Probiotic pill may soothe heartburn and stomach pain
NCT ID NCT07163637
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a daily probiotic supplement (Limosilactobacillus reuteri) can reduce symptoms like heartburn and stomach pain in healthy adults who have occasional upper gut discomfort. About 324 people will take either the supplement or a placebo for 8 weeks and report their symptoms every two weeks. The goal is to see if the supplement improves quality of life and is well tolerated.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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324 people
The number who actually took part.
- Started
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Sep 2025
- Finished
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May 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Be male or female. 2. Anyone with a BMI less than or equal to 32 kg/m². 3. Be aged 30-70. 4. Anyone currently experiencing occasional upper gastrointestinal discomfort (approximately 2 times/week over the past month), including the following: 1. Heartburn 2. Upper abdominal pain 3. Reflux 4. Pain or burning in the stomach 5. Anyone with an FSSG (Frequency Scale for the Symptoms of GERD) total score of 8 or above. 6. Anyone who is generally healthy - does not live with any uncontrolled chronic health conditions, such as cancer, mental health disorders, history of serious illness in the last three months, history of substance abuse, or planned surgery during the study period. 7. Willing to avoid introducing any new supplements, over-the-counter medications, or herbal remedies for the duration of this trial 8. If taking other supplements, over-the-counter medications, or herbal remedies unrelated to gut health, has been doing so consistently for a minimum of three months. 9. Willing to maintain current diet, sleep pattern, and activity levels for the duration of the trial. 10. Resides in the United States. Exclusion Criteria: * 1\. Anyone with any allergies or sensitivities to any of the study product ingredients. 2\. Any women who are pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period). 3\. Anyone unwilling to follow the study protocol. 4. Anyone taking any supplement, over-the-counter medication, or herbal remedy targeting gut health. 5\. Anyone with a known history of severe digestive disorders like GERD (Gastroesophageal Reflux Disease) and FD (Functional Dyspepsia), Irritable Bowel Syndrome (IBS), Irritable Bowel Disease (IBD), Crohn's disease, celiac disease, chronic constipation, chronic diarrhea, or gastrointestinal tract disorders or surgeries. 6\. Anyone currently or recently (within the past 2 weeks) taking probiotic foods, including yoghurts. 7\. Anyone currently or recently (within the last 12 weeks) taking medication, including proton pump inhibitors, anticoagulants, antihypertensives, anxiolytics, antidepressants, chemotherapy, immunotherapy, sedative hypnotics, medications that warn against grapefruit consumption, corticosteroids at doses greater than 5 mg per day, diabetic medications, oral anti-infectives (antibiotics, antifungals, antivirals) to treat an acute infection, antipsychotics, monoamine oxidase inhibitors (MAOIs), or thyroid products. 8\. Currently partaking in another research study or will partake in any other research study for the next eight weeks or at any point during this study's duration.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Citruslabs
Las Vegas, Nevada, 89118, United States
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