HEALTHY PARTICIPANTS

This study tests an experimental vaccine designed to protect against E. coli bacteria. Researchers want to see if it is safe and tolerable for healthy adults aged 18 to 64. Participants will receive the vaccine and be monitored for side effects like injection site pain, fever, an…

This study tests a new vaccine called GBP511, designed to protect against a family of viruses called sarbecoviruses (which includes SARS-CoV-2). The trial involves about 368 healthy adults aged 18 and older. Researchers will check the vaccine's safety and how well it triggers the…

This early-stage study tests a new drug called SR604 in healthy people and those with hemophilia A, B, or factor VII deficiency. The main goal is to check safety and how the drug moves through the body. About 31 participants will receive single or multiple doses to find the right…

This early-stage trial tests an experimental drug called TGM-312-SC01 in healthy volunteers and people with MASH, a serious fatty liver disease. The goal is to check the drug's safety and how the body processes it. About 99 adults aged 18 to 70 will take part, with some receiving…

This study aims to create a blood test that can find many types of cancer at an early stage. Researchers will analyze DNA from blood samples of 6,000 people, including those with and without cancer, to train an artificial intelligence platform. The goal is to improve early detect…

This study is testing whether a portable VR headset can help diagnose and monitor traumatic brain injury (TBI), like concussions. Researchers will measure how the pupils of 150 participants (including TBI patients, healthy people, and other trauma patients) react to colored light…

This study tests two new imaging drugs, [18F]ABBV-964i and [18F]ABBV-965i, used with PET scans to see tau protein buildup in the brain, which is linked to Progressive Supranuclear Palsy (PSP). The main goals are to check safety and how well these drugs show tau in the brain. Abou…

This study looks at whether taking a daily supplement called Alpha-Glycerophosphocholine (α-GPC) can improve thinking, memory, and physical performance in healthy adults aged 25 to 55. Over 6 weeks, 80 participants will take either α-GPC or a placebo pill, and complete tests of a…

This study tests whether a daily probiotic supplement (Limosilactobacillus reuteri) can reduce symptoms like heartburn and stomach pain in healthy adults who have occasional upper gut discomfort. About 324 people will take either the supplement or a placebo for 8 weeks and report…

This early-stage study tests a new drug called AZD1043 in healthy adults who are overweight or have obesity. The main goal is to check if the drug is safe and how the body handles it. About 104 participants will receive either the drug or a placebo, and the study includes people …

This early-stage study tests an experimental drug called PF-07832837 in healthy adults and people with moderate to severe atopic dermatitis (eczema). The main goal is to check safety and how the drug moves through the body. Researchers will also look for early signs that the drug…

This study tests whether muffins made from a special type of oat (Royal Ancient Oats™) can help control blood sugar and digestion better than regular oat muffins. About 38 healthy adults aged 35-65 with slightly high body weight will eat different muffins and have their blood sug…

This early-stage study tests a new drug called BGB-45035 for safety and how the body processes it. First, healthy volunteers (ages 18-55) will receive single or multiple doses. Then, people with autoimmune skin diseases like eczema or prurigo nodularis will receive the drug to ch…

This early-stage study tests an experimental oral drug called NTX-253 in healthy volunteers and people with stable schizophrenia. The main goal is to check safety and how the body processes the drug. 73 adults aged 18–55 will take single or multiple doses to find the right dose r…

This study looks at how drinking A2 milk, regular milk, or oat drink every day for 12 weeks affects bone health, heart health, and immune function in healthy adults aged 30 to 60. The main focus is on bone density, measured by a special scan. Researchers want to see if A2 milk, w…

This study tests two methods of teaching CPR to 550 primary school children in Spain. One group gets a 2-hour hands-on session with a nurse and mannequins; the other watches a short video and does a puzzle. Researchers will measure which group learns CPR better, aiming to improve…

This early-stage study tests the safety and how the body handles a new oral drug, YH35995, in 86 healthy adult men. Participants receive either the drug or a placebo, and researchers monitor side effects and drug levels in the blood. The goal is to gather safety information, not …

This study aims to collect body composition data from 40 healthy adults (young and elderly) to develop better measurement methods for cancer patients. Participants will undergo non-invasive tests like sodium bromide and deuterium dilution. No treatment is given; the goal is to im…

This study looks at how the body processes fructose, a type of sugar. Researchers want to see if the small intestine can turn fructose into glucose to protect the liver, and whether this process is weaker in people with obesity. The study will involve 40 healthy volunteers, some …

This study looks at how blood metabolites (small molecules from food and activity) change in healthy people during normal daily life. Over four weeks, 35 participants will provide finger-prick blood samples, keep food diaries, and wear activity trackers. No treatments are given—t…

This study tests a new device called ZenBud that uses ultrasound waves to stimulate the vagus nerve, a key nerve that controls relaxation and body functions. Researchers want to see if this method can safely change heart rate, brain activity, and mood in 30 healthy adults. The go…

This study compares two spinal stimulation devices in 10 healthy adults to see if the updated design works better. Participants lie on their back while electrodes send mild electrical pulses to the spine, and leg muscle activity is measured. The goal is to improve devices used in…

This study looks at how three experimental drugs (AZD6234, AZD9550, and their combination) affect the way birth control pills work in healthy women who are overweight or have obesity. About 50 participants will receive the drugs and then take a single dose of a combined oral cont…

This study looks at whether text messages and a built-in game can encourage Black college men who binge drink to use a mindfulness app more often. About 40 participants will use the app for 28 days and complete surveys. The goal is to see if these features help them engage with t…

This study looks at how the retina's ability to use oxygen changes as people age. Researchers will measure oxygen extraction in 50 healthy adults aged 18 to 80 using non-invasive eye scans. The goal is to understand normal aging, which may help future studies on eye diseases.

This early-stage study tests different versions of an experimental drug called AZD6234 in 21 healthy adults with overweight or obesity. The goal is to see how much of the drug gets into the blood and how safe it is. Participants receive a single injection of each formulation and …

This study looks at whether eating a high-fat, high-calorie meal changes how the body absorbs nalbuphine extended-release tablets. Sixty healthy adults will take the drug once with food and once without, in random order. The goal is to understand food's impact on drug levels, not…

This early-stage study aims to understand how a single dose of AGA2118 moves through the body in 30 healthy adults of Japanese, Chinese, or Caucasian background. Participants must be between 18 and 65 years old and have adequate vitamin D levels. The study does not treat any dise…

This study tests whether a new wet-granulation tablet of navlimetostat works the same in the body as the original dry-granulation tablet. It involves 64 healthy adult women who are not able to have children. Participants will take both tablet forms at different times, and researc…

This study tests a new device that prepares blood samples for liquid biopsy, a method to detect cancer cells and DNA in the blood. Researchers will enroll 45 people—20 healthy volunteers and 25 with metastatic breast cancer—to see if the device works well. The goal is to improve …

This study compares muscle oxygen levels in the thigh muscle of people with knee osteoarthritis and healthy adults. Researchers will measure oxygen during rest, after a mini-squat, and during recovery. The goal is to understand how knee OA affects muscle function and recovery, wh…

This study looks at how well the body absorbs omega-3 fatty acids from two different algae sources compared to fish oil and a placebo. Healthy adults aged 18-64 will take their assigned supplement for 6 weeks. The goal is to see if algae-based omega-3 is absorbed as well as fish-…

This study looks at how the body handles a single dose of the medicine vepdegestrant in people with moderate or severe liver problems compared to healthy people. About 24 adults (ages 18-70) will take one pill and stay at the clinic for 11 days for monitoring. The goal is to unde…

This study looks at how taking food or other medicines (itraconazole and carbamazepine) changes the way a new drug called INCB123667 moves through the body. It involves 51 healthy adults aged 19 to 55. The goal is to gather safety and drug interaction information, not to treat an…

This early-stage study tests whether a new inhaled drug called CPD704 is safe and how the body processes it. It involves 90 healthy Chinese adults aged 18-55. Participants receive single or multiple doses via inhalation and are monitored for side effects and drug levels in the bl…

This study looks at how aerobic exercise affects energy use in 80 sedentary adults. Participants will run five times a week for 12 weeks. Researchers will measure changes in energy expenditure, food intake, and physical activity before, right after, and 8 weeks after the exercise…

This study looks at whether practicing fine hand movements can affect how the brain processes language. Forty healthy adults aged 19-24 will be split into two groups: one doing detailed hand exercises and the other doing simpler tasks. Both groups will train online for 20 minutes…

This study looks at how much of the drug zilucoplan and its breakdown products end up in the breast milk of healthy women who are breastfeeding. Fifteen women who are at least 6 weeks postpartum and already planning to stop breastfeeding will receive daily injections of zilucopla…

This study looks at how anxiety and anhedonia (loss of interest or pleasure) affect learning and decision-making. Researchers will use a mild nerve stimulation technique (tVNS) and brain scans to see if they can change how people respond to rewards and threats. The goal is to bet…

This study tests a new machine called See.d that processes blood samples to create slides and plasma for liquid biopsy tests. Researchers want to see if the samples are stable and usable for detecting cancer cells or DNA. The study involves 200 healthy adults aged 18 and older. I…

This study tests a new drug called SYH2085 in healthy Chinese adults to see if it is safe and how the body handles it. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug levels in the blood. The goal is to gather safety in…

This study tests a new type of electrical brain stimulation called temporal interference to see if it can temporarily change how different parts of the brain communicate. Researchers will enroll 40 healthy adults aged 18-50. Participants will receive stimulation during sleep and …

This early-stage study tests the safety of a new drug, SV003, in 60 healthy adults. Participants receive either the drug or a placebo, and researchers monitor side effects and how the drug moves through the body. The goal is to gather safety information, not to treat any disease.

This early-stage study tests whether a new drug called KLA318-2 is safe and how the body processes it. About 48 healthy adults aged 18 to 45 will receive a single injection. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This study looks at how a new medicine called elecoglipron changes the way the body handles two common cholesterol-lowering drugs (atorvastatin and rosuvastatin). It involves 40 healthy volunteers who will take the drugs in a fixed order. The goal is to measure drug levels in the…

This early-stage trial tests the safety and how the body processes Debio 1453P in 88 healthy adults aged 18-55. Participants receive either the drug or a placebo in single or multiple doses. The goal is to check for side effects and measure drug levels in blood and urine, not to …

This study tests how two different forms of the drug evolocumab (used to lower cholesterol) behave in the body. About 400 healthy adults aged 18 to 60 will receive a single dose of one version, and researchers will measure drug levels and side effects. The goal is to compare the …

This study looks at how two drugs—povorcitinib (taken by mouth) and ruxolitinib cream (applied to the skin)—travel through the body and skin of 24 healthy adults aged 18 to 65. Researchers use a special device to sample fluid from the skin and take blood tests to measure drug lev…

This early-stage study tests a new drug called ACI-19764 in 78 healthy adults aged 18 to 65. The goal is to check its safety, how the body handles it, and its effect on immune markers. Participants receive either the drug or a placebo, with some taking a single dose and others da…

This study looks at how blood sugar levels change during exercise in healthy adults and those with type 1 diabetes. Researchers want to see if these changes are similar each time a person exercises. Participants will cycle or rest after a standard breakfast, and their glucose wil…

This early-stage study tests a new oral drug called LTG-321 in 236 healthy adults aged 18 to 55. The main goal is to check safety and how the body processes the drug. Some participants will also take a cold pressor test to measure pain tolerance, and a separate group will see how…

This study aims to collect normal walking and movement data from 200 healthy people of all ages using a wearable device called Syde®. Participants wear the device for 3-week periods every 6 months over two years, all from home via phone or video calls. The goal is to create a ref…

This early-stage study tests whether a new drug called AZD3974 is safe and how it moves through the body. About 176 healthy adults, including people of Japanese and Chinese descent, will receive either the drug or a placebo. The goal is to check for side effects and measure drug …

This study looks at how seeing, smelling, and interacting with food in virtual reality changes food cravings and body responses. Thirty-four healthy adults will have their brain activity, saliva, and blood sugar measured while viewing real and virtual food. The goal is to underst…

This study looks at how a new drug called vimseltinib changes the way the body processes birth control pills. About 24 healthy women will take both medications and have their blood levels measured over 35 days. The goal is to see if vimseltinib makes the birth control less effect…

This early-stage study is testing an experimental drug called HW201877 in 104 healthy adults to see if it is safe and how the body processes it. The drug is being developed for inflammatory bowel disease (IBD), but this trial does not involve people with IBD. Participants will re…

This study looks at how often people with neurological conditions have trouble swallowing their medications. Researchers will test if using a special gel or changing the pill to a semi-solid form makes swallowing safer. 500 adults with swallowing problems and healthy volunteers w…

This study looks at hearing in people with early-stage Alzheimer's or Parkinson's disease compared to healthy adults. Researchers want to find out how common certain hearing problems are, especially trouble understanding speech in noisy places even when standard hearing tests are…

This study uses a special eye scan (OCTA) to look at tiny blood vessels in the retina of people with heart disease and healthy volunteers. Researchers want to see if changes in these vessels can reliably indicate cardiovascular problems. The goal is to develop a quick, non-invasi…

This early-stage study tests whether TLC-1180 is safe in healthy adults aged 18 to 55. Researchers will measure how the drug moves through the body and look for side effects. Participants will receive either single or multiple doses of the drug or a placebo. No direct health bene…

This early-stage study is testing a new oral drug, KT-579, in 96 healthy adults to see if it is safe and how the body handles it. Participants receive either the drug or a placebo. The goal is to gather safety data, not to treat any disease.

This study looks at how a single dose of modafinil changes decision-making and brain activity in healthy adults. Researchers hope the results will improve understanding of psychosis spectrum disorders like schizophrenia. About 103 participants will take the drug, play computer br…

This study looks at levels of a brain protein called neurofilament in the blood of healthy late preterm babies (born at 34-37 weeks). Researchers want to know what normal levels are and how they change in the first weeks of life. Up to 15 newborns will provide extra blood during …

This study looks at how babies' brains develop after an injury around birth. Researchers will use fun games and brain wave tests (EEG) to see if they can predict which children might have trouble with thinking and memory later. About 100 babies, both healthy and those with brain …

This study follows 60 people with hip impingement who are scheduled for hip surgery. Researchers measure their strength, mobility, and function before surgery and at 3 and 6 months after. The goal is to learn what helps people recover best and identify any lasting problems after …

This study looks at how our beliefs and expectations influence the pain we feel when watching others suffer. Healthy adults will be placed in one of three groups: no treatment, a placebo nasal spray, or a spray with oxytocin. All participants in the spray groups are told they are…

This study tests if a non-invasive electrical stimulation method called TI-TES can temporarily alter brain activity during sleep, specifically sleep spindles. Up to 24 healthy adults in Wisconsin will each spend 3 nights in the lab. The goal is to understand how different stimula…

This early-stage study tests the safety of a new drug called SPH9788 in healthy Chinese adults aged 18 to 45. About 94 participants will receive either the drug or a placebo to check for side effects and how the drug moves through the body. The goal is to gather safety informatio…

This study looks at whether taking a dietary fiber called beta-glucan, along with exercise, can improve how your immune system recognizes and kills cancer cells. Healthy adults will take beta-glucan or a placebo daily for 4 weeks and do three exercise tests. Researchers will meas…

This study looks at how babies' thinking skills grow over time, including healthy infants and those who had a brain injury around birth. Researchers will use fun online games and parent questionnaires to measure attention and learning. The goal is to better understand how early b…

This study looks at how the drug capivasertib changes the way the body processes dextromethorphan, a common cough suppressant. It involves 42 healthy adults who will take both drugs in a fixed order. The goal is to measure drug levels in the blood, not to treat any disease.

This study looks at how resistance training (like lifting weights) helps children get stronger. Researchers will measure muscle size and nerve signals in 40 healthy kids before and after 12 weeks of training. The goal is to understand the body's changes, not to test a treatment.

This early-stage study tests the safety and tolerability of a new drug, DF5112, in 48 healthy adults aged 18 to 55. Participants receive either the drug or a placebo by injection and are monitored for about a week in a clinic, with follow-up visits through day 29. The goal is to …

This study is looking at whether a tiny molecule in the blood, called miR-1, can be used as a marker to track how muscle diseases like Duchenne muscular dystrophy and myotonic dystrophy progress. Researchers will compare miR-1 levels in 104 people, including healthy volunteers an…

This study tests whether applying heat pads or using a massage gun can reduce stiffness in the jaw muscle. Researchers will measure muscle tightness with a special ultrasound in 40 healthy adults. The goal is to find better ways to treat jaw pain and disorders like TMD.

This study looks at how a commercially available ketone drink (Ketone-IQ) affects sleep and breathing in 20 healthy adults aged 18-50. Participants take two different doses at home on separate nights and measure their ketone levels and sleep quality using a headband device. The g…

This study looks at how a person's beliefs about a treatment can change their mood, motivation, and reactions to rewards. Healthy volunteers aged 15-25 will receive a sham (fake) version of a brain stimulation treatment called accelerated TMS, which delivers no active stimulation…

This study is testing a new medicated patch (TK-254RX) to see how well it sticks to the skin. About 90 healthy adults will wear the patch, and researchers will measure adhesion, any side effects, and how much medicine remains in the used patch. The goal is to make sure the patch …

This early-stage study tests a new oral drug called E1018 in 32 healthy adults to see if it is safe and how the body absorbs and removes it. Participants receive a single dose and are monitored closely. The goal is not to treat malaria but to gather essential safety data before l…

This early-stage study is testing a new drug, UCB5285, in healthy volunteers to see if it is safe and how the body processes it. About 96 healthy adults, including some of Japanese descent, will receive either the drug or a placebo. The main goal is to check for side effects, not…

This study looks at three ways to help inactive adults exercise more: supervised group classes, a mobile app, or videos at home. Thirty people aged 18-35 who take fewer than 5,000 steps a day will try one of these for 8 weeks. The goal is to see which approach works best for boos…

This study tests whether using virtual reality (VR) makes a therapy exercise called 'chairwork' more effective than just imagining it. Thirty healthy students will try both versions and report how they feel. The goal is to see if VR helps people who have trouble picturing things …

This study tests how two experimental drugs (AZD0780 and AZD4954) affect each other's levels in the blood of 32 healthy adults. Participants take single doses of each drug alone and together. The goal is to gather safety and drug interaction information, not to treat any disease.

This early-stage study tests a single dose of JMT206 injection in 44 healthy volunteers aged 18 to 60. The main goal is to check if the drug is safe and how the body processes it. Participants are randomly assigned to receive either JMT206 or a placebo, and neither they nor the r…

This study tests the safety and how the body processes a new drug called JZP047 in healthy adults aged 18 to 55. It also checks if food changes how the drug works. About 86 people will take part. This is an early-phase trial with no direct treatment benefit.

This study tests a blood pressure medication called allisartan isoproxil in 54 healthy Chinese adults. Participants receive one of three doses or a placebo to see how the drug moves through the body and if it causes any side effects. The goal is to gather safety and processing in…

This study is an early-stage trial to check the safety of a new drug called AZD4954. It involves healthy volunteers and people with high cholesterol (dyslipidemia). Researchers will give single and multiple doses to see how the drug moves through the body and if it causes any sid…

This study looks at whether eating pistachios as a snack can help overweight and obese adults burn energy more efficiently. Researchers will compare four days of pistachio snacking to four days of normal eating in 60 healthy but overweight participants. The goal is to see if pist…

This study tests whether low-intensity focused ultrasound (LIFU) can improve thinking and memory in healthy adults. Researchers will use brain scans and thinking tests to see if the ultrasound can safely activate deep brain areas. The goal is to understand how ultrasound affects …