Can a simple Oxygen-Weaning protocol keep breathing patients off the ventilator?

NCT ID NCT07638293

Recruiting now Knowledge-focused Sponsor: University of Milan Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a step-by-step protocol for stopping high-flow nasal oxygen therapy against usual doctor-led care in 148 adults with acute respiratory failure. The protocol uses oxygen levels and breathing rate to decide when to stop. The goal is to see if a standard approach reduces the chance of needing to restart oxygen or move to a breathing machine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: high-flow nasal therapy weaning protocol
What this could lead to: If successful, this could establish a standard way to safely stop high-flow oxygen therapy, reducing hospital stays and preventing breathing setbacks.
What could go wrong: This is a small, early-stage trial (148 participants) testing a process, not a new drug. The protocol may not work better than doctors' judgment, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

acute respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE RESPIRATORY FAILURE (ARF)

Contacts and locations

Locations

Pulmonology Unit, ASST Santi Paolo e Carlo. Department of Health Sciences, University of Milan, Milan (Italy)
RECRUITING

Milan, Lombardy, 20142, Italy
Pulmonology Unit, University Hospital "G. Rodolico-San Marco"
NOT_YET_RECRUITING

Catania, Sicily, 95123, Italy

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