HEALTHY PARTICIPANTS

This early-stage study tested a daily pill called AZD4144 in 28 people with obesity to see if it is safe and how it affects inflammation in the body. Participants took either the drug or a placebo for a short time. The main goals were to check for side effects and measure changes…

This early-stage study tested a new drug called AZD6234 in 104 healthy adults with overweight or obesity. The main goal was to see if repeated doses of the drug are safe and tolerable compared to a placebo. Researchers also measured how the drug moves through the body. This is a …

This early-stage study tested the safety and tolerability of a new drug called IBI356 in 99 participants, including healthy volunteers and people with atopic dermatitis (a type of eczema). The main goal was to check for side effects and how the drug moves through the body. No cla…

This early-stage study tested a single dose of a new drug called IBI3002 in 52 healthy volunteers and people with mild to moderate asthma. The main goal was to check if the drug is safe and how the body processes it. Participants were randomly assigned to receive either the drug …

This pilot study tested whether a daily probiotic and grape extract supplement, taken as a capsule or in a chocolate bar, could improve well-being in 40 healthy adults with moderate stress. Participants took the product for 4 weeks, and researchers measured changes in perceived s…

This study tested PeptiSleep, a plant-based capsule, in 120 healthy adults over 6 weeks. Participants took either PeptiSleep or a placebo daily and wore a sleep tracker. The goal was to see if PeptiSleep improves sleep quality, morning alertness, and cognitive function.

This study tested whether a special electronic syringe (Dentapen) causes less pain and stress during dental numbing shots compared to a regular syringe. Forty healthy adults getting teeth pulled for braces took part. Researchers measured pain using a 0-100 scale and stress by tra…

This study looked at whether a 4-week program of elastic band exercises could improve hip strength and agility in 21 healthy young male basketball players aged 15-18. Players were split into two groups: one did the band exercises plus regular training, the other did only regular …

This early-stage study tested the safety and how the body processes a new drug called S-740792 in 99 healthy adults. Participants received either single or multiple doses, and some also had a high-fat meal or another drug to check for interactions. The goal was to gather safety i…

This study looked at whether a single session of roller massage can lower blood pressure in healthy young adults. Twenty-nine participants received both a roller massage session and a control session on different days. The researchers measured blood pressure and tissue hardness t…

This study tested a new formulation of the medicine semaglutide in healthy adults. The goal was to measure how much semaglutide gets into the blood from the new tablet compared to the current tablet. About 264 participants took different doses for up to 21 weeks, with blood sampl…

This study looked at how capivasertib, a cancer drug, affects the levels of rosuvastatin (a cholesterol-lowering drug) in the blood. Twenty healthy adults took rosuvastatin alone and then with capivasertib to see if there was a change. The goal was to understand potential drug in…

This early-stage study tested the safety and how the body handles different doses of an experimental drug called PF-06414300. 63 healthy adults aged 18-65 received either the drug or a placebo. The goal was to measure side effects and drug levels in the blood, not to treat any il…

This study tested whether a store-bought high-protein yogurt drink helps muscles recover after hard exercise. 62 healthy adults aged 18-45 took part. Researchers measured amino acid levels in the blood and checked muscle soreness, strength, and damage over 72 hours. The goal was …

This study looked at how an experimental drug called AZD0780 changes the way the body processes metformin, a standard diabetes medication. Fourteen healthy volunteers took both drugs in a fixed order, and researchers measured drug levels and side effects. The goal was purely to g…

This study looked at how breathing in simulated wildfire smoke for just one hour affects healthy adults. Researchers measured a blood marker called p-tau, which is linked to memory problems, and tested thinking skills before and after exposure. The goal was to see if short-term s…

This study tested whether a short session of neck stretching can lower blood pressure in 25 healthy adults. Researchers measured blood pressure, tissue stiffness, and heart rate before and after stretching. The goal was to see if stretching relaxes blood vessels and calms the ner…

This early-stage study tested a new drug called INCB160058 in 137 healthy adults aged 18 to 55. The main goal was to check the drug's safety and how the body processes it, not to treat any disease. Participants took a single dose by mouth, and researchers monitored side effects a…

This study tested whether a short, personalized virtual reality (VR) experience could help general practitioners (GPs) feel better and become more flexible in their thinking. Twenty-one healthy GPs took part in a single session where they used a VR headset and then reflected on t…

This early-stage study tested the safety and how the body processes an inhaled drug called AZD4604. It involved 56 healthy Japanese and Chinese volunteers who received either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not t…

This study looked at whether taking a short nap (25 or 45 minutes) helps teenage soccer players perform better. Sixteen male players from a competitive team completed agility and sprint tests after napping or staying awake. The results showed that napping improved their agility a…

This study looked at how a new extended-release painkiller (nalbuphine ER) interacts with two lung disease drugs (pirfenidone and nintedanib) in 132 healthy adults. Researchers measured drug levels in the blood and checked for side effects. The goal was to see if these drugs can …

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This study looked at how well healthy people tolerate an injection of immunoglobulin G (a type of antibody) given under the skin. Researchers tested different injection conditions in 82 healthy adults to see what caused the least pain and side effects. The goal was to gather safe…

This early-stage study tested a new drug called AZD8965 in 147 healthy adults, including Japanese and Chinese participants. The main goal was to check if the drug is safe and how the body processes it, both with and without food. No treatment was given for any disease, so this st…

This study measured how the number of calories and the time of day you eat affect your body's energy use and blood vessel health. Twenty healthy adults ate test meals while researchers tracked their metabolism and pulse. The goal was to understand how meal choices influence metab…

This early-stage study tested the safety of a new drug called CDX-622 in 85 healthy adults aged 18 to 55. Participants received either the drug or a placebo, and researchers monitored side effects, drug levels in the blood, and certain body chemicals. The goal was not to treat an…

This study looked at 45 healthy but sedentary adults to compare three cycling programs: eccentric high-intensity interval training, continuous eccentric cycling, and concentric high-intensity interval training. Researchers wanted to see which type best improves muscle strength, h…

This study looked at how taking ammoxetine hydrochloride enteric-coated tablets with or without food changes the drug levels in the blood. Fourteen healthy adults participated in this early-phase trial. The goal was purely to gather information, not to treat any disease.

This early-stage study tested the safety and how the body handles a new drug called AZD2389. It involved 120 healthy adults, including Japanese and Chinese participants, who received either the drug or a placebo. The goal was to check for side effects and measure drug levels in b…

This early-stage study looked at how different pill versions of a drug called AZD5004 move through the body and whether eating changes that. 65 healthy adults each took a single dose of the drug in different forms, and researchers measured levels in the blood. The goal was to pic…

This study looked at how much of the drug rozanolixizumab gets into the breast milk of healthy women who were already planning to stop breastfeeding. Fifteen women received a single dose, and researchers measured drug levels in their milk over a week. The goal was to understand p…

This early-stage study tested the safety and how the body handles a new drug called AZD6793 in 39 healthy Japanese and Chinese adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. The goal was to gath…

This study looked at how a gentle electrical current applied to the brain (tDCS) changes stress responses and the ability to imagine future events. Sixty healthy adults aged 18-30 took part in one MRI session while receiving either real or fake stimulation. The goal was to unders…

This study looked at how much of the COVID-19 treatment nirmatrelvir/ritonavir (Paxlovid) passes into breast milk. Eight healthy breastfeeding women took the medicine by mouth three times over two days. Researchers collected breast milk samples to measure drug levels and check sa…

This study looked at how well two different versions of an experimental oral drug (deuterium deuremidevir) are absorbed by the body. It involved 18 healthy Chinese adults aged 18 to 45. Participants took each version once, and researchers measured drug levels in their blood to co…

This study tested whether a 5-day course of an oral NAD+ supplement (LNAD+) could raise NAD+ levels and change health-related biological markers in 60 healthy adults aged 45-75. Participants were randomly assigned to receive the supplement or a placebo. The main goal was to measu…

This study looks at how two drugs (camizestrant and carbamazepine) affect each other in the body of healthy postmenopausal women. It does not aim to treat any disease—just to measure drug levels in the blood. Forty women will take the drugs in a fixed order, and researchers will …

This study tested whether a new drug called CHS-1420 works in the body the same way as the approved drug Humira (adalimumab). It involved 238 healthy Chinese adults who received a single injection of either drug. The main goal was to compare drug levels in the blood over time to …

This study looked at how the drug MK-8527 moves through the body in people with mild or moderate liver impairment compared to healthy volunteers. 18 participants received a single dose, and researchers measured drug levels in the blood over time. The goal was to understand how li…

This study tested 18 healthy, trained male athletes to see if eating carbohydrates at the start or end of a pre-exercise meal changes how the body burns fat and performs during cycling. Participants ate a standard meal in two different orders on separate days, then did a 60-minut…

This study looked at how a nature-based therapy program affects stress and quality of life in 100 healthy adults living near the coast in Barcelona. Participants took part in nature activities, and researchers measured their stress levels, emotional well-being, and overall health…

This study tested whether whole-wheat bread with added carob molasses and germ can improve blood sugar levels and antioxidant capacity in healthy adults. Twenty volunteers aged 19-35 ate both standard and enriched bread on separate days, and their blood was tested over three hour…

This study looked at how a high-fat, high-calorie meal changes the amount of two drugs (zibotentan and dapagliflozin) in the blood of healthy people. Twenty-six adults took a single dose of the combined pill once after eating and once on an empty stomach. The goal was to see if f…

This study looked at how taking plixorafenib with food or with cobicistat (a drug that boosts other medications) changes the amount of plixorafenib in the blood. 28 healthy adults aged 18 to 55 took single doses of plixorafenib under different conditions. The goal was to gather s…

This study looked at how carrying a school backpack on one shoulder versus both shoulders changes the pressure on the soles of the feet in 92 healthy teenagers. Researchers found that carrying a backpack on one shoulder increased the amount of foot touching the ground, but the ov…

This early-stage study tested the safety and tolerability of a new drug called LY4060874 in 121 healthy adults. Participants were monitored for side effects and how the drug moved through their bodies. The study did not aim to treat any disease, but to gather important safety inf…

This study looked at whether a 12-week exercise program (three times a week) could improve thinking skills in healthy adults aged 50 to 80. Researchers measured hormones like leptin and irisin, as well as other brain-related chemicals, before and after the program. The goal was t…

This early-stage study looked at how healthy adults absorb a drug called ZN-A-1041 when given as a tablet versus a capsule. 18 participants took part to help researchers understand which form works best and how food or stomach acid medicine might affect absorption. The study did …

This study tested how quickly Staccato alprazolam (an inhaled sedative) starts working compared to two other sedatives given by IV or nasal spray. Fifty-five healthy adults received single doses of each drug in a crossover design, and their brain waves were monitored to measure o…

This study looked at how a single dose of a drug called INCB123667 is absorbed, broken down, and removed from the body in 9 healthy men aged 18 to 55. Participants took the drug by mouth, and researchers measured radioactivity in blood, urine, and stool to track the drug's path. …

This study tested two different ultrasound-guided nerve stimulation protocols on 86 healthy adults to see which one improves handgrip strength more. Participants received a single 10-minute session targeting the median nerve. The goal was to gather knowledge for future rehabilita…

This study tested 50 healthy adolescents aged 15-16 to find normal handgrip strength values using a digital device. Participants did simple strength tests on their hands and legs. The goal is to create reference numbers that doctors can use to compare with people who have muscle …

This study tested how the drug AZD5004 interacts with itraconazole (an antifungal) and birth control pills in 51 healthy adults. The goal was to see if these drugs affect each other's levels in the body. Results will help guide safe dosing for future patients.

This study looked at whether taking a short, daily hot bath (5 minutes in 113°F water) for two weeks could help healthy adults adapt to heat. Twenty-six people took part. Researchers measured things like heart rate, body temperature, and sweating to see if the body adjusted. The …

This study looked at how healthy men absorb, process, and get rid of a drug called PF-07220060. Twelve men took the drug by mouth or by mouth plus a vein injection. Researchers measured the drug in blood, urine, and stool to understand its journey through the body. This study did…

This study tested whether foam rolling the neck could temporarily change blood pressure and improve neck flexibility in 24 healthy young adults. Researchers measured blood pressure, heart rate, and range of motion before and after rolling. The goal was to understand the body's sh…

This study looked at how a short, painless brain stimulation technique called continuous theta burst stimulation (cTBS) changes the way healthy young adults pay attention to emotional versus neutral pictures. 91 participants received either real or fake stimulation over the left …

This study looked at how a new tablet version of the drug minzasolmin is absorbed by the body compared to an older capsule form, and whether eating food changes its absorption. It involved 18 healthy adults aged 18 to 55. The goal was to gather information, not to treat any disea…

This early-stage study tested the safety and how the body processes a single dose of donzakimig in 32 healthy Chinese and Japanese adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. The goal was to …

This study looked at what makes it easier or harder for Turkish young people (ages 15-24) to be physically active. Researchers surveyed 318 healthy volunteers about their activity levels, stress, and daytime sleepiness. The goal is to understand these factors so better programs c…

This study tested whether stretching or using a foam roller on the neck could also improve hip flexibility in 30 healthy adults. Researchers measured range of motion and tissue stiffness before and after each technique. The goal was to see if these simple treatments have effects …

This study looked at whether placing tiny press-needles on the ear can change how parts of the brain talk to each other. Forty healthy adults aged 18-30 had brain scans before and after the acupuncture. The goal was to understand how ear acupuncture might help with conditions lik…

This study looked at how two different versions of the drug LY4064809 enter the bloodstream and how long the body takes to remove them. It involved 24 healthy adults who stayed at a research center for about a month. The goal was to gather information, not to treat any disease.

This early-stage study tested a new medicine, NNC0650-0013, which may one day treat type 2 diabetes. Eleven healthy men received a single injection of the drug or a placebo to check for safety and how the body processes it. The study lasted 11 to 17 weeks and required some overni…

This study tested whether a short virtual reality (VR) self-help program could increase hope and well-being in young adults aged 18-30. Forty healthy participants completed five sessions, starting with an in-person VR experience followed by self-guided audio and video materials. …

This early-stage study tested a single dose of the experimental drug UCB9741 in 40 healthy adults, half Caucasian and half Japanese. The goal was to check if the drug is safe and how the body processes it. No treatment or cure was being tested, so participants did not have any di…

This study tested whether giving the drug tozorakimab with two different injection devices (an autoinjector and a prefilled syringe) leads to similar drug levels in the body. It involved 254 healthy volunteers who received a single shot. The goal was to see if the devices work th…

This study looked at how a single dose of a drug called INCB099280 moves through and leaves the body. Five healthy men took one pill, and researchers measured the drug and its breakdown products in blood, urine, and stool. The goal was to understand the drug's balance and metabol…

This study looked at how a drug called elenestinib affects the way the body processes midazolam (a sedative) and a common birth control pill. Twenty healthy women took these medications with and without elenestinib, and researchers measured drug levels in their blood. The goal wa…

This study looked at how the drug MK-5684 moves through the bodies of men with severe kidney failure or end-stage kidney disease compared to healthy men. Twenty-four men took a single dose, and researchers measured drug levels in their blood over time. The goal was to understand …

This study looked at how eating a high-fat or low-fat meal changes the way the body handles a drug called ammoxetine. Eighteen healthy adults took a single dose under different meal conditions. The goal was to measure drug levels in the blood, not to treat any disease.

This study looked at how taking the drug admilparant with or without food changes its levels in the body. It involved 56 healthy adults and was completed by the sponsor Bristol-Myers Squibb. The goal was to gather information for future use, not to treat any disease.

This study looked at how a single dose of an insulin drug (THDB0206) works when injected into different areas of the body. It involved 27 healthy Chinese adults aged 18 to 40. The goal was to see how the body absorbs and responds to the drug depending on the injection site.

This study looked at whether getting real-time feedback from a virtual trainer avatar during virtual reality exercise helps people feel better and move more accurately. Twenty-eight healthy adults did three short VR workout sessions with no feedback, only verbal feedback, or both…

This study looked at how different amounts of water and delays before breakfast affect levels of a new semaglutide tablet in the blood. It involved 121 healthy men who took the tablet daily for 10 days. The goal was to find the best way to take the medicine for future use.

This study tested different versions of the drug TEV-56286 in 47 healthy adults to see how well each is absorbed by the body. Participants took a single dose of each formulation in a random order. The goal was to compare the new formulations to the original capsule and to monitor…

This study looked at how three common drugs (itraconazole, rifampin, and acid reducers) change the way the body handles a new medicine called INCB161734. It involved 63 healthy adults aged 18 to 55. The goal was to measure drug levels in the blood and check for side effects, help…

This study looked at how healthy adults' immune systems respond to the rabies vaccine. Thirty participants received the vaccine in different ways, some with added antibodies. The goal was to measure immune responses over time, not to treat or cure disease.

This study looked at how a new drug called vimseltinib affects the way the body processes rosuvastatin, a common cholesterol medication. Twenty healthy men took part to see if vimseltinib changes how much rosuvastatin gets into the blood. The goal is to understand potential drug …

This early-stage study tested the safety of a new drug called ATX101 in 24 healthy adults aged 18 to 50. Participants received a single dose through a vein, and researchers monitored for side effects and how the drug moved through the body. The goal was not to treat any disease, …

This study looked at whether the strength of a child's pinch grip is related to how well they write. About 100 children aged 9 to 11 had their handwriting scored and their pinch strength measured. The goal was simply to understand if a connection exists, not to test any treatment…

This study looked at whether a new drug called clofutriben affects how the body handles two common medicines, midazolam and prednisolone. Sixteen healthy adults took these drugs and had their blood levels measured. The goal was to check for any drug interactions, not to treat any…

This study tested how different versions of the experimental drug ziltivekimab move through the body when given as a single injection under the skin. It compared two different formulas and two injection methods: a manual syringe and a pen-injector. The study involved 267 healthy …

This study tested the safety of skin products by applying them to the skin of 26 healthy adults for 24 hours. Researchers checked for redness, dryness, swelling, and wrinkles to see if the products caused any reactions. The goal was to make sure the products are safe for people t…

This early-stage study tested a single dose of a new drug, AZD5148, in 84 healthy adults to see if it is safe and how the body processes it. Participants received the drug either as a shot into a muscle or a vein, or a placebo. The study did not aim to treat any disease, only to …

This study looked at how the experimental prostate cancer drug opevesostat moves through the body in men with moderate liver impairment compared to healthy men. Sixteen male participants received a single dose, and researchers measured drug levels over time. The goal was to under…

This study checked if a new insulin (NKF-INS(A)) is similar to two already-approved insulins (US-NovoLog and EU-NovoRapid). Fifty-four healthy men received a single dose of each insulin in random order. Researchers measured how fast the insulin entered the blood and how it contro…

This study looked at how a new experimental drug, AZD5004, affects the way the body processes several common medicines, including statins (for cholesterol) and repaglinide (for diabetes), and how an antibiotic (erythromycin) affects AZD5004. It involved 49 healthy adults aged 18 …

This study looked at how blood sugar levels after eating differ between normal-weight and overweight adults. Twenty healthy participants ate bread and juice, and their blood sugar was measured over two hours. The goal was to understand if body weight affects blood sugar spikes, w…

This study tested a new propellant (HFA-152a) in salbutamol inhalers to see if it works like the current propellant (HFA-134a). Sixty healthy adults aged 18-55 received single doses of salbutamol via both inhalers. The goal was to measure how much drug gets into the blood and how…

This study tested how a single session of resistance training, with or without added stretching, changes blood vessel function and blood pressure in healthy adults. Twenty-seven healthy men were assigned to either rest, exercise alone, or exercise plus stretching. Their blood ves…

This study tested whether immersive virtual reality affects memory in healthy adults. 16 participants from a university psychology course completed word recall tasks while using VR. The goal was to see if VR could distract people and change how well they remember information.

This study looked at how two common drugs—carbamazepine and itraconazole—change the way a new drug called AP31969 is processed in the body. Twenty-eight healthy adults took AP31969 alone and with each of the other drugs to measure differences in drug levels. The goal is to unders…

This study looked at how healthy adult men process and eliminate a single dose of the drug quemliclustat. Eight participants received a radioactive-labeled version of the drug so researchers could track it in blood, urine, and feces. The goal was to understand how the drug leaves…

This study looked at how a drug called vimseltinib changes the way the body handles metformin, a common diabetes medicine. Twenty-two healthy men took both drugs and had their blood levels measured. The goal was to understand drug interactions, not to treat any disease. The study…

This study looked at how a new drug called casdatifan interacts with two other common drugs (itraconazole and phenytoin) in 14 healthy adults. The goal was to measure drug levels in the blood and check for side effects. Participants were healthy volunteers aged 18-55 who did not …

This study looked at how the brain naturally reduces pain when a person feels two painful sensations at the same time. Researchers wanted to see if paying attention to one pain can help turn down the other. Twenty-four healthy University of Washington students took part, rating t…