HEALTHY PARTICIPANTS

This study tests a new vaccine called GBP511, designed to protect against a family of viruses called sarbecoviruses (which includes SARS-CoV-2). Researchers want to see if it is safe and triggers a strong immune response in healthy adults aged 18 and older. The trial involves up …

This study tests an experimental vaccine designed to protect against E. coli bacteria, which can cause serious infections. Researchers want to see if the vaccine is safe and tolerable in 310 healthy adults aged 18 to 64. Participants will receive the vaccine or a placebo and be m…

This early-stage study tests an investigational drug called TGM-312-SC01 in healthy volunteers and people with MASH, a serious liver condition. The main goal is to check the drug's safety and how the body processes it. About 99 participants will receive either the drug or a place…

This study tests two new imaging drugs that light up tau protein clumps in the brain during a PET scan. Researchers want to see if they are safe and can help diagnose Progressive Supranuclear Palsy (PSP), a rare movement and thinking disorder. About 24 adults—some healthy, some w…

This study explores whether virtual reality goggles can be used to diagnose and monitor traumatic brain injury (TBI) by measuring how the pupil reacts to light. Researchers will test 150 participants, including people with TBI, healthy volunteers, and those with other injuries. T…

This early-stage study tests a new drug called AZD1043 in healthy adults who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. About 104 participants, including people of Japanese and Chinese descent, will receive either the dru…

This study tests whether taking a daily supplement called Alpha-Glycerophosphocholine (α-GPC) can improve thinking, memory, and physical performance in healthy adults aged 25 to 55. Over 6 weeks, 80 participants will take either α-GPC or a placebo pill, and complete cognitive tes…

This study tests a device called ZenBud that uses ultrasound (sound waves) to stimulate the vagus nerve, which controls things like heart rate and digestion. Researchers want to see if this method causes any changes in the body, emotions, or thinking of 30 healthy adults. This is…

This early-stage trial tests the safety and how the body handles a new drug called Debio 1453P. About 88 healthy adults aged 18-55 will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels in blood and urine, not to treat any disease…

This early-stage study tests the safety of a new oral drug called KT-579 for the first time in people. About 96 healthy adults will receive either the drug or a placebo to see how the body processes it and if any side effects occur. The goal is to gather initial safety data, not …

This early-stage study tests whether a new inhaled drug, CPD704, is safe and how it moves through the body. About 90 healthy Chinese adults will receive single or multiple doses. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This early-stage study is testing a new injection called KLA318-2 in 48 healthy adults aged 18 to 45. The main goal is to check if it is safe and how the body handles it. No treatment for any disease is being tested here.

This early-stage study is testing an experimental drug called TLC-1180 in healthy adults aged 18 to 55. The main goal is to check if the drug is safe and how the body handles it. Participants will receive either single or multiple doses, and some will take a tablet form to see ho…

This study looks at whether eating pistachios as a snack can improve how the body uses energy (metabolic flexibility) in healthy overweight or obese adults aged 25-45. Sixty participants will compare four days of pistachio snacking with four days of their normal diet. Researchers…

This early-stage study is testing a new drug, UCB5285, in healthy volunteers to see if it is safe and how the body processes it. About 96 healthy adults, including some of Japanese descent, will receive either the drug or a placebo. The goal is to check for side effects and measu…

This study looks at whether text messages or a built-in gaming app can encourage Black college men who binge drink to use a mindfulness app more often. Forty participants will use the app for 28 days and complete surveys. The goal is to see if these features make the app more eng…

This early-phase study tests whether a common dietary fiber called beta-glucan can improve how immune cells recognize and kill cancer cells. Healthy adults will take beta-glucan or a placebo daily for 4 weeks and complete three exercise sessions. Researchers will measure immune c…

This study looks at how blood sugar levels change during exercise in healthy adults and those with type 1 diabetes. Researchers want to see if these changes are similar each time a person exercises. Participants will cycle or rest after a standard breakfast, and their glucose wil…

This early-stage study tests the safety of a new drug called SV003 in 60 healthy volunteers. It aims to see how the body processes the drug and if it causes any side effects. No treatment benefit is expected; the goal is to gather important safety information before testing in pa…

This early-stage study tests the safety of a new drug, DF5112, in 48 healthy adults aged 18 to 55. Participants receive either the drug or a placebo by injection and are monitored for about a week in a clinic, with follow-up visits over 29 days. The goal is to check for side effe…

This study looks at how heat pads and massage guns affect the stiffness of a jaw muscle in 40 healthy adults. Researchers will use a special ultrasound to measure muscle tightness before and after each treatment. The goal is to gather information that could lead to better treatme…

This study looks at hearing in people with early-stage Alzheimer's or Parkinson's disease, compared to healthy volunteers. The goal is to find out how common certain hearing issues are, especially trouble understanding speech in noisy places even when standard hearing tests are n…

This study looks at how healthy people's blood chemistry changes from day to day and after meals. Over four weeks, 35 participants will provide finger-prick blood samples, keep food diaries, and wear activity trackers. No treatments or lifestyle changes are involved—the goal is s…

This study tests whether a single tablet containing two drugs (laroprovstat and rosuvastatin) works as well as taking each drug separately. It involves 44 healthy adults aged 18 to 55 who will receive single doses of different tablet forms. The goal is to measure how much of each…

This early-phase study tests whether the experimental drug AZD4954 is safe and how it moves through the body. It involves healthy volunteers, some with high lipoprotein(a) levels, and people with dyslipidemia (abnormal blood fats). Participants receive single or multiple doses of…

This study looks at how two common drugs—carbamazepine (a CYP3A4 inducer) and itraconazole (a CYP3A4 inhibitor)—affect the levels of a single dose of AP31969 in the blood. 28 healthy adults aged 18-55 will take AP31969 alone and with each of the other drugs. The results will help…

This study looks at whether eating carbohydrates at the start or end of a pre-exercise meal changes how athletes use fat and carbs for energy and how well they perform in a cycling time trial. Nineteen healthy, trained male athletes will eat a standard meal in two different order…

This study checks if two different devices for injecting trastuzumab under the skin work the same way in the body. It involves 312 healthy men and does not aim to treat any disease. The goal is to see if the drug levels and safety are similar between a handheld syringe and an on-…

This study looks at the best way to teach schoolchildren how to perform CPR. Researchers will compare a two-hour hands-on session with a nurse to a short video and puzzle activity. About 550 healthy children from 1st to 6th grade will take part to see which method improves their …

This early-stage study tests the safety and tolerability of a new oral drug, YH35995, in healthy adult men. Researchers will give single or multiple doses and monitor for side effects and how the drug moves through the body. The goal is to gather essential safety data before test…

This early-stage study is testing how well andexanet reverses the effects of common blood thinners (rivaroxaban, apixaban) and how it interacts with another blood thinner, enoxaparin. About 186 healthy adults will receive andexanet or a placebo. The goal is to understand dosing a…

This early-stage study tests a new drug called ACI-19764 in 78 healthy adults aged 18-65. The goal is to check its safety, how the body handles it, and its effects on immune markers. Participants receive either the drug or a placebo, once or daily for 14 days. This study does not…

This study tests a new device that prepares blood samples to look for cancer cells and DNA. It includes 45 people: 20 healthy volunteers and 25 with advanced breast cancer. The goal is to see if the tool works well for liquid biopsy, which may help detect and monitor cancer witho…

This study looks at how babies' thinking skills grow over time, both in healthy infants and those who had a brain injury around birth. Researchers will use online games and parent questionnaires to measure attention, problem-solving, and language. The goal is to learn more about …

This study looks at how the drug capivasertib changes the way the body processes dextromethorphan, a common cough suppressant. It involves 42 healthy adults who will take both drugs in a set order. The goal is to understand potential drug interactions, not to treat any disease.

This study looks at how a commercially available ketone drink (Ketone-IQ) affects sleep and breathing in 20 healthy adults. Participants will take two different doses before bed at home and report on sleep quality and any stomach issues. The goal is to understand how the body res…

This study looks at how much of the drug zilucoplan gets into breast milk. Fifteen healthy women who are already planning to stop breastfeeding will receive daily injections of zilucoplan. Researchers will then measure the drug levels in their milk to estimate how much a nursing …

This study looks at how placing tiny needles on the ear (auricular acupuncture) changes communication between two key brain areas involved in emotion and body awareness. Researchers will use brain scans (fMRI) to compare these changes to those caused by a non-invasive nerve stimu…

This early-stage study is testing different pill versions of a new drug called AZD5004 in 64 healthy adults. The goal is to see how the body absorbs each version and whether taking it with food changes that. No treatment benefit is expected—this is purely to gather safety and dos…

This study explores whether a short virtual reality (VR) self-help program can increase hope and well-being in healthy young adults aged 18-30. Participants will attend one in-person VR session followed by four self-guided sessions using audio and video materials. The goal is to …

This study looks at how drinking A2 milk, regular milk, or oat drink every day for 12 weeks affects bone health, heart health, and immune function in healthy adults aged 30 to 60. A2 milk has a different protein type that may be easier on digestion. The goal is to see if A2 milk …

This study looks at how the retina uses oxygen as people age. Researchers will measure oxygen extraction in 50 healthy nonsmokers aged 18 to 80 using special eye scanners. The goal is to understand normal age-related changes, which may help future studies on eye diseases.

This study looks at how our beliefs and expectations can change the pain we feel when watching others suffer. Healthy adults will be split into three groups: one gets no treatment, one gets a placebo nasal spray, and one gets a real oxytocin spray. All are told they are getting a…

This study looks at whether practicing fine hand movements can improve how healthy young adults process language. Forty right-handed people aged 19 to 24 will be split into two groups: one does detailed hand exercises, the other does simpler tasks. Both groups train online for 20…