New disc implant could replace neck fusion surgery

NCT ID NCT04469231

Ongoing Disease control Sponsor: Synergy Spine Solutions Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a new artificial disc, the Synergy Disc, to standard spinal fusion surgery for people with one-level cervical degenerative disc disease that hasn't improved with other treatments. About 175 adults aged 18-70 with neck and arm pain or nerve symptoms are being followed for at least 2 years. The goal is to see if the disc is as safe and effective as fusion, with less pain and better movement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Synergy Disc (artificial disc replacement device)
What this could lead to: If successful, this could offer a motion-preserving alternative to spinal fusion for patients with cervical disc disease, potentially reducing long-term complications.
What could go wrong: This is a non-randomized, historically controlled trial with 175 participants, so results may be less reliable than a randomized study. The device could fail or cause complications requiring additional surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL DEGENERATIVE DISC DISEASE

Contacts and locations

Locations

Anschutz Medical Center

Aurora, Colorado, 80045, United States
Atlantic Brain & Spine

Reston, Virginia, 20190, United States
Austin Neurosurgeons

Austin, Texas, 78746, United States
Barrow Brain and Spine

Phoenix, Arizona, 85013, United States
Center for Sports Medicine and Orthopaedic Surgery (CSMO)

Chattanooga, Tennessee, 37404, United States
Central Texas Brain & Spine

Austin, Texas, 78705, United States
Exiamia EquiHealth

Durham, North Carolina, 27704, United States
HonorHealth Research Institute/Barrow Brain and Spine

Scottsdale, Arizona, 85251, United States
Hospital for Special Surgery

New York, New York, 10021, United States
Indiana Spine Group

Carmel, Indiana, 46032, United States
Institute of Neuro Innovation

Santa Monica, California, 90404, United States
Kennedy White Orthopaedic Center

Sarasota, Florida, 34232, United States
Michigan Orthopedic Surgeons

Southfield, Michigan, 48033, United States
Michigan Orthopedic Surgeons (2)

Southfield, Michigan, 48033, United States
Orthopedic Specialty Institute

Orange, California, 92868, United States
Summit Spine

Portland, Oregon, 97225, United States
Texas Spine Care Center

San Antonio, Texas, 78231, United States
The Disc Replacement Center

West Jordan, Utah, 84088, United States
Todd H. Lanman, M.D.

Beverly Hills, California, 90210, United States
Upstate Medical University

East Syracuse, New York, 13057, United States

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