Intervertebral disk degenerative disorder

This study tests a surgical technique to restore the natural curve (lordosis) of the lower spine in people who have had a previous spinal fusion that failed or caused ongoing pain. The procedure is done through the same incision used in the prior surgery. Researchers will measure…

This study compares two types of implants used in spinal fusion surgery: 3D-printed cages and titanium-coated cages. The goal is to see which leads to better bone fusion and less disability for patients with herniated discs or degenerative spine disease. About 78 adults undergoin…

This study follows 176 adults aged 21-80 who are already scheduled for a single-level lower back fusion surgery using screws and cages. The goal is to collect real-world data on pain, mobility, and safety over 24 months. It does not test a new treatment but observes standard care…

This study tests a new device called MOTUS, which replaces a worn-out joint in the lower back with an artificial one. The goal is to see if it works as well as the standard surgery (spinal fusion) for reducing pain and improving function. About 158 adults aged 21-80 with single-l…

This study tests a single injection of VIA Disc NP, a processed human disc tissue, for people with long-term lower back pain from degenerated discs. About 121 participants will receive either the injection or a sham procedure. The goal is to see if the injection safely reduces pa…

This study looks at a natural protein called Natural Matrix Protein (NMP) used as a bone graft substitute during lumbar spinal fusion surgery. Researchers will review the medical records of about 100 adults who had this surgery to see how well their bones fused and if there were …

This study tests whether a special clot made from a patient's own bone marrow can help spine bones heal together faster and more reliably after spinal fusion surgery. The trial involves 96 adults with degenerative spine disease. Half will receive the standard bone graft, and the …

This early-stage trial tests whether injecting stem cells from donated umbilical cords into the spine can help repair degenerated discs in people with lower back and leg pain. Twenty patients who have not improved with other treatments will receive the injection right after a min…

This study is tracking 1,000 people who received a bone graft material called Natural Matrix Protein (NMP) during spine surgery for degenerative disc disease. Researchers will monitor bone fusion, pain, and disability over two years to see if NMP is safe and helps the spine heal.…

This study tests a new titanium cage used in spinal fusion surgery for people with degenerative disc disease in the neck. Fifty participants will receive the device and be followed for up to 24 months to see if the bones fuse properly and if pain and function improve. It is a sma…

This study compares two types of implants used in back surgery for people with worn-out discs in the lower spine. About 60 adults will receive either a PEEK cage with bone-growing protein or a CONDUIT cage during a procedure called DLIF. Researchers will check which cage leads to…

This study follows 148 adults with cervical disc disease who received the Hexanium ACIF implant, a device placed between vertebrae to restore height and fuse the spine. Researchers will track pain, disability, and any serious side effects for up to 24 months after surgery. The go…

This study compares two types of spinal fusion cages used in back surgery: a new titanium cage with a special rough surface and a standard plastic cage. About 100 adults with spine problems like narrowing of the spinal canal or slipped vertebrae will be randomly assigned to recei…

This study tests whether a special bone graft (Infuse) helps spine bones fuse together better after back surgery. About 600 adults with degenerative spine disease will be followed for two years. The goal is to see if the graft reduces pain, improves function, and safely helps bon…

This study looks back at the medical records of 200 people who received a Prodisc C Vivo device to replace two damaged discs in their neck. The goal is to see how often patients need additional surgery and how well the device performs compared to published data. Participants will…

This study looks at two treatments for chronic low back pain caused by worn-out spinal discs: a type of keyhole surgery and a therapy using the patient's own stem cells. Researchers will track 120 adults to see which approach better reduces pain and improves daily function. The g…

This study follows 131 people who already received the Simplify Disc for cervical disc disease. Researchers will check the disc's safety and how well it works over 10 years. The goal is to see if patients have lasting pain relief and fewer complications.

This study is testing a metal plate (the NuVasive ACP system) used during neck spine surgery to treat conditions like disc disease, stenosis, or fractures. About 75 adults will receive the plate and be followed for up to 24 months to see how safe it is and how well it helps with …

This study follows 158 people who already received the Simplify artificial disc to treat cervical disc disease. Researchers will track how well the disc works over 10 years by measuring neck function, nerve health, and whether any additional surgeries or serious problems occur. T…

This study is tracking 1,050 adults who are getting NuVasive interbody implants during spine surgery for conditions like degenerative disc disease or spinal stenosis. Researchers are monitoring complications, bone fusion, and patient-reported pain relief over 24 months. The goal …

This study looks at how safe and effective special spinal implants are for people with worn-out discs or unstable neck bones. About 150 adults who need neck surgery will receive these implants and be followed for 24 months. The goal is to see if the bones fuse properly and if pat…

This study follows 300 adults aged 18-80 who need spinal fusion surgery for degenerative disc disease or spondylolisthesis. It compares three types of interbody implants (PEEK, 3D-printed titanium, and another) used with bone graft material. Researchers will track how well the bo…

This study is testing a special bone graft called Virtuos in people having spinal fusion surgery for degenerative disc disease. The goal is to see if it helps the bones heal together better and reduces pain and disability. About 150 adults will take part, and the study will compa…

This study compares a new artificial disc, the Synergy Disc, to standard spinal fusion surgery for people with one-level cervical degenerative disc disease that hasn't improved with other treatments. About 175 adults aged 18-70 with neck and arm pain or nerve symptoms are being f…

This study tests a new material called Natural Matrix Protein (NMP) fibers, made from human bone, for spine fusion surgery. It includes 200 adults with degenerative disc disease, spinal stenosis, or spondylolisthesis who need fusion of up to three vertebrae in the neck or lower b…

This study tests a new artificial disc called the Synergy Disc for people with two-level cervical degenerative disc disease (DDD) who haven't improved with non-surgical care. The disc is designed to replace damaged discs in the neck while preserving motion, unlike standard fusion…

This study tests a new artificial disc (M6-C) for people with two damaged discs in their neck. It compares the disc to standard fusion surgery. The goal is to see if the artificial disc can safely improve neck function and reduce pain. About 156 adults with neck and arm pain from…

This study tests a device called PCSS used alongside standard neck fusion surgery to treat degenerative disc disease in the neck. About 236 adults aged 18-80 who need surgery on three neck levels will be enrolled. The goal is to see if the device helps bones fuse better and safel…

This study tests a new bone graft material (P-15L) for spinal fusion surgery in people with degenerative disc disease. The goal is to see if it works as well as the standard bone graft in helping bones fuse together and reducing pain. About 290 adults aged 22-80 will take part, a…

This clinical trial tests whether injecting stem cells into the spinal discs can reduce pain and improve function in people with chronic low back pain from degenerative disc disease. About 113 adults aged 18-60 who haven't gotten relief from standard treatments will receive eithe…

This study is testing a material called Orthoss®, made from granules, to help bones in the spine fuse together after surgery. The trial includes 65 adults with lower back problems like slipped discs or narrowing of the spine canal. Doctors will check if the bones fuse properly an…

This study tests whether a specific ultrasound-guided nerve block can reduce pain after elective lower back surgery better than the usual method of injecting pain medicine into the wound. Adults aged 18-65 undergoing surgery for conditions like a herniated disc or spinal stenosis…

This study tests whether a single injection of rexlemestrocel-L (a type of stem cell) combined with hyaluronic acid can reduce chronic low back pain for at least 12 months. It involves 300 adults with moderate to severe pain from a worn spinal disc who haven't improved with stand…

This study looks at two different ways to manage pain after lower back surgery without relying on drugs. About 267 adults will be randomly assigned to either standard care or an enriched pain management plan. The goal is to see which approach better reduces pain and helps people …

This study looks at whether a non-surgical treatment called spinal decompression can help people with chronic low back pain. About 42 adults with back pain from disc problems or sciatica will receive the treatment over 12 weeks. Researchers will use MRI scans and movement tests t…

This study looks at two ways to numb people for lower back surgery: general anesthesia (being fully asleep) plus a nerve block, or spinal anesthesia (numbing only the lower body) plus a nerve block. The goal is to see which approach helps patients recover better and feel less pai…

This study looks at whether a digital health program (Hinge Health) plus a wearable pain relief device (Enso) can help people with chronic low back pain feel better and move more easily. About 196 adults with back pain for at least 3 months will be randomly assigned to either the…

This study tests if a wrap made from donated birth tissue (amniotic membrane) can reduce swelling after a two-level neck fusion surgery. About 50 adults with neck spine problems will take part. The main goal is to see if the wrap lessens soft tissue swelling one month after surge…

After lumbar spine surgery, many people stay inactive due to fear of pain or injury. This study tests a program that combines education, walking goals, and activity trackers to help 260 participants increase their daily walking. The goal is to see if this approach can reduce disa…

This study aimed to compare two treatments for chronic low back pain caused by worn-out discs: injections of a person's own stem cells (from bone marrow) versus steroid injections. It planned to enroll adults with pain lasting over 6 months who had not improved with other treatme…

This study is developing and testing a mobile app that guides people with lumbar disc herniation through fascia exercises. Participants will be taught exercises by a physiotherapist and then use either the app, a home brochure, or standard lumbar stabilization exercises. The goal…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study aimed to collect real-world information on the safety and effectiveness of the Synergy Disc, a device used to treat degenerative disc disease in the neck. It planned to look at past and future patients who received the disc. However, the study was withdrawn before enro…

This study compares robot-assisted spine surgery to the traditional method in 300 adults needing spinal fusion. The goal is to see if the robot helps place screws more accurately, reduces complications, and improves patient outcomes. Participants are randomly assigned to either r…

This study was designed to test a new tool that helps surgeons measure and adjust the spine during fusion surgery. The goal was to see if using the tool leads to better spinal alignment and improved patient outcomes, such as less disability. However, the study was withdrawn befor…

This study watches 24 adults who are getting standard neck fusion surgery with a special device called the BEE HA cage. The goal is to see how well the cage helps with pain and function over time. No new treatment is tested—just careful tracking of normal surgery results.

This study looks at three ways surgeons place screws in the spine during surgery: using a robot, using a navigation system, or doing it by hand. The goal is to see which method leads to fewer screws needing to be fixed in a second surgery within the first year. About 932 adults w…

This study reviews medical records of 40 adults with chronic leg pain from back problems who had a procedure called caudal epidural adhesiolysis. The procedure uses a thin tube to break up scar tissue around spinal nerves. Researchers want to find out which patient traits or proc…

This study looks at medical records of 3,500 adults who had a type of back surgery called ALIF between 2010 and 2020. The goal is to see if death rates from this surgery have gone down over the years and whether having a second surgery is riskier than the first. Researchers hope …

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…

This study aimed to understand how physical therapy affects spinal discs in people with low back pain. Researchers planned to use MRI scans to measure changes in the discs before and after 6 weeks of therapy. The goal was to see if these scans could predict which patients would f…

This study looks at whether common balance tests can tell doctors why a person is having trouble with balance. Researchers will test 330 people, including healthy volunteers and patients with stroke, vision problems, inner ear issues, spine problems, or spinal cord damage. The go…

This study looks at how well nerve monitoring works during spine surgery to prevent spinal cord damage. Researchers will track nerve signals in 500 adults having neck or upper back surgery. The goal is to make the alert system more accurate so surgeons can act faster to protect n…

This study follows 150 adults undergoing back-of-the-neck and upper spine surgery with metal screws and rods (posterior fixation) for injuries, tumors, or worn-out discs. Researchers track complications, X-ray results, and patient-reported pain over time. The goal is to better un…

This study planned to test a noninvasive device that stimulates the vagus nerve through the skin to see if it could help people recover consciousness more quickly after anesthesia. The researchers wanted to enroll adults undergoing lumbar spine surgery and measure how fast they w…

This study follows 22 adults undergoing spinal fusion surgery (LLIF or ALIF) to see how long hip and leg weakness lasts. Researchers measure muscle strength before surgery and again at 6 weeks, 12 weeks, and 6 months after. The goal is to give patients a clearer idea of when they…

This study was designed to check how well the Arcadius XP L spine fusion device works and if it is safe for people with chronic low-back pain from conditions like degenerative disc disease or instability. The plan was to follow 60 patients for at least one year after surgery. How…