Massive trial aims to find best treatments for breathing failure in ICU patients

NCT ID NCT05440851

Recruiting now Knowledge-focused Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing many different treatments for patients with severe breathing problems in the intensive care unit. It will include up to 6,250 participants and looks at various approaches like breathing machine settings, medications, and life support techniques. The goal is to find which treatments work best to help patients survive and recover.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTRACORPOREAL MEMBRANE OXYGENATION COMPLICATION MECHANICAL VENTILATION PRESSURE HIGH RESPIRATORY INSUFFICIENCY

Contacts and locations

Locations

ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, MI, 20162, Italy
Auckland City Hospital
RECRUITING

Grafton, Auckland, 1023, New Zealand
Azienda Socio-Sanitaria Territoriale Ovest Milanese
RECRUITING

Legnano, MI, 20025, Italy
Bendigo Health Victoria
RECRUITING

Bendigo, Victoria, 3550, Australia
Brantford General Hospital
RECRUITING

Brantford, Ontario, N3R 1G9, Canada
Centre Hospitalier Universite de Sherbrooke
RECRUITING

Sherbrooke, Quebec, J1J 3H5, Canada
Centre hospitalier de l'Université de Montréal (CHUM)
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Cité de la Santé Hospital
NOT_YET_RECRUITING

Laval, Quebec, H7M 3L9, Canada
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Clínica Universidad de La Sabana
RECRUITING

Chía, Cundinamarca, Colombia
Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States
Cortellucci Vaughan Hospital
RECRUITING

Vaughan, Ontario, L6A 4Z3, Canada
Flinders Medical Centre
RECRUITING

Bedford Park, Southern Adelaide, 5042, Australia
Grace Hospital
RECRUITING

Winnipeg, Manitoba, R3J 3M7, Canada
Halton Healthcare
RECRUITING

Oakville, Ontario, L6M 0L8, Canada
Hamilton Health Sciences Centre - General
RECRUITING

Hamilton, Ontario, L8L 2X2, Canada
Hamilton Health Sciences Centre - Juravinski
RECRUITING

Hamilton, Ontario, L8V 1C3, Canada
Health Sciences Centre - Winnipeg
RECRUITING

Winnipeg, Manitoba, R3A 1R9, Canada
Hospital Josep Trueta (Girona)
RECRUITING

Girona, 17007, Spain
Hospital Universitario de Getafe
NOT_YET_RECRUITING

Getafe, Madrid, 28905, Spain
King Abdulaziz Medical City- Riyadh
RECRUITING

Riyadh, 11426, Saudi Arabia
Kingston Health Sciences Centre
RECRUITING

Kingston, Ontario, K7L 2V7, Canada
Lakeridge Hospital
RECRUITING

Oshawa, Ontario, L1G 8A2, Canada
London Health Sciences Centre - University Hospital
NOT_YET_RECRUITING

London, Ontario, N6A 5W9, Canada
London Health Sciences Centre - Victoria Hospital
NOT_YET_RECRUITING

London, Ontario, N6A 5W9, Canada
MUHC - McGill University Health Centre (Glen Site)
RECRUITING

Montreal, Quebec, H4A 0B1, Canada
Mackenzie Health
RECRUITING

Richmond Hill, Ontario, L4C 4Z3, Canada
Medical University of South Carolina (MUSC)
RECRUITING

Charleston, South Carolina, 29425, United States
Middlemore Hospital
RECRUITING

Auckland, 2025, New Zealand
Mount Sinai New York City
RECRUITING

New York, New York, 10029, United States
Nanaimo Regional General Hospital
RECRUITING

Nanaimo, British Columbia, V9S 2B7, Canada
National University of Singapore
RECRUITING

Singapore, 119077, Singapore
Nepean Hospital
RECRUITING

Kingswood, New South Wales, 2747, Australia
Niagara Health Systems
RECRUITING

Saint Catherines, Ontario, L2S 0A9, Canada
North York General Hospital
RECRUITING

North York, Ontario, M2K 1E1, Canada
Nova Scotia Health Authority
RECRUITING

Halifax, Nova Scotia, B3S 0H6, Canada
Oak Valley Health
RECRUITING

Markham, Ontario, L3P 7P3, Canada
Oregon Health & Science University (OHSU)
RECRUITING

Portland, Oregon, 97239, United States
Ospedale Maggiore, Fondazione IRCCS Ca Granda, Milano
RECRUITING

Milan, MI, 20122, Italy
Ottawa Heart Research Institute
NOT_YET_RECRUITING

Ottawa, Ontario, K1Y 4W7, Canada
Parc Taulí University Hospital
ACTIVE_NOT_RECRUITING

Sabadell, Barcelona, 08208, Spain
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Rotorua Hospital
RECRUITING

Rotorua, 3010, New Zealand
Royal Jubilee Hospital
RECRUITING

Victoria, British Columbia, V8R 1J8, Canada
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Sacre Coeur du Montreal
RECRUITING

Montreal, Quebec, H4J 1C5, Canada
Scarborough Health Network
RECRUITING

Toronto, Ontario, M1P 2V5, Canada
Sentara Health
RECRUITING

Norfolk, Virginia, 23507, United States
Sinai Health, Mount Sinai Hospital
RECRUITING

Toronto, Ontario, M5G 1X5, Canada
St Vincents Sydney
RECRUITING

Darlinghurst, Sydney, 2010, Australia
St. Boniface Hospital
RECRUITING

Winnipeg, Manitoba, R2H 2A6, Canada
St. Joseph's Hamilton
RECRUITING

Hamilton, Ontario, L8N 4A6, Canada
St. Paul's Hospital
RECRUITING

Vancouver, British Columbia, V6Z 1Y6, Canada
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Surrey Memorial Hospital
RECRUITING

Surrey, British Columbia, V3V 1Z2, Canada
Taranaki Base Hospital
RECRUITING

New Plymouth, 4310, New Zealand
The Austin Hospital
RECRUITING

Heidelberg, Victoria, 3084, Australia
The Johns Hopkins Medicine
RECRUITING

Baltimore, Maryland, 21224, United States
The Ottawa Hospital
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Trois Riviere (CHAUR)
RECRUITING

Trois-Rivières, Quebec, G8Z 3R9, Canada
Unity Health Toronto
RECRUITING

Toronto, Ontario, M5C 2T2, Canada
Universidad de La Sabana
RECRUITING

Chía, Cundinamarca, Colombia
University Health Network
RECRUITING

Toronto, Ontario, Canada
University Hospital Geelong
RECRUITING

Geelong, Victoria, 3220, Australia
University of Alberta/Edmonton University Hospital
RECRUITING

Edmonton, Alberta, T6G 2X8, Canada
University of Arizona
RECRUITING

Tucson, Arizona, 85724, United States
University of Calgary
RECRUITING

Calgary, Alberta, T2N 1N4, Canada
University of California Los Angeles (UCLA)
RECRUITING

Los Angeles, California, 90095, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Cincinnati College of Medicine
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
University of Kentucky
RECRUITING

Lexington, Kentucky, 40506, United States
University of Maryland Medical System
RECRUITING

Baltimore, Maryland, 21201, United States
University of Michigan Health
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center (UPMC)
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of San Diego (UCSD)
RECRUITING

San Diego, California, 92121, United States
University of Saskatchewan
RECRUITING

Saskatoon, Saskatchewan, S7N 0W8, Canada
University of Utah Health
RECRUITING

Farmington, Utah, 84025, United States
VA Ann Arbor Healthcare System
NOT_YET_RECRUITING

Ann Arbor, Michigan, 48105, United States
Vancouver Island Health - Royal Jubilee Hospital & Nanaimo Hospital
RECRUITING

Victoria, British Columbia, V8R 1J8, Canada
Vanderbilt university medical center
RECRUITING

Nashville, Tennessee, 37232, United States
Wake Forest University School of Medicine
RECRUITING

Winston-Salem, North Carolina, 27101, United States
Washington University
RECRUITING

St Louis, Missouri, 63130, United States
William Osler Health System
RECRUITING

Brampton, Ontario, L6R 3J7, Canada
Windsor Regional Health
RECRUITING

Windsor, Ontario, N8W 1L9, Canada
Wollongong Hospital
RECRUITING

Wollongong, New South Wales, 2500, Australia

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