HEALTHY PARTICIPANTS

This study works with 26 African Methodist Episcopal churches in South Carolina to help older adults (50+) get more active through group walking. The program, called Walk Your Heart to Health, also teaches churches how to support healthy eating. Over 5 years, researchers will see…

This early-stage study tests a new drug called QL2302 against an approved drug, Tezspire, in 178 healthy adults aged 18-45. The goal is to compare how the body absorbs and processes each drug, check for side effects, and measure immune reactions. Participants receive a single dos…

This study tests whether a mild electrical pulse to the ear (called taVNS) can temporarily improve thinking skills like memory and attention in healthy adults aged 18-30. Each of the 60 participants will receive both the real stimulation and a fake (sham) version in separate sess…

This early-stage study tests the safety and how the body processes a new drug called NBX-100 in 8 healthy adults aged 21-50. Participants receive four weekly doses and have frequent check-ups and psychological support visits. The goal is to gather safety and drug-level informatio…

This study compares how well people with migraine can imagine movements (motor imagery) versus healthy individuals. Researchers will also check if these imagery skills relate to body awareness, balance, anxiety, and depression. About 136 adults aged 18-65 will participate, using …

This study looks at how the brain uses feedback to control speech in 90 adults aged 18-50, including people who stutter, have dyslexia, and those with typical speech. Participants will do speech tasks, have an MRI scan, and receive mild brain stimulation to see how different brai…

This early-stage study looks at how food and a common stomach-acid drug (rabeprazole) affect the amount of HMPL-760 in the blood. About 24 healthy adults will take the drug under different conditions—fasting, with a high-fat meal, or after rabeprazole. The goal is to learn how th…

This early-stage study is the first time AK0406 is being tested in humans. It will involve 32 healthy adults to check if the drug is safe and how the body processes it. No treatment is being given for any disease—this is purely a safety check.

This study looks at whether exercising in the morning or evening changes how we feel pain. Healthy adults aged 18-40 will do exercise sessions at different times and have their pain thresholds measured. The goal is to understand if our body's internal clock affects pain relief fr…

This study looks at how a special nutritional drink affects blood sugar levels in 30 healthy adults. Participants will drink both the test supplement and a sugar solution on different days to compare the effects. The goal is to measure the drink's glycemic index, which tells us h…

This early-stage study tests whether enicepatide is safe and how the body processes it in 36 healthy Chinese adults with a BMI of 23 or higher. Participants will receive either the drug or a placebo, and researchers will monitor side effects and drug levels in the blood. The goal…

This early-stage study is testing a single dose of a new drug, STLX-2012, in 32 healthy adults aged 18 to 55. The main goal is to check if the drug is safe and how the body processes it. Participants will be randomly assigned to receive either the drug or a placebo. This study do…

This early-stage study will test whether a single tablet containing two drugs (laroprovstat and ezetimibe) works the same in the body as taking each drug separately. It will also check if eating affects how the drugs are absorbed. The study involves 18 healthy adults aged 18 to 5…

This study aims to understand how a quick, non-invasive brain stimulation treatment called iTBS works in people with depression. Researchers will measure brain activity before and after stimulation in 100 participants (healthy volunteers and those with depression) using EEG and M…

This early-stage study looks at how a common antifungal drug (itraconazole) changes the way the body handles an experimental drug called HS-10506. It involves 20 healthy Chinese adults aged 18-45. The goal is to measure drug levels in the blood, not to treat any disease.

This study looks at how different amounts and patterns of manual pressure on the upper back affect the body in healthy adults aged 18 to 65. Researchers will measure changes in heart rate, stress hormones, pain sensitivity, and blood flow. The goal is to learn how to make manual …

This study watches how gut bacteria and their byproducts change over a year in 100 adults after gastric bypass surgery. It compares them to people with obesity on diet alone and healthy normal-weight adults. The goal is to link these gut changes to weight loss and better health, …

This study aims to better understand how a brain region called the dorsolateral prefrontal cortex (DLPFC) connects to other areas, which could improve a treatment called rTMS for depression. Researchers will use advanced MRI scans and brain stimulation with EEG in 34 healthy adul…

This early-stage study tests whether an experimental inhaled powder called SYH2059 is safe and how it moves through the body. It involves 84 healthy adults aged 18 to 55 who will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels i…

This study compares three fiber supplements—LOAM prebiotic fiber, inulin, and a placebo—to see which causes the least gas and digestive discomfort in healthy adults who eat a low-fiber diet. Participants take one daily serving for four weeks and wear a small device that tracks ga…

This study tests a new way to take CT scans of the knee while it is gently pressed, like standing, to see if it can spot implant movement earlier. It includes 15 people: healthy volunteers and those with a knee replacement. The goal is to improve future imaging, not to change cur…

This study looks at how different breathing patterns during strength exercises (like lifting weights) affect eye pressure and the tiny blood vessels in the back of the eye. Researchers will measure these changes in 60 healthy adults aged 18-40 before, during, and after exercise. …

This study tests two different versions of a deuterated remdesivir oral suspension in 48 healthy Chinese adults to see how well each is absorbed. Participants will receive both forms in a random order. The goal is to find out if the new formulation works as well as the original, …

This study gives 50 healthy adults a one-time dose of psilocybin (the active ingredient in magic mushrooms) or a placebo to measure changes in brain waves, blood chemicals, and empathy. Participants must have never used psychedelics before. The goal is to understand the biologica…

This study tests two different forms of the drug evolocumab in 400 healthy adults aged 18 to 60. The goal is to see how the body processes each version and to check for side effects. Participants receive a single dose and are monitored for about two months. This is not a treatmen…

This study aims to see if a mobile health (mHealth) tool, combined with decision aids, can help college students in Zimbabwe better access HIV prevention and contraception services. Researchers will work with 16,000 students to develop and test the tool over several stages, inclu…

This study aims to establish normal reference ranges for liver and other organ measurements in healthy adults from different ethnic backgrounds in Singapore. Researchers will use MRI scans to measure fat, inflammation, and organ sizes. The goal is to improve how doctors interpret…

This study looks at whether a special warm-up that includes balance and coordination exercises works better than a standard warm-up for improving balance and leg strength in healthy adults who go to the gym regularly. About 46 people aged 18 to 40 will take part in 6 weeks of sup…

This study looks at how plant sterols—natural compounds found in plants—affect a newly discovered protein called cholesin and its receptor GPR146, which helps control cholesterol production in the liver. Researchers will give 23 healthy adults three different test meals (low chol…