Could inflammation hold the key to preventing teen suicide?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria Study participants must: 1. Be adolescents (aged 12-18 years); 2. Have the ability to speak, read, and understand English. The parent(s) or legal guardians of minors must also speak, read and understand English; 3. Be willing to provide consent/assent. Consent will be provided by parents/LAR/guardian for youth under age 18 or by young adult participant, aged 18. Youth, aged 8-17, must be willing to provide assent; 4. Have the ability to complete clinical evaluations and self-report measures; 5. Meet criteria for one of these three groups: 1. Adolescent with suicidal behaviors, defined as having a recent (within 3 months) suicide attempt or suicidal ideation warranting urgent evaluation; 2. Adolescents at risk for mood disorders, defined by either personal history of anxiety disorder or substance use disorder or a history of trauma, or a first degree relative with a history of a mood disorder or suicidal history; 3. Healthy adolescents with no lifetime history of any psychiatric or substance use disorders or a history of trauma. Additionally, no first-degree family member with a history of a mood disorder or suicidal history.. Exclusion Criteria Study participants must not: 1. Have current poorly controlled asthma, acute/chronic infection or other medical condition(s) that may affect immune marker levels; 2. Have a current medication (e.g., corticosteroids) that may affect immune marker levels of reactivity; 3. Have any condition for which, in the opinion of the investigator or designee, study participation would not be in their best interest (including but not limited to cognitive impairment, unstable general medical condition, intoxication, active psychosis) or that could prevent, limit, or confound the protocol-specified assessments; 4. Be unable to provide a stable home address and contact information