Healthy participants

Researchers are testing an RSV vaccine in healthy adults aged 60 and older to see how safe it is and how well it triggers an immune response. The trial enrolls about 600 people in China and the United States. In China, participants receive either the vaccine or a placebo; in the …

Researchers are testing an experimental drug called RO7830698 to see if it is safe and well tolerated. The trial includes healthy volunteers and people with chronic obstructive pulmonary disease (COPD). Participants receive either RO7830698 or a placebo, and researchers track sid…

This early-stage trial evaluates an investigational drug called BMS-986446 (moponetug) in healthy adults and in people with early Alzheimer's disease. The study aims to understand how the drug moves through the body, its safety, and how well it is tolerated when given as a single…

This early-stage trial is testing an investigational drug called IBI3040, given as an injection under the skin. The study will first give a single dose to healthy adults to check safety, then multiple doses to overweight or obese adults to see how the drug behaves and whether it …

This first-in-human trial evaluates BYN-001, an antibody designed to block IL-25, a protein linked to atopic dermatitis (eczema). The study first tests the drug in healthy volunteers to assess safety and how it moves through the body, then in people with moderate to severe eczema…

This study partners with 26 AME churches in South Carolina to test a 32-week walking program called Walk Your Heart to Health. About 300 adults aged 50 and older will join in-person walking groups led by church committees. Researchers will measure changes in daily steps and group…

This trial tests two doses of the muscle relaxant metaxalone, 640 mg and 800 mg, in healthy adults aged 18 to 55. After taking each dose with a meal, researchers measure drowsiness, reaction time, and brain wave activity to assess fall risk. Each participant takes both doses one …

Researchers want to know how the body absorbs, breaks down, and clears an experimental oral drug called INCB161734. They give a single dose to 10 healthy men aged 19 to 55, tagging part of the drug with a tiny radioactive tracer. By measuring the tracer in blood, urine, and stool…

Researchers are running a Phase 1 trial of JZP269, an experimental drug, in healthy adults aged 18 to 55. The study gives single doses that increase step by step, with some participants receiving placebo, to check safety and tolerability. Blood tests will measure how the body abs…

Researchers at one site in the United Kingdom are studying how the experimental drug AZD4954 is absorbed, broken down, and removed from the body. The trial enrolls 16 healthy men aged 30 to 65, split into two groups of eight. In one part, participants take a single oral liquid do…

Researchers are testing whether romosozumab, a drug used to treat osteoporosis, reaches the bloodstream the same way when given as one larger injection or two smaller injections under the skin. The study enrolls healthy adults aged 18 to 60. Blood samples will measure drug levels…

This early-stage trial is testing an experimental oral drug called SYH2056 in healthy adults aged 18 to 55. The main goals are to see how safe and tolerable the drug is, how it moves through the body, and whether taking it with food changes its effects. Participants receive eithe…

Researchers are testing whether itraconazole, a known drug that blocks certain liver enzymes, changes how the body processes engasertib, an experimental drug. Healthy adults aged 18 to 55 will take engasertib alone and then with itraconazole. The study measures engasertib levels …

This Phase 1 trial is testing whether two common medications—phenytoin, a seizure drug, and itraconazole, an antifungal—change how the body processes pelabresib, an experimental cancer drug. Healthy adults aged 18 to 55 will receive a single dose of pelabresib alone and then agai…

This trial is testing an experimental drug called Lu AH69593 in healthy adults to understand how it interacts with other medications. It will look at how the body absorbs and processes Lu AH69593 when taken alone or with other drugs that affect liver enzymes. The goal is to gathe…

This Phase 1 trial is testing whether the antibiotic rifampin changes how the body processes an experimental drug called HS-10504. About 18 healthy adults will take HS-10504 alone and then again while also taking rifampin for 15 days. Researchers will measure drug levels in the b…

This study aims to understand how a quick, non-invasive brain stimulation treatment called iTBS works in people with depression. Researchers will measure brain activity before and after stimulation in 100 participants (healthy volunteers and those with depression) using EEG and M…

This Phase 1 trial is investigating whether itraconazole, an antifungal drug, affects the levels of an experimental drug called HS-10504 in the body. Healthy adult volunteers will receive HS-10504 alone and then again while taking itraconazole, allowing researchers to compare how…

This Phase 1 study in healthy adults aims to find out whether sevabertinib, an experimental cancer drug, changes how the body processes metformin, a common diabetes medication. Researchers suspect sevabertinib might block kidney transporters that help remove metformin from the bo…

This study tests a new way to take CT scans of the knee while it is bearing weight, like standing. The goal is to see if this method can detect small movements of a knee replacement implant earlier than standard X-rays. The study will include 15 people, some with healthy knees an…

This study looks at whether people with migraine have different motor imagery abilities—like mentally picturing movements—compared to healthy people. Researchers will use questionnaires, mental timing tests, and brain scans to measure these abilities. They also want to see if the…

This early-stage trial will test the safety and tolerability of a single dose of STLX-2012 in 32 healthy adults aged 18-55. Participants will receive either the drug or a placebo, and researchers will monitor side effects and how the drug moves through the body. The study is not …

This early-stage trial will test 20 healthy Chinese adults to see if taking itraconazole (a common antifungal) changes how the body processes HS-10506, an experimental drug. Participants will take HS-10506 alone and then again with itraconazole. The goal is to measure drug levels…

This study compares three fiber supplements—LOAM prebiotic fiber, inulin, and a placebo—to see which causes the least intestinal gas and digestive discomfort. 125 healthy adults on low-fiber diets will take one supplement daily for four weeks. A wearable device measures gas, and …

This Phase 1 trial will test the safety and tolerability of an inhaled drug called SYH2059 in 84 healthy adults. Participants will receive either single or multiple doses of the drug or a placebo. The study aims to understand how the body processes the drug and whether it causes …

This study tests two different versions of a deuterated remdesivir oral suspension in 48 healthy Chinese adults to see how well each is absorbed. Participants will receive both forms in a random order. The goal is to find out if the new formulation works as well as the original, …

This study looks at how a special nutritional drink (ONS) affects blood sugar levels in 30 healthy adults. Participants will drink both the ONS and a sugar solution on different days, and their blood sugar will be tracked. The goal is to calculate the drink's glycaemic index, whi…

This early-stage study is the first time AK0406 is being tested in humans. It will involve 32 healthy adults to check if the drug is safe and how the body processes it. No treatment is being given for any disease—this is purely a safety check.

This study gives 50 healthy adults a one-time dose of psilocybin (the active ingredient in magic mushrooms) or a placebo to measure changes in brain waves, blood chemicals, and empathy. Participants must have never used psychedelics before. The goal is to understand the biologica…

This study aims to see if a mobile health (mHealth) tool, combined with decision aids, can help college students in Zimbabwe better access HIV prevention and contraception services. Researchers will work with 16,000 students to develop and test the tool over several stages, inclu…

This early-stage study tests the safety and how the body processes a new drug called NBX-100 in 8 healthy adults aged 21-50. Participants receive four weekly doses and have frequent check-ups and psychological support visits. The goal is to gather safety and drug-level informatio…

This study will test how different intensities and patterns of manual pressure on the upper back affect heart rate, stress hormones, and pain sensitivity in 90 healthy adults. Participants will be randomly assigned to receive either sustained pressure at a single point, kneading …

This observational study tracks 100 adults to see how Roux-en-Y gastric bypass surgery changes gut bacteria and related metabolic products over 12 months. Participants include people having surgery, those with obesity on diet alone, and healthy normal-weight individuals. Research…

This study looks at whether a special warm-up that includes balance and coordination exercises works better than a standard warm-up for improving balance and leg strength in healthy adults who go to the gym regularly. About 46 people aged 18 to 40 will take part in 6 weeks of sup…

This Phase 1 trial will compare a single dose of QL2302, a proposed biosimilar of the asthma drug Tezspire, against the original drug in 178 healthy adults aged 18 to 45. The study is double-blinded and randomized, meaning neither participants nor researchers know who gets which …

This study looks at how different breathing patterns during strength exercises change eye pressure and blood flow in the retina. Sixty healthy adults aged 18-40 will perform exercises with normal breathing or a breath-holding technique called the Valsalva maneuver. Researchers wi…

This study looks at whether exercising at different times of day changes how we feel pain. Fifty-six healthy adults will do a 12-minute high-intensity workout in both the morning and evening. Researchers will measure pain thresholds before and after exercise to see if time of day…

This study tests whether a mild electrical pulse to the ear (called taVNS) can temporarily improve thinking skills like attention and memory in healthy adults aged 18-30. Each of the 60 participants will receive both the real stimulation and a fake (sham) version in separate sess…

This study tests whether plant sterols, found in some foods, change how a newly discovered protein called cholesin works. Cholesin is released from the gut after eating cholesterol and tells the liver to make less cholesterol. Researchers will give 23 healthy adults three differe…