Substance-related disorder

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tested a program that combines community-based fetal ultrasound with care navigation to help pregnant women with substance use disorder engage in prenatal care and substance use treatment. The program used motivational interviewing and strength-based education to suppo…

This study tests a new program to help people with HIV who also use substances stick to their HIV medications and stay in care. The program teaches coping skills and ways to manage substance use. Researchers want to see if the program is practical and acceptable to participants. …

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This study tests whether referring Veterans in early recovery from substance use disorder to work-focused programs (like supported employment) helps them stay sober and function better. About 100 Veterans will be randomly assigned to get the work referral or usual treatment alone…

This study tested a special program to help people with both bipolar disorder and substance use problems stick to their treatment after leaving the hospital. 178 adults were split into two groups: one received extra counseling and support, while the other got enhanced safety moni…

This pilot study looks at two strategies to help pregnant and postpartum people with substance use disorder stay in treatment. One strategy screens for social needs like housing or childcare and connects patients to support. The other offers rewards for recovery-supportive behavi…

This trial tests whether tailored SMS text messages can improve treatment attendance among justice-involved youth aged 13-18 who are referred to community-based substance use or dual diagnosis treatment. Participants receive either appointment reminders plus motivational messages…

This trial tests a web-based program called ePACE, which gives teens with mild to moderate substance use and mental health issues personalized choices about content and engagement. It compares ePACE to a fixed, non-tailored program (eFACE) and to a waitlist group. Researchers wil…

This study tests whether a rotigotine skin patch (Neupro), already approved for Parkinson's disease, can help people with cocaine use disorder cut back on cocaine use when combined with behavioral therapy. Forty adults aged 25 to 70 with moderate to severe cocaine use disorder wi…

This completed study tested a program called RISE (Resiliency in Stressful Experiences) for young men ages 18-35 leaving state prisons in Florida. The program combines trauma counseling with practical help like housing and job support. Researchers measured whether participants ha…

This study tests whether a smartphone app can help people with opioid use disorder stay drug-free. Participants use the app to submit video-recorded saliva drug tests, earn rewards for staying abstinent, complete therapy modules, and get support from a peer. The study involves 25…

This early-phase study tested whether adding a medication called Auvelity (a combination of dextromethorphan and bupropion) to standard buprenorphine treatment is safe and might help reduce cravings, withdrawal, and negative feelings in people with opioid use disorder. 18 adults …

This study tested a stepped care system to help Congolese refugees and local community members in Zambia reduce unhealthy alcohol and drug use. The program started with a quick screening and brief advice, then offered more support if needed. 400 adults took part, and the main goa…

This study tests whether an app that gives financial rewards for drug-negative saliva tests works for older adults with opioid, cocaine, or methamphetamine use disorder. Researchers will compare results between older and younger participants to see if age affects how well the app…

This trial tests whether a 'learning health system'—a structured partnership between juvenile justice agencies and community mental health centers—can improve the full continuum of substance use care for youth involved in the justice system. The approach uses local data to identi…

This study tested whether N-acetylcysteine (NAC), an over-the-counter supplement, can help people who use both tobacco and cannabis quit both substances. Fifty-nine regular smokers who also used cannabis took either NAC or a placebo for 8 weeks. Researchers tracked how often they…

This study tested whether giving caregivers prize draws for attending court hearings, treatment sessions, and probation meetings could reduce substance use and delinquency in teens already in juvenile drug court. Fifty-three teens aged 13-17 and their caregivers took part. The go…

This trial tests whether a structured psychoeducation program based on the solution-focused approach can improve self-efficacy, psychological well-being, and addiction outcomes in adults with substance use disorder. Participants who have completed detoxification are randomly assi…

This pilot study tested whether tailored text messages could help head and neck cancer survivors stop drinking alcohol, which is a major risk factor for cancer recurrence. 126 survivors from a hospital and a VA medical center were randomly assigned to receive either the text mess…

This study tested a special digital pill and smartphone app to help HIV-negative men who have sex with men and who also have substance use disorder take their daily HIV prevention medication (PrEP) consistently. Forty participants took a PrEP pill with a sensor that recorded when…

This study tests a home-based parenting program called BRIGHT for pregnant women receiving treatment for opioid use disorder. The program starts in the third trimester and continues for six months after birth, focusing on the parent-child relationship, mental health, and infant d…

This study tests two approaches to help people recently involved with the justice system start HIV prevention or treatment and substance use care. One group gets standard patient navigation; the other can choose from a menu of services including in-person clinics, a mobile health…

This study tests whether offering peer support, small incentives, telehealth visits, or prepaid phones helps people with hepatitis C and substance use disorders get linked to medical care. Participants are adults in Appalachia who have tested positive for hepatitis C and have a h…

This study tests a 6-week group program called Indigenous Recovery Planning (IRP) for American Indian adults with alcohol or drug use disorder. The program is led by trained community members and includes culturally adapted exercises to prevent relapse. Researchers want to see if…

This study tested whether a paced breathing app could help women with substance use disorder resist triggers in real time. 77 women used the app whenever they felt a craving or faced a trigger. Researchers tracked substance use and feedback to see if the app helped reduce drinkin…

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

This study tested whether a once-monthly injection of buprenorphine works as well as daily pills to treat opioid use disorder in 140 pregnant women. The goal was to see if the monthly shot could reduce illicit opioid use during pregnancy and after birth. Results help doctors choo…

This study tested whether a culturally adapted therapy called CMAP Plus is practical and acceptable for people with substance use disorder who also self-harm. The therapy combines problem-solving skills with motivational interviewing and was delivered weekly for 12 weeks. The tri…

This study tested a web-based addiction treatment program that was culturally adapted for American Indians and Alaska Natives. 53 adults in outpatient treatment used the program for 12 weeks. The goal was to see if it helped them stay away from drugs and alcohol and to decide if …

This study tested two versions of a remote therapy program for teens (ages 14-24) who came to the emergency room for a violent injury. One version was standard, the other used artificial intelligence to adapt the therapy in real time. The goal was to see if the AI version could b…

This study tested a culturally adapted relapse prevention program (RPM-08) for people with substance use disorder in Pakistan. 70 male participants in residential rehab either received the program plus usual care or usual care alone. The program consisted of eight weekly group se…

This study tested whether a once-monthly injection (XR-BUP) works as well as daily pills (SL-BUP) for treating opioid use disorder in rural settings. 140 adults with moderate to severe opioid use disorder took part. The goal was to see if the injection is practical and acceptable…

This study tested a therapy called Multisystemic Therapy-Emerging Adults (MST-EA) for young people aged 16-26 with substance use issues and recent arrests. The therapy works with the young adult and their social network at home and in the community to reduce criminal behavior and…

This study tested a comprehensive program to help women involved in the criminal justice system start and stay in opioid addiction treatment. The program included peer support, housing help, overdose training, and transportation or childcare. Half of the 42 women also joined a tr…

This study tested a mobile app (uMAT-R) designed to help pregnant and postpartum women with opioid use disorder stay on their medication and treatment. 125 women participated in a pilot trial to see if the app was easy to use and helped reduce cravings and improve attitudes towar…

This study tested a 12-month telephone-based nurse care program for 805 adults with depression and signs of opioid use disorder. Participants were randomly assigned to receive nurse support or usual care. The goal was to see if the program could improve treatment for opioid use a…

This early-stage study tested whether a brief therapy program plus a mobile app could help pregnant and postpartum women stay on their buprenorphine medication for opioid use disorder. Fifteen pregnant women took part, attending therapy sessions and using the app for up to 9 mont…

This pilot study tested whether paraprofessional coaches (with or without their own history of substance use) can help young adults aged 18-26 who have been involved with the justice system reduce their opioid and other drug use. The coaches used a combination of prize-based rewa…

This completed trial tested a workplace program designed to teach young employees (ages 16-24) skills like goal-setting, stress management, and communication. Over 1,100 workers from participating stores took part. The goal was to see if the program could improve job satisfaction…

This study tested different combinations of three programs—New Hope (coping skills), Elders Resilience (cultural strength), and Case Management—to see which best reduces suicidal thoughts and builds resilience in American Indian youth ages 10-29. The 304 participants were identif…

This small pilot study tested whether a type of brain stimulation called transcranial magnetic stimulation (TMS) could help people with methamphetamine use disorder. Nineteen participants received daily TMS sessions for two weeks, then three times a week for two more weeks, while…

This study tested a structured emotional regulation program for adults in residential rehab for substance use. The program combined techniques from behavior therapy, dialectical behavior therapy, and acceptance and commitment therapy over 11 weekly sessions. Researchers compared …

This study tested a mindfulness program designed for women in residential treatment for substance use disorders. The program, called Mindfulness-Based Relapse Prevention for Women (MBRP-W), teaches stress management skills to help women stay in treatment and avoid relapse. Resear…

This study tested a wearable device that guides users through slow, rhythmic breathing to help manage stress and cravings. 120 adults with substance use disorder used the device daily for 8 weeks while continuing their usual treatment. Researchers measured changes in mood, cravin…

This study tested whether semaglutide, a drug used for diabetes and weight loss, can safely reduce alcohol drinking in people with alcohol use disorder. 80 adults took either semaglutide or a placebo, and researchers tracked how much they drank over several weeks. The goal was to…

This study tested whether peer recovery coaches in emergency departments can help people with substance use disorders connect to treatment and support. 144 adults were randomly assigned to get in-person coaching, coaching via video call, or just a list of resources. Researchers f…

This study tested whether a once-monthly injection of extended-release buprenorphine helps hospitalized patients with moderate to severe opioid use disorder stay in treatment better than usual care (like daily pills or methadone). Over 300 adults were randomly assigned to receive…

This study tested a program called iSTRIVE for 42 adults with HIV who also use opioids or stimulants and were not well engaged in HIV care. The program combined emotion regulation and communication skills training with video check-ins and small rewards to encourage daily HIV medi…

This study tested a program to help HIV-positive men who have sex with men (MSM) who also struggle with substance use. The program aimed to reduce feelings of stigma and shame that can keep them from getting HIV care. Fifty men took part to see if the program was helpful and easy…

This study tested whether a trained peer recovery specialist could help low-income, minority individuals stick with their methadone treatment for opioid use disorder. 200 participants in Baltimore were assigned to either the peer-led support program or standard care. The goal was…

This completed trial tested a special support program for veterans with both bipolar disorder and substance use problems after they leave the hospital. Half of the 138 participants received the program, while the other half got enhanced safety monitoring. The goal was to see if t…

This study looked at whether juvenile probation officers can deliver a behavioral program called Contingency Management to teens on their caseload who have drug problems. The program uses rewards and counseling to encourage teens to stop using drugs. Researchers measured drug use…

This study tested a program where people living with HIV who use stimulants (like methamphetamine) could earn rewards for staying drug-free and taking their HIV medications. 37 adults took part in a primary care clinic. The goal was to see if this reward system was practical and …

This study tested a smartphone-based program that uses rewards, coaching, and breathalyzer tests to help 236 adults with alcohol use disorder reduce drinking. Participants earned money for staying sober, tracked via breath tests and self-reports. The goal was to see if this digit…

This study tested a program that pairs peer support with a mobile app to help Hispanic and Black people with HIV stay on treatment. 309 participants were randomly assigned to the program or standard care. The goal was to see if the program helps more people achieve an undetectabl…

This study tested a digital pill and smartphone app to help people with substance use disorders take their HIV prevention medication (PrEP) consistently. Thirty HIV-negative men who have sex with men and have moderate to severe substance use disorder participated. They used a dig…

This completed study tested a mindfulness-based program (MBS) against standard care in 130 adults recovering from polydrug addiction. The goal was to see if MBS could reduce cravings and relapse risk. Researchers also looked at improvements in emotional control, mood, and motivat…

This study tested a 12-session telehealth counseling program for young people aged 18-29 living with HIV. The program used text messaging and video calls to help them stay engaged in care, manage mental health, and reduce substance use. Fifty participants were enrolled to see if …

Researchers at the University of Washington are adapting a brief narrative therapy session for use in a low-barrier primary care clinic that serves people experiencing homelessness in North Seattle. The study enrolls 64 adults who have had at least one therapy appointment at the …

This study tested whether a new personalized feedback program helps young adults ages 18-25 reduce risky alcohol and drug use. Researchers enrolled 660 participants across the U.S. and measured changes in drinking, drug problems, and readiness to change. The goal is to prevent su…

This study tests whether a single counseling session aimed at reducing stigma can help Black men who have sex with men and use substances stay on PrEP, a daily pill that prevents HIV. Participants receive the counseling and are monitored for PrEP adherence through biological test…

This study tested a program where trained peer navigators (women with similar experiences) helped women in the criminal justice system access HIV prevention services like PrEP. The goal was to reduce stigma and improve linkage to care. Thirty women participated, and the study mea…

This trial tests a program designed for Latino fathers to help them reduce risky sexual behaviors, substance abuse, and domestic violence, and improve communication with their sons. The program combines two behavioral interventions: one that teaches fathers about HIV prevention a…

This study tested a program called PRE-FAIR to prevent opioid and methamphetamine addiction in young parents (ages 16-30) already involved with Oregon's child welfare system. 240 parents who were at risk but not yet addicted were randomly assigned to either the PRE-FAIR program o…

This study tested whether a mobile app (GeoPassport), financial incentives, and peer mentor support could help men who have sex with men and transgender women leaving jail access HIV prevention services like PrEP and testing. 233 participants were enrolled and followed for 9 mont…

This study tested a school-based program called Preventure in 3,900 Canadian teens. The program targets four personality traits linked to substance misuse, aiming to delay or prevent alcohol and drug use. Researchers also measured whether delaying substance use helps protect cogn…

This study tested a web-based simulation to help college students with ADHD prescriptions avoid giving away or misusing their medication. About 250 students from three universities used the program, which taught them how to say no to requests for their pills and how to talk to th…

This study tested a single online session called webCHAT to see if it could reduce impaired driving among teens. 198 adolescents aged 15.5 to 17 who were enrolled in driver education took part. The program aimed to help them make safer choices about alcohol, cannabis, and driving…

This study tested a program for high school students to prevent misuse of prescription drugs like painkillers and sedatives. Over 1,800 teens participated in either the program or standard classes. The program used online lessons and group activities to change attitudes and build…

This small pilot study tested an 8-week mindfulness and meditation program in 3 adults with substance use disorders. Participants reported lower stress and improved mindfulness after the program. One person stayed sober long-term, while two relapsed within a year. The study shows…

This study tested whether a program designed specifically for women who use drugs could help them reduce their risk of HIV and other sexually transmitted diseases. 501 women were randomly assigned to receive either standard counseling, standard counseling plus a well-woman exam, …

This pilot study tested whether giving the HIV prevention pill Descovy (PrEP) right at a syringe services program helps people stay HIV-negative. 90 adults who use the syringe program and tested negative for HIV took part. Researchers measured drug levels in blood to see if parti…

This study tested a program called Trust-based Relational Intervention (TBRI) to prevent opioid and other drug use in 250 teens aged 15-18 who were leaving juvenile justice facilities. Each teen worked with a trusted adult to build supportive relationships. The goal was to see if…

This study tested two strategies to prevent HIV among young couples (ages 18-30) in Cape Town who use alcohol or drugs. One strategy was a community workshop to reduce stigma around HIV and drug use. The other was a couples program that provided HIV testing and counseling to help…

This pilot study tested whether involving young people in designing and running substance misuse prevention programs makes those programs more effective. Four community organizations in North Carolina took part; some used the youth engagement approach while others did not. Resear…

This study tested whether giving homeless young people (ages 18-24) a place to live plus support services could help them avoid developing opioid use disorder. 240 participants who were homeless but did not yet have opioid addiction were randomly assigned to receive either housin…

Researchers are testing whether a 7-week attachment-focused therapy program can reduce the severity of substance use disorder in adults with insecure or disorganized attachment styles. The study enrolls 48 people receiving care at an addictology day hospital. Participants are ran…

This study tested whether a virtual reality experience where people see an avatar of their future self could help those in early recovery from opioid use disorder reduce drug use and stay abstinent. 104 participants were split into a VR group and a control group. Researchers meas…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study tests whether adding trauma-informed coping strategies and peer coaching to a standard mobile brief intervention helps young adults (ages 18-25) who drink heavily and have experienced interpersonal trauma reduce their alcohol use. 225 college students will be randomly …

This early-stage study tests whether diclofenac, an FDA-approved painkiller, can reduce alcohol cravings in people with alcohol use disorder. Researchers believe diclofenac may work by shifting brain chemistry away from harmful effects of alcohol. The study involves 24 adults who…

This pilot study tests whether a single session of narrative therapy, a type of talk therapy, can help reduce depression and anxiety in people living with HIV. Researchers will enroll 64 adults from a primary care HIV clinic to see if the therapy is acceptable, feasible, and bene…

This study tests whether a 4-week breathing muscle training program can improve lung function, reduce shortness of breath, and lessen cravings in people with substance use disorder. Thirty-four adults receiving inpatient treatment will either do breathing exercises with a device …

This pilot trial tests whether adding microcurrent neurofeedback (MCN) to standard residential treatment helps adults with substance use disorder more than standard care alone. MCN uses scalp sensors to deliver barely perceptible electrical pulses tailored to each person's brain …

This early-phase trial is testing whether a generative AI chatbot called Therabot-CALM is usable and acceptable for people with cannabis use disorder who also have anxiety or depression. Fifteen participants will use the app for 4 weeks and give feedback through interviews and su…

This pilot study tests whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help reduce PTSD symptoms in adults who are in residential treatment for substance use disorders. Participants complete five guided writing sessions about their trauma. The st…

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study looked at whether adding a type of talk therapy called prolonged exposure therapy (PET) to standard opioid addiction treatment can help reduce PTSD symptoms. 82 adults with both opioid use disorder and PTSD took part. Some got only addiction treatment, while others als…

This study tested a phone-based counseling program called SBIRT-PM for veterans with chronic pain who were also at risk for substance misuse. Over 1,100 veterans participated, receiving up to four phone calls over 12 weeks to help them engage in non-drug pain treatments and reduc…

This study looked at whether a special sports program, designed with an understanding of trauma, could help teens aged 14-18 with substance use disorder. 120 teens took part, with half joining an 8-week program of sports and group talks, while the other half received no extra act…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested a 6-week mindful self-compassion program for homeless women with PTSD and substance use. The program includes meditation, group discussions, and home practices. Researchers compared the program to usual care in 202 women living in a residential drug treatment fa…

This study tested whether low-intensity focused ultrasound (LIFU) can safely reduce cravings in people with cocaine use disorder. 25 adults received either real or fake (sham) ultrasound while their brain activity was measured with MRI. The goal was to see if LIFU lowers craving …

This study tested a 6-session therapy called Acceptance and Commitment Therapy (ACT) for cancer patients at risk of opioid misuse. 40 adults with cancer and a high score on an opioid risk tool participated. The goal was to see if the therapy was feasible and acceptable, not yet t…

This study tested whether adding a personalized therapy scale to standard treatment helps reduce cravings in people with substance use disorders or behavioral addictions like gambling. 151 adults seeking outpatient care participated. The approach aimed to tailor treatment to each…

This study tested whether a short, trauma-focused therapy called Narrative Exposure Therapy (NET) can help low-income urban teens aged 16–25 who have PTSD from violence and are at risk for substance use. Researchers measured changes in PTSD symptoms and alcohol use. The goal was …

This study tested a structured psychoeducation program for 60 adults with substance use disorder who were under probation supervision. Over six weeks, participants attended weekly group sessions focused on relapse prevention, coping skills, and craving management. The goal was to…

This study tested whether slowly reducing prescribed opioids (tapering) can help people with long-term chronic pain use fewer painkillers without worsening their pain or quality of life. 140 adults on daily opioids for chronic non-cancer pain were randomly assigned to start taper…

This study looked at whether a short sleep therapy program (BBTI) can improve sleep and help people stay in treatment for substance use disorders. About 83 adults living in a residential recovery program took part. They wore sleep trackers, completed surveys, and did sleep diarie…

This study tested a breathing technique called Holotropic Breathwork to see if it helps people recover from addiction. 25 adults took part, either in a residential treatment program or living in the community. The goal was to see if the practice is safe, acceptable, and might red…

This study tested two remotely delivered programs—mindfulness-based cognitive therapy and internet-based cognitive behavioral therapy—against standard remote monitoring alone for reducing depression and substance use related to COVID-19 stress. 113 adults from a health system par…

This study tested a breathing and meditation program called SKY Recovery in 100 people recovering from substance use disorder at a residential center. Participants either took the program right away or after a delay. Researchers measured changes in emotion regulation, cravings, a…

This study looked at whether an online cognitive behavioral therapy program, called Breaking Free Online, helps people with substance use disorder cut back on their drug or alcohol use. About 200 adults from an outpatient addiction program took part. Some got standard care with g…

This pilot study tested whether adding protein supplements twice a day could reduce cravings in 28 people hospitalized for addiction. Participants spent one week with protein and one week without, rating their cravings on a simple scale. The goal was to see if a simple dietary ch…

This small study tested a structured mindfulness program for adults with both substance use disorder and anxiety. Three participants completed the program to see if it was feasible and could help reduce stress and anxiety. The study focused on emotional awareness and coping skill…

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This pilot study tested a web-based mind-body program (Web-TIRELESS) in 5 adults with painful upper-limb conditions and risky substance use. Participants completed 4 video sessions at their own pace. The goal was to see if the program was feasible, acceptable, and helpful for bui…

This study tested a 9-session program that uses cognitive-behavioral techniques to help people living with HIV quit smoking by reducing anxiety and depression. 131 daily smokers who were motivated to quit took part. The goal was to see if the program led to more people staying sm…

This study looked at whether adding a brief writing therapy called Written Exposure Therapy (WET) to a standard 28-day residential addiction program helps veterans with both PTSD and substance use disorders. Fifty-six veterans were randomly assigned to either standard care alone …

This study tested a life-skills training program for 45 men aged 20 to 50 recovering from substance use disorders. The goal was to see if the program could improve their self-efficacy, or confidence in handling daily challenges. Participants completed a structured program after d…

This study tested whether suvorexant, a sleep medication, can reduce drug use and cravings while improving sleep and stress in people being treated for both opioid and stimulant use disorders. Twenty adults stable on methadone or buprenorphine took either suvorexant or a placebo …

This completed study looked at whether combining exercise with music can help people recovering from drug addiction. 92 adults in a Chinese rehab center were split into groups: exercise only, exercise with fast music, exercise with slow music, or a control group. Over six months,…

This study tested a program called "Choizitaconso" that teaches people with alcohol use disorder how to control their drinking and reduce harm. About 110 adults took part, learning skills to manage their alcohol use and avoid negative consequences. The goal was to see if the prog…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble reintegrating into civilian life. The workshop taught skills like emotional control, problem solving, and attention to improve daily function and reduce anger. It was designed as a non-stigma…

This study looked at how cannabidiol (CBD) affects the brain in people with opioid use disorder who are also taking methadone. Researchers used brain scans to see if CBD could reduce cravings and anxiety. The study involved 66 adults and tested a single dose of CBD or a placebo, …

This study tested whether Eye Movement Desensitization and Reprocessing (EMDR) therapy can help people with substance use disorders who have also experienced trauma. 64 participants completed the treatment. The goal was to see if EMDR reduces relapse and changes brain activity an…

This study looked at whether adding a brain wave monitor (pEEG) to standard sedation checks helps reduce delirium and time on a breathing machine in ICU patients. Researchers followed 150 adults on ventilators who needed sedation. They compared those who got both the brain monito…

This completed study looked at how genes influence addiction and related behaviors. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, drug users, and people with psychiatric disorders) complete questionnaires and computer tasks. The goal was to …

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This study tested whether portable devices like PDAs and GPS units can give a more accurate picture of stress and drug use as it happens. About 373 adults in treatment for heroin addiction carried these devices for 16 weeks, recording drug use and stress levels. The goal was to s…

This completed study looked at how a person's neighborhood environment might influence drug use, addiction, and whether they seek treatment. Over 1,600 adults from Baltimore took part, including people who never used drugs, past users, and current users. Researchers collected hea…

This completed study worked with 65 African American/Black adults who use cocaine or other illicit substances to develop a manual called I-DREM. The goal was to gather their feedback on how to improve recruitment and retention in substance use disorder clinical trials. Participan…

This study followed nearly 5,000 U.S. teenagers from 10th grade into their early twenties to track how their health behaviors—like diet, exercise, substance use, and driving—changed over time. Researchers collected surveys, genetic samples, and neighborhood data to understand wha…

This study looked at whether using a Fitbit activity tracker can help people receiving inpatient treatment for alcohol use disorder increase their physical activity and improve their emotional state. Ninety adults in treatment wore the tracker and completed questionnaires about t…

This study tested two methods to encourage COVID-19 testing among people who use opioids: having friends refer others (chain referral) and using trusted community members (credible messengers). About 500 people took part. The goal was to see which method got more people tested an…

This study tests a CE-marked mobile app that scans a person's eyes to detect whether they have used certain drugs. Healthy volunteers will take a common medicine that mimics the effects of cannabis or amphetamines, then use the app to see if the eye measurements change. The goal …

This study tested a coaching and training program for addiction clinics to help them better treat opioid use disorder. The program included training on tracking patient progress, using medications for opioid use disorder, and improving patient retention. Researchers worked with n…

This study will test if a new technology tool is helpful for people living in supportive housing who also have substance use issues. The tool includes videos and rewards to teach life skills and coping strategies. Researchers want to see if residents find it easy to use and if it…

This study looks at how sleep and body clock disruptions impact the brain's reward and impulse control systems in teenagers. Researchers will monitor sleep, brain activity, and decision-making in 100 healthy high school students. The goal is to understand why poor sleep may incre…

This study tested a culturally tailored mental health training called First Face for Mental Health in seven Tribal nations. Over 550 participants completed surveys before and after training to see if it increased knowledge, confidence, and ability to help during a mental health c…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This study looked at whether chewing gum before eating ice cream affects how much people eat. Twenty normal-weight adults who liked mint chocolate chip ice cream took part. They either chewed mint, cinnamon, or no gum before a computer task where they earned ice cream. The main g…

This study looked at brain activity in pregnant women with opioid use disorder who were taking medication therapy. Researchers compared their brain scans to those of healthy pregnant women to see if there were differences. The goal was to learn more about how the body processes t…

This study used artificial intelligence to analyze personality and behavior data from 155 adults in residential treatment for substance use disorder. The goal was to find hidden subtypes of addiction that could lead to more personalized treatment. No treatment was given; the stud…

This study tested whether a mobile app could help people on probation or parole who are receiving treatment for substance use disorder. 31 adults used the app alongside their usual care. Researchers measured how easy the app was to use and how satisfied participants were with it.

This study tested a mobile app called App for Independence-O (A4i-O) designed to support people with opioid use disorder. Fourteen adults used the app for one month while receiving outpatient treatment. The goal was to see if the app works well and is easy to use, not to measure …

This study tested a computer alert that pops up when a doctor prescribes an opioid or sedative, reminding them to check Colorado's prescription drug monitoring program (PDMP). The goal was to see if the alert helps doctors follow state law and reduce risky prescribing. Researcher…

This study tested a digital version of a family training program called CRAFT. It was designed to help concerned family members (called CSOs) encourage a loved one with opioid use disorder to enter treatment. 45 adults who had a loved one struggling with opioid use participated. …

This study looked at 106 people admitted for addiction treatment at Assiut University Hospital. Researchers collected information on their personal background, drug use patterns, and personality traits. The goal was to identify trends that could help improve addiction care and pr…

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching…

This study looked at whether a short, video-based parenting program called THRIVE could work for mothers with substance use disorder who are getting care at a special clinic. Nine mothers took part to see if the program was easy to use and helpful. The goal was to gather informat…

This study tested a digital toolkit designed to help leaders in child welfare and substance use treatment agencies choose partners and build effective collaborations. Nine implementation support professionals in Ohio used the guide and rated how acceptable, appropriate, and feasi…

This study screened nearly 7,000 volunteers to find people who could take part in future research on drug addiction and its effects on the brain and body. Participants completed phone and in-person interviews, medical exams, and lab tests. No treatment or clinical care was provid…

This study measured the amount of xylazine—a dangerous animal sedative often mixed with opioids—in the blood and urine of 75 emergency room patients who had a non-fatal opioid overdose. The goal was to see how common xylazine is and how well test strips can detect it. The finding…

This completed Phase 1 study at UCLA looked at how smoking cannabis with different amounts of THC and CBD affects drug levels in oral fluid and blood, as well as thinking and feeling. Nineteen adults who use cannabis occasionally took part. The goal was to better understand how t…

This study looked at whether a program called MISSION-CJ can help homeless veterans who have both substance use and mental health problems stay out of trouble with the law. 134 veterans took part, and researchers tracked arrests, substance use, housing, and employment. The goal w…

This study looked at pregnant women being treated for opioid use disorder with two different forms of buprenorphine: a monthly shot and a daily tablet. Researchers measured drug levels in the mother's blood and checked the baby's heart rate to see how each treatment affected both…

This study looked at 71 babies born to mothers who took either a monthly injection or a daily tablet of buprenorphine for opioid use disorder during pregnancy. Researchers measured the babies' thinking, language, and motor skills using a standard child development test. The goal …

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study tested whether a set of strategies—including community teamwork, tech-based training, and peer support—could improve HIV testing and substance use care for people about to be released from jail. Researchers worked with 65 incarcerated individuals in one New York county…

This study looked at whether a questionnaire called the Behavioral Activation for Depression Scale (BADS) is a good tool for measuring depression-related behaviors in people with substance use disorders. Researchers analyzed answers from 289 adults receiving treatment for substan…

This study tested a Spanish-language electronic screening tool called TAPS-ESP to identify tobacco, alcohol, prescription drug, and illicit substance use in primary care. About 1,000 Spanish-speaking adults from a clinic participated. The goal was to see if the tool accurately de…

This study worked with 51 healthcare professionals at primary care clinics to find ways to reduce stigma toward people who use drugs, especially in HIV prevention and care. The researchers tested a program that combined education for staff and changes to clinic policies. The goal…

This study tested a new way to help addiction treatment clinics use an AI platform that coaches counselors in evidence-based techniques. Researchers worked with 479 leaders and staff from state agencies and clinics in Oregon and Indiana. The goal was to see if this strategy impro…

This study tested a new brain-training method to help people with heroin addiction reduce cravings. Participants watched drug-related videos while getting real-time feedback on their brain activity, learning to match the brain patterns of people further along in recovery. The goa…

This study tested a program where trained peer providers help young people with early psychosis reduce or stop using alcohol and drugs. 113 participants from coordinated specialty care teams took part. The goal was to see if the program could be delivered as planned and whether i…

This study tested a new painkiller called cebranopadol, given as a nasal spray, to see how much recreational opioid users liked it compared to oxycodone and a placebo. 48 healthy volunteers who had used opioids for fun in the past took part. The goal was to measure the drug's abu…

This study looked at whether inflammation in the body is linked to suicidal thoughts and behaviors in teenagers. Researchers took blood samples and surveyed 225 teens aged 12-18, including those with recent suicidal behavior, those at risk for depression, and healthy controls. No…

This completed study surveyed 55 men who have sex with men who use psychostimulants (like synthetic cathinones) during sex. Researchers used a questionnaire called G-STAT during a regular addiction clinic visit to see if hypersexuality is caused by the drugs or existed before. Th…

This study looked at whether cannabis or a similar drug (dronabinol) can improve brain reward function in people with schizophrenia who also use cannabis. 263 participants took part to see if these substances help regulate brain circuits linked to motivation and pleasure. The goa…

This study looked at over 36,000 adults in the UK to see if people with vitiligo are more likely to have mental health problems like depression, anxiety, or self-harm compared to those without vitiligo. Researchers used medical records to compare risks and also checked if these r…

This study tested a training program called First Face for Mental Health, designed for staff at a Native American healing lodge. The training teaches people how to spot and respond to mental health crises and connect others to help. Researchers surveyed 92 trainees before, right …

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder (PTSD), depression, and burnout using standard questionnaires. The goal was to understand how c…

This study tested a program called CJC-TraC, where a nurse case manager helps incarcerated individuals with HIV, hepatitis C, or substance use disorder prepare for release and connect to community healthcare. The program involved up to 4 in-person or telehealth visits before rele…

This study looked at 129 teens aged 12-18 with substance use disorders to find out what parts of treatment cause the most improvement. The goal was to identify key factors that lead to better outcomes, like staying drug-free. Researchers measured urine drug tests and problem beha…

This study tested whether using electronic health records and support staff could help more people with alcohol use disorder get the care they need. Researchers looked at how often patients started and stayed in treatment when their doctors had extra reminders and help. The goal …

This early-phase trial tested the safety of a new drug called CS-1103 in 32 healthy adults. Researchers gave single doses by IV to see if it causes side effects and how the body processes it. The goal is to gather basic safety information before testing it in people with methamph…

This study created and tested a mobile app called VetEd for student veterans dealing with mental health issues like depression, PTSD, or anxiety. The goal was to help them manage academics, mental health, and find resources. Researchers worked with 13 veterans to see if the app w…

This study developed a computer program that can scan hospital records to find patients who may be misusing drugs or alcohol. Researchers tested it on nearly 65,000 adults admitted to the hospital. The goal was to see if the tool could help doctors offer counseling and support to…

This study tested whether combining a policy change with professional training can reduce stigma toward substance use in mental health clinics. Twelve providers from two sites participated. The goal was to see if the combined approach improves how often substance use is addressed…

This completed study tested a tablet-based screening system for substance use, depression, and anxiety in over 10,000 HIV-positive adults during routine clinic visits. Patients who screened positive were offered behavioral treatments like motivational interviewing and cognitive b…

This study looked at what might happen if cigarette filter ventilation holes were banned. Researchers created a virtual store where 142 smokers could buy different tobacco products at various prices. The goal was to see how smokers would react if only low-ventilated or non-ventil…

This study tested an educational program designed to improve teenagers' knowledge and behavior around substance abuse. The program used a model called the Behavior Change Wheel to guide learning. Researchers worked with 226 adolescents aged 10 to 18 who had not received similar e…

This study tested whether pop-up alerts in electronic medical records help doctors check a state database before prescribing opioids or sedatives. Over 3,600 providers were randomly assigned to different alert designs. The goal was to see if the alerts increase use of the Prescri…