HEALTHY PARTICIPANTS

This early-stage study tests a new vaccine called VXB-251 in 240 healthy adults aged 60-83. The vaccine is designed to protect against three viruses that can cause serious lung infections: RSV, hMPV, and PIV3. Researchers will check if the vaccine is safe and how well it triggers…

This study looks at whether two herbal supplements, CL19183 and CL24212, can help overweight adults lose weight and improve their health. About 150 healthy but overweight people (BMI 25-30) aged 25-55 will take the supplements or a placebo, plus walk 30 minutes daily and follow a…

This early-stage study tests a new drug called AZD0780 in 40 healthy adults with high LDL (bad) cholesterol. Participants receive either the drug or a placebo to see if it safely lowers cholesterol levels. The goal is to gather initial safety and effectiveness data before moving …

This early-stage trial is testing whether a new long-acting antiviral medicine called CD388 can be safely given at the same time as the high-dose flu vaccine. About 100 healthy adults aged 18 to 49 will receive either the vaccine plus CD388 or the vaccine plus a placebo. Research…

This study tests the safety of giving repeated annual doses of an experimental drug called CD388 to healthy adults. About 400 people who already tolerated one dose without serious side effects will receive two more doses over two years. Researchers will monitor for side effects a…

This study tests whether a virtual reality (VR) game can help primary schoolchildren (ages 6-12) learn and practice better hygiene to prevent the spread of COVID-19 and other respiratory viruses. About 2,160 children will either play the VR game for two weeks or receive standard …

This study tested whether taking 400 mg of magnesium citrate daily for 90 days could improve sleep quality and cognitive function in healthy Saudi adults who reported poor sleep. Researchers compared 41 participants who took the supplement to a control group that took nothing. Th…

This study compares a new surgical approach (gingivalstat) to the standard crown-lengthening surgery for people with a gummy smile due to altered passive eruption. The goal is to see which method keeps the gum line more stable over 6 months. About 22 healthy adults will participa…

This study looks at whether a special breathing warm-up can temporarily strengthen the muscles you use to breathe, helping athletes during exercise. About 28 trained athletes aged 14-30 will try three conditions: a breathing warm-up, a fake warm-up, and no warm-up. Researchers wi…

This early-phase trial is testing the safety and tolerability of a new drug called AZD0292 in 18 healthy Japanese adults. Participants receive a single dose of the drug or a placebo by IV infusion. The study aims to understand how the drug moves through the body and whether it ca…

This early-stage trial is testing the safety and how the body handles a single dose of IBI3033 in 32 healthy Chinese adults. Participants receive either the drug or a placebo and are monitored for side effects and drug levels over 12 weeks. Since it involves healthy people, there…

This study aims to find the best schedule for follow-up visits for contact lens wearers. Researchers will track 300 new and experienced users aged 18–40 over one year to see if fewer visits can still keep eyes healthy and comfortable. The goal is to create clear guidelines that s…

This study looks at whether using a heating pad or a foam roller before exercise can help athletes produce more force in their legs during a squat jump. Researchers will measure jump force in 38 college athletes. The goal is to see if these simple tools can improve muscle perform…

This study was designed to see if two new tablet forms of the COVID-19 drug nirmatrelvir/ritonavir (Paxlovid) are absorbed the same way as the current marketed tablets. About 28 healthy adults would have received single doses of each formulation under fasting conditions. The stud…

This early-stage study is testing a single injection of a new drug called AG-236 in 24 healthy adults aged 18 to 55. The main goal is to see if it is safe and how the body processes it. No treatment for any disease is being tested here.

This study involves 400 healthy adults aged 60-85 to test new computerized measures of thinking and daily function. Participants are randomly assigned to take either the new tests or standard tests over one year. The goal is to see if the new tests are better at detecting changes…

This early-stage study tests whether IBI3033 is safe and how the body processes it. Eight healthy adults in China will receive either the drug or a placebo. The goal is to check for side effects and measure drug levels in the blood, not to treat any disease.

This study looks at whether doing very short, intense bike sprints (10–20 seconds each) just two days a week can improve heart and lung fitness in adults who are inactive and overweight. Sixty healthy but inactive adults will do these sprints for 9 weeks, and their results will b…

This study tests whether a simple pillow can be used to teach CPR chest compressions as effectively as a standard manikin. Researchers will train 128 healthy adults using either a pillow or a manikin and compare compression depth, number, and hand position. If successful, this co…

This early-stage study is testing a new drug, INCA033989, in 72 healthy adults aged 18 to 55. The goal is to see how the drug moves through the body and whether it is safe when given as a shot under the skin or through an IV. No disease is being treated — this is a first step to …

This study looks at whether wearing inflatable compression boots after exercise helps collegiate athletes recover faster. Researchers will measure blood lactate, ankle flexibility, and jump height in 38 NCAA athletes. The goal is to see if these boots improve muscle readiness and…

This study looks at whether a special education program about patient safety can shift the views of nursing leaders and educators in a Saudi medical city. About 102 head nurses, assistant head nurses, and educators will take a survey before the training, then again 3 and 6 months…

This study looks at how a single session of Swedish massage or light touch therapy changes brain activity, heart rate, blood pressure, and mood in healthy adults. Thirty participants will be randomly assigned to receive either massage or light touch. Brain scans (MRI) are done be…

This study looks at whether four one-hour coaching sessions with a psycho-oncologist can help doctors and nurses who treat cancer patients. The goal is to improve how they communicate with patients and handle their own stress. 62 oncology physicians and nurses will take part. The…

This study checks if two different devices for injecting trastuzumab under the skin work the same way in the body. It involves 312 healthy men who will get a single dose. The goal is to see if the drug levels are similar, not to treat any disease.

This early-stage study tests whether the experimental drug mRNA-0184 is safe in healthy adults. About 52 participants will receive one or more doses and be monitored for side effects. The study does not aim to treat any disease, but to gather important safety and drug-level infor…

This study tests whether focused ultrasound to the brain can change how the anesthetic propofol works. Ten healthy adults will receive both real and fake ultrasound while under sedation. Researchers will measure brain signals and response times to see if ultrasound alters anesthe…

This study tests a new drug called QL2106 against an approved drug, Tremfye® (guselkumab), in 190 healthy adults aged 18-45. The goal is to compare how the body processes each drug, their safety, and immune response after a single dose. Participants receive one injection and are …

This study looks at whether listening to self-chosen Levantine music can change how much pressure pain a person can tolerate, compared to sitting in silence. Thirty-two healthy young adults in Lebanon will take part, each experiencing both silence and music in a random order. The…

This study looks at how a new drug called AZD5004 changes the way the body handles two diabetes medications, mitiglinide and pioglitazone. It involves 32 healthy adults and does not aim to treat any disease. The goal is to gather safety and drug-level information to guide future …

This study looks at whether vitamin D levels are linked to certain immune markers in people with active tuberculosis (TB), with or without a chronic fungal lung infection called aspergillosis. Researchers will compare blood samples from 300 adults—including healthy volunteers—to …

This study tests whether a new biosimilar medicine (CT-P52) works similarly to the approved drug Taltz in the body. It involves 218 healthy adults aged 19 to 55 who receive a single dose of either the biosimilar or Taltz. The main goal is to compare how the drug is absorbed and i…

This study looks at how well three different tablet versions of the drug LY4100511 are absorbed by the body in 48 healthy adults. It also checks if taking a common stomach acid medicine (a proton pump inhibitor) changes absorption. The goal is to find the best tablet form for fut…

This study looks at how healthy men absorb, break down, and get rid of a test medicine called AZD4144. Eight men aged 30 to 65 will receive a single dose either by mouth or through a vein. A tiny radioactive tag lets researchers follow the drug's path in the body.

This early-stage study tests a new drug called STAR-0310 in 40 healthy adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor for side effects. This study does not aim to treat any disease; it is a fir…

This study looks at brain activity and heart patterns in people who have had a stroke and compares them to healthy adults. Researchers use special head sensors and heart monitors to measure differences. The goal is to better understand how stroke changes the brain and heart. No t…

This study tests whether a single tablet containing both laroprovstat and rosuvastatin works the same as taking each drug separately. It involves 44 healthy adults aged 18 to 55 who will receive single doses of different tablet forms. The goal is to compare how the body absorbs t…

This early-stage study tests how different doses of andexanet reverse the effects of common blood thinners (rivaroxaban or apixaban) and how it interacts with another blood thinner, enoxaparin. It involves 179 healthy adults and measures blood clotting activity. The goal is to ga…