HEALTHY PARTICIPANTS

This study tests an experimental vaccine designed to protect against E. coli bacteria. Researchers want to see if the vaccine is safe and tolerable in healthy adults aged 18 to 64. About 310 volunteers will receive the vaccine or a placebo and be monitored for side effects like i…

This study tests a new vaccine called GBP511, designed to protect against a family of viruses called sarbecoviruses (which includes SARS-CoV-2). The trial involves about 368 healthy adults aged 18 and older. Researchers will check the vaccine's safety and how well it triggers the…

This early-stage study tests a new drug called SR604 in healthy people and those with hemophilia A, B, or factor VII deficiency. The main goal is to check safety and how the body processes the drug. About 31 participants will receive injections to find the right dose and see if i…

This early-stage study tests a new drug called TGM-312-SC01 in healthy adults and people with MASH, a type of fatty liver disease. The main goal is to check the drug's safety and how the body processes it. About 99 participants will receive either the drug or a placebo to gather …

This study is testing whether a portable virtual reality (VR) headset can help diagnose and monitor traumatic brain injury (TBI), like concussions. The device shines colored lights into the eyes and uses a camera to measure how the pupils react. Researchers will compare results f…

This study tests two new imaging drugs that light up tau protein clumps in the brain during a PET scan. Researchers want to see if they are safe and can help diagnose Progressive Supranuclear Palsy (PSP), a rare movement and thinking disorder. About 24 adults—some healthy, some w…

This study tests whether muffins made from a special type of oat (Royal Ancient Oats™) can help control blood sugar and digestion better than regular oat muffins or white flour muffins. About 38 healthy adults aged 35-65 with slightly high body weight will eat different muffins a…

This study looks at whether taking a daily supplement called Alpha-Glycerophosphocholine (α-GPC) can improve thinking, mood, and physical performance in healthy adults aged 25-55. Eighty participants will take either α-GPC or a placebo for 6 weeks and complete cognitive tests and…

This early-stage study tests an experimental drug called AZD1043 in healthy adults who are overweight or have obesity. The main goal is to check if the drug is safe and how the body processes it. About 104 participants, including people of Japanese and Chinese descent, will recei…

This study tests whether a daily probiotic supplement (Limosilactobacillus reuteri) can reduce symptoms like heartburn and stomach pain in healthy adults. About 324 people will take either the supplement or a placebo for 8 weeks and report their symptoms every two weeks. The goal…

This early-stage study tests a new oral drug, NTX-253, in healthy adults and people with stable schizophrenia. The main goal is to check safety and how the body processes the drug. About 73 participants aged 18–55 will take single or multiple doses to see if it is well tolerated.…

This study tests a new drug called BGB-45035 for the first time in humans. It will check safety and how the body processes the drug in healthy volunteers, then test it in people with autoimmune skin diseases like eczema and prurigo nodularis. The goal is to see if the drug is saf…

This early-stage study tests a new drug called PF-07832837 in healthy volunteers and people with moderate to severe atopic dermatitis (eczema). The main goal is to check if the drug is safe and how the body processes it. Researchers will also look for early signs that it might im…

This study looks at how the drug vepdegestrant is processed by the body in people with moderate to severe liver problems compared to healthy people. About 24 adults (ages 18-70) will take a single dose and stay at the clinic for 11 days. The goal is to understand how liver functi…

This study looks at how a high-fat, high-calorie meal changes the way the body absorbs nalbuphine extended-release tablets. Sixty healthy adults will take the drug once with food and once without, and researchers will compare the levels in their blood. The goal is simply to under…

This study looks at how our beliefs and expectations influence the pain we feel when watching others suffer. Healthy adults will be placed into one of three groups: no treatment, a placebo nasal spray, or a nasal spray with oxytocin. All participants in the spray groups will be t…

This study tests a new machine called See.d that prepares blood samples for liquid biopsy, a method to detect cancer from a simple blood draw. Researchers will check if the machine produces stable slides and clean plasma for analysis. 200 healthy adults aged 18 and older will par…

This study looks at how food and two other drugs (itraconazole and carbamazepine) affect a new medicine called INCB123667 in healthy adults aged 19 to 55. About 51 participants will take single doses of the study drug under different conditions. The goal is to measure how the dru…

This early-stage study tests the safety and how the body handles an inhaled drug called CPD704. It involves 90 healthy Chinese adults aged 18-55. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This study checks if a new device can properly prepare blood samples for liquid biopsy, which looks for cancer clues in the blood. It involves 20 healthy volunteers and 25 people with advanced breast cancer. No treatment is given—only blood is drawn to see if the tool works well.…

This study looks at how a person's beliefs about a treatment can change their mood, motivation, and reactions to rewards. Healthy volunteers aged 15-25 will receive a fake (sham) version of a brain stimulation treatment called accelerated TMS, which delivers no active stimulation…

This study is testing a new device called ZenBud that uses ultrasound (sound waves) to stimulate the vagus nerve, which controls things like heart rate and digestion. Researchers want to see if this method can safely change certain body signals, brain activity, and emotions in 30…

This study looks at how a mild nerve stimulation (tVNS) affects decision-making in people with high anxiety or anhedonia (loss of pleasure). Participants will do tasks in VR and brain scanners to see if stimulation changes how they seek rewards or avoid threats. The goal is to un…

This study compares muscle oxygen levels in the thigh muscle of people with knee osteoarthritis and healthy volunteers. Researchers will measure oxygen during rest, a simple squat exercise, and recovery to see how the disease affects muscle function. The goal is to better underst…

This study looks at how a new medicine called elecoglipron changes the way the body processes two common cholesterol drugs (atorvastatin and rosuvastatin) in 40 healthy adults. Participants will take the statins alone and then with elecoglipron to compare drug levels and safety. …

This study looks at a protein called neurofilament in the blood of healthy late preterm babies (born 34-37 weeks). High levels of this protein can signal nerve damage, but normal levels for preterm infants are unknown. Researchers will collect small extra blood samples during rou…

This study looks at how a drug called capivasertib changes the way the body processes another drug, dextromethorphan. About 42 healthy adults will take both drugs in a fixed order. The goal is to measure drug levels in the blood, not to treat any disease.

This study looks at how a single dose of modafinil changes decision-making and brain activity in healthy adults. Researchers hope to learn more about psychosis spectrum disorders like schizophrenia. Participants will take modafinil, play computer brain games, and wear an EEG cap …

This early-stage study tests the safety of a new drug, TLC-1180, in healthy adults aged 18 to 55. Researchers will give single or multiple doses to see how the body handles the drug and if it causes side effects. About 288 participants will take part. This study does not aim to t…

This study tests whether using virtual reality (VR) for a therapy exercise called 'chairwork' works better than just imagining it. Thirty healthy students will try both versions and report how they feel. The goal is to see if VR helps people who have trouble imagining things get …

This study explores whether a non-invasive electrical brain stimulation method, called temporal interference, can temporarily change how different brain regions talk to each other. Researchers will recruit 40 healthy adults aged 18-50 to undergo stimulation during sleep and wakef…

This study tests two different forms of the cholesterol-lowering drug evolocumab in 400 healthy adults aged 18 to 60. The main goal is to see how the body absorbs and processes each version. Participants receive a single dose and are monitored for side effects and drug levels ove…

This early-stage study tests an experimental drug called HW201877 in 104 healthy adults to see if it is safe and how the body handles it. The drug is being developed for inflammatory bowel disease (IBD). Participants will receive either the drug or a placebo, and researchers will…

This study looks at how often people with neurological diseases have trouble swallowing their medications. Researchers will test whether using a swallow gel or semi-solid form of the medicine makes swallowing safer. About 500 adults, including healthy volunteers, will take part. …

This study looks at how brain injuries at birth affect a child's thinking and attention as they grow. Researchers will watch healthy babies and babies with brain injury play simple games and measure their brain waves with a safe EEG cap. Parents also answer questions about behavi…

This study follows 60 people aged 18 to 40 who are having hip surgery for a condition called femoroacetabular impingement. Researchers will measure their strength, mobility, and function before surgery and again at 3 and 6 months after. The goal is to learn what helps people reco…

This study tests how well the body absorbs omega-3 fatty acids (EPA and DHA) from two different algae sources compared to a fish oil source and a placebo. Healthy adults aged 18-64 will take their assigned supplement for 6 weeks, and researchers will measure omega-3 levels in the…

This study tests two methods for teaching CPR to children in grades 1-6. One group gets a 2-hour hands-on session with a nurse and mannequin; the other watches a short video and does a puzzle. Researchers will measure which approach boosts CPR knowledge and skills better. About 5…

This early-stage study tests whether a new drug called KLA318-2 is safe and how the body processes it. About 48 healthy adults aged 18-45 will receive a single injection and be monitored for side effects and drug levels. No treatment or cure is being tested—only safety and drug b…

This study looks at whether eating the fast-digesting carbs at the start or the end of a pre-exercise meal changes how your body burns fat and carbs, and how well you perform during endurance cycling. Nineteen healthy, trained male athletes will eat a standard meal in two differe…

This study looks at how blood sugar levels change during exercise in healthy adults and those with type 1 diabetes. Researchers want to see if these changes are similar each time a person exercises. Participants will cycle or rest after a standard breakfast, and their glucose wil…

This study tests different versions of a drug called AZD6234 in 21 healthy adults aged 18-55 who are overweight or obese. The goal is to see how well each version is absorbed by the body and check for side effects. Participants receive a single dose of each formulation in a rando…

This study tests whether a new wet-granulation tablet of navlimetostat works the same as the current dry-granulation tablet in healthy adult women. About 64 participants will receive both tablet forms at different times to compare how the drug is absorbed and processed. The goal …

This early-stage study tests a single dose of an experimental oral drug called E1018 in 32 healthy adults aged 18 to 55. The main goal is to check if the drug is safe and how the body absorbs and removes it. No treatment or prevention benefit is expected for participants. The res…

This study looks at whether practicing fine hand movements can improve how the brain processes language. It involves 40 healthy right-handed adults aged 19-24. Participants are split into two groups: one does detailed hand exercises, the other does simpler tasks. Both groups prac…

This study looks at how resistance training (like lifting weights) makes children stronger. Researchers will compare 40 healthy kids who do 12 weeks of training with those who don't. They use ultrasound and muscle signal tests to see if strength comes from bigger muscles or bette…

This study looks at how babies' brains develop over time, including healthy infants and those who had a brain injury around birth. Researchers will use virtual games and parent questionnaires to measure attention, thinking, and language skills. All visits happen online, so famili…

This study looks at hearing in people with early Alzheimer's or Parkinson's to see if certain hearing problems are more common. Researchers will test hearing in 309 adults aged 50-85, including healthy volunteers. The goal is to find hidden hearing loss (trouble hearing in noise …

This study looks at which type of exercise program works best for inactive adults aged 18 to 35. Thirty people who are not very active will be placed into one of three groups: supervised group exercise, a mobile app program, or a video-based home workout. They will exercise three…

This early-stage study tests the safety of a new drug called SV003 in 60 healthy volunteers. Participants receive a single dose and are monitored for side effects and how the drug moves through the body. The goal is to gather safety information, not to treat any disease.

This study looks at whether text message reminders or a built-in gaming app can help Black male college students who binge drink use a mindfulness app more often. Forty participants will use the app for 28 days and complete surveys. The goal is to see if these features make the a…

This study looks at whether two experimental drugs (AZD6234 and AZD9550) change how the body processes a common birth control pill. About 50 healthy overweight women will take the birth control pill alone and then again after receiving the study drugs. The goal is to see if the d…

This study looks at how two experimental drugs, laroprovstat and AZD4954, affect each other in the body. It involves 32 healthy adults who will take both drugs and have their blood levels measured. The goal is to understand drug interactions, not to treat any disease.

This early-stage study tests a new drug called SYH2085 in healthy Chinese adults to see if it is safe and how the body processes it. About 74 participants will receive either the drug or a placebo. The goal is to gather safety data, not to treat any disease.

This study tests two updated spinal stimulation devices in 10 healthy adults to see how they compare to the current device. Participants lie on their back while electrodes on the spine send mild electrical pulses, and leg muscle activity is measured. The goal is to improve device…

This early-stage study tests the safety and tolerability of a new drug called DF5112 in 48 healthy adults aged 18 to 55. Participants receive either the drug or a placebo by injection and are monitored for about a week in a clinic, with follow-up visits up to 29 days. The goal is…

This study aims to collect body composition data from 40 healthy adults (young and elderly) using precise measurement methods. The information will be used to develop better ways to assess muscle mass and body water in cancer patients. Participants will undergo non-invasive tests…

This study looks at how the small intestine turns fructose into glucose, and whether this process protects the liver from harm. Researchers want to see if this protection is weaker in people with obesity. The study will involve 40 healthy volunteers, some with a normal weight and…

This early-stage study tests the safety of a new drug called YH35995 in 86 healthy adult men. Participants receive either the drug or a placebo to see how the body processes it and if any side effects occur. The goal is to gather important safety information, not to treat any dis…

This early-stage study tests a single dose of JMT206 injection in healthy volunteers aged 18 to 60. The main goal is to check if the drug is safe and how the body processes it. No treatment benefit is expected; the study gathers important safety information for future research.

This early-stage study tests the safety and tolerability of a new drug called AZD4954 in healthy volunteers and people with high Lp(a) or dyslipidemia (abnormal cholesterol levels). About 136 participants will receive either the drug or a placebo to see how the body processes it …

This early-stage study is the first time the drug KT-579 is being tested in humans. It aims to check the drug's safety and how the body processes it in 96 healthy adults. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and mea…

This study is for 200 healthy volunteers of all ages who can walk at least 10 meters without help. Participants wear a small device called Syde® for 3-week periods every 6 months over two years, all from home via phone or video. The goal is to collect normal walking and movement …

This study tests a blood pressure medication called allisartan isoproxil in healthy Chinese adults aged 18 to 65. Researchers will give different doses (240, 480, or 720 mg) or a placebo to see how the body processes the drug and if it causes side effects. The goal is to gather s…

This early-stage study is testing a new drug, UCB5285, in healthy volunteers to see if it is safe and how the body processes it. About 96 healthy adults, including some of Japanese descent, will receive a single dose. This study does not aim to treat any disease, but to gather im…

This study looks at how drinking A2 milk, regular milk, or oat drink every day for 12 weeks affects bone health, heart health, and the immune system in healthy adults aged 30 to 60. Researchers want to see if A2 milk, which lacks a certain protein fragment, leads to better health…

This study uses a special, non-invasive eye scan called OCTA to look at tiny blood vessels in the retina. Researchers want to see if these scans can reliably show differences between people with cardiovascular disease (like high blood pressure or diabetes) and healthy volunteers.…

This early-stage study tests the safety of a new drug, AZD3974, in 176 healthy adults, including people of Japanese and Chinese descent. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug levels in the blood. The goal is t…

This study looks at how aerobic exercise affects energy use in adults who are not very active. Eighty participants will run five times a week for 12 weeks. Researchers will measure changes in total energy use, food intake, and physical activity before, right after, and 8 weeks af…

This early-stage study tests the safety of a new drug, JZP047, in healthy adults aged 18 to 55. Participants receive either a single dose of the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. A separate part looks at whether food …

This study looks at whether eating pistachios as a snack can help overweight and obese adults burn energy more efficiently. Researchers will compare four days of pistachio snacking to four days of normal eating in 60 healthy but overweight participants. The goal is to see if pist…

This early-stage study in 64 healthy adults aims to see how different pill versions of AZD5004 are absorbed by the body and whether eating changes that. Participants receive a single dose of each formulation on separate days. The goal is to gather safety and absorption data, not …

This study is testing a new patch that delivers pain medicine through the skin. Researchers want to see how well it sticks and how safe it is. About 90 healthy adults aged 18 to 64 will wear the patch. The main goal is to measure how much of the patch stays attached over time.

This early-phase study aims to understand how a single dose of AGA2118 moves through and leaves the body in 30 healthy adults of Japanese, Chinese, and Caucasian descent. Participants must be 18-65, have adequate vitamin D levels, and agree to take calcium and vitamin D supplemen…

This early-stage study tests a new drug called ACI-19764 in healthy adults aged 18 to 65. The goal is to check its safety, how the body absorbs and processes it, and its effect on immune markers. Participants receive either the drug or a placebo, and the study involves single or …

This study looks at how much of the drug zilucoplan and its breakdown products end up in the breast milk of healthy women who are breastfeeding. About 15 women who are at least 6 weeks postpartum and plan to stop breastfeeding will take daily injections of zilucoplan. Researchers…

This study looks at how placing tiny needles on the ear (auricular acupuncture) changes communication between two key brain areas involved in emotion and body awareness. Researchers will use brain scans (fMRI) to compare these changes to those caused by a non-invasive nerve stimu…

This study looks at how a commercially available ketone drink, Ketone-IQ, affects sleep and breathing in 20 healthy adults. Participants will take two different doses of the drink before bed at home. They will measure their ketone levels and wear a headband to track sleep pattern…

This study is for healthy adults to see how well andexanet reverses the effects of common blood thinners (rivaroxaban or apixaban) and how it interacts with another blood thinner, enoxaparin. Participants will receive andexanet or a placebo, and researchers will measure blood clo…

This study looks at how seeing, smelling, and interacting with food in virtual reality changes food cravings and body responses. Thirty-four healthy adults will have their brain activity, saliva, blood sugar, and temperature measured while exposed to real and virtual food cues. T…

This study looks at whether taking beta-glucan, a type of dietary fiber, can improve how your immune cells recognize and kill cancer cells. It also checks if adding exercise makes it work even better. Healthy adults will take beta-glucan or a placebo daily for 4 weeks, do three e…

This early-stage study tests a new oral drug, LTG-321, in 236 healthy adults aged 18 to 55 to see if it is safe and how the body processes it. Some participants will also take a cold pressor test to measure pain tolerance. The study does not aim to treat any disease, but to gathe…

This study tests whether vimseltinib, an experimental drug, affects the levels of birth control hormones in the blood. About 24 healthy women will take birth control pills with and without vimseltinib over 35 days. The results will help doctors know if extra contraception is need…

This early-stage study is testing an experimental drug called Debio 1453P in 88 healthy adults aged 18 to 55. The goal is to check if the drug is safe and how the body handles it at different doses. Participants will receive either the drug or a placebo. This study does not aim t…

This study looks at how the retina's ability to use oxygen changes as people age. Researchers will measure oxygen extraction in healthy adults aged 18 to 80 using non-invasive eye scans. Participants will also breathe pure oxygen to see short-term effects. The goal is to understa…

This study tests whether low-intensity focused ultrasound (LIFU) can improve thinking and memory in healthy adults. Researchers will use brain scans and thinking tests to see if the ultrasound can safely activate deep brain areas. The goal is to understand how ultrasound affects …

This study is looking at whether a molecule in the blood called miR-1 can be used as a marker to track how muscle diseases like Duchenne muscular dystrophy and myotonic dystrophy progress. Researchers will compare miR-1 levels in 104 people, including healthy volunteers and patie…

This study looks at how heat pads and massage guns affect the stiffness of a jaw muscle in 40 healthy adults. Researchers will use a special ultrasound to measure muscle tightness before and after each treatment. The goal is to gather information that could lead to better treatme…