knee

Contacts and locations

Locations

  • Istanbul University-Cerrahpaşa, Faculty of Health Sciences, Physiotherapy and Rehabilitation Lab.

    Istanbul, Büyükçekmece, 34000, Turkey (Türkiye)

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