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Mango vs. sugar: which is better for your gut?

NCT ID NCT07650058

Knowledge-focused Sponsor: Ball State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether replacing table sugar with fresh mango in a high-sugar breakfast can reduce gut inflammation and leakiness. Thirty-five healthy adults will eat two different breakfasts—one sweetened with mango, the other with sugar—and have their blood tested over three hours. The goal is to see if mango's fiber and natural compounds help protect the gut barrier.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fresh mango
What this could lead to
If it works, this could point toward a simple dietary swap to reduce gut inflammation and lower future heart disease risk.
What could go wrong
This is a small, early-stage study in healthy people, so results may not apply to those with health conditions. The effect may be small or not meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 35 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 - 45 years. * Body mass index between 18.5-35.0 kg/m2 * Not pregnant or expecting to become pregnant (females only) * Not postmenopausal (females only). * No known chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.) * No history of using tobacco/illicit drugs * No history of using glucose-lowering medications/supplements. * No history of using prescribed anti-inflammatory medications * Does not use over-the-counter anti-inflammatory medications ≥2x/week * Does not have a pacemaker. * No relevant food allergies/intolerances * Able to lay supine for at least ten minutes. Exclusion Criteria: * Not between the ages of 18-45 * Body mass index \< 18.5 kg/m2 or \>35.0 kg/m2 * Pregnant (females only) * Postmenopausal status (females only). * Been diagnosed with a chronic medical conditions (e.g., type 2 diabetes, cardiovascular disease, inflammatory diseases, etc.) * Uses tobacco products or any illicit drugs. * Uses glucose-lowering drugs/supplements. * Regularly takes anti-inflammatory drugs (more than 2x week). * Have a pacemaker. * Allergic to mango, wheat, gluten, and/or milk. * Unable to lay in supine position in the dark for at least ten minutes.

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Conditions

The condition(s) this trial relates to.

Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy participants

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Health Professions Building, Ball State University

    RECRUITING

    Muncie, Indiana, 47306, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.