HEALTHY PARTICIPANTS

This study tests a new vaccine called GBP511, designed to protect against several sarbecoviruses (a group that includes SARS-CoV-2). About 368 healthy adults will receive one or two doses at different strengths, with or without an adjuvant to boost immune response. The goal is to…

Pfizer is testing several experimental vaccines designed to protect against E. coli bacteria. This early-stage study involves 310 healthy adults aged 18 to 64. The main goal is to check if the vaccines are safe and tolerable, not yet whether they work. Participants will receive t…

This early-stage study tests a new drug called AZD1043 in healthy adults who are overweight or have obesity. The main goal is to check if the drug is safe and how the body processes it. About 104 participants, including people of Japanese and Chinese descent, will receive either …

This early-stage study tests a new drug called SR604 in healthy people and those with hemophilia A, B, or factor VII deficiency. The main goal is to check safety and how the drug moves through the body. About 31 participants will receive single or multiple doses to find the right…

This early-stage trial tests an experimental drug called TGM-312-SC01 in healthy volunteers and people with MASH, a serious fatty liver disease. The goal is to check the drug's safety and how the body processes it. About 99 adults aged 18 to 70 will take part, with some receiving…

This early-phase study tests two new imaging drugs, [18F]ABBV-964i and [18F]ABBV-965i, designed to light up tau protein buildup in the brain during a PET scan. Tau buildup is linked to Progressive Supranuclear Palsy (PSP), a rare movement and thinking disorder. The trial includes…

This study is testing whether a portable virtual reality headset can help diagnose and monitor traumatic brain injury (TBI) by measuring how the pupils react to light. Researchers will compare pupil responses in 150 people: those with mild to moderate TBI, those with other injuri…

This study aims to create a blood test that can find many types of cancer at an early stage. Researchers will analyze DNA from blood samples of 6,000 people, including those with and without cancer, to train an artificial intelligence platform. The goal is to improve early detect…

This study looks at whether taking a daily supplement called Alpha-Glycerophosphocholine (α-GPC) can improve thinking, memory, and physical performance in healthy adults aged 25 to 55. Over 6 weeks, 80 participants will take either α-GPC or a placebo pill, and complete tests of a…

This study tests whether a daily probiotic supplement (Limosilactobacillus reuteri) can reduce symptoms like heartburn and stomach pain in healthy adults who have occasional upper gut discomfort. About 324 people will take either the supplement or a placebo for 8 weeks and report…

This early-stage study tests an experimental drug called PF-07832837 in healthy adults and people with moderate to severe atopic dermatitis (eczema). The main goal is to check safety and how the drug moves through the body. Researchers will also look for early signs that the drug…

This study tests whether muffins made from a special type of oat (Royal Ancient Oats™) can help control blood sugar and digestion better than regular oat muffins. About 38 healthy adults aged 35-65 with slightly high body weight will eat different muffins and have their blood sug…

This early-stage study tests an experimental oral drug called NTX-253 in healthy volunteers and people with stable schizophrenia. The main goal is to check safety and how the body processes the drug. 73 adults aged 18–55 will take single or multiple doses to find the right dose r…

This early-stage study tests a new drug, JZP047, in 86 healthy adults aged 18 to 55. The goal is to check its safety, how the body handles it, and whether food affects its absorption. Participants receive either a single dose of JZP047 or a placebo. This research does not aim to …

This study looks at whether snacking on pistachios for four days can improve how the body uses energy (metabolic flexibility) in healthy overweight and obese adults aged 25-45. Participants will compare pistachio snacking to their normal diet, with measurements taken at rest, dur…

This study is looking at hearing in people with early-stage Alzheimer's or Parkinson's disease, compared to healthy volunteers. Researchers will use detailed hearing tests to find out how common different types of hearing loss are, especially 'hidden hearing loss' where standard …

This study tests whether practicing a precise manual task—placing colored beads with tweezers after solving math problems—can improve how healthy young adults process language. Forty right-handed participants aged 19-24 will be split into two groups: one doing the context-specifi…

This study tests a new device called See.d that processes whole blood into slides and plasma for liquid biopsy. Researchers want to see if the device can standardize sample preparation, making it easier to detect cancer cells or DNA in the blood. The study involves 200 healthy ad…

This study is testing how much of the drug zilucoplan gets into breast milk after daily injections. Fifteen healthy lactating women who have already decided to stop breastfeeding will provide milk samples over 24 hours. The goal is to estimate how much drug an infant might consum…

This study tests a new device that prepares blood samples to look for cancer cells and DNA. Researchers will collect blood from 20 healthy volunteers and 25 people with advanced breast cancer. The goal is to see if the device works well for liquid biopsy, a less invasive way to d…

This study tests whether doing a schema therapy exercise in virtual reality feels different from the usual imagination-based version. Thirty healthy students will try both methods in one session. Researchers will measure emotions, self-compassion, and how real the experience feel…

This early-stage trial is testing a new drug called ACI-19764 in 78 healthy adults to see if it is safe and how the body handles it. The drug targets a protein in the brain linked to inflammation. Participants will receive either the drug or a placebo, and researchers will monito…

This early-stage trial is testing whether a single tablet containing both laroprovstat and ezetimibe works as well as taking the two drugs separately. The study involves 18 healthy adults who will receive different pill combinations in random order. Researchers will measure how t…

This early-phase trial is testing a new drug called TLC-1180 in 288 healthy adults aged 18 to 55. The main goal is to check if the drug is safe and how the body handles it, not to treat any disease. Participants will receive either the drug or a placebo, and researchers will moni…

This study is recruiting 200 healthy volunteers of all ages to wear a device called Syde, which looks like a watch, for three-week periods every six months over two years. The device records movement data like walking patterns and arm motion. The goal is to create a reference dat…

This study gives healthy adults a single 200 mg dose of modafinil, a drug that promotes wakefulness, and then measures how they perform on computer-based brain games and brain activity via EEG. The goal is to learn more about decision-making processes that go wrong in psychosis s…

This early-stage study in 50 healthy women with overweight or obesity examines whether two experimental weight-loss injections, AZD6234 and AZD9550, change how the body processes a common birth control pill. Participants will receive the drugs alone and together, and researchers …

This study is looking at whether a molecule in the blood called miR-1 can help doctors understand how muscle diseases like Duchenne muscular dystrophy and myotonic dystrophy are progressing. Researchers will compare miR-1 levels in 104 people, including patients with different mu…

This early-stage study is testing a single dose of a drug called AGA2118 in 30 healthy adults of Japanese, Chinese, and Caucasian backgrounds. Researchers want to see how the drug moves through the body and if it causes any side effects. The goal is to gather basic safety and dos…

This early-stage trial is testing an experimental drug called SYH2072 in 112 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo as single or multiple doses. The study aims to gather basic safety information be…

This study follows 200 infants (3-24 months old) with and without a history of perinatal brain injury to understand how their cognitive skills grow over time. Researchers use virtual games and parent questionnaires to measure attention, language, and problem-solving. All visits h…

This early-stage study compares two forms of the cholesterol-lowering drug evolocumab in 400 healthy adults aged 18 to 60. Participants receive a single injection of one version, and researchers measure how much drug gets into the blood and how long it stays. The goal is to see i…

This early-stage study tests a new drug, DF5112, in 48 healthy adults to see if it is safe and how the body handles it. Participants receive a single dose of the drug or a placebo and are monitored for about a week in a clinic, with follow-up visits for a month. The goal is to ga…

This study looks at how two experimental drugs, laroprovstat and AZD4954, affect each other in the body. It involves 32 healthy adults who will take both drugs and have their blood levels measured. The goal is to gather safety and dosing information, not to treat any disease.

This study looks at how the body handles a single dose of the drug vepdegestrant in people with moderate to severe liver problems compared to healthy people. About 24 adults (ages 18-70) will take one pill and stay at the clinic for 11 days. The goal is to see if liver function a…

This study tests whether low-intensity focused ultrasound can safely target deep brain areas and improve thinking skills like attention and memory. Researchers will enroll 100 healthy adults aged 18 and older. Participants will undergo brain scans and thinking tests to measure an…

This early-stage study is testing the safety of a new drug called SPH9788 in healthy Chinese adults aged 18 to 45. About 94 participants will receive either the drug or a placebo to check for side effects and how the drug moves through the body. The goal is to gather safety infor…

This study looks at how drinking different types of milk—A2 milk, regular milk, and oat drink—affects bone health, heart health, and immune function in healthy adults aged 30 to 60. Participants will drink 500 ml of one of these beverages daily for 12 weeks. The goal is to see if…

This early-stage study tests a new oral drug, LTG-321, in 236 healthy adults aged 18-55 to see if it is safe and how the body processes it. Researchers will also measure pain tolerance using a cold water test and check if a high-fat meal changes drug absorption. The goal is to ga…

This study tests how well the body absorbs omega-3 fatty acids (EPA and DHA) from two different algae sources compared to fish oil and a placebo. Healthy adults aged 18-64 will take their assigned supplement for 6 weeks, and researchers will measure omega-3 levels in their blood.…

This study tests whether a new wet-granulation tablet of the drug navlimetostat works the same as the current dry-granulation tablet. It involves 64 healthy women who are not of childbearing potential. Participants will receive both tablet forms at different times, and researcher…

This study tests whether mild electrical stimulation of the vagus nerve (via the ear) can change how people learn from rewards and avoid threats. About 104 participants with high anxiety, high anhedonia, or both will play VR foraging tasks and brain-scan games. The goal is to und…

This early-stage study is testing four different versions of an experimental drug called AZD6234 in 21 healthy adults who are overweight or obese. The goal is to see which formulation gets absorbed best into the blood and to check for any side effects. Participants will receive a…

This study looks at whether replacing table sugar with fresh mango in a high-sugar breakfast can reduce gut inflammation and leakiness. Thirty-five healthy adults will eat two different breakfasts—one sweetened with mango, the other with sugar—and have their blood tested over thr…

This study is testing whether people's expectations about a treatment can influence their mood, motivation, and reactions to rewards. Healthy volunteers aged 15-25 will receive a sham (fake) version of accelerated transcranial magnetic stimulation (TMS) — no actual brain stimulat…

This early-stage study tests a new drug called SYH2085 in 74 healthy Chinese adults to see if it is safe and how the body processes it. Participants receive a single dose of the drug or a placebo and are monitored for side effects. The study does not aim to treat any disease.

This early-stage study tests whether a new drug called KLA318-2 is safe and how the body processes it. About 48 healthy adults aged 18-45 will receive a single injection. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This study looks at how healthy Chinese adults handle different doses of Allisartan Isoproxil, a blood pressure medication. About 54 participants will receive either a single dose (240, 480, or 720 mg) or a placebo. Researchers will monitor safety and measure drug levels in the b…

This study looks at how the drug casdatifan is processed in the body when taken as different tablet strengths and with or without food. It involves 24 healthy adults who will receive single doses under various conditions. The goal is to check if the different forms are equivalent…

This study tests whether applying heat pads or using a massage gun can reduce stiffness in the jaw muscle (masseter). Researchers will measure muscle stiffness with a special ultrasound in 40 healthy adults. The goal is to gather data that could lead to better treatments for jaw …

This study looks at how seeing, hearing, and smelling food in a virtual reality (VR) environment changes food cravings and body responses. Thirty-four healthy adults will have their brain activity, saliva, blood sugar, and temperature measured while exposed to real and virtual fo…

This study aims to collect body composition data from 40 healthy adults to develop better measurement methods for cancer patients. Participants will undergo tests like sodium bromide and deuterium dilution to measure muscle mass and body water. The study does not involve any trea…

This study looks at how a new drug called vimseltinib changes the way the body processes birth control pills. It involves 24 healthy women and lasts about 35 days. The goal is to see if vimseltinib makes birth control less effective, which is important for women who might take th…

This study is testing a new medicated patch (TK-254RX) that delivers the pain reliever esflurbiprofen through the skin. Researchers want to see how well the patch stays on over time in 90 healthy adults aged 18 to 64. They will also check for any side effects and measure how much…

This study tests if a gentle, non-invasive electrical stimulation applied to the brain during sleep can temporarily change brain activity, specifically sleep spindles (brain waves linked to memory). Up to 24 healthy adults will have 3 overnight visits to compare real stimulation …

This study looks at whether text messages and a built-in game can encourage Black college men who binge drink to use a mindfulness app more often. Forty participants will use the app for 28 days and complete surveys. The goal is to see if these features make the app more engaging…

This study is testing two drugs—povorcitinib (taken by mouth) and ruxolitinib cream (applied to the skin)—in 24 healthy adults aged 18 to 65. Researchers will use a special device to measure drug levels in the skin and blood. The goal is to understand how these drugs behave in th…

This study tests a new type of brain stimulation called temporal interference to see if it can temporarily change how different brain regions communicate. Forty healthy adults aged 18-50 will receive stimulation during sleep and wakefulness, and have their brain activity measured…

This early-stage study tests the safety and how the body processes a new drug called Debio 1453P. About 88 healthy adults aged 18-55 will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels in blood and urine, not to treat any disea…

This study looks at how a 12-week running program changes the way sedentary adults burn energy. Researchers will measure calories used, food eaten, and blood sugar levels before, right after, and 8 weeks after the exercise program ends. The goal is to understand why exercise does…

This study tests two methods of teaching CPR to 550 primary school children in Spain. One group gets a 2-hour hands-on session with a nurse and mannequins; the other watches a short video and does a puzzle. Researchers will measure which group learns CPR better, aiming to improve…

This early-stage study tests the safety and how the body handles a new oral drug, YH35995, in 86 healthy adult men. Participants receive either the drug or a placebo, and researchers monitor side effects and drug levels in the blood. The goal is to gather safety information, not …

This study looks at how the body processes fructose, a type of sugar. Researchers want to see if the small intestine can turn fructose into glucose to protect the liver, and whether this process is weaker in people with obesity. The study will involve 40 healthy volunteers, some …

This study looks at how blood metabolites (small molecules from food and activity) change in healthy people during normal daily life. Over four weeks, 35 participants will provide finger-prick blood samples, keep food diaries, and wear activity trackers. No treatments are given—t…

This study tests a new device called ZenBud that uses ultrasound waves to stimulate the vagus nerve, a key nerve that controls relaxation and body functions. Researchers want to see if this method can safely change heart rate, brain activity, and mood in 30 healthy adults. The go…

This study compares two spinal stimulation devices in 10 healthy adults to see if the updated design works better. Participants lie on their back while electrodes send mild electrical pulses to the spine, and leg muscle activity is measured. The goal is to improve devices used in…

This study looks at how the retina's ability to use oxygen changes as people age. Researchers will measure oxygen extraction in 50 healthy adults aged 18 to 80 using non-invasive eye scans. The goal is to understand normal aging, which may help future studies on eye diseases.

This study looks at whether eating a high-fat, high-calorie meal changes how the body absorbs nalbuphine extended-release tablets. Sixty healthy adults will take the drug once with food and once without, in random order. The goal is to understand food's impact on drug levels, not…

This study compares muscle oxygen levels in the thigh muscle of people with knee osteoarthritis and healthy adults. Researchers will measure oxygen during rest, after a mini-squat, and during recovery. The goal is to understand how knee OA affects muscle function and recovery, wh…

This study looks at how taking food or other medicines (itraconazole and carbamazepine) changes the way a new drug called INCB123667 moves through the body. It involves 51 healthy adults aged 19 to 55. The goal is to gather safety and drug interaction information, not to treat an…

This early-stage study tests whether a new inhaled drug called CPD704 is safe and how the body processes it. It involves 90 healthy Chinese adults aged 18-55. Participants receive single or multiple doses via inhalation and are monitored for side effects and drug levels in the bl…

This early-stage study tests the safety of a new drug, SV003, in 60 healthy adults. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. The goal is to gather safety information, not to treat any disease.

This study looks at how a new medicine called elecoglipron changes the way the body handles two common cholesterol-lowering drugs (atorvastatin and rosuvastatin). It involves 40 healthy volunteers who will take the drugs in a fixed order. The goal is to measure drug levels in the…

This study looks at how blood sugar levels change during exercise in healthy adults and those with type 1 diabetes. Researchers want to see if these changes are similar each time a person exercises. Participants will cycle or rest after a standard breakfast, and their glucose wil…

This early-stage study tests whether a new drug called AZD3974 is safe and how it moves through the body. About 176 healthy adults, including people of Japanese and Chinese descent, will receive either the drug or a placebo. The goal is to check for side effects and measure drug …

This early-stage study is testing an experimental drug called HW201877 in 104 healthy adults to see if it is safe and how the body processes it. The drug is being developed for inflammatory bowel disease (IBD), but this trial does not involve people with IBD. Participants will re…

This study looks at how often people with neurological conditions have trouble swallowing their medications. Researchers will test if using a special gel or changing the pill to a semi-solid form makes swallowing safer. 500 adults with swallowing problems and healthy volunteers w…

This study uses a special eye scan (OCTA) to look at tiny blood vessels in the retina of people with heart disease and healthy volunteers. Researchers want to see if changes in these vessels can reliably indicate cardiovascular problems. The goal is to develop a quick, non-invasi…

This early-stage study is testing a new oral drug, KT-579, in 96 healthy adults to see if it is safe and how the body handles it. Participants receive either the drug or a placebo. The goal is to gather safety data, not to treat any disease.

This study looks at levels of a brain protein called neurofilament in the blood of healthy late preterm babies (born at 34-37 weeks). Researchers want to know what normal levels are and how they change in the first weeks of life. Up to 15 newborns will provide extra blood during …

This study looks at how babies' brains develop after an injury around birth. Researchers will use fun games and brain wave tests (EEG) to see if they can predict which children might have trouble with thinking and memory later. About 100 babies, both healthy and those with brain …

This study follows 60 people with hip impingement who are scheduled for hip surgery. Researchers measure their strength, mobility, and function before surgery and at 3 and 6 months after. The goal is to learn what helps people recover best and identify any lasting problems after …

This study looks at how our beliefs and expectations influence the pain we feel when watching others suffer. Healthy adults will be placed in one of three groups: no treatment, a placebo nasal spray, or a spray with oxytocin. All participants in the spray groups are told they are…

This study looks at whether taking a dietary fiber called beta-glucan, along with exercise, can improve how your immune system recognizes and kills cancer cells. Healthy adults will take beta-glucan or a placebo daily for 4 weeks and do three exercise tests. Researchers will meas…

This study looks at how the drug capivasertib changes the way the body processes dextromethorphan, a common cough suppressant. It involves 42 healthy adults who will take both drugs in a fixed order. The goal is to measure drug levels in the blood, not to treat any disease.

This study looks at how resistance training (like lifting weights) helps children get stronger. Researchers will measure muscle size and nerve signals in 40 healthy kids before and after 12 weeks of training. The goal is to understand the body's changes, not to test a treatment.

This study looks at how a commercially available ketone drink (Ketone-IQ) affects sleep and breathing in 20 healthy adults aged 18-50. Participants take two different doses at home on separate nights and measure their ketone levels and sleep quality using a headband device. The g…

This early-stage study tests a new oral drug called E1018 in 32 healthy adults to see if it is safe and how the body absorbs and removes it. Participants receive a single dose and are monitored closely. The goal is not to treat malaria but to gather essential safety data before l…

This early-stage study is testing a new drug, UCB5285, in healthy volunteers to see if it is safe and how the body processes it. About 96 healthy adults, including some of Japanese descent, will receive either the drug or a placebo. The main goal is to check for side effects, not…

This study looks at three ways to help inactive adults exercise more: supervised group classes, a mobile app, or videos at home. Thirty people aged 18-35 who take fewer than 5,000 steps a day will try one of these for 8 weeks. The goal is to see which approach works best for boos…

This early-stage study tests a single dose of JMT206 injection in 44 healthy volunteers aged 18 to 60. The main goal is to check if the drug is safe and how the body processes it. Participants are randomly assigned to receive either JMT206 or a placebo, and neither they nor the r…

This study is an early-stage trial to check the safety of a new drug called AZD4954. It involves healthy volunteers and people with high cholesterol (dyslipidemia). Researchers will give single and multiple doses to see how the drug moves through the body and if it causes any sid…