Arthritic joint disease

Researchers at a Korean hospital are following 210 adults who receive a cementless total hip replacement using the collarless Actis femoral stem. The study focuses on Asian patients, who tend to be younger at surgery and more often need the operation because of lost blood supply …

This Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…

This study tests whether wearing a knee sleeve daily for five years can slow the progression of knee arthritis and reduce pain in adults aged 50 to 64 who have had knee pain for at least three months. Participants are randomly assigned to either wear a knee sleeve every day or no…

This study looks at the long-term safety and effectiveness of the drug baricitinib for children aged 1 to 17 with juvenile idiopathic arthritis (JIA). It includes 190 participants who have already taken baricitinib in a previous study. Researchers will monitor side effects and ho…

This trial tests whether transferring gut bacteria from a healthy donor (fecal microbiota transplantation, or FMT) can reduce disease activity in people with axial spondyloarthritis (axSpA) who haven't fully responded to biologic therapy. Participants receive a single enema with …

This trial tests whether a new type of hip resurfacing implant, called the H1, can be as successful as a standard total hip replacement for people with hip arthritis. Participants will receive either the H1 implant or a traditional replacement, and researchers will compare their …

This study is testing the LEGION Medial Stabilized knee implant in 144 people who need total knee replacement due to arthritis or joint damage. The goal is to see how well the implant holds up over 10 years without needing revision surgery. Participants will receive one of three …

This study compares two ways to perform a knee realignment surgery (high tibial osteotomy) in 50 adults with knee arthritis and bow-legged deformity. One group gets the standard surgery using X-ray guidance; the other uses a custom 3D-printed guide to make the bone cut. Researche…

This study tests a drug called bimekizumab in children aged 2 to 17 with specific types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). The goal is to see how the drug moves through the body and if it is safe. About 40 children will take par…

This study compares two types of wrist fusion surgery for people with post-traumatic wrist arthritis. One surgery fuses four wrist bones and removes the scaphoid. The other fuses three or two bones and also removes the triquetrum. The goal is to see which approach gives better gr…

This study is testing a new prosthetic implant for the elbow joint in people with arthritis, instability, or limited motion. The implant replaces the damaged joint to reduce pain and improve function. About 84 participants will be followed for two years to see if the device is sa…

This study follows 50 people who receive a Zimmer Biomet shoulder replacement implant to see if it safely improves pain, movement, and quality of life over two years. Participants have shoulder arthritis, fractures, or other joint damage. The main goal is to measure a meaningful …

This study compares two types of knee implants (medial congruent vs. posterior stabilized) in people having total knee replacement for arthritis. All surgeries will be done with the ROSA robotic system. Researchers will track 200 participants for up to 5 years to see which implan…

This study tests whether a new surgical irrigation solution called XPERIENCE can lower the risk of joint infection after hip or knee replacement better than the standard dilute Betadine wash. About 7,600 adults having primary hip or knee replacement will be randomly assigned to r…

This study compares two types of shoulder replacement surgery for people aged 65-85 with shoulder arthritis. The goal is to see if a newer type of replacement (reverse shoulder) works as well as the standard one. Participants will be randomly assigned to one surgery and followed …

This study follows over 1,000 people who receive a shoulder replacement with FX Shoulder Solutions systems. Researchers will track how often the implant needs to be replaced (revision) and measure pain, movement, and quality of life for up to 10 years after surgery. The goal is t…

This study is testing a new synthetic implant for the big toe joint in people with arthritis. The implant replaces the damaged joint surface to reduce pain and improve function. About 20 adults aged 21-75 with moderate to severe arthritis will be enrolled and followed for safety …

This study is testing a drug called olokizumab in children aged 2 to 18 with active juvenile idiopathic arthritis. The drug is given as a shot under the skin every 4 weeks. Researchers want to see how the drug moves through the body, if it helps control arthritis symptoms, and if…

This study compares the usual surgery for thumb arthritis to a newer procedure that implants donated tissue at the base of the thumb. Researchers will track hand function and pain in 200 adults for one year after surgery. The goal is to see if the new approach leads to better rec…

This early-phase trial is testing a new treatment called KN5601, which uses a patient's own immune cells (NK cells) that have been engineered to target and destroy harmful B cells. The goal is to see if it is safe and can help children aged 5 and older with rheumatic diseases lik…

This study compares two versions of a shoulder replacement surgery for people with shoulder arthritis. In one version, surgeons repair a small but important tendon called the subscapularis; in the other, they leave it unrepaired. The goal is to see which approach gives better sho…

This study compares two types of knee replacement surgery for people with advanced knee arthritis: a standard total knee replacement and a robotic-assisted partial knee replacement. The goal is to see which one leads to better knee function and is more cost-effective. About 159 a…

This study is tracking 550 adults aged 18–75 who receive the Medacta SMS femoral stem during total hip replacement. Researchers will monitor how long the implant lasts, how well the hip functions, patient satisfaction, and quality of life. The goal is to confirm the device's safe…

This study follows 150 people aged 18 to 65 who receive the ROMAX hip resurfacing system to treat hip arthritis or dysplasia. Researchers will track how long the implant lasts and how well the hip functions over 10 years. The goal is to monitor the device's safety and performance…

This study tests a portable device that sends mild electrical pulses to the vagus nerve through the ear, aiming to calm the immune system and reduce joint inflammation. It involves 128 adults with moderate-to-severe rheumatoid arthritis who have not responded well to standard bio…

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned t…

This trial compares two injection sites for steroid shots in people with moderate-to-severe knee osteoarthritis. Participants get the injection on either the inside or outside of the knee, then report pain and function over 12 weeks. The goal is to see if one spot provides better…

This study tests an online wellness course that teaches diet, exercise, stress reduction, and self-care to people with rheumatoid arthritis, lupus, Sjogren's syndrome, and similar conditions. Researchers want to see if the program reduces fatigue and improves quality of life. Abo…

This pilot study tests a care model called Patient Priorities Care (PPC) for older African Americans with heart disease plus other chronic conditions like diabetes or COPD. The approach shifts focus from treating each disease separately to aligning care with what matters most to …

This study looks at whether a Mediterranean-style diet can improve arthritis symptoms in children by changing the bacteria in their gut. Fifty-four children aged 8-18 with juvenile idiopathic arthritis will follow the diet for 8 weeks, with an option to continue for 4 more weeks.…

This study looks at whether formal hand therapy is needed after surgery for thumb arthritis. About 180 adults having thumb joint surgery will be randomly assigned to either get standard in-clinic therapy or not. The goal is to see if skipping therapy affects thumb movement and fu…

This study tests whether sleeping near a special device that claims to emit 'biophotons' can reduce chronic severe arthritis pain. About 102 adults with long-term arthritis pain will use either the active device or a placebo (inactive) device for 12 weeks. Researchers will measur…

This study tests whether Multiprofen-CC cream, applied three times daily, reduces pain in adults with hand osteoarthritis. Forty-two participants will use both the active cream and a placebo for two weeks each, in random order. Researchers will measure pain, hand function, and si…

This study compares a standard opioid painkiller (oxycodone) to a placebo in people recovering from orthopedic surgery like joint replacements. The goal is to see if a non-opioid pain management plan can control pain just as well. About 80 adults having various orthopedic procedu…

This study tests whether a group exercise program done over video calls is practical and helpful for Veterans with knee or hip arthritis. Fifty participants will exercise together online for 3 months, then get either text reminders or extra group sessions for 6 more months. Resea…

This study tests a procedure called transarterial microembolization (TAME) for people with knee osteoarthritis and long-lasting pain that hasn't improved with standard treatments. Doctors will inject tiny beads into blood vessels around the knee to block abnormal blood flow, aimi…

This study tests whether freezing certain nerves (cryoablation) during total knee replacement surgery can reduce pain and the need for opioid painkillers afterward. About 215 adults scheduled for knee replacement will be randomly assigned to receive either standard surgery or sur…

This study looks at how three different levels of physical activity—45, 90, or 150 minutes per week—affect arthritis symptoms like pain and mobility. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. Participant…

This study tests whether dapansutrile tablets can reduce joint pain from an acute gout flare better than a placebo. About 300 adults with confirmed gout will take the drug or a dummy pill for 7 days. The main goal is to see if pain drops significantly within 72 hours of the first…

This study tests whether the drug adalimumab can help people with arthritis caused by cancer immunotherapy use less steroids. About 30 adults will be randomly assigned to receive either adalimumab or standard steroid treatment. The goal is to see if adalimumab can control arthrit…

This study compares two common shoulder injections—corticosteroids and platelet-rich plasma (PRP)—to see which provides better pain relief for people with advanced shoulder arthritis. About 200 adults with bone-on-bone arthritis will receive one of the two injections and report t…

This study tests whether a type of exercise called diagonal proprioceptive neuromuscular facilitation (PNF) can reduce pain and improve function in people with knee osteoarthritis. Researchers will compare PNF exercises to standard strength training in 150 adults aged 40-60. Both…

This study tests a self-management program for people recently diagnosed with inflammatory arthritis. The program includes nurse sessions to help patients learn skills to manage their condition. Researchers will compare the program plus usual care to usual care alone in 130 adult…

This study tests whether eating freeze-dried wild blueberry powder every day for 12 weeks can improve gut health, reduce inflammation, and ease joint pain in adults with arthritis. Fifty participants will take either the blueberry powder or a placebo, with a 2-week break between …

This study is testing whether herbal medicine and vitamin IV therapy can reduce symptoms of anxiety, fibromyalgia, arthritis, chronic pain, and high blood pressure. Researchers plan to enroll 25 people and measure improvements in health and quality of life. The approach uses natu…

This study follows up to 2,000 people with spondyloarthritis (a group of inflammatory joint and spine conditions) and their healthy relatives. Researchers aim to identify symptoms, genetic factors, and medical tests that predict who will develop more severe forms of the disease. …

This study aims to learn more about alkaptonuria, a rare genetic disease that causes a pigment to build up in bones and tissues, leading to arthritis and other problems. Researchers will evaluate 300 patients over several years using advanced medical tests. The goal is to better …

This study aims to learn more about the causes of rheumatic diseases—conditions that cause joint pain, stiffness, and swelling—and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing…

This study aims to understand the causes and progression of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) by observing up to 2,000 participants over time. Researchers will collect medical history, blood samples, and genetic data to identify …

This observational study follows up to 20,000 children and young adults with pediatric-onset rheumatic diseases, such as juvenile idiopathic arthritis. Researchers collect data on treatments, safety, and long-term outcomes to better understand these conditions. The registry does …

This study looks at how the rotator cuff muscles are doing one and two years after total shoulder replacement surgery. Researchers will use EMG and CT scans to check for nerve damage or tears in the muscles. About 30 adults who had shoulder replacement for osteoarthritis will tak…

This study follows 300 adults with systemic lupus erythematosus (SLE) who are seen by a team of specialists at a hospital in Brest, France. Researchers will collect data on disease patterns, symptoms, and test results over time. The goal is to better understand lupus and improve …

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study is creating a large collection of joint fluid and blood samples from 500 people with different types of arthritis. Researchers will use these samples to test new biomarkers that could help diagnose arthritis earlier and monitor how the disease changes over time or with…

This study looks at whether a doctor's computer tool (MedSafer) and patient brochures (EMPOWER) can help reduce the use of potentially harmful medications in adults aged 60 and older with rheumatic diseases who take five or more regular drugs. Researchers will follow 100 particip…

This study aims to better understand why people with inflammatory arthritis experience chronic pain. Researchers will look at how the brain processes pain and how it affects daily life. 350 adults starting or switching arthritis medications will be followed over time. The goal is…

This study aims to understand how rheumatic side effects (like arthritis) from cancer immunotherapy affect patients' daily lives. Researchers will interview 20 adults who have experienced these side effects to learn about their severity and impact. The goal is to improve future c…

This study aims to better understand rare forms of inflammatory arthritis, including those linked to other autoimmune diseases or cancer immunotherapy. Researchers will analyze joint tissue samples from 100 adults to compare the immune cells and molecules involved. The goal is to…

This study looks at whether palliative and supportive care, usually given to people near the end of life, could also help those with long-term inflammatory arthritis like rheumatoid arthritis. Researchers will interview patients and survey healthcare professionals to understand u…

This study looks at whether brain scans can predict if someone will be satisfied after knee replacement surgery. Up to 1 in 5 patients still have pain or trouble moving after surgery, and doctors can't currently predict who. Researchers will scan the brains of 50 adults before an…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect bone issues like cancer, infection, or arthritis. About 200 adults will receive a tiny amount of radioactive tracer and be scanned on a high-sensitivity machine. The go…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…