Lymphatic system disorder

This early study tests the drug ruxolitinib for a rare but serious condition called IEC-HS, which can happen after CAR-T therapy for cancer. The condition causes a dangerous overreaction of the immune system. The trial will include 16 adults and aims to see if the drug is safe an…

This early-stage trial tests a new drug called LY4152199 in about 215 adults with certain types of blood cancer (like follicular lymphoma or diffuse large B-cell lymphoma) that have already been treated. The drug is designed to help the body's immune cells attack the cancer. The …

This pilot study tests whether a connected blood pressure monitor, supervised daily by a healthcare assistant, helps patients with blood cancers like CLL or lymphoma stick to home monitoring. The goal is to catch and manage high blood pressure early, a common side effect of BTK i…

This study tests whether removing a specific type of immune cell (naive T cells) from a donor's stem cell graft can prevent graft-versus-host disease (GVHD), a serious complication where donor cells attack the recipient's body. The trial enrolls people with non-malignant blood di…

This phase 2 trial tests whether giving rituximab maintenance therapy after initial treatment with rituximab and lenalidomide (R2) can improve outcomes for people with untreated marginal zone lymphoma. About 144 patients who respond to R2 will be randomly assigned to receive ritu…

This phase II trial tests whether a drug called mosunetuzumab works better alone or combined with either zanubrutinib or polatuzumab vedotin for people with marginal zone lymphoma that has returned or stopped responding to treatment. The study will enroll 138 participants and mea…

This study tests a drug called all-trans retinoic acid (ATRA) as a first treatment for hemophagocytic lymphohistiocytosis (HLH), a rare but life-threatening condition where the immune system goes into overdrive. ATRA is an oral medication already used for other blood diseases and…

This Phase II trial will test a combination of pomalidomide, an anti-CD20 antibody, and prednisone as a first treatment for people with indolent (slow-growing) B-cell lymphomas. About 30 adults who have not had prior therapy will receive six cycles of the combo, followed by two y…

This study tests a new way to deliver radiation for gastric MALT lymphoma. Using AI, the treatment adapts each session to better protect nearby organs. About 25 adults with early-stage disease will take part. The goal is to see if this approach is safe and effective.

This early-stage study tests a new drug called JL19001 in people with advanced solid tumors or a type of lymphoma that has come back or not responded to treatment. The main goal is to find a safe dose and check for side effects. About 14 participants will receive the drug as a sh…

This trial tests a gene therapy for FHL3, a rare immune disorder caused by a gene mutation. Instead of a donor stem cell transplant, patients receive their own stem cells that have been corrected with a healthy gene. The goal is to restore immune function while avoiding transplan…

This trial tests whether bendamustine causes fewer severe side effects than the standard fludarabine/cyclophosphamide combination when given before CAR-T cell therapy for B-cell lymphoma. About 92 people will be randomly assigned to one of the two chemotherapy regimens. The main …

This study tests a combination of two drugs, nemtabrutinib and rituximab, in about 35 adults with marginal zone lymphoma, a slow-growing blood cancer. The goal is to see if the combo is safe and can shrink or eliminate tumors. Participants will receive the drugs by mouth and thro…

This study compares two strategies for starting the drug etoposide in adults with severe hemophagocytic lymphohistiocytosis (HLH) who are in the intensive care unit. HLH is a life-threatening overreaction of the immune system that can cause organ failure. The goal is to see if gi…

This study tests a combination of two immune-boosting drugs (iparomlimab and tuvonralimab) plus chemotherapy given before surgery for people with a specific type of advanced lung cancer (stage III-N2b non-small cell lung cancer). The goal is to see if this treatment can completel…

This study tests whether children with bacterial infections like urinary tract infections, cellulitis, or pneumonia can safely stop oral antibiotics once their symptoms go away, instead of finishing the entire course. About 200 children aged 1 to 17 who have already received IV a…

This study will test a new line of massive prosthetic implants (the Pantheon range) in 375 people who have lost large amounts of bone due to cancer, complex fractures, or failed previous surgeries. The implants are designed to restore function quickly and stay stable long-term. R…

This early-phase study tests a new cell therapy called ALA-101 for people with CD19+ non-Hodgkin lymphoma or leukemia. The therapy uses donor immune cells that are specially designed to find and attack cancer cells. The main goals are to check safety and find the best dose, with …

This study will test the Symani Surgical System, a robotic device designed to help surgeons perform delicate microsurgery on lymph vessels in the head and neck. The goal is to see if the robot can safely and effectively reconnect lymph channels to reduce swelling (lymphedema) in …

This study tests whether regular ultrasound checks of the groin can safely replace the standard surgery to remove lymph nodes in women with early-stage vulvar cancer. The goal is to reduce side effects and improve recovery while still keeping the cancer under control. About 640 w…

This study looks at three different drug combinations for people newly diagnosed with a slow-growing blood cancer called marginal zone lymphoma. The goal is to see which combination works best to shrink tumors and keep the cancer from coming back, while also checking for side eff…

This phase 2 trial tests the drug everolimus in 67 people with vascular anomalies (abnormal blood vessels) that haven't responded to standard treatments. The goal is to shrink the lesions and improve symptoms. Participants take everolimus daily for 6 months, with doses adjusted b…

This early study tests a new drug called MTM-H-001 in 69 adults with B-cell blood cancers (like certain lymphomas and leukemias) that have come back or stopped responding to treatment. The main goal is to check safety and find the right dose, while also seeing if it can shrink tu…

This Phase 2 trial tests lisaftoclax, an oral drug that blocks a protein helping cancer cells survive. It enrolls 75 adults with certain slow-growing lymphomas (CLL, WM, or MZL) who either cannot take standard BTK inhibitors due to health issues or have stopped them due to side e…

This study tests a combination of two drugs, pomalidomide and obinutuzumab, in people with slow-growing lymphomas (like follicular lymphoma) that have returned or not responded to prior therapy. The first part finds the safest dose, and the second part checks how well the combina…

This trial tests whether two approved drugs, dabrafenib and trametinib, can treat rare cancers that have a specific genetic change called BRAF V600. These drugs are already used for melanoma and lung cancer, but researchers want to see if they help people with other cancer types.…

This early-stage trial tests a daily pill called APG-3288 in 180 adults with blood cancers like leukemia or lymphoma that have come back or not responded to standard treatments. The main goals are to find the safest dose and check for side effects. Researchers will also look for …

This early-phase study tests a new treatment called QH103 for adults with B-cell lymphoma that has come back or not responded to standard therapy. QH103 uses specially engineered immune cells (CAR-γδT cells) from healthy donors to target and kill cancer cells. The main goals are …

This study tests a new procedure using an endoscopic ultrasound to guide the injection of tiny particles into the spleen, reducing blood flow and lowering the risk of dangerous bleeding in people with liver cirrhosis. The goal is to see if this method is safer and more effective …

This study compares two injected drugs, bleomycin and doxycycline, to treat lymphatic malformations (abnormal fluid-filled sacs) in children under 12. About 92 kids will be randomly assigned to one treatment, and doctors will measure how much the malformation shrinks over six mon…

This early study tests a new treatment for people with B-cell blood cancers that have come back or not responded to standard therapy. The treatment uses donor immune cells (CAR-T cells) designed to find and attack cancer cells. The main goal is to check if it's safe, with a small…

This study tests a combination of three drugs—zanubrutinib, rituximab, and lenalidomide—as the first treatment for people with marginal zone lymphoma that has spread or requires therapy. Researchers want to see if this drug mix helps tumors shrink or disappear and how safe it is.…

This Phase 3 trial tests an oral drug called KP-001 in 150 people aged 2 and older with venous malformations, lymphatic malformations, or KTS/CLOVES syndrome. Participants receive either KP-001 or a placebo for 24 weeks, then everyone gets the drug for another 28 weeks. The goal …

This early-phase trial tests a new treatment for people with B-cell non-Hodgkin lymphoma that has not responded to at least two prior therapies. Participants receive donor immune cells (NK cells) along with two antibody drugs (rituximab and tafasitamab) and a support drug (IL-2) …

This large study in Fiji tests whether a new combination of drugs (moxidectin plus two others) can safely treat three common parasitic infections: lymphatic filariasis, scabies, and strongyloidiasis. About 5,100 people will receive either the new combo or the standard treatment o…

This study looks at whether a special ultrasound can accurately detect if breast cancer has completely disappeared from lymph nodes after chemotherapy. About 150 women with cancer that spread to their lymph nodes will have a small clip placed in a cancerous node before treatment.…

This study aims to see if a less invasive biopsy method, using ultrasound guidance, can accurately detect whether breast cancer has spread to nearby lymph nodes. Researchers will enroll 200 adults with newly diagnosed breast cancer. The goal is to find the best way to identify su…

This study will compare two different PET/MRI scans to see which one is better at finding lymph node metastases in people with middle to high rectal cancer. Thirty participants will receive both types of scans before surgery. The goal is to see if the newer tracer, [68Ga]Ga-CTR-F…

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This study will test a rapid finger-prick blood test for heart failure in 618 people with leg swelling (lymphoedema) who have not been diagnosed with heart failure. The test measures a substance called NT-proBNP and gives results in 12 minutes, compared to the usual lab test that…

This study will test a new rapid diagnostic test for plague in the Ituri province of DR Congo. Researchers will collect samples like blood, saliva, and bubo fluid from 300 people with suspected plague to see how well the new test works compared to standard lab methods. The goal i…

This trial tests a new biopsy method called EBUS-TBMC against the standard needle approach for diagnosing tuberculosis in chest lymph nodes. About 108 adults with suspected TB will undergo both procedures in one session to see which yields better tissue samples. The goal is to im…

This study will test whether an artificial intelligence system can spot signs of Kawasaki disease in children's chest X-rays earlier than standard methods. Researchers will analyze data from 20,000 children to see if the AI can predict the best time for treatment and reduce heart…

This study tests whether a combination of contrast-enhanced ultrasound and spleen stiffness measurement can accurately detect high blood pressure in the liver (portal hypertension) in people with cirrhosis. Currently, doctors must insert a catheter into a neck vein to measure thi…

This study tests whether a device that delivers sound waves (shock wave therapy) can help reduce leg swelling and improve quality of life in people with lower limb lymphedema. Thirty-six adults who are already using standard care will either get real or fake (sham) treatments twi…

This study tests if a new dynamic compression device, used with compression stockings, works as well as current treatments for reducing leg swelling in people with lymphedema. About 98 adults with stage II or III lymphedema will use either the new device or standard wraps and pum…

This study compares a new dynamic compression device to traditional bandages for reducing leg swelling in people with lymphedema. Over 5 days of intensive treatment, 110 participants will wear either the device or standard bandages. The goal is to see which method reduces excess …

This study tests whether a simple home exercise program done for at least three weeks before breast cancer surgery can help women recover better. 54 women with early-stage breast cancer will be randomly assigned to either the exercise program or usual care. Researchers will measu…

This study tests whether a daily 15-minute massage for 14 days can reduce swelling (lymphedema) and improve comfort in 40 premature babies in the NICU. Half the infants will receive standard care, and the other half will also get gentle massage on their arms and legs. Researchers…

This study tests whether a new adjustable sleeve called MOBIDERM Autofit works better than standard bandages for managing breast cancer-related lymphedema at night. Sixteen women with arm swelling will wear each device for one month to compare changes in arm volume and pressure. …

This study tests whether listening to positive self-affirmation audio recordings can help reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two women will be randomly assigned to either listen to the affirmations or receive standard care. The …

This study compares two treatments for arm swelling (lymphedema) that can happen after breast cancer surgery. The goal is to see which therapy works better to reduce pain, swelling, and improve movement and quality of life. The study will include 52 women aged 30-60 who had a mas…

This study tests a 3-month exercise program for women with breast cancer who have arm swelling (lymphedema) and nerve pain (neuropathy) from treatment. Thirty women will do general and arm-specific exercises twice a week. Researchers will measure changes in arm size and pain leve…

This observational study will analyze tissue samples from 400 people with MALT lymphoma, a slow-growing cancer. Researchers aim to build a comprehensive molecular and cellular map of the disease across different body sites. The goal is to identify tumor subtypes and biomarkers th…

This study looks at whether a tumor's DNA repair status (MMR) changes how well the presence of cancer cells in lymph vessels predicts spread to lymph nodes in stomach cancer. Researchers will review medical records of 3,000 patients who had surgery. The goal is to improve risk as…

This study will test whether doctors can quickly and accurately monitor minimal residual disease (tiny amounts of cancer left after treatment) in people with aggressive B-cell lymphoma. Researchers will use blood tests to look for tumor DNA and PET scans to see if results can be …

This study will collect blood samples from 1,000 people with small colon growths to see if a liquid biopsy can accurately tell benign from malignant lesions and predict cancer spread to lymph nodes. Current methods often lead to unnecessary surgery. The goal is to create a bioban…

This study will test whether special imaging scans (ICG lymphography and high-frequency ultrasound) can predict how well a surgery called lymphaticovenous anastomosis works for arm swelling after breast cancer treatment. Thirty women with mild to moderate lymphedema will be scann…

This pilot study tests whether a new compression pattern in a leg sleeve device (Flexitouch Plus) moves lymph fluid better than the current version. Five adults with leg lymphedema will receive both treatments in separate visits, and doctors will measure how far and how often lym…

This study tests whether a special headset (extended reality) can help surgeons plan the removal of cancer-affected lymph nodes in the neck for people with lung cancer. Ten patients will have their PET and CT scans combined into a 3D model that the surgeon views just before surge…

This study follows 30 adults with liver cirrhosis who are having their spleen removed (laparoscopic splenectomy) to treat an enlarged spleen and low blood counts. Researchers will measure kidney function before surgery and for two years after to see if the surgery helps or harms …

This study follows 30 adults with liver cirrhosis, an enlarged spleen, and hypersplenism who are having their spleen removed by keyhole surgery. Researchers will measure changes in cholesterol and other blood fats before surgery and for two years afterward. The goal is to learn w…

This study follows 30 people with liver cirrhosis who need spleen surgery to treat bleeding from high blood pressure in the liver. Researchers will check their cholesterol and fat levels before and for two years after surgery. The goal is to see if the surgery improves abnormal f…

This study looks at how well immunotherapy shrinks tumors and lymph node metastases in 5,000 people with various cancers. Researchers will track changes in tumor and lymph node size after treatment and explore factors like beta-blocker use that might affect results. The goal is t…

This study looks back at the medical records of 350 adults diagnosed with cutaneous T-cell lymphoma, a rare type of skin cancer, treated at Hospital México in Costa Rica between 2019 and 2025. Researchers aim to describe the patients' backgrounds, the treatments they received, an…

This study will observe 150 children with Kawasaki disease to learn more about a rare but serious complication called Macrophage Activation Syndrome (MAS). Researchers will collect data on symptoms, lab results, and treatments across multiple European hospitals. The goal is to be…

This study will test a specially trained AI model (like ChatGPT) to see if it can help doctors correctly diagnose and recommend treatments for lymphedema, lipedema, and venous insufficiency. Researchers will compare the AI's suggestions to current medical guidelines. The goal is …

This study will follow 1,500 people with lupus or other autoimmune diseases to see if advanced heart scans can predict heart attacks, strokes, or other heart problems. Participants will have one of three types of heart imaging. The goal is to learn if these scans can help doctors…

This study looks at why people with Noonan syndrome often bleed easily, especially from the skin, mouth, or nose. Researchers will compare a simple questionnaire about bleeding history with blood tests in 100 patients. The goal is to find better ways to predict serious bleeding, …

This study will test a new way to care for people in Ghana who have both a neglected tropical skin disease (like leprosy or Buruli ulcer) and mental health challenges like depression or anxiety. Researchers will work with 200 affected adults and local health workers to create a G…

This study will collect blood, saliva, urine, and stool samples from 500 adults with systemic histiocytosis—a group of rare inflammatory disorders. Researchers aim to identify biomarkers that could improve diagnosis, predict disease progression, and enable less invasive monitorin…