HEALTHY PARTICIPANTS

This early-stage study tests a new vaccine called VXB-251 in 240 healthy adults aged 60-83. The vaccine is designed to protect against three viruses that can cause serious lung infections: RSV, hMPV, and PIV3. Researchers will check if the vaccine is safe and how well it triggers…

This study tests whether two herbal supplements (CL19183 and CL24212) can help overweight adults lose weight and improve metabolic health. About 150 healthy but overweight participants (BMI 25-30) will take the supplements or a placebo, follow a standard diet, and walk 30 minutes…

This early-stage study tests a new drug called AZD0780 in 40 healthy adults with high LDL (bad) cholesterol. Participants receive either the drug or a placebo to see if it safely lowers cholesterol levels. The goal is to gather initial safety and effectiveness data before moving …

This study tests the safety of giving repeated annual doses of an experimental drug called CD388 to healthy adults. About 400 people who already tolerated one dose without serious side effects will receive two more doses over two years. Researchers will monitor for side effects a…

This study tests whether a virtual reality (VR) game can help primary schoolchildren (ages 6-12) learn and practice better hygiene to prevent the spread of COVID-19 and other respiratory viruses. About 2,160 children will either play the VR game for two weeks or receive standard …

This study tests whether giving a high-dose flu vaccine together with a new long-acting antiviral drug, CD388, is safe and does not weaken the body's immune response. About 100 healthy adults aged 18 to 49 will receive either the vaccine plus CD388 or the vaccine plus a placebo. …

This study compares a new surgical method (gingivalstat) to the standard approach for correcting a gummy smile in 22 adults. The goal is to see which method keeps the gum line more stable over 6 months after surgery. Participants must have a specific type of gummy smile and be in…

This study looked at whether taking 400 mg of magnesium citrate daily for 90 days could improve sleep quality and thinking skills in healthy Saudi adults who had poor sleep. 41 adults took part, with one group getting the supplement and another group getting nothing. Researchers …

This study checks if two different devices for injecting trastuzumab under the skin work the same way in the body. It involves 312 healthy men who will get a single dose. The goal is to see if the drug levels are similar, not to treat any disease.

This early-stage study tests whether the experimental drug mRNA-0184 is safe in healthy adults. About 52 participants will receive one or more doses and be monitored for side effects. The study does not aim to treat any disease, but to gather important safety and drug-level infor…

This study tests whether focused ultrasound to the brain can change how the anesthetic propofol works. Ten healthy adults will receive both real and fake ultrasound while under sedation. Researchers will measure brain signals and response times to see if ultrasound alters anesthe…

This study tests a new drug called QL2106 against an approved drug, Tremfye® (guselkumab), in 190 healthy adults aged 18-45. The goal is to compare how the body processes each drug, their safety, and immune response after a single dose. Participants receive one injection and are …

This study looks at whether listening to self-chosen Levantine music can change how much pressure pain a person can tolerate, compared to sitting in silence. Thirty-two healthy young adults in Lebanon will take part, each experiencing both silence and music in a random order. The…

This study looks at whether using intermittent pneumatic compression (IPC) boots after exercise helps college athletes recover faster. Researchers will measure blood lactate (a sign of muscle fatigue), ankle flexibility, and jump performance in 38 NCAA athletes. The goal is to se…

This study looks at how a new drug called AZD5004 changes the way the body handles two diabetes medications, mitiglinide and pioglitazone. It involves 32 healthy adults and does not aim to treat any disease. The goal is to gather safety and drug-level information to guide future …

This early-phase study tests the safety and tolerability of a new drug called AZD0292 in 18 healthy Japanese adults. Participants receive a single dose of the drug or a placebo by IV infusion. The goal is to see how the body processes the drug and check for any side effects.

This study looks at whether a very short, intense workout—just one or two 10-20 second bike sprints, twice a week—can improve heart and lung fitness in inactive adults. Sixty healthy, overweight but otherwise healthy participants will do this for 9 weeks. Researchers will measure…

This early-stage study tests the safety and how the body handles a single dose of IBI3033 in 32 healthy Chinese adults. Participants receive either the drug or a placebo and are monitored for side effects and drug levels over 12 weeks. The goal is to gather safety data, not to tr…

This early-stage study tests a new drug called INCA033989 in 72 healthy adults aged 18 to 55. Participants receive a single dose either as an injection under the skin or through an IV. The goal is to measure how the drug moves through the body and check for any side effects. This…

This study looks at whether vitamin D levels are linked to certain immune markers in people with active tuberculosis (TB), with or without a chronic fungal lung infection called aspergillosis. Researchers will compare blood samples from 300 adults—including healthy volunteers—to …

This study looks at whether a special breathing warm-up can improve the strength of muscles used for breathing in athletes during exercise. About 28 trained athletes aged 14-30 will try three different routines: a breathing warm-up, a fake warm-up, and no warm-up. The goal is to …

This study tests whether a new biosimilar medicine (CT-P52) works similarly to the approved drug Taltz in the body. It involves 218 healthy adults aged 19 to 55 who receive a single dose of either the biosimilar or Taltz. The main goal is to compare how the drug is absorbed and i…

This study looks at how well three different tablet versions of the drug LY4100511 are absorbed by the body in 48 healthy adults. It also checks if taking a common stomach acid medicine (a proton pump inhibitor) changes absorption. The goal is to find the best tablet form for fut…

This study tests whether using a simple pillow can teach CPR as effectively as a standard manikin. Researchers will compare compression depth, number of compressions, and hand position in 128 healthy adults. The goal is to find a more affordable and accessible training tool for n…

This study looks at how healthy men absorb, break down, and get rid of a test medicine called AZD4144. Eight men aged 30 to 65 will receive a single dose either by mouth or through a vein. A tiny radioactive tag lets researchers follow the drug's path in the body.

This study looks at how a single session of Swedish massage or light touch therapy changes brain activity, heart rate, blood pressure, breathing, and mood in healthy adults. Thirty participants will be randomly assigned to receive either massage or light touch. Brain scans (MRI) …

This early-stage study tests a new drug called STAR-0310 in 40 healthy adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor for side effects. This study does not aim to treat any disease; it is a fir…

This study looks at brain activity and heart patterns in people who have had a stroke and compares them to healthy adults. Researchers use special head sensors and heart monitors to measure differences. The goal is to better understand how stroke changes the brain and heart. No t…

This study was designed to check if new combination tablets of nirmatrelvir and ritonavir work the same as the already-approved Paxlovid tablets. It was planned for about 28 healthy adults aged 18 and older, who would take single doses of different tablet forms under fasting cond…

This study looks at whether four one-hour coaching sessions with a psycho-oncologist can help doctors and nurses who treat cancer patients. The goal is to improve how they talk with patients and handle difficult emotions. 62 oncology physicians and nurses will take part, and rese…

This study tests whether a single tablet containing both laroprovstat and rosuvastatin works the same as taking each drug separately. It involves 44 healthy adults aged 18 to 55 who will receive single doses of different tablet forms. The goal is to compare how the body absorbs t…

This study looks at how often people who wear contact lenses need to visit their optician. Right now, there are no clear rules on the number of follow-up visits needed. The goal is to create better guidelines to make care both safe and efficient. About 300 healthy adults aged 18 …

This early-stage study tests how different doses of andexanet reverse the effects of common blood thinners (rivaroxaban or apixaban) and how it interacts with another blood thinner, enoxaparin. It involves 179 healthy adults and measures blood clotting activity. The goal is to ga…

This early-stage study tests whether a single injection of AG-236 is safe and tolerable in healthy adults aged 18 to 55. About 24 participants will receive either the drug or a placebo. The study does not aim to treat any disease, but to gather important safety and drug-level inf…

This study looks at how heat therapy and foam rolling change the force athletes can produce in their legs during a squat jump. Researchers will measure jump force and leg strength in 38 healthy college athletes. The goal is to understand if these simple treatments can improve mus…

This early-stage study tests the safety and how the body handles a new drug called IBI3033 in 8 healthy Chinese adults. Participants receive either the drug or a placebo and are monitored for side effects and drug levels over 20 weeks. The study does not aim to treat any disease,…

This study looks at whether an educational program on patient safety can shift the perceptions of nursing leaders and educators in a Saudi medical city. About 102 head nurses, assistant head nurses, supervisors, and educators will take a survey before the training, then again at …

This study aims to develop better tools for measuring thinking skills and daily function in healthy older adults. Researchers will compare new computerized tests with standard ones over one year. The goal is to find measures that are more accurate and less affected by practice, w…