Acute respiratory failure

This study tests whether reducing immunosuppressive drugs (along with giving a steroid) helps kidney transplant patients recover from septic shock or severe breathing failure in the ICU. About 212 adults whose transplant was at least 3 months ago will be randomly assigned to eith…

This study tests a temporary device that stimulates the diaphragm (the main breathing muscle) in ICU patients on breathing machines. The goal is to see if it helps patients breathe more on their own and recover from lung injury. About 30 adults with severe breathing failure will …

This study tests whether awake patients with acute breathing failure who lie face down (prone positioning) for at least 10 hours a day for 3 days are less likely to need a breathing tube or die within 28 days, compared to standard care. The trial will include 342 intensive care u…

This study compares two oxygen therapy strategies for adults in the ICU with severe breathing failure. One group gets high-flow oxygen alone, the other gets high-flow oxygen plus CPAP sessions. The goal is to see if adding CPAP reduces the need for a breathing tube and lowers the…

This study looks at whether a special vibrating device placed on the chest can improve breathing in older patients with a hip fracture who also have respiratory failure. 60 participants will receive the therapy for 5 days, and doctors will check their blood oxygen levels and lung…

This study tests a new method for setting ventilator support in ICU patients with acute hypoxic respiratory failure. Instead of using traditional targets like breath size and rate, the new approach adjusts support based on how hard the patient is breathing. The goal is to see if …

This study tests whether measuring a blood marker called interleukin-6 (IL-6) can help doctors decide when to give anti-inflammatory drugs to patients hospitalized with acute respiratory failure. Patients with high IL-6 levels will receive either standard care, a single dose of t…

This study tests a new AI device called EMILY that automatically adjusts oxygen levels for people with acute or chronic respiratory failure. Researchers will enroll 20 adults in the hospital to see how well the device keeps oxygen in a safe range and how quickly it responds to ch…

This study is testing a small device called the MiniLung petite kit, which helps oxygenate blood and remove carbon dioxide in newborns and children weighing 2 to 8 kilograms who have severe breathing or heart failure. The device works with a console to temporarily take over the w…

This study tests three ways to help patients with severe low oxygen levels breathe better without needing a breathing tube. About 1,200 adults will be randomly assigned to receive either a helmet mask that pushes air, a helmet mask that keeps airways open, or high-flow oxygen thr…

This study tests whether the sedative dexmedetomidine can help critically ill patients tolerate non-invasive ventilation (a mask that helps breathing) and avoid needing a breathing tube. About 846 adults with acute respiratory failure will receive either the drug or a placebo. Th…

This study is testing a new way to check the health of ICU patients who are on breathing machines. Researchers collect a small sample of the air patients breathe out and analyze its proteins. They also take a blood sample to look for related changes in DNA, RNA, and other molecul…

This study looks at whether a bedside ultrasound of a large vein (the inferior vena cava) can help emergency doctors quickly tell if a patient's breathing trouble is caused by fluid buildup in the lungs from heart failure or from another cause. Researchers will enroll 200 adults …

This study tests a new device called Heecap that uses gentle electrical stimulation to keep the breathing muscles active in ICU patients on mechanical ventilators. Many patients on ventilators develop weak breathing muscles, which can make it hard to breathe on their own later. T…

This study tests whether giving acetaminophen (Tylenol) and ketorolac (Toradol) to children on ventilators can better control pain and reduce the need for strong opioids. About 644 children aged 2 months to 17 years with acute respiratory failure will be randomly assigned to rece…

This pilot study tests a self-management program based on cognitive behavioral therapy to help people who survived acute respiratory failure and now struggle with anxiety. Sixty ICU survivors will either receive the program or usual care. The goal is to see if the program is prac…

This study looks at whether placing infants with breathing problems from infections like RSV on their stomach (prone) helps them breathe better than lying on their back (supine). Forty babies under 1 year old on breathing support will be placed in each position for one hour. Rese…

This study compares two ways of giving breathing support to adults with acute respiratory failure in the ICU. One group gets standard noninvasive ventilation (a mask that helps breathing), while two other groups get that plus a high-flow nasal cannula (a device that delivers warm…

This study tests whether using a bougie—a thin, flexible guide—on the first attempt helps doctors insert a breathing tube more successfully in emergency situations outside the hospital. About 710 adults needing emergency intubation will be randomly assigned to receive either a bo…

This study compares two types of video laryngoscope blades—hyperangulated and Macintosh—to see which leads to successful intubation on the first try in ICU patients. Over 1,000 adults needing a breathing tube will be randomly assigned to one blade type. The goal is to find out if…

Researchers at Evangelismos Hospital are studying adults who arrive in the emergency department with sudden acute hypoxemic respiratory failure, a condition where the blood oxygen drops dangerously low. The team collects clinical, imaging, physiological, and biological data early…

This study looks at 60 ICU patients with low oxygen levels who are receiving high-flow oxygen therapy. Researchers will use a non-invasive sensor to measure breathing variability, which may help doctors decide the best time to switch to a breathing tube. The goal is to find early…

This study aims to find out how often rhinovirus (the virus behind many common colds) causes serious breathing problems that require hospital care in children. Researchers will follow 120 young children at home for 3 years and study 450 hospitalized infants and children, plus 100…

This study looks at two different approaches to deciding when to place a breathing tube in patients with acute hypoxemic respiratory failure (dangerously low oxygen levels). One strategy is more liberal (intubate earlier to prevent complications from low oxygen), while the other …

This pilot study tests whether using a lower breathing rate on ventilators is safe and practical for critically ill patients. About 56 adults on breathing machines will be randomly assigned to either the new lower-rate approach or standard care. The goal is to see if the new meth…

This study tests whether a live video connection between paramedics and pediatric emergency doctors improves care for critically ill children. Paramedics will treat infant mannequins in simulated ambulance scenarios, with some getting video support and others only audio. The goal…

This study compares a step-by-step protocol for stopping high-flow nasal oxygen therapy against usual doctor-led care in 148 adults with acute respiratory failure. The protocol uses oxygen levels and breathing rate to decide when to stop. The goal is to see if a standard approach…

This observational study with 300 ICU patients aims to see if combining blood markers (metabolomics) with standard clinical data can better predict when high-flow nasal cannula fails, requiring a breathing tube. Researchers will collect blood samples and monitor outcomes to build…

This study tests whether a new measure called the Pressure-Muscle Index (PMI) can help doctors set ventilators more precisely for ICU patients with acute breathing failure. The goal is to avoid giving too much breathing support, which can harm the diaphragm and lungs. Thirty-six …

This study is testing whether two non-invasive tools—ultrasound and electrical impedance tomography (EIT)—can help doctors monitor breathing muscles in patients with acute respiratory failure who are using non-invasive breathing support. Up to 100 adults will be enrolled, with me…

This study tests whether a special imaging technique called electrical impedance tomography (EIT) can safely measure blood flow and air distribution in the lungs of children with acute respiratory failure. Twenty children under 12 who are on breathing machines will receive a smal…

This observational study looks at 30 adults with acute respiratory failure on mechanical ventilation. Researchers want to see if a bedside device called electrical impedance tomography (EIT) can reliably guide ventilator pressure settings, compared to the current gold standard (C…

This study looks at whether using an EEG (a device that measures brain activity) can give a more accurate picture of sleep quality in intensive care patients with acute respiratory failure, compared to the usual nurse assessments. About 47 adults in the ICU will have their sleep …

This study compares two methods—waveform capnography and a color-changing carbon dioxide detector—to see which more accurately confirms that a breathing tube is in the right place (the windpipe) in critically ill adults. About 2,000 patients in emergency departments or intensive …

This study is testing many different treatments for patients with severe breathing problems in the intensive care unit. It will include up to 6,250 participants and looks at various approaches like breathing machine settings, medications, and life support techniques. The goal is …

This study looks at how the brain and lungs communicate in patients with severe breathing failure who are getting high-flow oxygen. Researchers will use brain wave monitors (EEG), oxygen sensors (NIRS), and muscle activity sensors (EMG) before and after starting oxygen therapy. T…

This study is collecting data from 250 patients with acute respiratory failure to develop an AI model that groups patients by their characteristics. The goal is to personalize treatment and improve outcomes. It is an observational study, meaning no new drug or device is being tes…

This pilot study tests whether sodium bicarbonate (baking soda) can be used safely as a contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on breathing machines. Researchers will compare it to standard hypertonic saline in 41 ICU patients.…

This study looks at whether a special ultrasound technique can help doctors choose the right oxygen flow for patients who have trouble breathing. Researchers will measure how the diaphragm moves in healthy people and in patients with respiratory failure. The goal is to see if thi…

This study looks at how the type of oxygen monitor and the oxygen level target affect the amount of oxygen given to ICU patients on high-flow nasal oxygen therapy. Researchers will test two different monitors and two oxygen targets in 30 adults. The goal is to see which combinati…

This study looks at how changing the pressure inside the lungs (called PEEP) affects how hard patients have to work to breathe while on a ventilator. Twelve adults in the ICU who are already breathing with some help from a machine will have their PEEP set to four different levels…

This study looks at whether patients with severe breathing problems in the ICU should be allowed to eat or drink before they need a breathing tube. Currently, patients are often kept fasting to prevent food from entering the lungs, but this can cause discomfort and malnutrition. …

This study follows 235 adults who survived acute respiratory failure (ARF) and their family caregivers. Over 6 months, they complete surveys about their expectations, mood, and coping. The goal is to see if positive or negative expectations are linked to anxiety, depression, and …

This study compares two ways to place a breathing tube in emergency patients who are still breathing on their own but need help. The methods are Rapid Sequence Intubation (RSI) and Delayed Sequence Intubation (DSI). Researchers will measure oxygen levels, complications, and survi…

This observational study will enroll 50 mechanically ventilated patients with acute respiratory failure to compare two methods of assessing lung recruitment: the recruitment-to-inflation ratio (R/I ratio) and 2D/3D electrical impedance tomography (EIT). Participants will undergo …

This study looks at whether measuring oxygen levels on a facemask is reliable for critically ill patients who need a breathing tube. Doctors usually rely on pulse oximetry, but that can be misleading. The researchers will compare facemask readings with a more accurate pharyngeal …

This study uses a non-invasive imaging technique called electrical impedance tomography to watch how air moves through the lungs of children with acute respiratory failure in the pediatric ICU. Researchers will observe how changes in ventilator settings, body position, suctioning…

This study observes 325 adults with acute breathing failure who are using non-invasive breathing support like high-flow oxygen or a mask ventilator. Researchers want to find out which patients end up needing a breathing tube. The goal is to better predict and prevent treatment fa…

This study is testing a new method for giving muscle relaxants to patients with severe breathing problems who are on a breathing machine. The goal is to see if this approach is safe and possible, and if it helps patients breathe on their own more easily. About 23 adults in the ho…

This study looks back at medical records of about 59 ICU patients who used a low-flow carbon dioxide removal (ECCO2R) machine for breathing failure. The goal is to describe how the device was used and what happened to patients, including survival and side effects. It does not tes…

This study looks at 100 patients with acute respiratory failure who are on a breathing machine (ventilator). Researchers want to measure lung instability, which happens when parts of the lung open and close with each breath. They will use a safe, quick method to analyze data from…

This study tests whether providing gentle nasal airflow to sedated, intubated patients with low oxygen levels can improve brain activity and lung function. Researchers will measure brain waves, blood flow, and lung ventilation under different airflow settings. The goal is to unde…

This study looks at how changing the pressure in a breathing machine (ventilator) affects the effort and drive to breathe in 20 ICU patients with severe lung failure. Researchers will test six different pressure levels and measure breathing muscles, lung activity, and oxygen leve…

This study compares three different facemasks used with a breathing machine (noninvasive ventilation) in 20 people whose lungs are not removing carbon dioxide well. The goal is to see which mask reduces the work of breathing and helps clear CO2 more effectively. Participants will…