HEALTHY PARTICIPANTS

This study tested a new drug called BGB-45035 for the first time in humans. It looked at safety in healthy volunteers and then in people with autoimmune skin diseases like atopic dermatitis (eczema) and prurigo nodularis (a condition causing intensely itchy bumps). The goal was t…

This early-stage study tested a new drug called AZD6234 in 104 healthy adults with overweight or obesity. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored side effects and d…

This early-stage study tested a daily pill called AZD4144 in 28 people with obesity to see if it is safe and how it affects inflammation in the body. Participants took either the drug or a placebo for a short time. The main goals were to check for side effects and measure changes…

This study tested whether a 4-week program of eccentric hip exercises using elastic bands could improve hip strength and agility in young male basketball players aged 15-18. Twenty-one healthy players were split into two groups: one did the band exercises plus regular training, t…

This study tested whether a short, 3-minute neck stretch could lower blood pressure in 25 healthy adults. Participants did a gentle stretch on one side of the neck, and researchers measured blood pressure, tissue stiffness, and heart rate changes. The goal was to see if stretchin…

This completed trial tested PeptiSleep, a plant-based supplement made from rice protein, to see if it improves sleep quality in healthy adults. 120 participants took either PeptiSleep or a placebo daily for 6 weeks while wearing a sleep tracker and completing surveys. The study m…

This pilot study tested whether a daily probiotic and grape extract supplement (in a capsule or chocolate bar) could improve stress and sleep in 40 healthy adults with moderate stress. Participants took the product for 4 weeks, and researchers measured changes in perceived stress…

This early-stage study tested the safety and tolerability of a new drug called IBI356 in 99 participants, including healthy volunteers and people with atopic dermatitis (a type of eczema). The main goal was to check for side effects and how the drug moves through the body. No cla…

This early-stage study tested a single dose of a new drug called IBI3002 in 52 healthy volunteers and people with mild to moderate asthma. The main goal was to check if the drug is safe and how the body processes it. Participants were randomly assigned to receive either the drug …

This study tested whether a special electronic syringe (Dentapen) causes less pain and stress during dental numbing shots compared to a regular syringe. Forty healthy adults getting teeth pulled for braces took part. Researchers measured pain using a 0-100 scale and stress by tra…

This study looked at 100 children aged 9 to 11 to see if pinch grip strength is related to how well they write. Kids did a handwriting test and had their pinch strength measured with a special gauge. The goal was simply to understand the connection better, not to test any treatme…

This phase 1 study looked at how the drug casdatifan interacts with two other drugs (itraconazole and phenytoin) in 14 healthy adults. The goal was to see how these drugs affect the levels of casdatifan in the body and to check for any side effects. The results will help guide fu…

This study tested different versions of the drug TEV-56286 (emrusolmin) in 47 healthy adults to see how well the body absorbs each form. Participants took a single dose of either a new formulation or a reference capsule, and researchers measured drug levels in the blood. The goal…

This study tested how well healthy adults tolerate immunoglobulin G (IgG) injections given under the skin. Researchers tried different injection conditions to see which caused the least pain and side effects. The goal was to gather information to improve future treatments for peo…

This study looked at how 12 months of personalized endurance training—swimming, cycling, and running—affects the body and mind of healthy adults who were not regular exercisers. Fifty-eight people aged 19-39 took part, with some training up to 20 hours a week and others serving a…

This study looked at whether eating carbohydrates at the end of a pre-exercise meal (instead of at the start) changes how the body burns fat and carbs during exercise and affects cycling performance. Eighteen healthy, trained male athletes ate a standard meal in two different ord…

This completed Phase 1 study looked at how vimseltinib affects the way the body processes metformin, a common diabetes drug. Twenty-two healthy men took vimseltinib and metformin to measure drug levels and check for side effects. The goal was to understand drug interactions, not …

This completed Phase 1 study in 20 healthy adults tested whether taking capivasertib changes how the body absorbs and clears rosuvastatin, a common cholesterol-lowering drug. Participants received rosuvastatin alone and then again with capivasertib, and researchers measured drug …

This completed Phase 1 study looked at how healthy men absorb, process, and eliminate the experimental drug PF-07220060. Twelve men took a single dose by mouth or by mouth plus a vein injection. Researchers measured the drug in blood, urine, and feces to understand its journey th…

This completed Phase 1 study in 14 healthy volunteers looked at whether an experimental drug called AZD0780 changes how the body processes metformin, a standard diabetes medication. Participants took both drugs in a fixed order, and researchers measured drug levels in the blood. …

This study tested whether a virtual trainer avatar giving real-time feedback during VR exercise helps people exercise more accurately and feel better. Twenty-eight healthy adults each tried three short VR workouts: one with no feedback, one with verbal feedback, and one with both…

This early-stage study tested the safety and how the body handles a new drug called S-740792 in 99 healthy adults. Participants received single or multiple doses as a liquid or tablet, and some also took midazolam to check for drug interactions. The trial is complete and helps de…

This completed study tested 18 different transdermal patches on 26 healthy adults to see if they cause skin irritation. Patches were applied for 24 hours and skin reactions like redness and swelling were checked. The goal was to confirm the patches are safe for the skin.

This study compared three types of cycling training in 45 sedentary but healthy adults over 14 weeks. One group did high-intensity eccentric cycling (resisting the pedals), another did moderate eccentric cycling, and the third did high-intensity regular (concentric) cycling. Rese…

This completed Phase 1 study looked at how a single dose of the insulin drug THDB0206 behaves when injected into the upper arm, abdomen, or thigh. Twenty-seven healthy Chinese adults each received the same dose at all three sites in a random order. The goal was to see if the inje…

This early-stage study tested a single dose of the drug UCB9741 in 40 healthy adults, half of Caucasian descent and half of Japanese descent. The goal was to check for side effects and how the drug moves through the body. No treatment benefit was expected, as this was purely a sa…

This completed phase 1 study tested how quickly an inhaled form of alprazolam (Staccato) affects brain activity compared to intravenous midazolam and nasal diazepam. Fifty-five healthy adults received single doses of each drug in a crossover design. Researchers used EEG brain wav…

This completed study tested whether a short session of neck stretching or using a massage roller on the neck could improve flexibility not only in the neck but also in the hip. Thirty healthy adults participated, and researchers measured range of motion and tissue stiffness. The …

This study tested whether taking a daily 5-minute bath in hot water (45°C) for two weeks could help healthy young adults adapt to heat. Researchers measured changes in body temperature, heart rate, and other signs of heat stress in 26 participants. The goal was to see if such a s…

This study looked at whether a 40-second magnetic brain stimulation (called continuous theta burst stimulation) over the left or right prefrontal cortex changes how quickly healthy adults pay attention to emotional versus neutral images. Ninety-one participants received either re…

This early-stage study tested different oral versions of the drug AZD5004 in 65 healthy adults. The goal was to see how the body absorbs and processes each version, and whether taking it with food changes those effects. The study is complete, but results are not yet available.

This completed phase 1 study looked at how three common drugs—an antifungal (itraconazole), an antibiotic (rifampin), and acid reducers (esomeprazole, famotidine)—change the way a new experimental drug (INCB161734) moves through the body. Sixty-three healthy adults aged 18 to 55 …

This completed Phase 1 trial tested a new formulation of oral semaglutide in 264 healthy participants. The goal was to compare how much of the drug gets into the blood from the new tablet versus the current version. Participants took different doses over 21 weeks, and researchers…

This study tested whether the drug tozorakimab enters the body the same way when given by two different injection devices: an autoinjector and a prefilled syringe. 254 healthy adults each received one injection. The goal was to see if the devices deliver the drug consistently, wh…

This study tested whether a new biosimilar drug called CHS-1420 works similarly to the approved drug Humira (adalimumab) in the body. It involved 238 healthy Chinese adults who received a single injection of either drug. The goal was to compare how the drugs are absorbed and proc…

This study looked at how taking the drug Admilparant with or without food changes the amount of drug in the blood. Fifty-six healthy adults took the tablet in two different conditions. The results will help doctors know whether to take this medicine with meals.

This study looked at how a long-acting painkiller (nalbuphine ER) affects and is affected by two lung fibrosis drugs (pirfenidone and nintedanib) in 132 healthy adults. Researchers measured drug levels in the blood and monitored for side effects. The goal was to see if these drug…

This study looked at how much of the COVID-19 treatment nirmatrelvir (taken with ritonavir) passes into breast milk. Eight healthy breastfeeding women took the medicine by mouth three times over two days. Researchers collected breast milk samples to measure drug levels and safety…

This study looked at how foam rolling the neck affects blood pressure and neck flexibility in 24 healthy young adults. Researchers measured blood pressure, heart rate, and range of motion before and after the rolling. The goal was to understand if this simple technique can influe…

This study looked at how two common drugs—carbamazepine (a strong inducer) and itraconazole (a strong inhibitor)—affect the levels of a single dose of AP31969 in the blood of 28 healthy adults. The goal was to understand how these interactions might change the drug's breakdown, w…

This study looked at how taking ammoxetine tablets with or without food changes the drug levels in the body. Fourteen healthy adults participated in a two-period crossover design. The goal was to understand food's impact on drug absorption to guide future dosing recommendations.

This study looked at what makes it easier or harder for Turkish young people (ages 15-24) to be physically active. Researchers surveyed 318 healthy volunteers about their activity levels, stress, and daytime sleepiness. The goal is to understand these factors so better programs c…

This study tested a 5-day course of an oral NAD+ supplement in 60 healthy adults aged 45-75. Researchers measured changes in blood markers and NAD+ levels compared to a placebo. The goal was to understand the supplement's effects on health-related molecules and confirm safety, no…

This study looked at how much of the drug rozanolixizumab appears in breast milk after a single dose. Fifteen healthy lactating women who had already decided to stop breastfeeding took part. Researchers measured drug levels in milk over 7 days to estimate how much a baby might be…

This study looked at whether short daytime naps help teenage soccer players perform better. Sixteen male athletes tried no nap, a 25-minute nap, or a 45-minute nap before agility and sprint tests. Results showed that napping improved agility and made exercise feel easier, but did…

This early-stage study tested the safety of a new drug called AZD2389 in 120 healthy adults. Researchers gave single or multiple doses to see how the body handles the drug and if it causes side effects. No treatment benefit was expected, as the goal was simply to gather safety an…

This study looked at how a single dose of a drug called INCB123667 moves through and leaves the bodies of 9 healthy men. The drug was tagged with a tiny amount of radioactivity to track it in blood, urine, and stool. The goal was to understand how the drug is processed and elimin…

This study tested whether immersive virtual reality affects memory and distraction. 16 healthy adults tried to remember word lists while either using VR or not. The goal was to see if VR changes how well we recall information and how distracted we feel.

This completed Phase 1 study looked at how a new drug called elenestinib affects the way the body processes midazolam (a sedative) and a common birth control pill. Twenty healthy adult women took these drugs with and without elenestinib, and researchers measured drug levels in th…

This completed early-phase study looked at how healthy adults' immune systems respond to the rabies vaccine when given alone or with an extra immune booster (rabies immune globulin). Thirty participants received different combinations of vaccine and booster at various times. The …

This completed study looked at whether whole-wheat bread with added carob molasses pulp and germ can improve blood sugar response and antioxidant levels in healthy adults. Twenty volunteers aged 19-35 ate both standard and enriched breads, then had blood samples taken over three …

This early-stage study involved 18 healthy adults to see how a new tablet version of the drug minzasolmin is absorbed compared to an older capsule form, and whether food changes absorption. Participants took single doses under fasting or fed conditions. The study is complete and …

This completed study looked at how much of the pain-relieving gel diclofenac (Voltaren) ends up in rinse water after people apply it by hand or with an applicator and then wash or wipe the area. Thirty-three healthy adults took part. The goal was simply to measure the amount in t…

This study looked at how a drug called vimseltinib affects two important proteins (BCRP and OATP1B1) that help move medicines in the body. Twenty healthy men took rosuvastatin, a common cholesterol drug, with and without vimseltinib to see if vimseltinib changes how much rosuvast…

This study looked at whether a roller massage (like using a foam roller) can temporarily lower blood pressure in healthy young adults. Researchers measured changes in tissue hardness and blood pressure after a short massage session. The goal was to understand how massage might af…

This early-stage study looked at how well two tablet versions of the experimental drug ZN-A-1041 are absorbed compared to a capsule form. It involved 18 healthy adults and also planned to check if food or a stomach-acid drug changes absorption, though that part was canceled. The …

This early-stage study tested the safety and how the body processes a single dose of donzakimig in 32 healthy Chinese and Japanese adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. The goal was to …

This study tested whether a store-bought high-protein yogurt drink helps muscles recover after intense exercise. Healthy adults aged 18 to 45 drank either the protein drink, a plain protein drink, or a flavored water placebo. Researchers measured amino acid levels in the blood an…

This study looked at how a type of ear acupuncture (using tiny press needles) changes brain connections and nerve activity in 40 healthy adults. Researchers used brain scans to see if the acupuncture affects areas linked to emotion and body awareness, similar to vagus nerve stimu…

This study looked at whether a new drug called clofutriben affects how the body handles two common medicines, midazolam and prednisolone. Sixteen healthy adults took clofutriben daily for 16 days along with single doses of the other drugs. The goal was to measure drug levels in t…

This study looked at how a new drug called AZD5004 affects the way the body processes several common medicines, including statins (for cholesterol) and repaglinide (for diabetes), in healthy adults aged 18 to 55. It also checked how another drug, erythromycin, affects AZD5004. Th…

This completed Phase 1 study enrolled 5 healthy men aged 35-55 to see how a single oral dose of a radioactive form of the drug INCB099280 is absorbed, processed, and eliminated. Researchers measured radioactivity in urine, feces, and blood over time. The study does not test treat…

This study looked at how well two different tablet versions of an experimental drug (PF-07220060) enter the bloodstream. It also tested whether taking the drug with food or with a stomach acid medication (rabeprazole) changes absorption. About 113 healthy adults aged 18–65 took p…

This early-stage study tested the safety and how the body handles a new drug called AZD6793 in 39 healthy Japanese and Chinese adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in the blood. The study was comple…

This study looked at how a gentle, non-invasive brain stimulation technique called tDCS affects stress and the ability to imagine future events. Sixty healthy adults aged 18-30 took part in an MRI session where they received either real or fake stimulation. The goal was to unders…

This study tested 50 healthy adolescents aged 15-16 to find normal handgrip strength values using a digital device. Participants squeezed the device as hard as possible, and their results were compared across two sessions to check reliability. The goal is to create reference data…

This early-stage study tested the safety and how the body handles different doses of an experimental drug called PF-06414300. 63 healthy adults aged 18-65 received either the drug or a placebo. The goal was to measure side effects and drug levels in the blood, not to treat any il…

This study looked at how breathing in simulated wildfire smoke for just one hour affects healthy adults. Researchers measured a blood marker called p-tau, which is linked to memory problems, and tested thinking skills before and after exposure. The goal was to see if short-term s…

This early-stage study tested a new drug called INCB160058 in 137 healthy adults aged 18 to 55. The main goal was to check the drug's safety and how the body processes it, not to treat any disease. Participants took a single dose by mouth, and researchers monitored side effects a…

This study tested whether a short, personalized virtual reality (VR) experience could help general practitioners (GPs) feel better and become more flexible in their thinking. Twenty-one healthy GPs took part in a single session where they used a VR headset and then reflected on t…

This early-stage study tested the safety and how the body processes an inhaled drug called AZD4604. It involved 56 healthy Japanese and Chinese volunteers who received either the drug or a placebo. The goal was to check for side effects and measure drug levels in the blood, not t…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This early-stage study tested a new drug called AZD8965 in 147 healthy adults, including Japanese and Chinese participants. The main goal was to check if the drug is safe and how the body processes it, both with and without food. No treatment was given for any disease, so this st…

This study measured how the number of calories and the time of day you eat affect your body's energy use and blood vessel health. Twenty healthy adults ate test meals while researchers tracked their metabolism and pulse. The goal was to understand how meal choices influence metab…

This early-stage study tested the safety of a new drug called CDX-622 in 85 healthy adults aged 18 to 55. Participants received either the drug or a placebo, and researchers monitored side effects, drug levels in the blood, and certain body chemicals. The goal was not to treat an…

This study looked at how well two different versions of an experimental oral drug (deuterium deuremidevir) are absorbed by the body. It involved 18 healthy Chinese adults aged 18 to 45. Participants took each version once, and researchers measured drug levels in their blood to co…

This study looks at how two drugs (camizestrant and carbamazepine) affect each other in the body of healthy postmenopausal women. It does not aim to treat any disease—just to measure drug levels in the blood. Forty women will take the drugs in a fixed order, and researchers will …

This study looked at how the drug MK-8527 moves through the body in people with mild or moderate liver impairment compared to healthy volunteers. 18 participants received a single dose, and researchers measured drug levels in the blood over time. The goal was to understand how li…

This study looked at how a nature-based therapy program affects stress and quality of life in 100 healthy adults living near the coast in Barcelona. Participants took part in nature activities, and researchers measured their stress levels, emotional well-being, and overall health…

This study looked at how a high-fat, high-calorie meal changes the amount of two drugs (zibotentan and dapagliflozin) in the blood of healthy people. Twenty-six adults took a single dose of the combined pill once after eating and once on an empty stomach. The goal was to see if f…

This study looked at how taking plixorafenib with food or with cobicistat (a drug that boosts other medications) changes the amount of plixorafenib in the blood. 28 healthy adults aged 18 to 55 took single doses of plixorafenib under different conditions. The goal was to gather s…

This study looked at how carrying a school backpack on one shoulder versus both shoulders changes the pressure on the soles of the feet in 92 healthy teenagers. Researchers found that carrying a backpack on one shoulder increased the amount of foot touching the ground, but the ov…

This early-stage study tested the safety and tolerability of a new drug called LY4060874 in 121 healthy adults. Participants were monitored for side effects and how the drug moved through their bodies. The study did not aim to treat any disease, but to gather important safety inf…

This study looked at whether a 12-week exercise program (three times a week) could improve thinking skills in healthy adults aged 50 to 80. Researchers measured hormones like leptin and irisin, as well as other brain-related chemicals, before and after the program. The goal was t…

This study tested two different ultrasound-guided nerve stimulation protocols on 86 healthy adults to see which one improves handgrip strength more. Participants received a single 10-minute session targeting the median nerve. The goal was to gather knowledge for future rehabilita…

This study tested how the drug AZD5004 interacts with itraconazole (an antifungal) and birth control pills in 51 healthy adults. The goal was to see if these drugs affect each other's levels in the body. Results will help guide safe dosing for future patients.

This study looked at how two different versions of the drug LY4064809 enter the bloodstream and how long the body takes to remove them. It involved 24 healthy adults who stayed at a research center for about a month. The goal was to gather information, not to treat any disease.

This early-stage study tested a new medicine, NNC0650-0013, which may one day treat type 2 diabetes. Eleven healthy men received a single injection of the drug or a placebo to check for safety and how the body processes it. The study lasted 11 to 17 weeks and required some overni…

This study tested whether a short virtual reality (VR) self-help program could increase hope and well-being in young adults aged 18-30. Forty healthy participants completed five sessions, starting with an in-person VR experience followed by self-guided audio and video materials. …

This study looked at how the drug MK-5684 moves through the bodies of men with severe kidney failure or end-stage kidney disease compared to healthy men. Twenty-four men took a single dose, and researchers measured drug levels in their blood over time. The goal was to understand …

This study looked at how eating a high-fat or low-fat meal changes the way the body handles a drug called ammoxetine. Eighteen healthy adults took a single dose under different meal conditions. The goal was to measure drug levels in the blood, not to treat any disease.

This study looked at how different amounts of water and delays before breakfast affect levels of a new semaglutide tablet in the blood. It involved 121 healthy men who took the tablet daily for 10 days. The goal was to find the best way to take the medicine for future use.

This early-stage study tested the safety of a new drug called ATX101 in 24 healthy adults aged 18 to 50. Participants received a single dose through a vein, and researchers monitored for side effects and how the drug moved through the body. The goal was not to treat any disease, …

This study tested how different versions of the experimental drug ziltivekimab move through the body when given as a single injection under the skin. It compared two different formulas and two injection methods: a manual syringe and a pen-injector. The study involved 267 healthy …

This early-stage study tested a single dose of a new drug, AZD5148, in 84 healthy adults to see if it is safe and how the body processes it. Participants received the drug either as a shot into a muscle or a vein, or a placebo. The study did not aim to treat any disease, only to …

This study looked at how the experimental prostate cancer drug opevesostat moves through the body in men with moderate liver impairment compared to healthy men. Sixteen male participants received a single dose, and researchers measured drug levels over time. The goal was to under…

This study checked if a new insulin (NKF-INS(A)) is similar to two already-approved insulins (US-NovoLog and EU-NovoRapid). Fifty-four healthy men received a single dose of each insulin in random order. Researchers measured how fast the insulin entered the blood and how it contro…

This study looked at how blood sugar levels after eating differ between normal-weight and overweight adults. Twenty healthy participants ate bread and juice, and their blood sugar was measured over two hours. The goal was to understand if body weight affects blood sugar spikes, w…

This study tested a new propellant (HFA-152a) in salbutamol inhalers to see if it works like the current propellant (HFA-134a). Sixty healthy adults aged 18-55 received single doses of salbutamol via both inhalers. The goal was to measure how much drug gets into the blood and how…

This study tested how a single session of resistance training, with or without added stretching, changes blood vessel function and blood pressure in healthy adults. Twenty-seven healthy men were assigned to either rest, exercise alone, or exercise plus stretching. Their blood ves…

This study looked at how healthy adult men process and eliminate a single dose of the drug quemliclustat. Eight participants received a radioactive-labeled version of the drug so researchers could track it in blood, urine, and feces. The goal was to understand how the drug leaves…

This study looked at how the brain naturally reduces pain when a person feels two painful sensations at the same time. Researchers wanted to see if paying attention to one pain can help turn down the other. Twenty-four healthy University of Washington students took part, rating t…