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Carbs last or first? study tests best pre-workout meal order for athletes

NCT ID NCT07503990

Knowledge-focused Sponsor: Universidade do Porto Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether eating carbohydrates at the end of a pre-exercise meal (instead of at the start) changes how the body burns fat and carbs during exercise and affects cycling performance. Eighteen healthy, trained male athletes ate a standard meal in two different orders on separate days, then did a cycling test. Researchers measured fat burning, blood sugar, and time-trial performance to see if meal order matters.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
meal pattern (carbohydrate-last vs carbohydrate-first)
What this could lead to
If it works, this could help athletes optimize their pre-exercise meal for better fat burning and performance.
What could go wrong
This is a small, early study in healthy male athletes only, so results may not apply to others. The effect on performance may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

18 people

The number who actually took part.

Started

Apr 2026

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 64 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult (18-64 years old) * Men * Endurance-trained athletes (meeting training and performance caliber criteria ≥Tier 2; McKay et al., 2022) * Healthy (meeting the exclusion criteria for medical conditions) * Normal glucose tolerant according to the latest criteria established by the American Diabetes Association (2024): HbA1c \<5.7%, fasting plasma glucose \<5.6 mmol/L (100 mg/dL) or 2-h plasma glucose \<7.8 mmol/L (140 mg/dL) during a 75-g OGTT * Able and willing to provide informed consent and safely comply with study procedures Exclusion Criteria: * Any medical condition or behaviour deemed either to pose undue personal risk to the participant or introduce bias into the experiment (e.g. cardiovascular disease; alcohol or substance abuse; any condition affecting the glucose or lipid metabolism, reviewed on a case by case basis) * Any reported medication or supplementation that may interfere with the glucose metabolism (e.g., acarbose, insulin, metformin, semaglutide, thiazolidinediones, sulfonylureas, corticosteroids, thiazide diuretics) or lipid metabolism (e.g., statins, nicotinic acid, colestyramine anhydrous, ezetimibe, fibrates, L-carnitine). Other medication and supplementation will be reviewed on a case by case basis. * Known food allergy, intolerance or hypersensitivity to any of the test meal ingredients * Recent change in body mass (± 2 kg in the last 2 months) * Smoking

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Conditions

The condition(s) this trial relates to.

metabolic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endurance exercise Healthy participants Substrate metabolism

Contacts and locations

Locations

  • Cidade do Futebol

    Lisbon, Oeiras, 1495-433, Portugal

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