Intervertebral disk degenerative disorder

This study looks at people who received a total lumbar disc prosthesis (Baguera®L) for lower back pain or sciatica caused by disc degeneration or herniation. The goal is to see how many return to their original job five years after surgery. Unlike spinal fusion, which often limit…

This study followed 77 adults who received spinal implants (PASS LP, PASS DEGEN, or PASS TULIP PRIME) to treat degenerative spine conditions like disc degeneration or spinal deformity. The main goal was to see if the bones fused properly after 24 months. Researchers also tracked …

This study tested whether using a patient's own bone marrow stem cells (BMAC) mixed with donor bone works as well as the standard bone graft taken from the hip for spinal fusion surgery. Seventeen adults with degenerative disc disease were randomly assigned to one of the two meth…

This study looked at how well ViviGen, a bone graft made from donated human bone cells, helps fuse neck bones in people having 2- or 3-level neck surgery. 100 patients were followed to see if their bones fused and how their pain and function improved. The goal was to gather real-…

This study tested a new device called the HYDRAFIL system for people with long-term low back pain from worn-out spinal discs. 35 adults who had not gotten better with standard treatments received the implant. The main goal was to see if the device could be safely placed and help …

This study tested a special spinal implant (the Keos Lumbar Interbody Fusion Device) in 25 adults with degenerative disc disease or related spine conditions. The goal was to see how well the device helped bones fuse and how it affected pain and quality of life. Participants had s…

This study followed 361 adults with degenerative disc disease who had minimally invasive spinal fusion surgery. The goal was to see how well these procedures reduce disability and pain over 5 years. Researchers compared different surgical approaches to find which works best for p…

This study tested a new artificial disc called Simplify® for people with severe neck and arm pain from cervical degenerative disc disease. The trial involved 150 adults who received the disc and were compared to a historical group that had spinal fusion surgery. The goal was to s…

This study followed 145 people who received the Simplify Cervical Artificial Disc to treat neck problems caused by worn-out discs. Researchers checked if the disc was still working safely after 5 years, looking for pain improvement, device failures, or need for more surgery. The …

This study tested a new artificial disc called the Simplify Disc for people with two-level cervical disc disease causing arm pain, neck pain, or nerve problems. The trial involved 182 participants and compared the disc to standard fusion surgery. The goal was to see if the disc i…

This study followed 291 patients for 5 years after receiving the Simplify Disc, an artificial disc for the neck. The goal was to see if the disc remains safe and effective over time. Researchers measured pain, nerve function, and whether any further surgeries were needed.

This study tested a new type of spine surgery called ILIF for people with degenerative disc disease, a condition where spinal discs wear down causing pain and nerve issues. 77 adults over 40 who had not improved with other treatments received the surgery. Researchers measured cha…

This study looked at whether a special bone graft called Osteocel Plus, which contains stem cells, helps the spine bones fuse together after surgery. It included 51 adults with degenerative disc disease who had not improved with other treatments. The goal was to see if this graft…

This study compared two surgical techniques for treating lumbar degenerative disc disease: traditional open surgery (open PLIF) and a newer, less invasive version (MAS PLIF). Researchers tracked complications and pain relief in 67 adults who needed spinal fusion. The goal was to …

This study looked at a product called Osteocel Plus used during neck fusion surgery for people with degenerative disc disease. The goal was to see how well the bones fused together and how safe the product was. 182 adults were followed for 24 months after surgery. The results wer…

This study tested Osteocel Plus, a bone graft material that contains stem cells, in 28 adults with degenerative disc disease who needed spinal fusion surgery. The goal was to see if it helps the spine bones fuse together as well as standard bone grafts. Researchers measured fusio…

This study tested Osteocel Plus, a special bone graft that contains stem cells, in 19 people with degenerative disc disease who needed spinal fusion surgery. The goal was to see if the graft helps bones fuse together as well as the standard method using the patient's own bone. Th…

This study looked at using Osteocel Plus, a bone graft material, in a type of spine surgery called XLIF for people with degenerative disc disease and back pain. 104 adults aged 18-80 who needed fusion of one or two lower spine segments were enrolled. The main goal was to see how …

This study looked at the safety and performance of two types of expandable spine implants (MLX and XLX ACR) in 109 adults with degenerative disc disease, spondylolisthesis, or scoliosis. Researchers tracked complications, bone fusion, and improvement in nerve symptoms after surge…

This study tested a new plate system used during spine fusion surgery in 75 adults with conditions like degenerative disc disease or scoliosis. The goal was to see if the plate is safe and helps bones fuse together properly. Researchers measured pain relief and fusion success ove…

This study looked at how safe and well a new spinal implant (Modulus ALIF System) works in 123 adults having back surgery. The patients had conditions like worn-out discs or slipped vertebrae. The main goals were to check for complications and see if the bones fused properly afte…

This study tested a new 3D-printed titanium implant for spine fusion surgery in 36 adults with degenerative disc disease, spondylolisthesis, or scoliosis. The implant is designed to help bones in the spine grow together after surgery. Researchers looked at safety, how well the bo…

This study tested whether a man-made bone graft putty (AttraX) works as well as using the patient's own bone for spinal fusion surgery. 45 adults with degenerative spine conditions were enrolled. The main goal was to see if the putty helped bones fuse together just as well as the…

This study tested a new artificial disc called NeoDisc against standard fusion surgery (ACDF) in 488 people with a damaged disc in the neck. The goal was to see if NeoDisc is as safe and effective at relieving pain and improving function over two years. Participants were randomly…

This completed study tested two doses of the drug tranexamic acid (TXA) in 62 adults undergoing multilevel spinal surgery. The goal was to see which dose better reduces blood loss and the need for blood transfusions. Results could help surgeons choose the safest and most effectiv…

This early-stage trial tested an experimental treatment called IDCT (injectable disc cell therapy) in 38 people with chronic low back pain due to degenerative disc disease. Participants received either a low or high dose of the cell therapy or a sham procedure. The goal was to ch…

This study looked at how well a bone graft material called Natural Matrix Protein (NMP™) works in 53 patients who had spinal fusion surgery for degenerative disc disease. The main goal was to see if the bones fused properly on CT scans and X-rays. Researchers also measured change…

This study looked at different bone graft materials used during spinal fusion surgery for people with degenerative disc disease. About 119 patients were randomly assigned to receive either their own bone, a protein that stimulates bone growth, or one of three stem-cell-based graf…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study tests a new, long-lasting painkiller (liposomal bupivacaine) that works for up to 72 hours after spine surgery, compared to the standard 6-8 hour painkiller. About 204 adults having lower back surgery will be randomly assigned to receive one of the two painkillers. The…

This completed study compared two minimally invasive surgeries for herniated discs: full endoscopic lumbar discectomy (FELD) and microdiscectomy (MD). Researchers enrolled 200 adults aged 18-85 with single-level disc herniation and sciatica. The goal was to see which technique pr…

This study tested whether a continuous drip of numbing medicine into the surgical wound for two days after back fusion surgery could reduce pain and speed recovery better than a placebo. Fifty adults having lumbar fusion for degenerative spine disease took part. The goal was to i…

This study looked at different rehabilitation programs for 90 adults who had back surgery for degenerative lumbar disease. The goal was to see which rehab approach best reduces nerve pain, helps patients regain function, and improves quality of life. Participants were randomly as…

This study tested two methods of giving a nerve block to control pain after a type of back surgery called unilateral biportal endoscopic discectomy. One method used ultrasound to guide the injection, and the other was done by the surgeon during the operation without ultrasound. T…

This study compared two surgical approaches for people with a single level of lumbar spinal stenosis (a narrowed spine canal causing leg pain and trouble walking). 96 adults aged 40-75 were randomly assigned to receive either minimally invasive decompression and fusion or traditi…

This study looked at whether adding local anesthetics to standard steroid injections in the neck helps people with long-term neck pain. Sixty patients who were already scheduled for the injection took part. Researchers measured pain levels and neck function to see if the combinat…

This study compared two methods of pain control for people having back fusion surgery: a nerve block given before surgery versus numbing medicine injected at the end. Researchers measured pain, inflammation, confusion after surgery, and overall recovery in 29 adults. The goal is …

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This study looked at whether giving patients menthol ice or frozen saline after lumbar disc surgery could reduce thirst and sore throat. 102 adults who had surgery under general anesthesia took part. The researchers measured thirst discomfort and throat pain to see if these simpl…

This study tested a procedure called 'PRP Spinoplasty' for people with long-term lower back pain from disc disease, facet joint arthritis, and muscle spasms. 35 adults who had not improved with standard care received injections of platelet-rich plasma (PRP) into multiple areas of…

This completed study tested a nerve block called the erector spinae plane block in 40 adults with chronic low back pain from degenerative disc disease. The procedure aims to reduce pain and improve daily function. Researchers measured pain levels and disability scores to see if t…

This study looked at ways to manage pain after elective lower back surgery without relying on opioids. The goal was to see if using a combination of non-opioid pain medicines could reduce pain and avoid side effects like nausea or breathing problems. 75 adults having lumbar disc …

This study looked at whether wearing a back brace after spinal fusion surgery improves pain and quality of life. 43 adults with degenerative spine conditions were randomly assigned to wear a brace or not. Researchers measured disability, pain, and general health at 6 weeks and 3 …

This study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…

This pilot study tested whether using ultrasound to guide pharmacopuncture (herbal injections) is safe and effective for neck and back pain. Fifty adults with spinal disorders received the treatment, and researchers tracked side effects, pain levels, disability, and quality of li…

This study looked at whether lumbar traction therapy (a device that gently pulls on the spine) can reduce pain and improve function in people with obesity and chronic low back pain. 49 participants received 30 minutes of traction daily for 4 weeks. Researchers measured pain, disa…

This completed trial tested whether adding battlefield acupuncture (a quick ear-needle technique) to standard electroacupuncture and pain medication can better relieve chronic low back pain caused by spine degeneration. Sixty adults in Vietnam with moderate to severe pain for at …

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This study tested whether using a screening questionnaire called the STarT Back Tool helps doctors tailor low back pain treatment for military members. 290 adults aged 18-50 with low back pain were randomly assigned to either risk-stratified care or usual care. The goal was to se…

This study gathered information from 193 adults who had surgery or orthopedic treatment for spine problems. Researchers collected clinical, functional, and social data to create a detailed database. The goal was to better understand patient outcomes and standardize how data is co…

This study looked at 120 adults with neck or lower back spine issues to compare two types of scans: contrast-enhanced MRI and FDG-PET/CT. Researchers checked how clear the images were and whether the scans caused any short-term changes in kidney function or blood counts. The goal…

This study looked at whether using a special 3D scan during surgery, combined with a navigation system, helps place screws more accurately in the lower back compared to the usual X-ray method. It involved 126 adults having lumbar spine surgery. The main goal was to see if the new…

This completed study looked at how the skeleton is aligned with gravity in adults with postural problems. Researchers used a low-dose X-ray device called EOS to create 3D images of the spine and pelvis. The goal was to better understand the body's geometry in people with balance …

This study looked at 128 adults with back pain from a herniated disc. Researchers measured certain inflammation-related substances in the blood before and after physical therapy or a steroid injection. The goal was to see if these substances change with treatment and if they rela…

This study followed 50 people with chronic low back pain for 10 years after they had a procedure that punctured a spinal disc. Researchers used MRI scans to check if the punctured disc wore out faster than expected. The main goal was to see if the puncture itself caused extra dam…

This study tested a new lightweight device called PYTHEAS ODYSSEE that helps surgeons place screws in the spine more accurately. Fourteen adults having spine surgery used the device to guide screw placement. The goal was to see if the device reduces screw misplacement and is safe…

This study tested whether an internet-based app could improve how well people follow their home rehabilitation exercises after lumbar disc surgery. One hundred adults aged 18 to 59 used the app, which sent reminders, exercise videos, and daily tips, and answered online surveys fo…

This study reviewed records of 107 adults who received steroid injections in the neck for arm and neck pain caused by a pinched nerve. The goal was to find out which patient traits or injection details were linked to better pain relief at 6 months. By identifying these predictors…

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This study looked at using 3D navigation to help guide spine fusion surgery in 11 adults with worn-out discs. The goal was to see if the technology helps place screws more accurately and reduces complications. Researchers measured things like surgery time, blood loss, and pain re…

This study tested whether injecting a contrast dye into the disc space during TLIF spine surgery helps surgeons assess how well they have removed the disc. 56 patients having spinal fusion for degenerative spine disease were randomly assigned to either have the dye used as a chec…

This study looked at how well nerve monitoring works during a type of spine surgery called XLIF. It involved 323 adults with worn-out discs in their lower back. The goal was to see if the monitoring could accurately detect nerve problems during the operation.

This study collected information from over 8,000 people who had spine surgery for conditions like degeneration, deformity, or trauma. Researchers gathered X-ray and health data to learn which treatments work best for different patients. The goal was to build a database to answer …

This study tested a method to monitor nerve health during a specific type of spine surgery called XLIF. Researchers used mild electrical stimulation on the lower back nerves during surgery and checked if changes in nerve signals could predict nerve problems after surgery. 324 adu…

This study tested a new method to monitor nerves during spine surgery for degenerative lumbar disc disease. Researchers used surface electrodes on the skin to stimulate nerves in the lower back and record muscle responses in the legs. The goal was to see if this approach is relia…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study looked back at 465 patients who had lumbar spine fusion surgery for degenerative disc disease. Researchers compared two types of implants (expandable cages and static cages) to see which ones were less likely to sink into the bone after surgery. The goal is to help sur…

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This study reviewed the records of 978 adults who had spinal fusion surgery to see how often routine follow-up X-rays led to additional tests or changes in treatment. The goal is to find out whether these X-rays are truly helpful or if they can be skipped. The results could help …