Experimental immune cell cocktail targets tough lymphoma

NCT ID NCT07225439

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests a new treatment for people with B-cell non-Hodgkin lymphoma that has not responded to at least two prior therapies. Participants receive donor immune cells (NK cells) along with two antibody drugs (rituximab and tafasitamab) and a support drug (IL-2) to help the cells work. The main goal is to find a safe dose and check for side effects, while also seeing if the combination can shrink tumors. About 15 adults will take part, and the study lasts roughly 12 months.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia B-cell neoplasm B-cell non-Hodgkin lymphoma diffuse large B-cell lymphoma follicular lymphoma high grade B-cell lymphoma Lymphoma, B-Cell, Marginal Zone mantle cell lymphoma marginal zone lymphoma non-Hodgkin lymphoma primary mediastinal large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute

    Cleveland, Ohio, 44195, United States

    Contact Email: •••••@•••••

    Contact

  • Case Comprehensive Cancer Center, University Hospitals Seidman Cancer Center

    Cleveland, Ohio, 44106, United States

    Contact Email: •••••@•••••

    Contact