Disease

Researchers are testing an experimental therapy called SRN-101 in adults with recurrent high-grade glioma, an aggressive brain cancer that has returned after standard treatment. Participants receive SRN-101 directly into the tumor before planned surgery to remove it. The trial's …

Researchers are comparing two ways of performing robotic surgery to remove stomach cancer: a single-port approach and a standard multi-port approach. The trial enrolls 212 adults with stomach cancer that can be removed with distal gastrectomy. The main question is whether the sin…

This phase 3 trial tests whether adding sintilimab, an immunotherapy drug, to chemotherapy before surgery helps people with early-stage oral squamous cell carcinoma. Participants are adults aged 18 to 75 with cT2N0M0 oral cancer that can be removed by surgery. Half receive sintil…

Researchers test whether daily oral immunotherapy can safely treat food allergy in children aged 0 to 2 with peanut, tree nut, or sesame allergy. Half the children receive the therapy, starting with tiny amounts of the allergen and building up over about six months, then a year o…

Researchers test a surgical technique that uses a boomerang-shaped piece of the patient's own cartilage and tissue to repair hard-to-close eardrum perforations. The study includes 50 adults with anterior or subtotal perforations that have been dry for at least three months. Surge…

Researchers are testing an experimental oral drug called PRO-1562 in healthy adults and in adults with relapsing multiple sclerosis who also have long-term vision damage from chronic optic neuropathy. The trial has two parts: a phase 1 safety and absorption study in healthy volun…

Researchers test a new surgical approach for thyroid cancer that has invaded the windpipe. They replace the affected section with a preserved aortic graft supported by a silicone stent. The goal is to remove all cancer and improve survival. The trial includes patients whose cance…

This early-stage trial will test a new HIV vaccine in 22 infants who were exposed to HIV during birth but are not infected. The vaccine is designed to train the immune system to recognize and fight HIV. The main goal is to see if the vaccine is safe and whether it triggers an imm…

This study tests a new type of COVID-19 booster vaccine given as a nasal spray. The vaccine uses a weakened live virus to train the immune system, potentially offering stronger protection in the nose and throat where the virus enters. Researchers are enrolling 80 healthy adults a…

This trial is testing whether an experimental mRNA vaccine can safely reduce moderate-to-severe acne in adolescents aged 12 to 17. Participants receive either the vaccine at different dose levels or a placebo, and researchers monitor safety and changes in facial acne lesions. The…

This Phase 1 trial tests experimental mRNA vaccines designed to protect against many types of influenza A by targeting a stable part of the virus. Healthy adults aged 18 to 59 receive one or two doses of the vaccine candidates, alone or in combination. The study checks for side e…

This study tests a new COVID-19 vaccine (LUNAR-COV19) in 56 adults who received a blood stem cell transplant within the past year. These patients often have weaker immune responses to standard vaccines. The new vaccine uses a self-amplifying mRNA that may produce a stronger and l…

Researchers test whether a short course of targeted radiation followed by the immunotherapy drug adebrelimab and NALIRIFOX chemotherapy can shrink locally advanced pancreatic cancer enough to allow surgery. The trial enrolls 36 adults with previously untreated pancreatic ductal a…

This study tests whether adjusting chemotherapy doses for each patient can improve outcomes after a stem cell transplant for blood cancers caused by a RUNX1 gene mutation. Up to 98 people aged 4 to 70 with these cancers will receive a transplant from a half-matched donor. The goa…

Researchers are testing whether an educational and implementation tool helps hospitals follow best-practice guidelines for preventing second strokes caused by heart conditions. The trial enrolls about 2,400 patients who have had an ischemic stroke or a transient ischemic attack. …

Researchers are testing whether a liver-sparing form of chemoembolization, called partial TACE, can boost the anti-tumor effects of the drug lenvatinib in people with liver cancer that cannot be removed by surgery. The trial enrolls about 40 adults with hepatocellular carcinoma w…

Researchers are observing how satisfied people with relapsing-remitting multiple sclerosis are when they receive ocrelizumab as an injection under the skin instead of an intravenous infusion. The study follows about 1,800 participants across multiple countries for 12 months, incl…

Researchers are testing a radiopharmaceutical called 161Tb-PSMA-1 in adults with metastatic clear cell renal cell carcinoma that has worsened after at least two prior treatments, including immunotherapy and drugs that block blood vessel growth. The trial has two parts: a dose-esc…

This study tests a radioactive drug called 177Lu-DOTA-EB-TATE in 18 adults with a rare thyroid cancer (Hurthle cell) that has spread and not responded to standard radioactive iodine treatment. The drug is designed to seek out and attach to cancer cells. Participants will receive …

This study tests a minimally invasive procedure called SESAME for people with thickened heart muscle that blocks blood flow from the heart. The procedure uses a catheter to make a controlled slice in the muscle, aiming to relieve symptoms like shortness of breath. Researchers wil…

This study looks at the safety and effectiveness of Rybelsus, a pill for type 2 diabetes, in everyday medical practice in Korea. About 600 adults will take the medicine as their doctor prescribes, and researchers will track side effects and blood sugar control for 26 weeks. The g…

Researchers are testing an experimental oral drug called VC005 in teenagers aged 12 to 17 who have non-segmental vitiligo, a condition where patches of skin lose their color. The study measures how the drug moves through the body and checks for safety over up to 24 weeks of treat…

Researchers are studying whether patients can safely leave the hospital within 48 hours after minimally invasive colorectal surgery. The trial follows 97 adults having elective laparoscopic or robotic surgery for benign or malignant disease. It checks how many meet predefined cli…

Researchers are testing whether combining BL-B01D1, an experimental antibody-drug conjugate, with glecirasib, a targeted KRAS G12C inhibitor, can shrink tumors in adults with locally advanced or metastatic non-small cell lung cancer that carries a KRAS G12C mutation. The phase 2 …

This study tests whether adding digital nutrition education—via SMS or group sessions—to daily micronutrient supplements can lower anemia rates in 1,200 adolescents aged 15-19 in Dar es Salaam, Tanzania. All participants get supplements and basic nutrition info; some also receive…

This trial tests an experimental drug called SFL-0821 in adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes progressive muscle weakness. Researchers give the drug by intravenous infusion, either once or multiple times, and compare it agains…

This trial is testing an experimental eye gel called BETA-TT8 for people with wet age-related macular degeneration (AMD), a condition that causes rapid vision loss. The gel is applied to the eye up to three times daily for 12 weeks, and standard injections remain available if nee…

Researchers are testing whether seltoplasmid, a gene therapy injected into the calf muscle, can improve outcomes for people with type 2 diabetes who have poor blood flow to the foot and a non-healing ulcer. All participants first undergo a standard procedure to restore blood flow…

This trial tests whether mazdutide, an experimental weekly injection, can reduce fat buildup in the pancreas of adults with overweight or obesity. About 194 participants will receive either mazdutide or a placebo, alongside standard lifestyle advice, for 48 weeks. Researchers wil…

Researchers are testing whether adding an experimental drug called F182112 to isatuximab and lenalidomide is safe and can help people with newly diagnosed multiple myeloma who are eligible for a stem cell transplant. The trial enrolls about 10 adults aged 18 to 70. Participants r…

Researchers test whether rituximab helps maintain lung function in adults with systemic sclerosis and interstitial lung disease whose disease has stabilized after initial rituximab treatment. Participants receive rituximab or placebo infusions at months 0, 6, and 12. The main mea…

Researchers are testing a three-drug regimen called VAM for older or unfit adults with newly diagnosed acute myeloid leukemia (AML). The regimen combines liposomal mitoxantrone, azacitidine, and venetoclax. The trial aims to find the safest and most tolerable dose of liposomal mi…

Researchers are studying depemokimab, an injected biologic drug, in adults aged 18 to 75 who have allergic bronchopulmonary aspergillosis (ABPA) along with severe eosinophilic asthma. The study tracks how many asthma attacks need systemic steroids and whether participants' qualit…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This study tests whether a one-time infusion of specially engineered immune cells (CAR T cells) can improve lung function and skin hardening better than current treatments for people with active systemic sclerosis, a rare autoimmune disease. About 92 adults with lung involvement …

This early-stage trial tests an oral capsule containing a genetically modified probiotic yeast designed to neutralize toxins produced by C. diff bacteria. The study first evaluates safety in healthy adults, then in people at risk for recurrent C. diff infection. Participants take…

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This trial tests whether treating high blood pressure in pregnancy to a stricter target (below 140/90) is better than the usual approach (below 160/110) for women with gestational hypertension or preeclampsia without severe features. About 4,120 pregnant women will be randomly as…

Many people who have bariatric surgery do not lose as much weight as expected or regain it over time. This trial tests whether tirzepatide, a weekly injection that acts on two gut hormones, helps adults with obesity lose more weight after surgery. Participants receive either tirz…

This Phase 2 trial tests whether combining the supplement alpha-lipoic acid with the drug mirabegron can improve how the body processes sugar in people with obesity. Sixty adults aged 18 to 65 with a BMI between 30 and 45 will take the combination or a placebo for 4 weeks. The st…

This trial tests whether a smartphone app can enhance parent management training (PMT) for children aged 8 to 13 with disruptive behavior disorders, such as conduct disorder or ADHD. Parents receive 12 weekly PMT sessions, and half also use a digital tool with videos, a resource …

This phase II trial tests whether combining bevacizumab, a drug that limits blood vessel growth, with PRGN-2012, a vaccine-based therapy, can help adults with recurrent respiratory papillomatosis (RRP) avoid needing more surgeries. RRP causes wart-like growths in the airway that …

This trial tests a new approach for people with solid tumors that have returned or not responded to standard treatments. The therapy uses the patient's own myeloid cells, a type of immune cell, which are genetically modified in a lab to produce a cancer-fighting protein called IL…

This trial tests whether a daily routine of tummy time and careful positioning can help correct cranial asymmetry—a flattened head shape—in premature newborns. About 300 babies born before 37 weeks who are in the neonatal ICU or intermediate care unit will be split into two group…

Researchers are testing whether drug testing in patient-derived organoids can guide chemotherapy for low-grade non-muscle invasive bladder cancer. Adults with primary or recurrent low-grade bladder cancer receive one of four chemo drugs, epirubicin, mitomycin C, gemcitabine, or d…

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

This phase 2 trial tests an oral drug called nemtabrutinib in people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) whose cancer has stopped responding to other targeted therapies. Participants take nemtabrutinib once daily in 28-day cycles until the …

This trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…

Researchers are testing whether a shared checklist used during lung cancer surgery helps surgeons achieve cleaner, more complete tumor removal. The trial enrolls adults with early-stage non-small cell lung cancer who are scheduled for surgery. Half the participating hospitals use…

This study tests whether a continuous glucose monitor (CGM) is better than standard finger-prick tests for managing blood sugar in 100 pregnant women with gestational diabetes. Participants will either wear a small sensor or continue finger-pricking. The goal is to see if CGM is …

This early-stage trial is testing an experimental drug called SNC116 in people with refractory systemic lupus erythematosus (SLE), a form of lupus that hasn't improved with standard treatments. The study aims to see if a single intravenous infusion of SNC116 is safe and tolerable…

Researchers are testing REGEND001, a therapy made from a patient's own airway basal stem cells, to see if it can improve lung function in people with chronic obstructive pulmonary disease (COPD) and emphysema. The trial enrolls adults aged 40 to 75 with moderate to severe COPD. P…

This study provides continued access to alpelisib for people who are already benefiting from it in a previous Novartis trial. It focuses on tracking long-term safety, including any side effects, in participants with PIK3CA-related overgrowth spectrum or certain breast cancers. Pa…

Researchers are testing a chemotherapy combination built around albumin-bound paclitaxel (II) for people with pancreatic cancer. The study has three groups: one for advanced cancer that cannot be removed by surgery, one for cancer that may be removable and receives treatment befo…

Researchers are testing an experimental topical gel called PP405 in men with androgenetic alopecia, the most common form of male pattern hair loss. The trial enrolls about 600 men aged 18 to 55 with moderate hair loss at the top of the scalp. Participants apply either the PP405 g…

This trial tests whether efgartigimod, a drug that lowers harmful antibody levels, can improve recovery in people with Guillain-Barré syndrome (GBS), a rare nerve condition that can cause weakness and paralysis. Adults aged 18 to 70 with recent GBS onset will receive either efgar…

Researchers test whether Bacillus probiotics, given alongside standard four-drug antibiotics for H. pylori infection, reduce gut side effects and improve treatment tolerance. The trial enrolls 336 adults with H. pylori who receive either a single-strain probiotic, a multi-strain …

Researchers are testing a new biological therapy called BI 4060107 in adults with advanced solid tumors that cannot be removed by surgery. The trial is for people who have tried all available treatments and have no other options. The main goal is to find the highest dose that peo…

This early-phase trial tests a new therapy for people with advanced small cell lung cancer or similar neuroendocrine cancers that have not responded to prior treatment. The approach involves collecting a patient's own immune cells, modifying them in a lab to recognize a protein c…

Researchers are testing a new immunotherapy called Lm-LLO-TT in adults with advanced pancreatic ductal adenocarcinoma that has already been treated with chemotherapy. Lm-LLO-TT uses a weakened form of Listeria bacteria engineered to carry a tetanus toxoid antigen, aiming to spark…

This early study tests a new, noninvasive laser treatment called Nano-Pulsed Laser Therapy (NPLT) for people with moderate to severe traumatic brain injury (TBI). The goal is to see if the treatment is safe and can be given soon after injury. Researchers will also check if the la…

Researchers at the University of Oklahoma are testing whether adding pentamidine, an antiparasitic drug, to standard modified FOLFIRINOX chemotherapy is safe and helps shrink tumors in people with advanced or metastatic pancreatic cancer. Up to 30 adults with confirmed locally ad…

Researchers are testing whether an oral drug called vepugratinib can clear low-grade, intermediate-risk bladder cancer that has not invaded muscle, or low-grade upper tract urothelial cancer. The trial enrolls adults whose tumors carry a specific change in the FGFR3 gene. Partici…

This phase 2 trial tests a combination of a vaccine (TriAdeno) and an immune-boosting drug (N-803) in 52 men with early-stage, low- or medium-risk prostate cancer who are currently on active surveillance. The vaccine targets three proteins found in prostate cancer cells, while N-…

This trial is for people with ER-positive, HER2-negative advanced breast cancer whose disease has started to grow in a few spots while on hormone therapy and a CDK4/6 inhibitor. It tests whether adding targeted radiation (SABR) to those spots allows patients to stay on their curr…

Researchers are testing whether combining an experimental dual immunotherapy drug called QL1706 with standard chemotherapy (docetaxel, oxaliplatin and S-1) before surgery can help patients with locally advanced gastric or gastroesophageal junction cancer. The study enrolls 34 adu…

Researchers are studying giredestrant, an experimental daily pill, in people with estrogen receptor-positive, HER2-negative early breast cancer. The trial enrolls about 1,500 participants, including some who switch to giredestrant after other treatments. It tracks how many people…

This study compares four different sequences of biologic drugs (infliximab, filgotinib, ustekinumab, and vedolizumab) in 240 adults with moderate to severe ulcerative colitis. The goal is to see which order of treatments works best to achieve and maintain remission without steroi…

Researchers are testing an experimental oral drug called ONO-2808 in adults with the Parkinsonian subtype of multiple system atrophy (MSA-P), a rare and progressive brain disorder. The phase 3 trial enrolls about 486 people in the early stages of the disease, within five years of…

Researchers are comparing an experimental oral drug called VT3989 with standard chemotherapy drugs gemcitabine or vinorelbine in adults with advanced epithelioid pleural mesothelioma. All participants have already received platinum-based chemotherapy and immunotherapy, and their …

Researchers are testing whether a standardized care pathway helps adults with advanced heart failure in Latin America complete a multidisciplinary evaluation and receive a documented treatment decision within 90 days. The trial includes 360 adults with acquired or structural hear…

This phase 2 trial tests whether adding a gene therapy called nadofaragene firadenovec to standard chemotherapy and immunotherapy can improve outcomes for people with muscle invasive bladder cancer before they have their bladder removed. The gene therapy is placed directly into t…

Researchers are testing whether adding CT-guided thermal ablation of liver or lung metastases to standard systemic therapy improves tumor response in people with nasopharyngeal carcinoma. The trial enrolls 138 adults whose primary tumor was cured but who later developed up to fiv…

This study tests an experimental drug called centhaquine in 80 adults with moderate to severe ARDS, a life-threatening lung condition. The drug is added to standard care to see if it improves oxygen levels and reduces deaths. Participants must be in the ICU and start treatment wi…

This study tests whether the drug telaglenastat, taken twice daily for 12 weeks, can safely lower blood pressure in the lungs and improve heart and lung function in adults with pulmonary hypertension. About 28 participants will receive the drug on top of their usual care. The mai…

Researchers are testing a new way to deliver antibiotics to the brain in people with moderate to severe bacterial meningitis who are not improving on standard intravenous treatment. The approach combines standard IV antibiotics with a continuous infusion of three antibiotics (van…

Researchers are running a first-in-human Phase 1 trial of JUR-003, an intravenous biologic, in adults with metastatic prostate cancer. The study has two parts: a dose-escalation phase to find the highest dose people can tolerate, and a dose-expansion phase to look at early anti-t…

Researchers are testing whether adding an experimental drug called HLX22 to standard trastuzumab and chemotherapy helps people with locally advanced or metastatic HER2-positive breast cancer that has already been treated with a HER2 ADC. About 90 adults will receive either HLX22 …

Researchers are testing whether adding two oral drugs, avutometinib and defactinib, to standard chemotherapy (mFOLFIRINOX) is safe and can slow or shrink pancreatic ductal adenocarcinoma. The trial has two parts: one for people whose cancer has spread, and one for people whose ca…

Researchers are running a Phase I trial of HEC-921, an experimental drug given by intravenous infusion, in adults with advanced malignant solid tumors. The study first gives HEC-921 alone to find the highest dose people can tolerate, then tests it in combination with oxaliplatin,…

Researchers are testing whether infusions of bone marrow-derived mesenchymal stem cells, called MesenCell, are safe for adults with moderate or severe chronic graft-versus-host disease that has not responded to steroids and other standard treatments. The trial enrolls up to 20 pe…

This study tests a new imaging and guidance system called VERAFEYE that creates a 3D model of the heart to help doctors navigate during catheter ablation for atrial fibrillation. About 50 adults with paroxysmal or persistent atrial fibrillation will have their standard ablation p…

This study tests a program for new mothers who had high blood pressure during pregnancy. Participants wear a FitBit and receive weekly messages with personalized activity goals. The goal is to see if this approach increases daily steps and improves blood pressure, and whether mom…

This study tests a new immunotherapy designed to help the immune system recognize and attack cancer cells in people with high-risk Ewing sarcoma or desmoplastic small round cell tumor (DSRCT). The treatment targets a specific genetic change found only in these cancer cells, aimin…

People with end-stage kidney disease need a reliable blood vessel connection, called a fistula, for hemodialysis. This study tests a device called the ePATH System, which creates that connection from inside the blood vessels rather than through open surgery. Researchers will foll…

Researchers are testing whether women aged 65 and older with early-stage, lymph node-positive, ER+/HER2- breast cancer can safely skip chemotherapy. Participants receive CDK4/6 inhibitors, with or without endocrine therapy, after surgery. The trial tracks how many women remain fr…

When children lose bone to injury, infection, or surgery, doctors can rebuild the limb in different ways. This French study compares two established techniques: the induced membrane method and the vascularized fibula flap, which moves a piece of the calf bone with its blood suppl…

This study looks back at the experiences of 35 adults with a rare kidney disease called C3G who received the drug iptacopan through a special early access program in Spain. Researchers will collect information on patient health, lab results, and how the disease responds to treatm…

This study compares two FDA-approved drugs, momelotinib and ruxolitinib, in people with myelofibrosis who also have low blood cell counts. The main goal is to see which drug does a better job at shrinking the spleen and reducing the need for blood transfusions. About 268 particip…

Researchers are testing an experimental drug called MWN117 to see if it is safe and how the body handles it. The trial enrolls 48 healthy and obese Chinese adults who receive a single injection under the skin of either MWN117 or a placebo. Participants are split into groups that …

Adults with a secundum atrial septal defect (a hole in the heart) who are scheduled for device closure receive either dapagliflozin or a placebo for six months. Researchers use advanced echocardiography to measure how well the right side of the heart recovers and reverses its enl…

This Phase II trial tests whether an immune-boosting drug (N-803) alone or combined with a vaccine (ETBX-071) can lower PSA levels in men whose prostate cancer has returned after targeted radiation therapy. Participants receive up to eight cycles of treatment and are followed for…

Acute uncomplicated diverticulitis is often treated with antibiotics, but evidence suggests they are not always needed. This study evaluates whether a standardized treatment approach based on clinical findings, lab results, other health conditions, and CT scans can reduce unneces…

Researchers are testing an experimental injectable drug called SHR-1179 in obese adults. The trial aims to see how safe and tolerable a single dose is, and how the body processes the drug. About 50 participants with a body mass index between 28 and 35 will receive either SHR-1179…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

Researchers compare two oral antifungal medicines, itraconazole and posaconazole, in people with chronic pulmonary aspergillosis, a fungal infection that damages the lungs over time. The trial enrolls 220 adults who have not yet received antifungal treatment and assigns them to o…

Researchers are testing an experimental injectable drug called ALK-N001 in adults with advanced gastrointestinal tumors, including esophageal and colorectal cancers that have worsened after standard treatment. The phase II trial gives the drug intravenously every two weeks at one…

Researchers at UT Southwestern Medical Center are testing whether tirzepatide, a drug approved for diabetes and weight loss, can help people with moderate to severe methamphetamine use disorder reduce or stop using the drug. The trial enrolls 228 adults aged 18 to 65 who are over…

Researchers are testing whether measuring specific proteins in tumors can help match patients with advanced pancreatic or breast cancer to antibody-drug conjugates that are more likely to work for them. The trial enrolls 225 adults whose cancer has progressed after prior treatmen…

Researchers are testing whether a lower dose of the clot-dissolving drug alteplase can treat life-threatening pulmonary embolism as effectively as the standard full dose while causing less severe bleeding. The trial enrolls adults with acute high-risk pulmonary embolism, a condit…

Researchers are testing whether adding the immunotherapy adebrelimab to HS-20093 (risvutatug rezetecan) works better than HS-20093 alone in adults with advanced or metastatic non-squamous non-small cell lung cancer that has already been treated and has no actionable gene changes.…

Researchers are studying whether adding local treatments such as ablation, radiotherapy, or transarterial therapy to the drug combination atezolizumab plus bevacizumab helps certain patients with unresectable hepatocellular carcinoma live longer. The study uses medical records an…

Choledochal cyst is a congenital bile duct problem that surgeons treat by removing the cyst and rebuilding the bile duct with a Roux-en-Y hepaticojejunostomy, often using a surgical robot. Surgeons usually leave an abdominal drainage tube in place afterward, but better robot prec…

This phase 2 trial is investigating whether an experimental drug called ARGX-121 can improve outcomes for adults with IgA nephropathy, a kidney disease that can lead to kidney failure. Participants will receive either ARGX-121 or a placebo, while continuing their usual care. The …

Researchers are testing a one-time CAR-T cell therapy called C-CAR168 in adults with progressive multiple sclerosis that has not responded to standard treatments. The therapy uses a patient's own immune cells, engineered to target two proteins, and is given as a single intravenou…

This study tests whether a virtual team of clinical pharmacists and cardiologists can help doctors prescribe the right heart failure medications for Veterans. Many patients do not receive all recommended drugs at effective doses after a hospital stay. The team reviews patient rec…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

Researchers test whether coconut oil pulling or a moringa mouthwash can reduce gingivitis in children with diabetes, compared with chlorhexidine. Thirty children aged 6 to 12 with mild to moderate gingivitis use one of the three rinses. The team measures gum inflammation and leve…

Researchers are testing whether a new combination of two antibodies, JS207 and JS007, works better than the standard first-line treatment of toripalimab plus bevacizumab for advanced liver cancer. The trial enrolls about 560 adults with liver cancer that cannot be removed by surg…

This study tests whether a citrate-based dialysis fluid with extra magnesium can slow or prevent blood vessel hardening in adults on long-term hemodialysis. Eighty stable patients will receive either the new fluid or a standard one for 12 months. Researchers will measure blood ma…

Researchers are testing whether giving sacituzumab tirumotecan plus toripalimab before surgery helps people with locally advanced esophageal squamous cell carcinoma. Participants receive three cycles of the combination, then undergo standard surgery to remove the tumor. The main …

This phase II trial tests whether the experimental drug BL-B01D1, given with or without a PD-1 antibody, can improve tumor shrinkage in people with high-risk locally advanced nasopharyngeal carcinoma, a type of throat cancer. Participants also receive standard chemotherapy drugs …

This trial is testing whether a combination of drugs—inavolisib plus fulvestrant, with or without palbociclib—is safe for people with a specific type of advanced breast cancer (HR+, HER2-negative) that has a PIK3CA mutation, and who also have type 2 diabetes. The main focus is on…

Researchers are testing whether a standardized automated blood pressure measurement protocol in Australian general practice clinics improves hypertension control among adults. The protocol uses a validated device that takes several readings automatically after a five-minute rest,…

Researchers compare two ways to treat deep defects in the gums of people with advanced periodontitis. One approach cleans the pockets with minimally invasive non-surgical therapy, while the other uses a single flap surgical procedure. The trial measures gum attachment gain and us…

Researchers are testing whether combining enfortumab vedotin and pembrolizumab can shrink muscle-invasive bladder cancer enough to avoid removing the bladder or using radiation. The trial enrolls 25 adults with confirmed muscle-invasive urothelial carcinoma that has not spread. P…

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

This study tests a digital health program designed to support people with psoriatic arthritis in managing their condition. Participants use a mobile app for symptom tracking and lifestyle tips, plus tools for sleep, stress, and physical activity, along with a smartwatch. The goal…

This study compares two treatments for when a leg artery stent narrows again (in-stent restenosis). About 578 patients will receive either a drug-coated balloon or a drug-eluting stent, both of which release medication to keep the artery open. The goal is to see which approach re…

Guillain-Barré syndrome (GBS) is a rare condition where the immune system attacks nerves, causing weakness that can progress to paralysis. Standard treatment is intravenous immunoglobulin (IVIg), but recovery is often slow. This phase 2 trial tests whether adding an experimental …

Researchers are testing whether adding the experimental oral drug HS-10370 to platinum-based chemotherapy, with or without the immunotherapy adebrelimab, works better than tislelizumab plus chemotherapy. The trial enrolls about 448 adults with previously untreated, locally advanc…

Researchers are testing an oral drug called enlicitide decanoate in adults with hyperlipidemia, a condition marked by high cholesterol. The phase 3 trial enrolls 150 people in India who have had a heart-related event or face high risk, and who still have elevated LDL cholesterol.…

Researchers are testing whether a combination of four experimental oral drugs, AD-233A, AD-233B, AD-233C and AD-233D, can improve blood sugar control in adults with type 2 diabetes. The Phase III trial enrolls about 354 participants and compares the drug combination against an ac…

Researchers are running a first-in-human study of MGC030, an antibody-drug conjugate, in people with advanced solid tumors that have come back or stopped responding to standard treatment. The trial includes participants with urothelial, colorectal, gastric, gastroesophageal, esop…

This study tests a new drug called zanzalitinib in people with a type of advanced prostate cancer that no longer responds to hormone therapy and has spread to soft tissues or organs. The goal is to see if the drug can slow or stop cancer growth. About 19 participants will receive…

This trial tests whether a single 10-minute lesson from an artificially intelligent robot can improve inhaler technique and asthma control in children ages 4 to 11. Researchers will compare standard asthma education with the robot-led session, measuring inhaler skills, medication…

Researchers are testing whether adding focused radiation to the few remaining cancer spots helps people with advanced EGFR-mutant non-small cell lung cancer live longer without their disease getting worse. Participants first receive a third-generation EGFR-targeted drug plus plat…

This study tests if a single high dose of an antifungal drug works better than the standard daily dose for treating moderate to severe histoplasmosis, a serious lung infection. It also compares a newer oral drug to the standard one, and checks if 6 months of treatment is as good …

This phase III trial tests whether the oral drug nerandomilast can improve symptoms of idiopathic inflammatory myopathies, a group of rare autoimmune diseases that cause muscle weakness and inflammation. Adults with active myositis are randomly assigned to take nerandomilast or a…

Researchers at Assiut University Children Hospital are studying whether a specially prepared medical milk formula called Modulen IBD can bring Crohn's disease into remission and keep it there in children and teenagers. About 40 young patients with mild to moderate active Crohn's …

This study tests whether using a 21-question tool to understand a person's daily habits, then giving tailored advice, can lower blood pressure more than routine counseling. Researchers will compare two groups of adults with hypertension over three months. The goal is to see if pe…

Researchers are testing an experimental drug called RO7830698 to see if it is safe and well tolerated. The trial includes healthy volunteers and people with chronic obstructive pulmonary disease (COPD). Participants receive either RO7830698 or a placebo, and researchers track sid…

Researchers are testing whether an experimental drug called telisotuzumab adizutecan works better than standard chemotherapy for people with non-squamous non-small cell lung cancer that has grown after earlier treatment. The trial enrolls about 660 participants whose tumors are E…

Researchers test whether a rinse made from frankincense (Boswellia sacra) removes bacteria from infected root canals as well as the standard sodium hypochlorite rinse. Thirty adults aged 18 to 50 with a dead or infected tooth take part. Each person is randomly assigned to one of …

This study tests whether a pharmacist-led electronic consultation can improve lung health for people with HIV who smoke or use certain medications that raise pneumonia risk. Pharmacists will review records and suggest changes like smoking cessation aids, vaccines, or stopping unn…

This trial tests whether the antioxidant N-acetylcysteine (NAC) can help platelets recover faster after a stem cell transplant in people with severe aplastic anemia. Participants take NAC capsules three times daily from two weeks before transplant until two months after. The stud…

Researchers at a Malaysian hospital reviewed ten years of records for 160 adults who received intrapleural fibrinolytic therapy, a mix of alteplase and DNase delivered through a chest tube, for complicated pleural infection. The study compares how well the treatment cleared fluid…

This trial tests an experimental drug called TUB-040 in adults with advanced non-small cell lung cancer that cannot be removed with surgery or has spread. TUB-040 is designed to attach to a protein on cancer cells and deliver a toxic payload directly to the tumor, potentially kil…

Many people with diabetes skip regular eye exams, even though early treatment can prevent vision loss. This pilot study tests whether offering retinal photography during routine occupational health visits makes screening easier to access. Workers with diabetes attend one visit wh…

Autistic children in the emergency department often miss full vital sign checks because standard equipment can be distressing. This pilot study randomizes 100 children aged 2 to 17 to have their heart rate, breathing, oxygen and temperature measured either with wireless wearable …

Researchers are testing a new PET/CT imaging tracer called [68Ga]-LY4257529 that targets a protein called GRPR, which some cancers make in large amounts. The study includes up to 60 adults with breast cancer or other tumors known or suspected to express GRPR, such as prostate, ov…

Researchers are testing whether a smartphone app called Stethophone can help primary care doctors find moderate or severe aortic stenosis in adults aged 70 and older. The app turns a phone into a digital stethoscope and analyzes heart sounds for murmurs that may signal the condit…

Researchers at Mayo Clinic are testing an investigational radioactive tracer called 68Ga-FAPI-46 to see how it distributes in the lungs of people with interstitial lung disease. About 10 participants with a clinical diagnosis of ILD and lung abnormalities on a recent CT scan rece…

Researchers are testing whether adding a brain-injury blood test to standard clinical guidelines can safely reduce the number of brain CT scans ordered for adults who come to the emergency department with a suspected head injury. The blood test measures two proteins, GFAP and UCH…

Researchers are studying whether immune markers in a blood sample taken before pancreatic cancer surgery can predict a serious complication called postoperative pancreatic fistula, where digestive fluids leak from the surgical connection. Adults scheduled for curative-intent panc…

Researchers at Corewell Health West are testing whether medical assistants can use a handheld ultrasound device to estimate heart pumping function in people with new heart symptoms. The trial enrolls up to 100 adults at rural outpatient clinics who have not had a recent echocardi…

Researchers at Assiut University are testing whether a specialized MRI technique called multi-echo fast field echo (mFFE) can detect cortical bone changes in knee osteoarthritis as accurately as CT scans. The study enrolls 80 adults aged 40 and older with suspected or confirmed k…

Researchers are testing whether sex work managers, called queen mothers, can hand out and collect HIV self-tests and self-collected STI test kits at places where female sex workers meet and work in Lusaka. The study compares this peer-supported approach with the current standard …

Radiation pneumonitis is a lung inflammation that can appear weeks after radiotherapy for lung cancer, and patients may not link their symptoms to the earlier treatment. Researchers developed a smartphone app called PneumoCheck for patients to use at home, hoping it helps detect …

Researchers are studying whether the total time from heart attack symptom onset to balloon inflation during angioplasty helps predict contrast-induced nephropathy, a kidney complication that can occur after the procedure. The trial enrolls 400 adults with ST-segment elevation myo…

Doctors usually send colorectal tissue to a lab and wait days for results. This pilot study tests a miniaturized device called MULTISCOPE that uses light-based imaging to tell healthy tissue from cancerous tissue in real time. Researchers will examine 30 tissue samples removed du…

Researchers are reviewing medical records from about 1,125 women in Italy with newly diagnosed advanced high-grade epithelial ovarian cancer. The study focuses on how hospitals test tumors for homologous recombination deficiency (HRD), a DNA repair flaw that can make PARP inhibit…

This trial tests a new AI device that helps surgeons see brain tumors on ultrasound images during surgery. The AI highlights tumor tissue in real time, which may help remove more of the tumor while protecting healthy brain. The study involves 100 adults scheduled for brain tumor …

This study checks if a simpler way to collect blood samples works as well as the standard method for the HepQuant DuO liver test. The test involves drinking a natural substance and taking blood samples 20 and 60 minutes later. Researchers will compare different blood collection t…

Doctors often wait days for genetic tests to classify acute myeloid leukaemia (AML) and guide treatment. This trial tests whether breath analysis can detect metabolic products from leukaemia and classify the disease faster. Participants give breath samples and extra blood tests d…

This study will test a 4D virtual simulator called Modjaw to see if it helps doctors diagnose temporomandibular joint (TMJ) disorders more accurately. About 20 adults with suspected disc displacement will use the device, and the results will be compared to MRI scans. The goal is …

Placenta accreta spectrum is a serious pregnancy complication where the placenta grows too deeply into the uterus, risking severe bleeding during delivery. Doctors usually rely on ultrasound to detect it, but ultrasound accuracy varies. This study checks whether simple blood test…

Researchers are testing whether a smartphone app called DETECTRA can help doctors diagnose rheumatoid arthritis earlier in adults who have joint symptoms and a positive ACPA blood test. Participants are randomly assigned to receive standard care alone or standard care plus the ap…

Researchers are testing an AI software tool called DSA-VDet v1.0 that highlights suspected bleeding on angiography images in real time. The trial enrolls adults with suspected acute bleeding in various body regions who need a digital subtraction angiography (DSA) procedure. Docto…

Researchers at Washington University School of Medicine are studying whether a fluorescent dye called indocyanine green can help visualize the edges of head and neck squamous cell carcinoma during surgery. The study plans to enroll 25 adults who are having surgery for confirmed o…

Researchers are testing a soft, wearable ultrasound patch that sticks to the chest and continuously images the heart in adults and children with severe heart conditions in intensive care. The study compares heart function measurements from the patch with results from standard bed…

Researchers are testing whether early symptom relief from tegoprazan can help diagnose gastroesophageal reflux disease (GERD). Adults with frequent heartburn or acid regurgitation take tegoprazan or a placebo once daily for one week. By comparing symptom improvement between the g…

Researchers are running a large observational registry to see how a blood test called metagenomic sequencing is used in routine care for people with or at risk of serious infections, including those with weakened immune systems. The study enrolls participants at multiple hospital…

Researchers compare automated software with manual scoring by expert sleep specialists for sleep study records from adults with obstructive sleep apnea. The study measures how closely the two methods agree on the apnea-hypopnea index, a key measure of breathing pauses during slee…

Researchers at Massachusetts General Hospital are studying whether molecular imaging and detailed biological profiling can predict how quickly aortic stenosis gets worse. The trial enrolls 100 adults with mild to moderate calcific aortic stenosis. Participants receive a baseline …

Researchers at Assiut University Hospitals are studying how well fetal heart scans before birth match the heart diagnoses babies receive after delivery. The study includes pregnant women referred for fetal echocardiography and newborns with confirmed critical congenital heart dis…

Sepsis is hard to spot early because its first symptoms look like many other conditions. Researchers at emergency departments in Taiwan are studying whether two blood markers, presepsin and immature granulocytes, can help doctors tell sepsis apart from other causes of inflammatio…

Researchers are testing whether a non-invasive device that reads the heart's magnetic signals can help emergency department doctors tell high-risk from low-risk chest pain. The study enrolls adults 22 and older who arrive with symptoms suggesting a possible heart attack and who f…

This study tests whether an artificial intelligence (AI) system can help doctors spot more precancerous polyps and colorectal cancers during colonoscopy compared to standard procedures. Over 3,300 adults scheduled for screening or surveillance will be randomly assigned to AI-assi…

Acute kidney injury is a common complication after coronary artery bypass grafting. This observational study examines whether two measurements from kidney Doppler ultrasound, the renal augmented velocity index and the renal resistive index, can predict which patients will develop…

Researchers are testing whether a minimally invasive electrode placed under the scalp, called subgaleal EEG, can detect seizures as well as the standard approach that places electrodes inside the brain. The study enrolls 15 adults with drug-resistant epilepsy who are already sche…

Researchers at Assiut University are studying whether two ultrasound measures of fetal heart function and blood flow can predict poor outcomes in pregnancies complicated by diabetes or preeclampsia. The study enrolls 69 pregnant women, including those with gestational diabetes, p…

Trastuzumab deruxtecan (T-DXd) treats metastatic breast cancer but can cause interstitial lung disease (ILD), a form of lung inflammation that sometimes forces patients to stop treatment. Researchers are testing whether giving dexamethasone before each T-DXd infusion lowers the c…

Researchers test a hybrid breast cancer education program for women aged 20 to 65 who visit an obstetrics and gynecology clinic. The program combines a face-to-face session using a breast model with four weeks of educational messages and reminders sent through a mobile app. The t…

Researchers at the University of Washington are studying whether an online community of practice helps pharmacists learn to prescribe PrEP, a daily pill that prevents HIV. The study enrolls about 500 pharmacists and pharmacy staff across the United States whose pharmacies do not …

Researchers are testing whether a single dose of the antiviral drug baloxavir marboxil can stop influenza from spreading among people who live with someone who has the flu. The trial enrolls households in China where one person has confirmed influenza and up to five other members…

Researchers are testing an experimental vaccine called AV-1959R in adults aged 55 to 80 who have amyloid buildup in the brain but no memory or thinking problems. The trial compares the vaccine with a placebo to see whether it is safe, triggers an immune response, and lowers brain…

Researchers are testing a behavioral program that sends supportive text messages and offers small rewards to pregnant women who test positive for alcohol, tobacco, or cannabis use in South Africa. The program aims to reduce substance use during pregnancy and breastfeeding, which …

Paraffin disease happens when people inject paraffin oil into muscle for cosmetic enlargement, causing chronic inflammation, high blood calcium, kidney stones, and kidney damage. Researchers are testing whether empagliflozin or losartan, two drugs already used for kidney protecti…

Researchers are testing whether a digital program that combines a smart bracelet and a mobile app can help people who have had an ischemic stroke avoid another one. The study enrolls adults who recently had a stroke and also have high blood pressure and diabetes. Half receive usu…

Clesrovimab is an FDA-approved antibody shot for infants under 8 months entering their first RSV season when their mothers did not get an RSV vaccine in pregnancy. Researchers at Emory University are measuring antibody levels in the blood and noses of 24 healthy infants who recei…

This study tests whether the drug rituximab can safely clear Epstein-Barr virus (EBV) from the blood of people who have received a solid organ transplant. High levels of EBV can lead to a serious cancer called post-transplant lymphoproliferative disorder (PTLD). The trial will en…

Researchers are testing an AI chatbot that gives personalized, culturally tailored advice on nutrition, physical activity, and goal setting to adults at risk for type 2 diabetes. About 30 adults aged 18 to 55 will use the chatbot for 6 weeks. The study will check whether the chat…

This trial tests whether a nursing care bundle created with the help of artificial intelligence can prevent medical device-related pressure injuries in intensive care patients. These injuries, which can be painful and serious, affect about 1 in 5 ICU patients. The study will comp…

Researchers are testing whether an artificial intelligence tool can sort children by their risk of nearsightedness and guide personalized prevention, such as more outdoor time and special glasses. The trial enrolls about 1,600 students in grades 1 through 3 from public primary sc…

Researchers are testing whether mild electrical stimulation of a nerve in the ear can prevent atrial fibrillation, a common irregular heartbeat, after off-pump coronary artery bypass surgery. Adults scheduled for this heart surgery receive either the stimulation plus standard car…

This study tests whether an enhanced version of the Intensive Diabetes Prevention Program (IDPP) works better than the standard program at recruiting and keeping participants in district health centres. Researchers will compare the two approaches in 170 adults with prediabetes, l…

This study tests an 8-week program called KINDER, designed to help family caregivers of people with dementia reduce psychological elder abuse and improve the quality of care. The program includes group discussions over Zoom and a self-paced workbook. Researchers will enroll 260 c…

Researchers are testing whether a quadrivalent HPV vaccine can be given at the same time as a tetanus-diphtheria booster in healthy children and adolescents aged 9 to 15 in Indonesia. The trial compares children who receive both vaccines together with those who receive the HPV va…

Pancreatitis is a painful inflammation of the pancreas that can happen after an ERCP procedure. Doctors often give rectal indomethacin around the time of ERCP to lower that risk, but it still occurs. This trial randomly assigns adults having ERCP to receive either rectal indometh…

Spinal anesthesia for cesarean delivery often causes a sudden drop in blood pressure. Researchers are testing different infusion rates of phenylephrine, a drug that narrows blood vessels, to find the dose that prevents this drop in most women. The trial enrolls 200 women with ful…

This study tests whether a program led by community health workers can improve lung health for 800 people in Bhaktapur, Nepal, who are at risk for chronic respiratory diseases. The program includes tobacco cessation counseling, mask use during high pollution, handwashing, and flu…

Researchers at Emory University are running a rapid randomized controlled trial to see if small changes to digital messages and website design can help more people start and stay on HIV prevention medication (PrEP) through telehealth. The study includes adults in the United State…

Chronic pain after heart surgery through a breastbone incision affects many patients and can last for years. Researchers are testing whether an ultrasound-guided nerve block, given after anaesthesia but before the first cut, can reduce the chance of chronic pain three months late…

Researchers are testing an experimental drug called INCA33890 in people with stage II or III colorectal cancer who have finished surgery and chemotherapy but still have tiny amounts of tumor DNA in their blood. This leftover DNA, called circulating tumor DNA or ctDNA, can signal …

This study will test if using two heat probes instead of one can better prevent cervical cancer in 300 women with HIV in Zimbabwe. The standard single-probe treatment often fails in these women. The goal is to see if the two-probe method is safe, acceptable, and more effective at…

This trial tests whether a short educational session during a routine primary care visit can help young people aged 13 to 26 understand overdose risks, recognize an overdose, and respond with naloxone. Providers in the intervention group deliver the education and offer naloxone a…

Researchers are testing a new injectable drug called VH5356136 to see if it is safe and how the body processes it. The trial enrolls about 160 healthy adults without HIV, ages 18 to 55. Participants receive a single dose of the drug or a placebo, and researchers monitor side effe…

Researchers are testing whether an intensive Mediterranean diet program started in the first trimester of pregnancy lowers the chance of developing gestational diabetes in women at high risk. The trial enrolls about 1,200 pregnant women aged 18 to 50 with a single, unassisted pre…

This trial tests whether an animated health coach on a smartphone can help people who have abnormal cervical cancer screening results get the follow-up care they need. Many people skip these appointments, which can lead to preventable cancer. The study will enroll 750 adults aged…

Researchers at Sveti Ivan Psychiatric Hospital are testing whether high-frequency repetitive transcranial magnetic stimulation (rTMS) with the H7 coil reduces gambling disorder symptoms. The trial enrolls 60 men aged 18 to 64 who are starting treatment at a gambling disorder day …

Researchers are testing whether transcranial magnetic stimulation (TMS) can improve social perception in adolescents with autism spectrum disorder. The trial targets the right posterior superior temporal sulcus, a brain region involved in processing social information. Sixteen pa…

Researchers are studying a surgical method for repairing rotator cuff tears that uses two rows of anchors and sutures without knots, called the Montgolfier technique. The sutures spread tension evenly around the repair, similar to the cables of a hot air balloon. Adults scheduled…

Researchers are studying whether a broad-spectrum oral tincture containing CBD, CBN, and CBG changes anxiety symptoms in adults with generalized anxiety disorder. About 60 participants will take the tincture under the tongue or by mouth roughly every 12 hours for 8 weeks, with fo…

This study tests whether giving high-flow oxygen through special nasal prongs during a less-invasive heart valve replacement (TAVR) can prevent low oxygen levels and breathing complications. About 452 older adults undergoing TAVR under sedation will be randomly assigned to receiv…

Researchers are testing whether a structured educational program based on Kolcaba's Comfort Theory can improve quality of life for adults with epilepsy. The program addresses physical, emotional, social, and environmental comfort needs through planned sessions delivered alongside…

This early-phase trial tests whether giving adults with autism a 6-week course of vancomycin followed by a fecal transplant from a close relative can improve social and language problems. Ten participants will be tracked for changes in autism symptoms, quality of life, and gut he…

This early-stage trial tests whether a single dose of pembrolizumab (Keytruda), a drug used for cancer, can safely reduce long-term neurological symptoms like brain fog and dizziness in people with long COVID. Fifteen adults who had COVID-19 at least six months ago and still have…

Researchers are testing an experimental oral drug called soquelitinib in adults with moderate-to-severe hidradenitis suppurativa, a chronic skin condition that causes painful lumps and tunnels. The trial aims to see if the drug is safe and can reduce the number of inflammatory le…

This study compares three types of therapy for children aged 8 to 16.5 with severe irritability. Participants will receive either exposure-based cognitive behavioral therapy, parent management training, or supportive psychoeducation over 12 sessions. The goal is to see which appr…

This trial tests whether a single, two-hour online class called Empowered Relief can help American Indian adults with cancer-related pain. Participants learn three pain relief skills, create a personal plan, and get access to a free audio app for daily practice. The study aims to…

Researchers are comparing two forms of shockwave therapy, focused and radial, for adults with chronic plantar fasciitis, a common cause of heel pain. About 150 participants receive three weekly treatment sessions and then answer questions about pain and foot function for up to a …

Researchers compare two rehabilitation approaches for children with cerebral palsy and immature brain injury: virtual reality training and task-oriented circuit training. Both aim to improve upper limb sensorimotor function, pinch grip, and quality of life. Forty-four children ag…

Researchers are testing whether an AI chatbot on WeChat helps early-stage cancer patients quit smoking. The chatbot uses the Multi-Theory Model to offer personalized advice, emotional support, and habit tracking around the clock. The trial compares the chatbot with phone-based pr…

Researchers at the University of North Carolina are testing a support program for young adults aged 18 to 39 who are receiving cancer treatment. A trained navigator contacts each participant at least once a month for four months by phone, text, email, or video, based on what the …

This study tests whether using a person's brain scan (MRI) to guide TMS treatment for depression works better than the standard scalp-measurement method. 160 adults with major depression will receive accelerated TMS (10 sessions a day for 5 days) with either MRI or scalp targetin…

Researchers at the University of Bergen are testing whether a two-week, self-guided smartphone screen time reduction program can reduce depression symptoms in young adults. The trial enrolls 200 students in Oslo who have sought help at the student mental health service. Participa…

Adults with sickle cell disease often face severe pain crises that require hospital treatment with intravenous morphine. This trial compares standard morphine treatment with combinations that add paracetamol, ketamine, or nefopam. Researchers want to see if these combinations eas…

This pilot study tests a 12-month structured nursing program called RESPiraIA-Asma for adults with poorly controlled, non-severe asthma. The program combines education, inhaler training, home peak-flow monitoring, and personalized care plans, offered in-person, digitally, or mixe…

Endometriosis is a long-term condition where tissue like the uterine lining grows outside the uterus, often causing lasting pelvic pain. Surgery can help, but pain sometimes remains afterward. Researchers are testing whether a structured pelvic floor physiotherapy program done be…

This study tests whether a full-spectrum screen bar light can reduce eye fatigue and dry eye symptoms after two hours of computer work. Healthy adults aged 18 to 35 who use screens at least four hours daily will be randomly assigned to use the light or a standard screen without i…

Researchers are testing a five-session meaning-centered psychotherapy called CASA in Puerto Rican patients with Stage III or IV breast cancer and their caregivers. The trial compares CASA with usual care in about 114 people to see whether the therapy reduces psychological distres…

Endometriosis causes chronic pelvic pain and painful periods, and current treatments do not work for everyone. Researchers are testing whether desloratadine, an antihistamine usually taken for allergies, can reduce pain and improve quality of life. The trial enrolls 60 women aged…

Researchers are testing a program that combines mindful eating and yoga-based movement for adults with type 2 diabetes. The trial enrolls 60 people aged 40 and older who have had diabetes for at least six months. Half receive the mindfulness program and half receive standard diet…

This study tests whether taking dronabinol (a cannabis-derived medication) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. Th…

Researchers test whether adding inspiratory muscle training to a walking program helps adults on hemodialysis who also have atrial fibrillation. Participants do breathing exercises through a mouthpiece and walk for six minutes, while the study tracks heart rate, blood pressure, k…

Researchers test whether a combination of orofacial myofunctional therapy and cervical stabilization exercises can reduce jaw pain and improve function in adults with anterior disc displacement with reduction, a common temporomandibular disorder. The trial enrolls 80 adults aged …

Researchers compare two exercise-based therapies for children with spastic cerebral palsy: virtual reality therapy and plyometric exercise training. The trial enrolls 44 children aged 12 to 18 who can stand alone and have mild to moderate mobility limits. Children in the virtual …

Researchers at Tongji Hospital are testing a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in 26 people with Parkinson's disease. The study uses MRI scans to customize electrode placement so the stimulation reaches deep brai…

Researchers are testing whether older adults with high blood pressure who report insomnia can improve their sleep by pressing six acupoints on themselves each night for 28 days. The trial compares this self-acupressure routine with sleep hygiene training in 94 participants aged 6…

Researchers compare how people with paraplegia perform and feel about four daily tasks when using a self-balancing exoskeleton versus a manual wheelchair. Five participants attend daily sessions where they do tasks like making coffee or brushing teeth with each device. The study …

This pilot trial tests whether adding virtual pain neuroscience education to standard spinal cord stimulation can help chronic pain patients better manage their condition. The education teaches how the brain processes pain, aiming to reduce fear, anxiety, and catastrophizing. Par…

Researchers are testing whether mazdutide, a weekly injected drug, reduces the number of gout flares in adults who have both obesity and gout. The study enrolls 30 people aged 18 to 65 with a BMI of at least 30 and at least two gout flares in the past six months. Everyone receive…

Researchers at Dana-Farber Cancer Institute are testing Healing Gardens, a mobile game that delivers pain-focused cognitive behavioral therapy and cancer pain education. The study enrolls 46 adults with advanced solid tumors who have chronic pain related to cancer or its treatmen…

Many people with lumbar spinal stenosis get pain relief from decompression surgery but still do not walk more afterward. This pilot trial tests whether a behavioral program can change that. Researchers randomly assign 75 patients aged 40 to 85 to either the program, which pairs m…

This study tests an online self-help tool called e-couch for adults with social anxiety. Over 5 weeks, 200 participants will use the program, which is based on cognitive behavioral therapy. Researchers will use surveys and computer tasks to predict who improves the most.

Researchers are testing the F&P Licorice mask, a device used with PAP or NIV breathing machines, in people who have obstructive sleep apnea or other chronic respiratory conditions. The study follows about 45 adults who already use this type of therapy at home. Over roughly two we…

This study tests a spiritual health program called PATH for cancer patients struggling with feelings of disconnection, loss of meaning, or existential distress. Twenty adults with any stage of cancer will attend six workshops combining role-playing, psychology, and dignity therap…

Doctors insert a chest tube to drain air or fluid from around the lungs, but the procedure often causes severe pain. This trial compares two ultrasound-guided nerve blocks, the serratus anterior plane block and the erector spinae plane block, to see which one better controls pain…

This Phase 3 trial will test a web-based program called IMPACT for 250 veterans who have both opioid use disorder and chronic pain. The program includes 9 online modules and weekly feedback from a coach, all done from home. The goal is to see if it reduces how much pain interfere…

This trial tests whether an artificial intelligence chatbot can help men with prostate cancer better understand radiation therapy. Participants will use a plain-language chatbot alongside standard education from their care team. Researchers will measure changes in patients' confi…

Researchers compare two approaches to care after ileostomy reversal surgery in children. One group receives the Enhanced Recovery After Surgery (ERAS) protocol, which includes early feeding, early catheter removal, early walking, and multimodal pain control. The other group recei…

Aortic arch surgery temporarily cuts blood flow to the brain, which can leave patients with lasting thinking and memory problems. Researchers at Seoul National University Hospital are testing whether anesthesia with remimazolam, rather than propofol, lowers the chance of that cog…

This study tests two simple activities—volunteering inside the assisted living community or joining a current events discussion group—to see if they can reduce apathy in residents with mild to moderate memory problems. About 200 people aged 55 and older will take part for 6 month…

Researchers are testing whether intermittent fasting improves quality of life for adults with acute or chronic pancreatitis. Participants follow a daily 16-hour fast or receive standard calorie guidance. The study measures pancreas-related quality of life, pain, opioid use, weigh…

Researchers are testing whether nurse-led lessons delivered through virtual reality or a tablet help people with coronary artery disease understand their heart risks and take their antiplatelet medicines as prescribed. The trial enrolls 54 adults aged 18 to 65 who have coronary a…

Researchers test whether adding lumateperone to ongoing antidepressant treatment reduces emotional blunting in adults with major depressive disorder. Emotional blunting means feeling numb or unable to experience pleasure or sadness. Thirty participants who score high on the Oxfor…

This study tests whether prucalopride, a drug used for gut issues, can improve thinking and memory in people with schizophrenia. About 34 adults will take the drug for 4 weeks while staying on their usual medications. Researchers will measure changes in memory, attention, and pro…

Researchers are testing whether a carbohydrate-rich clear drink given two hours before bariatric surgery helps patients with metabolic syndrome recover normal gastrointestinal function faster. About 208 adults scheduled for gastric bypass or sleeve gastrectomy will be randomly as…

Researchers are testing whether a one-time injection of an experimental drug called paliroden into the middle ear is safe and can help adults with chronic, constant tinnitus in both ears. Participants, ages 18 to 75, have normal hearing thresholds but struggle to understand speec…

Researchers are studying whether a procedure called fluoroscopy-guided transdiscal splanchnic nerve neurolysis can safely reduce severe upper abdominal pain in adults with pancreatic, gastric, or hepatobiliary cancer. Participants first receive a diagnostic nerve block with local…

This study tests two types of exercise for people with a common knee condition called patellofemoral pain. One group does neuromuscular control exercises (like balance and coordination), the other does muscle strengthening. Researchers will measure pain, function, and movement in…

Researchers are testing whether adding whole-body electromyostimulation (WB-EMS) to a supervised exercise program improves body composition, heart health, fitness, and quality of life in overweight or obese postmenopausal women. Thirty women aged 48 to 60 will join a 16-week prog…

This study tests whether brief mindfulness and identity-affirming exercises can improve well-being and reduce mental health symptoms in LGBTQ youth aged 16-26 who are currently or recently unhoused. Two hundred participants will be randomly assigned to either the mindfulness prog…

Researchers test whether a single intravenous dose of anrikefon, given near the end of kidney stone removal surgery, can reduce opioid-related side effects such as nausea, vomiting, itching, oversedation, and breathing problems in the first 24 hours after surgery. All 160 adult p…

Researchers are testing whether a dietary supplement called KA-EX helps young elite football players recover after training. Players on the Udine Primavera team receive either KA-EX or a placebo powder mixed in water right after training for two months. The team tracks heart rate…

Researchers are testing whether time-restricted eating, where all food is eaten within a 10-hour window each day, can reduce fatigue and slow frailty in older adults living with prostate cancer or metastatic breast cancer. The trial enrolls 132 people aged 55 and older who typica…

Many people treated with aromatase inhibitors for early-stage breast cancer develop joint pain and stiffness that can make it hard to continue the therapy. This Phase II pilot study tests whether hydroxychloroquine, an anti-inflammatory drug often used for inflammatory joint cond…

Researchers are testing whether ultrasound-guided microwave ablation can safely treat breast fibroadenomas, which are non-cancerous lumps that can cause pain or change the shape of the breast. The procedure uses a thin needle to deliver heat that destroys the lump under local ane…

Researchers at Emory University are studying a modified Argentine tango program called Adaptango for adults with Parkinson's disease, mild cognitive impairment, or dementia, alongside younger adults. Over three months, participants take part in biweekly choreographic sessions tha…

Researchers are testing whether tranexamic acid, a drug that helps prevent bleeding, reduces blood loss and wound complications during high tibial osteotomy. This surgery realigns bow-legged knees to ease osteoarthritis pain and slow joint damage. The trial enrolls 200 adults wit…

Researchers are testing whether a digital nutrition app called STRONG, paired with remote dietitian counseling, is practical and helpful for adults with pancreatic ductal adenocarcinoma who are starting chemotherapy or radiation. About 80 participants join the study and are assig…

Many burn survivors live with persistent pain that disrupts daily life, and negative thoughts about pain can make it worse. Researchers are testing an 8-week cognitive behavioral therapy program delivered by video to see if it reduces pain interference and pain catastrophizing mo…

Researchers at the University of North Carolina at Chapel Hill are testing whether daily exposure to S-cone stimulating colored light can reduce pain severity and pain sensitivity in adults with fibromyalgia or chronic widespread pain and fatigue. Participants use programmed ligh…

Researchers are testing an experimental drug called GMDTC in adults with solid tumors who have mild kidney problems caused by cisplatin chemotherapy. The trial aims to find out if GMDTC is safe, what side effects it causes, and how the body processes it. Participants receive cisp…

This study tests whether an 8-week home exercise program can reduce pain and improve walking and brain function in young women with painful periods. Eighty-six single women aged 18-25 with moderate to severe period pain will do 30-minute sessions three times a week, including rel…

Plantar fasciitis causes heel pain when the tissue supporting the foot arch degenerates. Standard treatments like physical therapy, anti-inflammatory drugs, and orthotics help most people, but some continue to have pain for months. Researchers are testing three ultrasound-guided …

This study looks at whether bringing in palliative care early during an unplanned hospital stay can reduce aggressive treatments at the end of life for people with advanced cancer. About 493 adults with metastatic digestive, gynecological, ENT, or sarcoma cancers will be randomly…

Researchers test anrikefon injection to see if it eases pain after laparoscopic liver surgery. Adults aged 18 to 75 scheduled for this operation receive either anrikefon or flurbiprofen after surgery. The trial measures pain scores over 24 hours and checks for side effects.

Researchers test whether TECAR therapy, a radiofrequency treatment that warms deep shoulder tissues, adds benefit to a standard exercise program for people with rotator cuff tendinopathy. Thirty-six participants receive either TECAR plus exercise or exercise alone. The trial meas…

This Phase 2 trial tests whether combining psilocybin—a compound from certain mushrooms—with daily cognitive training can enhance brain plasticity in adults aged 65 and older. Participants include healthy older adults and those with mild cognitive impairment or early-stage Alzhei…

Some brain tumors, including meningiomas, hemangioblastomas, and certain metastases, have a rich blood supply that makes surgical removal difficult and risky. This study tests whether blocking the tumor's feeding blood vessels with a catheter procedure before surgery reduces blee…

Researchers compare two rehabilitation methods for children with hemiplegic cerebral palsy, a condition that causes muscle tightness and limited arm movement on one side. The trial enrolls 40 children aged 8 to 12 who receive either electromyography biofeedback training, which us…

Researchers at Indiana University are testing whether a food carbohydrate powder made from raw corn and potato starch can raise levels of GLP-1, a gut hormone that helps people feel full. The trial enrolls 62 adolescents aged 12 to 18 with obesity. For two months, participants dr…

Researchers compare two methods for replacing a missing front upper tooth with an implant right after extraction. One method, the Socket-Shield technique, leaves a thin piece of the tooth root in place to help protect the jawbone and gums. The other method uses the standard appro…

Researchers are testing whether intravenous ferric carboxymaltose, an iron replacement, eases severe restless legs syndrome that has not responded to standard drugs. The trial enrolls 66 adults with drug-resistant RLS and assigns them to receive the infusion either right away or …

Researchers at the University of Miami are testing a non-invasive ear stimulation treatment to understand nerve pain in older adults living with HIV. The study enrolls 70 people with HIV-associated peripheral neuropathy, a condition that causes tingling, numbness, or pain in the …

Researchers are testing whether personalised nutritional care from a trained dietitian improves quality of life for people aged 65 and older with pancreatic ductal adenocarcinoma. About 250 participants will be randomly assigned to either six months of individualised nutrition su…

Researchers test whether adding one structured cognitive behavioral therapy session to standard brief quit-smoking advice helps cancer patients stop smoking. The trial enrolls 446 adults with cancer in Vietnam who smoked at diagnosis and still smoke. Everyone gets brief counselin…

Researchers at the University of Michigan are studying whether a home device called Transcutaneous Electrical Acustimulation (TEA) can help adults with cirrhosis manage chronic pain. The trial enrolls 100 people who report ongoing pain on most days. Participants use either a real…

This trial tests whether a traditional Chinese music therapy, called Ziwu Liuzhu Five-Element Music Therapy, can reduce anxiety in people with pancreatic cancer who are undergoing chemotherapy. The study will enroll 320 patients with mild-to-moderate anxiety and randomly assign t…

Researchers are testing a gel made from orange peel extract to see if it can reduce the severity of mouth sores caused by radiation therapy in people with head and neck cancer. Thirty adults receiving radiation will be split into two groups: one gets the orange peel gel, the othe…

This study tests whether a virtual reality program can improve vision in 120 children, teens, and young adults who have lost part of their visual field (hemianopsia) after a brain tumor. Participants will use a VR headset at home for 8 weeks to do visual exercises. The goal is to…

Researchers compare two surgical methods for removing an inflamed appendix in obese patients: laparoscopic (keyhole) surgery and traditional open surgery. The trial enrolls 166 obese adults with acute appendicitis, randomly assigning each to one of the two procedures. The main go…

Researchers are testing a diabetes education program that combines standard self-management lessons with hands-on activities involving miniature horses. Children and teens ages 8 to 20 with type 1 or type 2 diabetes, along with their caregivers, attend four sessions led by a diab…

Researchers are testing whether an intravenous lidocaine infusion works as well as a thoracic paravertebral nerve block for helping women recover after breast cancer surgery. The trial enrolls 112 adults scheduled for mastectomy or breast-conserving surgery. Participants receive …

Many people with Parkinson's disease develop hand tremor that standard drugs cannot control. This Phase 3 trial tests whether botulinum toxin injections, guided by each patient's tremor pattern, can reduce that shaking. Participants receive either the toxin or a placebo injection…

This study looks at whether an 8-week aerobic exercise program can improve blood vessel function in women who have finished chemotherapy for non-metastatic breast cancer. Forty women will exercise three times a week for 30 minutes at a moderate pace. Researchers will measure arte…

This study tests whether regular breathing exercises can improve symptoms of Postural Tachycardia Syndrome (POTS), a condition that causes dizziness and rapid heartbeat when standing. Twelve adults with POTS will practice breathing exercises daily for four weeks while researchers…

Intrahepatic cholestasis of pregnancy is a liver condition that causes severe itching and can pose risks to both mother and baby. Researchers are testing whether an oral drug called maralixibat is safe and well tolerated in pregnant women with this condition. All 15 participants …

Researchers compare two palliative radiation schedules for people with incurable head and neck cancer. The standard Split Course takes several weeks and often causes hard-to-tolerate side effects. The study tests whether a shorter Quad Shot regimen can shrink tumors and ease symp…

This study looks at whether children, teens, and young adults with newly diagnosed osteosarcoma can safely leave the hospital when their methotrexate levels are slightly higher than usual after standard chemotherapy. The goal is to shorten hospital stays without increasing side e…

Researchers compare two ways to perform knee surgery for simple problems like meniscal tears, cartilage damage, and loose bodies. One method uses a needle arthroscopy with a 1.9mm camera through tiny openings, and the other uses standard arthroscopy. Adults aged 18 to 65 join the…

This study compares two ways to give steroid medicine to people with chronic sinusitis who have lost their sense of smell due to blocked nasal passages. One group will get standard steroid spray, while the other gets steroid drops placed directly where smell happens. The goal is …

This study tests whether an 8-week group program teaching dialectical behaviour therapy (DBT) skills is feasible and acceptable for people aged 14–35 who have experienced a first episode of psychosis. The program focuses on managing emotions, tolerating distress, and improving re…

Many preschoolers with neurodevelopmental disorders struggle with sleep, which can worsen behavior and stress at home. This Hong Kong trial compares two ways of teaching parents sleep strategies: group sessions in person and a self-help mobile app, both added to usual care, again…

This trial tests whether an experimental oral drug called BR005-036C can quickly relieve migraine attacks in adults. Researchers will compare two doses of the drug against a placebo in about 2,079 people who have migraines with or without aura. The main goals are to see if the dr…

Researchers are testing a new device called the Solutio™ catheter to see if it can safely deliver numbing medicine (tumescent anesthesia) from inside the great saphenous vein before endothermal ablation, a common treatment for varicose veins. The trial enrolls 30 adults with veno…

This study tests whether a self-balancing exoskeleton called XoMotion-R can help people with spinal cord injury (SCI) walk hands-free during rehab. Researchers will recruit 16 participants (8 inpatients and 8 outpatients) with specific levels of SCI to try the device. The goal is…

This study looks at whether using a pillow placed behind the shoulder after rotator cuff repair surgery can lower pain and improve sleep. About 126 adults aged 40 to 70 will choose whether to use the pillow or not. Their pain, sleep quality, and shoulder function will be checked …

This study follows 500 adults and children who are getting a stem cell transplant to see how their liver is affected. Researchers will track liver function, perform biopsies and scans, and look for factors that lead to liver damage. The goal is to better understand and eventually…

Researchers at the University of California, San Francisco are studying how well a calibrated touch device measures sensation in the larynx and throat. The study includes adults with larynx or throat disorders, including those whose condition followed radiation or other cancer tr…

Researchers at Assiut University are studying whether an underactive thyroid makes liver scarring worse in people with metabolic dysfunction-associated steatotic liver disease (MASLD). The trial enrolls 120 adults with MASLD, half of whom have overt or subclinical hypothyroidism …

This study tests whether having a neurologist consult via video during ambulance transport helps decide the best hospital for suspected stroke patients. About 484 adults with stroke symptoms will be randomly assigned to standard care or standard care plus a telemedicine consultat…

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

Researchers at the University of California, San Francisco are testing whether short bursts of high-intensity exercise control blood sugar as well as longer, moderate workouts. The study enrolls 12 non-diabetic or pre-diabetic adults who wear a continuous glucose monitor for 11 d…

This natural history study will explore how life experiences and environmental factors affect heart health and metabolism among 50 Bhutanese adults living in the US. Participants will complete a survey and discuss their views on providing biological samples. The goal is to identi…

Researchers at Marmara University are studying whether alexithymia, a trait where people struggle to identify and describe their feelings, relates to pain intensity, quality of life, anxiety, depression, and childhood trauma in adults with chronic coccydynia. Participants have ha…

Researchers at Suleyman Demirel University are surveying lawyers registered with the Isparta Bar Association to understand how physical activity, stress, burnout, and job satisfaction relate to musculoskeletal pain. About 102 lawyers with at least five years of experience answer …

This pilot study will test a new method to see how two pain medicines, naproxen and pregabalin, work in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order. They will undergo several short, controlled pain tests, like a cold water hand b…

This trial tests whether a structured training program for ICU nurses, focusing on respiratory and renal care with case-based discussions, improves their clinical reasoning, knowledge, and collaboration with doctors. The study involves 140 participants, including nurses and mecha…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

Researchers in Korea are reviewing medical records from about 2,000 patients with triple-negative breast cancer who received pembrolizumab plus chemotherapy before surgery. The study measures how many patients had no detectable cancer left in their breast and lymph nodes at surge…

This study follows 125 pregnant women from 30 weeks of pregnancy through their baby's first year. Researchers want to learn how diet, food access, and other social factors affect mothers' health, breastfeeding success, and baby growth. Participants will complete remote visits and…

This study looks at how eating a high-fat or high-carb breakfast changes fat levels in the blood over 8 hours. Researchers will compare results among people with conditions like diabetes, fatty liver, or kidney disease, as well as healthy volunteers. Participants will have two ov…

This study will take standard heart CT scans from 1000 adults with structural heart disease and use a super-computer to create ultra-high-resolution images. The goal is to see if these enhanced images show more detail than the originals. No new treatments are being tested; it's a…

Researchers are observing 300 adults aged 60 and older with inflammatory bowel disease who are starting an advanced therapy chosen by their usual care team. The study tracks immune-aging markers such as CD4/CD8 ratio and IL-6, along with frailty and nutrition, over 52 weeks. The …

Researchers at Marmara University are studying why some people with chronic low back pain and nerve-related leg pain respond better than others to a standard steroid injection near the spine. The team follows 60 adults who are already scheduled for this routine procedure. Before …

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

This study investigates how eating three high-fat meals in a row changes vitamin E levels in the blood. Researchers will compare people with normal blood fats to those with high blood fats (hyperlipidemia). The goal is to understand whether fats in the blood can trap vitamin E, p…

This early-stage study tests a new form of transcranial magnetic stimulation (TMS) called high-density theta burst stimulation (hdTBS) in 35 healthy adults aged 22 to 60. The goal is to check if hdTBS is safe and to compare its effects on the brain to standard TMS. Participants w…

Researchers at Emile Muller Hospital in Mulhouse, France, want to estimate how many mothers develop post-traumatic stress disorder after giving birth. About 1,000 women who deliver at the hospital are asked to fill out the City Birth Trauma Scale and a short survey about their he…

Researchers at Poitiers University Hospital are studying whether changes in how people with Alzheimer's use their smartphones track with changes in their ability to handle daily tasks. About 100 participants aged 60 and older will have their Android phone usage and battery data c…

This study follows 400 children aged 5 to 7 with obesity or normal weight until age 12. Researchers will track puberty signs, hormones, genes, diet, and chemical exposures to see what predicts early puberty. No treatments are given; the goal is to gather information.

Researchers at the University of California, San Francisco are following 100 adolescents and young adults, ages 12 to 21, who are starting GLP-1 weight-loss drugs like Ozempic, Wegovy, or Mounjaro. Over one year, participants answer online surveys about their eating behaviors and…

This pilot study will check if it's possible to collect useful nutrition and health information from 30 adults with diabetic foot ulcers. Researchers want to see if they can recruit enough people and gather complete data. The goal is to learn about patients' diet, body compositio…

Researchers are studying whether navigational memory fades before other spatial memory in people with Parkinson's disease and related conditions. The pilot includes 80 participants: those with mild or advanced Parkinson's, those with parkinsonism, and healthy volunteers. Particip…

This study will follow 3,000 French patients with severe or complicated obesity who are taking semaglutide (Wegovy) as part of an early access program. Researchers will track weight changes, treatment patterns, and well-being over time using questionnaires. The goal is to underst…

This study looks at over 500,000 critically ill adults in Swedish ICUs to see if starting continuous kidney dialysis (CRRT) earlier affects how long they stay in the ICU. About 5% of these patients receive CRRT. Researchers will compare early versus late initiation of dialysis an…

This study will give 50 women a Fitbit Inspire 3 to wear before and after DIEP flap breast reconstruction surgery. Researchers will track steps, heart rate, and sleep, and compare that data with short questionnaires about recovery. The goal is to learn more about how patients rec…

Autoimmune hepatitis makes a child's immune system attack their liver. Researchers at Assiut University Children's Hospital want to know how many children with this liver condition also develop thyroid disorders such as Hashimoto thyroiditis or Graves' disease. The team will test…

This study is testing a new questionnaire (called the QLQ-OV39) to see how well it measures quality of life in people with ovarian cancer. About 50 adults with early or advanced ovarian cancer will fill out the questionnaire and give feedback. The goal is to make sure the questio…

This study will follow 100 adults with Crohn's disease, ulcerative colitis, or other IBD, plus their healthy relatives, for up to 3 years. Researchers will collect blood, stool, tissue samples, and imaging to track how immune cells and genetics change over time. The goal is to fi…

This study is creating a large collection of blood samples and medical information from 1000 adults with or suspected of having pulmonary hypertension (PH). Researchers hope this resource will help them find new ways to diagnose and treat PH. Participants will provide a blood sam…

This study compares two approaches to notify relatives of people diagnosed with familial hypercholesterolemia (FH), a genetic condition causing very high cholesterol. One method lets patients share information themselves; the other has the study team contact relatives directly. R…

This study looks at how stress from being a refugee—like trauma, discrimination, and adjusting to a new culture—affects sleep in Bhutanese refugees living in Ohio. Researchers will hold focus groups and interviews with 70 adults to understand their sleep problems and coping strat…

This natural history study looks at how life events during childhood might affect eating behaviors and weight gain in adults. Researchers will observe 110 healthy volunteers aged 18 to 60, measuring food intake, physical activity, blood sugar, and body fat. Participants will also…

Researchers at Changhai Hospital are setting up a nationwide system to monitor how well devices and procedures for cerebrovascular conditions perform after they reach the market. The study plans to enroll about 2,000 adults with acute ischemic stroke, narrowed brain or neck arter…

This study follows 70 people with PRKN- or PINK1-linked Parkinson's disease, as well as those with typical Parkinson's and healthy volunteers, over 5 years. Researchers will track movement, thinking, and mood symptoms, and collect blood, urine, and optional spinal fluid or muscle…

Researchers want to know whether CGRP, a protein involved in migraine, also affects the vestibulo-ocular reflex, the automatic eye movement that keeps vision steady when the head turns. The trial gives 80 people at the University Hospital Zurich either a single dose of atogepant,…

This study will test whether cancer patients receiving chemotherapy and radiation therapy can use wearable health devices, like fitness trackers, to monitor their heart rate and activity levels. Twenty adults will wear the device during treatment and for four weeks after, uploadi…

Researchers at Assiut University are studying adults with blood cancers who receive an autologous hematopoietic stem cell transplant, a procedure that uses a patient's own stem cells. The study follows 123 participants to measure survival, progression-free survival, complications…

This study will measure normal blood clotting values in 240 children under 18 who are having surgery or a procedure with anesthesia. The goal is to establish reference ranges for the Quantra system, a device that checks how well blood clots. This information will help doctors bet…

Researchers at Assiut University Hospitals are studying how often adults with multiple sclerosis also get primary headaches such as migraine and tension-type headache. About 100 patients will complete a single visit that includes a neurological exam, headache history, disability …

Researchers want to understand why most IVF embryo transfers fail to implant and what goes wrong in pregnancies complicated by preeclampsia. They will collect small tissue samples from the womb lining of up to 500 women aged 18 to 50 who are already scheduled for a diagnostic hys…

This observational study will take small liver samples from 8 adults with hemophilia A or B who had gene therapy at least 6 months ago. Researchers want to see how the gene therapy affected liver cells, including how many cells still carry the therapy and whether there is any liv…

Multiple myeloma is a blood cancer in which abnormal plasma cells build up in bone marrow, and inflammation may shape how the disease behaves. Researchers at Assiut University plan to study 60 people newly diagnosed with myeloma before any anti-myeloma treatment begins. They will…

This study follows 80 people with spinal muscular atrophy (SMA) in Japan who receive Zolgensma (onasemnogene abeparvovec) as an intrathecal injection. The goal is to track safety issues, such as liver problems or blood clotting abnormalities, and to measure changes in motor funct…

Researchers at Shanghai General Hospital are studying whether exercise relates to visual function in people with glaucoma. About 100 patients aged 18 to 100 answer a questionnaire about their physical activity. The team then measures central visual field, retinal nerve fiber laye…

Researchers at Assiut University Children Hospital are studying whether abnormal brain-wave patterns on an EEG can predict how well children with encephalopathy recover. The study follows 147 children aged 1 month to 18 years who have altered consciousness from encephalopathy. Ea…

This observational study gathers information from routine care on how localized rectal cancer is treated across Austrian hospitals. It aims to document the variety of treatment approaches, including total neoadjuvant therapy and immunotherapy, and their outcomes. By analyzing thi…

This study will test whether combining continuous glucose monitor (CGM) data with information from a smartwatch and a phone app (like meals and activity) can better predict blood sugar levels in people with type 2 diabetes. Thirty-six adults will wear a CGM and smartwatch and log…

This pilot study looks at whether it is safe to stop giving antibiotics after surgery for a burst (perforated) appendix. About 100 adults will be randomly assigned to receive either antibiotics or no antibiotics after their operation. The main goal is to see if a larger study is …

Researchers are testing whether blocking three inflammation pathways at once (TL1A, IL-23, and α4β7) calms inflamed intestinal tissue more effectively than blocking each pathway alone. The study enrolls 30 people: 10 with ulcerative colitis, 10 with Crohn's disease, and 10 withou…

People with rheumatic heart disease and atrial fibrillation take warfarin to prevent strokes, but the drug only works safely when blood clotting stays in a narrow target range. Researchers at Assiut University are studying about 90 Egyptian adults on warfarin for at least six mon…

This study will test if an AI chatbot can give helpful nutrition advice to pregnant women. About 100 women will either use the chatbot or get standard care. The goal is to see if the chatbot is easy to use and if it helps improve diet and knowledge about conditions like gestation…

This study will follow 200 children with acute lymphoblastic leukemia or lymphoma to learn more about the short- and long-term side effects of asparaginase drugs. Researchers will track how often serious toxicities occur during standard treatment and a newer therapy called SJALL2…

This study will measure how the body uses energy and burns fat in 10 people with extreme obesity (BMI of 60 or higher). Participants will spend 23 hours in a special metabolic chamber and drink a labeled water to track energy use over a week. The goal is to better understand meta…

Researchers at Assiut University Hospitals are following 250 adults with chronic heart failure and reduced ejection fraction who are on or starting guideline-directed medical therapy. Over three months, the team measures changes in heart pumping function, kidney filtration, quali…

This study tests whether a new questionnaire called PLATO can help dentists track how well oral appliance therapy works for people with obstructive sleep apnea. The questionnaire, developed by the American Academy of Sleep Medicine, measures patient-reported outcomes. Researchers…

Anti-VEGF injections treat conditions like diabetic macular edema, age-related macular degeneration, and retinal vein occlusion by adding fluid inside the eye, which can briefly raise eye pressure. This observational study at Assiut University follows 50 adults receiving these ro…

This study tests better ways to screen and treat cervical cancer in women living with HIV in Kenya, who face a much higher risk. Researchers will use HPV self-testing, care navigators, and a mobile app to help more women get diagnosed and treated. The goal is to find strategies t…

Researchers are examining health records from adults diagnosed with diffuse large B-cell lymphoma, a fast-growing blood cancer, across multiple UK hospitals. The study asks whether a patient's ethnicity, level of socioeconomic deprivation, and other health conditions influence ho…

Researchers at Tufts Medical Center are testing an advance care planning program for people 65 and older who have Alzheimer's disease or related dementias, or who face a higher risk of dying within a year. The program pairs participants with counselors and videos that explain car…

Researchers at Assiut University Hospitals compare adults with kidney failure who receive hemodialysis twice a week versus three times a week. The study tracks health-related quality of life, dialysis adequacy, urine output, and hospitalizations over time. About 130 participants …

Researchers want to know whether caffeine consumption is linked to irregular heartbeats and daily physical activity in adults with heart failure, reduced left ventricular ejection fraction, and an implantable cardioverter-defibrillator (ICD). About 170 participants fill out a one…

Researchers at Assiut University Children Hospital are studying how often children who come to the emergency department have an abnormal heart rhythm. The study includes children aged 1 month to 18 years who arrive with symptoms such as palpitations, chest pain, fainting, or trou…

This study follows 250 people with cystinosis, a rare genetic disorder that causes a buildup of the amino acid cystine, leading to damage in the kidneys, eyes, and other organs. Researchers will track how the disease progresses over time, including kidney function, eye problems, …

Researchers are studying whether aerobic fitness relates to walking, balance, and fatigue in people with multiple sclerosis. About 70 adults with relapsing-remitting or progressive MS will take walking tests and balance challenges that involve soft surfaces and head movements. Th…

This study will give 28 women with obesity either a calorie-restricted DASH diet or a standard American diet for 4 weeks. Researchers will track weight changes and analyze stool samples to see how diet affects gut bacteria and related health markers. The goal is to understand how…

This study asks whether healthcare providers in cancer centers hold negative attitudes toward patients with mental disorders, and what factors influence those views. Researchers will survey about 1,000 oncology professionals using a stigma questionnaire and interview some of them…

Researchers at Assiut University Children Hospital are tracking 100 preterm infants who need invasive mechanical ventilation in the neonatal intensive care unit. The study aims to identify which early factors predict prolonged ventilation, defined as more than 7 days or frequent …

This study will use advanced MRI scans to look at kidney transplants in 140 patients. The goal is to see if MRI can measure how well the kidney is working and tell the difference between stable function and problems like rejection. Researchers hope this could lead to a non-invasi…

Filoviruses such as Ebola and Marburg cause severe hemorrhagic fevers with high death rates, and doctors know little about rare types like Bundibugyo virus. This observational study follows patients in France with confirmed filovirus disease to record how the illness unfolds. Res…

Researchers at Sohag University Hospitals are reviewing the medical records of 30 people treated for papillary thyroid cancer, the most common type of thyroid cancer. The study examines how far tumors extended beyond the thyroid gland and which complications appeared soon after s…

Researchers at Mayo Clinic are studying whether an implantable Doppler monitor can record the sound of blood flowing through a free flap and convert it into a visual signal. The trial enrolls 100 adults scheduled for free flap surgery, a procedure that moves tissue to rebuild par…

This Mayo Clinic study will test whether a special ultrasound technique, called shear wave elastography, can measure how stiff brain tumors are compared to healthy brain tissue during surgery. Researchers will enroll 30 adults with newly diagnosed or recurrent brain tumors. The g…

This study tests whether a video app that explains 'Undetectable = Untransmittable' (U=U) can help people with HIV stay on treatment and keep the virus under control. About 880 people from clinics in South Africa will use the app during counseling. The goal is to see if better un…

This study will follow 85 adults receiving stem cell transplants to track a serious but often missed complication called TA-TMA. Researchers want to find out how common it is and how it affects survival. Participants will provide blood samples and have standard follow-up care.

This study will investigate whether exposure to persistent organic pollutants (POPs) like dioxins and PCBs is linked to more severe endometriosis. Researchers will analyze blood samples from 650 women with endometriosis living in the Ile-de-France region of France. The goal is to…

This study collects tumor tissue and blood samples from 120 cancer patients who are receiving or will receive immunotherapy. The samples will be stored in a biobank for future research to better understand how these treatments work. No direct treatment is given; the goal is to ga…

Researchers at Assiut University Hospitals are studying whether a simple calculation from two routine blood tests, the leukocyte glucose index, relates to how severe diabetic ketoacidosis becomes in adults with diabetes. The index multiplies white blood cell count by blood sugar …

Researchers at Shanghai Mental Health Center are following 500 people with obsessive-compulsive disorder to see how symptoms, daily functioning, and treatment responses change over time. The study includes adults aged 18 to 60, including some who have never received OCD treatment…

Many older adults with knee osteoarthritis believe their pain comes mainly from joint wear and tear, which can lead to fear of movement and less activity. Researchers at McMaster University are comparing two web-based education programs: one that explains pain as a mix of biologi…

Researchers at Chang Gung Memorial Hospital are studying whether an interactive web-based training platform improves how gerontology students handle dementia care decisions. The study first interviews second-year students about the challenges they face when caring for people with…

Researchers at a Turkish hospital are observing 400 adults who visit a pain clinic with cervical radicular pain, the shooting or aching arm pain that comes from a pinched nerve root in the neck. Participants receive routine neurological exams, including the Hoffmann sign, and cer…

After thyroid surgery for differentiated thyroid cancer, patients often need to take thyroid hormone at doses that keep TSH in a specific target range. Researchers at West China Hospital are testing whether adding a short educational video to standard instructions helps patients …

This study aims to find the best way to dose the antibiotic ceftazidime for patients in intensive care with serious infections. Many ICU patients don't get enough of the drug because their bodies process it differently. The researchers will test a personalized dosing plan to keep…

Researchers are testing whether people with non-small cell lung cancer can collect their own small blood samples at home using a finger-prick kit. Participants receive standard treatment with docetaxel, paclitaxel, alectinib, or lorlatinib, and the samples measure how much cancer…

ARDS is a severe lung condition that damages the tiny air sacs and blood vessels in the lungs, leading to low oxygen and unstable circulation. Researchers at Hospices Civils de Lyon are measuring blood viscosity, or how thick and resistant to flow the blood is, in ICU patients wi…

This study will track 320 people in Hong Kong who have a heart attack complicated by cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will collect data on standard treatments, including the use of a heart pump called Impella, to…

Researchers are studying how four types of brain stimulation for depression, ECT, TMS, VNS, and taVNS, affect decision-making and reward learning over time. About 100 patients receiving these treatments at a German hospital complete repeated online tasks that measure how they lea…

Researchers at Sheba Medical Center are testing whether AI-generated medical summaries help pregnant patients hospitalized for high-risk pregnancies feel more informed and involved in their care. Half of the 200 participants receive up to three AI-written summaries of their medic…

Researchers are reviewing medical records of 100 people with esophageal squamous cell carcinoma who received immunotherapy plus chemotherapy before surgery to remove the cancer. The study examines when and where cancer returns and which patient traits, treatment details, scan res…

This study looks at how the brains of women with anorexia nervosa respond to fatty food smells and images. Researchers will use brain scans to compare their reactions to those of healthy women. The goal is to understand why fatty foods cause aversion, which could help improve fut…

Researchers at the University of Texas at Dallas are studying how physical activity, sedentary behavior and self-control relate to loss of control eating in children. The study follows 200 children aged 10 to 12 for three years, using brain scans, activity monitors, and real-time…

This study will test a new mobile mental health app designed to help people with schizophrenia or schizoaffective disorder stick to their medication routine. Researchers will enroll 50 adults who are in remission and see if using the app is practical and well-liked. The goal is t…

Researchers at Lokman Hekim University are studying how migraine affects daily life and which factors track with worse disability. About 100 adults diagnosed with primary migraine complete questionnaires on headache features, sleep quality, fatigue, neck pain, and lifestyle, plus…

This study will observe 3,000 adults in China with a type of heart failure called HFpEF who are starting the drug Jardiance. Researchers will track how many patients are hospitalized for heart failure or die from heart-related causes over time. The goal is to see how effective an…