New artificial disc could replace fusion for neck pain

NCT ID NCT04982835

Ongoing Disease control Sponsor: Orthofix Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new artificial disc (M6-C) for people with two damaged discs in their neck. It compares the disc to standard fusion surgery. The goal is to see if the artificial disc can safely improve neck function and reduce pain. About 156 adults with neck and arm pain from disc disease are taking part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: M6-C artificial cervical disc (a medical device)
What this could lead to: If successful, this could offer a motion-preserving alternative to spinal fusion for people with two-level disc disease, potentially reducing pain and improving neck function.
What could go wrong: This is a mid-stage study with 156 participants, so results may not apply to everyone. Device-related risks include implant failure, infection, or need for additional surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical disk degenerative disorder intervertebral disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL DISC DEGENERATIVE DISORDER

Contacts and locations

Locations

American Neurospine Institute/Medical City Frisco

Frisco, Texas, 75033, United States
Axis Spine

Coeur d'Alene, Idaho, 83815, United States
Beverly Hills Spine Surgery

Beverly Hills, California, 90210, United States
Brigham & Women's Hospital

Boston, Massachusetts, 02115, United States
Carle Health

Urbana, Illinois, 61801, United States
Desert Institute for Spine Care

Phoenix, Arizona, 85020, United States
Disc Sports & Spine Center

Newport Beach, California, 92660, United States
Institute of Neuro Innovation

Santa Monica, California, 90404, United States
Joseph Spine Institute

Tampa, Florida, 33607, United States
Longstreet Clinic

Gainesville, Georgia, 30801, United States
Mayfield Clinic

Cincinnati, Ohio, 45209, United States
Memorial Orthopaedic Surgical Group

Long Beach, California, 90806, United States
Metropolitan Neurosurgery Associates - Englewood Health

Englewood, New Jersey, 07631, United States
Michigan Orthopedic Surgeons

Southfield, Michigan, 48033, United States
Orlando Health

Orlando, Florida, 32809, United States
St. Charles Spine Institute

Thousand Oaks, California, 91860, United States
St. David's Healthcare

Austin, Texas, 78705, United States
Steadman Philipon Research Institute

Vail, Colorado, 81657, United States
The Orthopedic Center of St. Louis

St Louis, Missouri, 63017, United States
UC Irvine Medical Center

Orange, California, 92868, United States
University of Colorado School of Medicine - Department of Orthopedics

Aurora, Colorado, 80045, United States

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